| 1. |
- Holmdahl, Viktor, et al.
(författare)
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Autologous full-thickness skin graft as reinforcement in parastomal hernia repair : a feasibility study
- 2021
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Ingår i: Techniques in Coloproctology. - : Springer. - 1123-6337 .- 1128-045X. ; 25:1, s. 131-136
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Tidskriftsartikel (refereegranskat)abstract
- Background: Parastomal hernia is a common complication of stoma formation and the methods of repair available today are unsatisfactory with high recurrence and complication rates. To improve outcome after surgical repair of parastomal hernia, a surgical method using autologous full-thickness skin grafts as intraperitoneal reinforcement has been developed. The purpose of this study was to evaluate the feasibility of this novel surgical technique in the repair of parastomal hernia.Methods: A pilot study was conducted between January 2018 and June 2019 on four patients with symptomatic parastomal hernia. They had a laparotomy with suture reduction of the hernia and reinforcement of the abdominal wall with autologous full-thickness skin. They were then monitored for at least 1 year postoperatively for technique-related complications and recurrence.Results: No major technique-related complications were noted during the follow-up Two patients developed a recurrent parastomal hernia at the long term follow-up. The other two had no recurrence.Conclusions: Autologous full-thickness skin graft as reinforcement in parastomal hernia repair is feasible and should be evaluated in a larger clinical trial.
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| 2. |
- Holmdahl, Viktor, 1990-, et al.
(författare)
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Autologous full-thickness skin graft as reinforcement in parastomal hernia repair : a randomised controlled trial
- 2021
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Ingår i: Trials. - : BioMed Central. - 1745-6215. ; 22:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Parastomal hernia is a common complication of an enterostomy and can have a significant impact on health-related quality of life. Currently used methods of repair have high recurrence rates and considerable risk for complications. We have developed a new technique for parastomal hernia repair that uses full-thickness skin graft as reinforcement.Methods: This study protocol describes a multicentre randomised controlled trial on parastomal hernia repair comparing a new full-thickness skin graft technique with conventional synthetic composite mesh as reinforcement of the abdominal wall. Patients with a symptomatic parastomal hernia will be included and followed up at 3, 12 and 36 months, with surgical complication as the primary outcome. Secondary outcomes will be recurrence rate and health-related quality of life assessed with VHPQ, EORTC C30 and CR29. Tissue biology and collagen metabolism will be investigated pre- and postoperatively using biopsies of the abdominal wall fascia and blood samples.Discussion: Parastomal hernia constitutes a major clinical problem where the prospects of a good result after hernia repair are presently poor. This new method of repair with full-thickness skin grafting could be a new alternative in our surgical toolbox, but before then, it must be evaluated properly.
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| 3. |
- Holmdahl, Viktor, 1990-
(författare)
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Autologous full-thickness skin graft as reinforcement material in the repair of complex hernias
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Background: Abdominal wall hernia is a common issue in the realm of surgery. Many patients suffering from a hernia