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1.
  • Alexandersson, Bjarki T., et al. (author)
  • Diverticulosis is not associated with altered gut microbiota nor is it predictive of future diverticulitis : a population-based colonoscopy study
  • 2023
  • In: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 0036-5521 .- 1502-7708. ; 58:10, s. 1131-1138
  • Journal article (peer-reviewed)abstract
    • Background: The etiopathogenesis of diverticular disease is unknown.Objective: To compare the fecal and mucosa-associated microbiota between participants with and without diverticulosis and participants who later developed diverticulitis versus those that did not from a population-based study.Methods: The PopCol study, conducted in Stockholm, Sweden, invited a random sample of 3556 adults to participate, of which 745 underwent colonoscopy. Overall, 130 participants (17.5%) had diverticulosis. 16S rRNA gene sequencing was conducted on available sigmoid biopsy samples from 529 and fecal samples from 251 individuals. We identified individuals who subsequently developed acute diverticulitis up to 13 years after sample collection. In a case-control design matching for gender, age (+/−5 years), smoking and antibiotic exposure, we compared taxonomic composition, richness and diversity of the microbiota between participants with or without diverticulosis, and between participants who later developed acute diverticulitis versus those who did not.Results: No differences in microbiota richness or diversity were observed between participants with or without diverticulosis, nor for those who developed diverticulitis compared with those who did not. No bacterial taxa were significantly different between participants with diverticulosis compared with those without diverticulosis. Individuals who later developed acute diverticulitis (2.8%) had a higher abundance of genus Comamonas than those who did not (p = .027).Conclusions: In a population-based cohort study the only significant difference was that those who later develop diverticulitis had more abundance of genus Comamonas. The significance of Comamonas is unclear, suggesting a limited role for the gut microbiota in the etiopathogenesis of diverticular disease.
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4.
  • Aldi, Silvia, et al. (author)
  • Dual roles of heparanase in human carotid plaque calcification
  • 2019
  • In: Atherosclerosis. - : ELSEVIER IRELAND LTD. - 0021-9150 .- 1879-1484. ; 283, s. 127-136
  • Journal article (peer-reviewed)abstract
    • Background and aims: Calcification is a hallmark of advanced atherosclerosis and an active process akin to bone remodeling. Heparanase (HPSE) is an endo-beta-glucuronidase, which cleaves glycosaminoglycan chains of heparan sulfate proteoglycans. The role of HPSE is controversial in osteogenesis and bone remodeling while it is unexplored in vascular calcification. Previously, we reported upregulation of HPSE in human carotid endarterectomies from symptomatic patients and showed correlation of HPSE expression with markers of inflammation and increased thrombogenicity. The present aim is to investigate HPSE expression in relation to genes associated with osteogenesis and osteolysis and the effect of elevated HPSE expression on calcification and osteolysis in vitro.Methods: Transcriptomic and immunohistochemical analyses were performed using the Biobank of Karolinska Endarterectomies (BiKE). In vitro calcification and osteolysis were analysed in human carotid smooth muscle cells overexpressing HPSE and bone marrow-derived osteoclasts from HPSE-transgenic mice respectively.Results: HPSE expression correlated primarily with genes coupled to osteoclast differentiation and function in human carotid atheromas. HPSE was expressed in osteoclast-like cells in atherosclerotic lesions, and HPSE-transgenic bone marrow-derived osteoclasts displayed a higher osteolytic activity compared to wild-type cells. Contrarily, human carotid SMCs with an elevated HPSE expression demonstrated markedly increased mineralization upon osteogenic differentiation.Conclusions: We suggest that HPSE may have dual functions in vascular calcification, depending on the stage of the disease and presence of inflammatory cells. While HPSE plausibly enhances mineralization and osteogenic differentiation of vascular smooth muscle cells, it is associated with inflammation-induced osteoclast differentiation and activity in advanced atherosclerotic plaques.
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  • Almbladh, Carl-Olof, et al. (author)
  • THEORY OF RESONANT EMISSION PROCESSES IN METALS
  • 1984
  • In: Annals of the Israel Physical Society. - 0309-8710. ; 6, s. 309-311
  • Conference paper (peer-reviewed)abstract
    • A simple and transparent formalism is presented to treat emission processes in general and resonant emission processes in metals in particular. As an example resonant photoemission in Cu metal is discussed.
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7.
  • Aryasetiawan, F., et al. (author)
  • Multiple Plasmon Satellites in Na and Al Spectral Functions from Ab Initio Cumulant Expansion
  • 1996
  • In: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 77:11, s. 2268-2271
  • Journal article (peer-reviewed)abstract
    • The valence photoemission spectra of alkali metals exhibit multiple plasmon satellite structure. The calculated spectral functions within the GW approximation show only one plasmon satellite at too large binding energy. In this Letter we use the cumulant expansion approach to obtain the spectral functions of Na and Al from ab initio calculations including the effects of band structure. The GW spectral functions are dramatically improved and the positions of the multiple plasmon satellites are in very good agreement with experiment while their intensities cannot be explained from intrinsic effects only.
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8.
  • Bardyszewski, Witold, et al. (author)
  • A New Approach to the Theory of Photoemission from Solids
  • 1985
  • In: Physica Scripta. - : IOP Publishing. - 0031-8949 .- 1402-4896. ; 32, s. 439-439
  • Journal article (peer-reviewed)abstract
    • By neglecting certain terms in the Hamiltonian (of importance only in the immediate neighbourhood of the threshold energy) we are able to write an exact expression for the photoemission intensity which involves the standard time inverted LEED state and broadened hole-states. If inelastic extrinsic losses are neglected our expression is similar to the one used by e.g. Feibelman and Eastman [1], Pendry [2] and Spanjaard et al. [3]. Our theory also allows inelastic losses (including interference between intrinsic and extrinsic losses) to be evaluated. The expressions are similar to those obtained by Inglesfield [4], but the damping effect no longer has to be put in by hand. Our theory further can handle not only core electron but also valence electron photoemission and it is not restricted to metals but applies to all types of solids. We have also traced why and when Inglesfield's one step theory agrees with a semiclassical calculation.
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9.
  • Bardyszewski, Witold, et al. (author)
  • EFFECTS OF MANY-BODY INTERACTIONS IN EXTENDED X-RAY ABSORPTION FINE STRUCTURE SPECTROSCOPY (EXAFS)
  • 1987
  • In: Journal de Physique Colloques. - : EDP Sciences. - 0449-1947. ; 48 (C9), s. 1101-1104
  • Conference paper (peer-reviewed)abstract
    • Abstract : We present the first a priori derivation of a many-body theory for EXAFS with clearly defined approximations and with final expressions which are feasible for quantitative evaluations. We conclude that the conventional EXAFS expression should be complemented with a term that crudely is the main term, energy-shifted and scaled down by a factor of order 0.2-0.3. Further the f-factors depend significantly, not only on the scattering properties of the individual ions, but also on the electron energy-loss properties of the material itself.
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10.
  • Baron, Tomasz, et al. (author)
  • Test-retest reliability of new and conventional echocardiographic parameters of left ventricular systolic function
  • 2019
  • In: Clinical Research in Cardiology. - : Springer Science and Business Media LLC. - 1861-0684 .- 1861-0692. ; 108:4, s. 355-365
  • Journal article (peer-reviewed)abstract
    • Background: Reliability of left ventricular function measurements depends on actual biological conditions, repeated registrations and their analyses.Objective: To investigate test–retest reliability of speckle-tracking-derived strain measurements and its determinants compared to the conventional parameters, such as ejection fraction (EF), LV volumes and mitral annular plane systolic excursion (MAPSE).Methods: In 30 patients with a wide range of left ventricular function (mean EF 46.4 ± 16.4%, range 14–73%), standard echo views were acquired independently in a blinded fashion by two different echocardiographers in immediate sequence and analyzed off-line by two independent readers, creating 4 data sets per patient. Test–retest reliability of studied parameters was calculated using the smallest detectable change (SDC) and a total, inter-acquisition and inter-reader intra-class correlation coefficient (ICC).Results: The smallest detectable change normalized to the mean absolute value of the measured parameter (SDCrel) was lowest for MAPSE (10.7%). SDCrel for EF was similar to GLS (14.2 and 14.7%, respectively), while SDCrel for CS was much higher (35.6%). The intra-class correlation coefficient was excellent (> 0.9) for all measures of the left ventricular function. Intra-patient inter-acquisition reliability (ICCacq) was significantly better than inter-reader reliability (ICCread) (0.984 vs. 0.950, p = 0.03) only for EF, while no significant difference was observed for any other LV function parameter. Mean intra-subject standard deviations were significantly correlated to the mean values for CS and LV volumes, but not for the other studied parameters.Conclusions: In a test–retest setting, both with normal and impaired left ventricular function, the smallest relative detectable change of EF, GLS and MAPSE was similar (11–15%), but was much higher for CS (35%). Surprisingly, reliability of GLS was not superior to that of EF. Acquisition and reader to a similar extent influenced the reliability of measurements of all left ventricular function measures except for ejection fraction, where the reliability was more dependent on the reader than on the acquisition.
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  • Bendix, Lars, et al. (author)
  • Teaching software development using extreme programming
  • 2008
  • In: Lecture Notes in Computer Science. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 1611-3349 .- 0302-9743. - 9783540779339 - 9783540779346 ; 4821, s. 166-189
  • Journal article (peer-reviewed)abstract
    • Software development is a complex area and extensive practice and reflection is required in order to obtain a good understanding of the different tasks involved in going from idea to deliverable software. To help in providing this understanding, we have developed a team programming course based on extreme programming and a coaching course. We discuss how these courses affect the curriculum, the design of the courses, and our experience from running them for four years, involving over 100 students per year. We also discuss how we have used the extreme programming approach to support the learning cycle through the use of iterative learning, peer learning and a fixed-time budge
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14.
  • Buckler, Andrew J., et al. (author)
  • Virtual Transcriptomics Noninvasive Phenotyping of Atherosclerosis by Decoding Plaque Biology From Computed Tomography Angiography Imaging
  • 2021
  • In: Arteriosclerosis, Thrombosis and Vascular Biology. - : Ovid Technologies (Wolters Kluwer Health). - 1079-5642 .- 1524-4636. ; 41:5, s. 1738-1750
  • Journal article (peer-reviewed)abstract
    • Objective: Therapeutic advancements in atherosclerotic cardiovascular disease have improved prevention of ischemic stroke and myocardial infarction, but diagnostic methods for atherosclerotic plaque phenotyping to aid individualized therapy are lacking. In this feasibility study, we aimed to elucidate plaque biology by decoding the molecular phenotype of plaques through analysis of computed-tomography angiography images, making a predictive model for plaque biology referred to as virtual transcriptomics. Approach and Results: We employed machine intelligence using paired computed-tomography angiography and transcriptomics from carotid endarterectomies of 40 patients undergoing stroke-preventive surgery for carotid stenosis. Computed tomography angiographies were analyzed with novel software for accurate characterization of plaque morphology and plaque transcriptomes obtained from microarrays, followed by mathematical modeling for prediction of molecular signatures. Four hundred fourteen coding and noncoding RNAs were robustly predicted using supervised models to estimate gene expression based on plaque morphology. Examples of predicted transcripts included ion transporters, cytokine receptors, and a number of microRNAs whereas pathway analyses demonstrated enrichment of several biological processes relevant for the pathophysiology of atherosclerosis and plaque instability. Finally, the ability of the models to predict plaque gene expression was demonstrated using computed tomography angiographies from 4 sequestered patients and comparisons with transcriptomes of corresponding lesions. Conclusions: The results of this pilot study show that atherosclerotic plaque phenotyping by image analysis of conventional computed-tomography angiography can elucidate the molecular signature of atherosclerotic lesions in a multiscale setting. The study holds promise for optimized personalized therapy in the prevention of myocardial infarction and ischemic stroke, which warrants further investigations in larger cohorts.
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15.
  • Campbell, L, et al. (author)
  • Interference between extrinsic and intrinsic losses in x-ray absorption fine structure
  • 2002
  • In: Physical Review B. - 1550-235X. ; 65:6, s. 1-13
  • Journal article (peer-reviewed)abstract
    • The interference between extrinsic and intrinsic losses in x-ray absorption fine structure (XAFS) is treated within a Green's-function formalism, without explicit reference to final states. The approach makes use of a quasiboson representation of excitations and perturbation theory in the interaction potential between electrons and quasibosons. These losses lead to an asymmetric broadening of the main quasiparticle peak plus an energy-dependent satellite in the spectral function. The x-ray absorption spectra (XAS) is then given by a convolution of an effective spectral function over a one-electron cross section. It is shown that extrinsic and intrinsic losses tend to cancel near excitation thresholds, and correspondingly, the strength in the main peak increases. At high energies, the theory crosses over to the sudden approximation. These results thus explain the observed weakness of multielectron excitations in XAS. The approach is applied to estimate the many-body corrections to XAFS, beyond the usual mean-free path, using a phasor summation over the spectral function. The asymmetry of the spectral function gives rise to an additional many-body phase shift in the XAFS formula.
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16.
  • Danhäll, D, et al. (author)
  • Naturligt grupperat arbete vid Volvo Lastvagnar – Delrapport 1
  • 1989
  • Reports (other academic/artistic)abstract
    • Consumer report for the company in question (the Volvo Truck Company) which is financed by the company and partly also by a research foundation. It is a matter of a work that in this particular case were carried out during nine years in a number of experimental workshops located outside the Chalmers University of Technology. These workshops were financed by the Volvo Automobile and Truck companies. This achievement, as the final contribution to the Swedish automotive industry after having already treated this research field/problem area for more than two decades before this particular period if time (involving several junior and senior research competencies, as well as industrial and governmental foundings). Specifically, this publication explains how the authors dealt with the product architecture and product variation of the automotive products disassembled, which proved to necessary to be carried out in one of the experimental workshops (several complete automobiles and one heavy truck chassis were disassembled combined with having product data accessible in form of paper print-outs as well as by appropriate computer connections to the two Volvo companies etc.). That is, by using a special sort of “design analysis by means of axonometric hand-drawn illustrations” (see a conference contribution from 1992 that also is registered and available as o PDF-document at Chalmers Public Library (CPL) (a self-developed method found out together with a junior research competency from the School of Architecture at Chalmers).
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17.
  • Danhäll, D, et al. (author)
  • Naturligt grupperat arbete vid Volvo Lastvagnar – Delrapport 2
  • 1989
  • Reports (other academic/artistic)abstract
    • Consumer report for the company in question (the Volvo Truck Company) which is financed by the company and partly also by a research foundation. It is a matter of a work that in this particular case were carried out during nine years in a number of experimental workshops located outside the Chalmers University of Technology. These workshops were financed by the Volvo Automobile and Truck companies. This achievement, as the final contribution to the Swedish automotive industry after having already treated this research field/problem area for more than two decades before this particular period if time (involving several junior and senior research competencies, as well as industrial and governmental foundings). Specifically (and as stated for the previous report), this publication explains how the authors dealt with the product architecture and product variation of the automotive products disassembled, which proved to necessary to be carried out in one of the experimental workshops (several complete automobiles and one heavy truck chassis were disassembled combined with having product data accessible in form of paper print-outs as well as by appropriate computer connections to the two Volvo companies etc.). That is, by using a special sort of “design analysis by means of axonometric hand-drawn illustrations” (see a conference contribution from 1992 that also is registered and available as o PDF-document at Chalmers Public Library (CPL) (a self-developed method found out together with a junior research competency from the School of Architecture at Chalmers).
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18.
  • Danhäll, D, et al. (author)
  • Naturligt grupperat arbete vid Volvo Lastvagnar – Slutrapport
  • 1990
  • Reports (other academic/artistic)abstract
    • Consumer report for the company in question (the Volvo Truck Company) which is financed by the company and partly also by a research foundation. It is a matter of a work that in this particular case were carried out during nine years in a number of experimental workshops located outside the Chalmers University of Technology. These workshops were financed by the Volvo Automobile and Truck companies. This achievement, as the final contribution to the Swedish automotive industry after having already treated this research field/problem area for more than two decades before this particular period if time (involving several junior and senior research competencies, as well as industrial and governmental foundings). A comment: As was the praxis during this (early) period of time at Chalmers University of Technology, as well as probably at some other universities. This means that frequent and vast academic publication by means of e.g. conference papers and refereed contributions to scientific journals was almost unheard of. At least so for some of the applied science disciplines. However, today are the situation indeed very different (i.e. earlier was the publication in many respects focused on trying to satisfy the executive administrator the research foundation in question etc.). To be more precise, this early praxis was definitively the case for the research and development work carried out at the Department of Transportation (a broadly applied science discipline), which was characterized by more practical strives to e.g. engineer research results. Rather than relying on truer scientific efforts in a narrower sense. Functional satisfaction (i.e. something engineered work as planned instead verification/falsification of a hypothesis) was judged as being a primary aim of this research and development work.  Therefore are (in the context of the publications registered in Chalmers Public Library CPL) the author making distinctions between consumer reports, on one hand. And, one the other hand, reports and preprints (manuscripts), while instead the academically orientated publications are various sort of scientific contributions presented at conferences or published in scientific journals (actually it is somewhat more complex, but further explanations are omitted here). The consumer reports were aimed at a various external organization with who the authors cooperated, and these are in many cases not available in PDF format to be easily read by logging in at CPL.  This particular approach has judged as being fair/relevant fair in order to mirror of work conducted by the author or authors during the passing decades. Besides, the competencies at Chalmers Library, who actually have been very helpful, have not managed to provide appropriate answers to the various questions implied being at hand just above (this despite trying to get hold of such answers, hence this very comment).
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19.
  • Engström, Tomas, 1950, et al. (author)
  • Design Analysis by Means of Axonometric Hand–drawn Illustrations
  • 1992
  • Conference paper (other academic/artistic)abstract
    • This scientific contribution summarizes some of the research and development work carried out by the authors while we were engaged in the Volvo Automobile Company’s assembly plant in Uddevalla. It explains how we managed the illustrate the product architecture and product variation of the automobile model in question (the Volvo 700 model).  Comment: Our clients (the project organisation at Volvo) allowed us to make scientific contributions reporting on e.g. principles and practises during the life of this assembly plant, but they were not keen letting us publish any hard information (many other scientists were far interested publishing just anything). For strategic reasons would, in fact, the principles be kept secret instead (however these principles, though practised by Volvo, were actually never officially/publically absorbed by the Volvo companies) (nowadays are all of the knowledgeable individuals etíher dead or retired). Most probably do similar efforts calling for an experimental workshop in connection with an industrial change, as well as access to similar competencies (various knowledgeable practitioners, as well as senior and junior research competencies, were inventible called for) (just to master the specific nomenclature at hand within the various Volvo companies was really difficult for us) (who will help an external scientist if this requires extra work just to understand what he or she wants?). This is a situation that is almost an impossibility today, with the ways research and development work are organised and financed today at Chalmers University of Technology (in fact, it was far more anarchistic earlier, as long as you were able to finance the efforts in question).
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20.
  • Engström, Tomas, 1950, et al. (author)
  • Naturligt grupperat arbete vid Volvo Lastvagnar – Förstudie
  • 1989
  • Reports (other academic/artistic)abstract
    • Consumer report for the company in question (the Volvo Truck Company) which is financed by the company and partly also by a research foundation. It is a matter of a work that in this particular case were carried out during nine years in a number of experimental workshops located outside the Chalmers University of Technology. These workshops were financed by the Volvo Automobile and Truck companies. This achievement, as the final contribution to the Swedish automotive industry after having already treated this research field/problem area for more than two decades before this particular period if time (involving several junior and senior research competencies, as well as industrial and governmental foundings). More specifically, this publication shows how the initiation of e long cooperation project with the Volvo Truck Company as started. It illustrated how an engine preheater for a heavy truck chassis is assembled on one of the two assembly lines in the Volvo Tuve plant in Gothenburg. It became obvious for others and us that the original logic of this engine preheater was lost as the components required alternately were fitted at different work stations (implying the fact that the logic of the product architecture and product variation of the physical product are totally destroyed) (in fact, the situation was even worse while taking the computer formalized product information on both of the two Volvo companies into consideration.
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22.
  • Fischer, Kerstin, et al. (author)
  • Five-year results from a randomized, controlled trial on early and delayed loading of implants supporting full-arch prosthesis in the edentulous maxilla.
  • 2008
  • In: Clin Oral Implants Res. - 1600-0501. ; 19:5, s. 433-41
  • Journal article (peer-reviewed)abstract
    • OBJECTIVES: The overall aim was to compare the clinical outcomes of early and delayed implant loading in the totally edentulous maxilla during 5 years of function. MATERIALS AND METHODS: Twenty-four patients with edentulous maxillae were randomized in two groups and subjected to early (test, n=16) or delayed (control, n=8) loading. A total of 142 implants were placed and 139 implants (Straumann AG) were loaded with full-arch bridges and followed for 5 years. RESULTS: All patients received and maintained a fixed bridge throughout the study period. Five (5.3%) test implants in three patients and two (4.3%) control implants in two patients were lost during the 5 years (NS). There were no differences in implant stability as measured with resonance frequency analysis at 5 years. More bone loss occurred at test than at control implants, -0.8 mm (SD 1.2) vs. -0.3 mm (SD 1.1), respectively. However, test implants showed a more coronal marginal bone level than control implants after 5 years, 2.9 mm (SD 1.1) vs. 3.7 mm (SD 1.2) from the implant shoulder, respectively. No control implants and four (4.4%) test implants in three (18.8%) patients showed >3 mm bone loss after 5 years. Two of the latter implants in one patient also showed increased probing depths, bleeding at probing and plaque accumulation. Tooth fracture was the most common prosthetic complication. The use of lingual gold onlay effectively reduced the number of resin-related complications as opposed to a resilient mouth guard. CONCLUSIONS: The present randomized controlled trial showed no important differences between early and delayed loading of implants in the edentulous maxilla after 5 years of function. A favourable long-term marginal bone response to the sandblasted large-grit acid-etched (SLA) surface was observed. Technical complications were mainly resin-related which could be avoided by the use of a lingual gold onlay. It is concluded that early loading of SLA-surface implants for support of full-arch bridges represents a viable therapy for the totally edentulous maxilla.
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23.
  • Fleck, Marcus, et al. (author)
  • Dynamical Mean-Field Theory for Doped Antiferromagnets
  • 1998
  • In: Physical Review Letters. - 1079-7114. ; 80, s. 2393-2393
  • Journal article (peer-reviewed)abstract
    • We have generalized the dynamical mean-field theory to study the doping dependence of the crossover from antiferromagnetic to short-range order modeled by an incommensurate spin density wave in the Hubbard model. The local self-energy which includes spin fluctuations gives quasiparticle weights and spectral properties in good agreement with quantum Monte Carlo and exact diagonalization data in two dimensions. The spectra at finite doping are characterized by a Mott-Hubbard “gap” accompanied by a pseudogap induced by the local spin order.
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24.
  • Fleck, Marcus, et al. (author)
  • Magnetic phases near the Van Hove singularity in s- and d-band Hubbard models
  • 1997
  • In: Physical Review B. - 1550-235X. ; 56:6, s. 3159-3159
  • Journal article (peer-reviewed)abstract
    • We investigate the magnetic instabilities of the nondegenerate (s-band) and a degenerate (d-band) Hubbard model in two dimensions using many-body effects due to particle-particle diagrams and Hund’s rule local correlations. The density of states and the position of the Van Hove singularity change depending on the value of next-nearest-neighbor hopping t′. The Stoner parameter is strongly reduced in the s-band case, and ferromagnetism survives only if the electron density is small and the band has flat regions. Due to next-nearest-neighbor hopping there are flat regions in Γ−X and Γ−Y directions. In contrast, for the d-band case the reduction of the Stoner parameter which follows from particle-particle correlations is much smaller and ferromagnetism survives to a large extent. Inclusion of local spin-spin correlations has a limited destabilizing effect on the magnetic states.
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25.
  • Fleck, M., et al. (author)
  • Magnetism near the Van Hove singularity
  • 1998
  • In: Journal of Magnetism and Magnetic Materials. - 0304-8853. ; 177-181, s. 599-601
  • Journal article (peer-reviewed)abstract
    • We study the phase diagrams of the s-band and d-band Hubbard model in two dimensions including electron correlations. While the ferromagnetic instability in the s-band case occurs only near the Van Hove singularity, ferromagnetism is more stable in the d-band model, and the values of the Stoner parameters in transition metals are reduced below their LDA values.(14 refs)
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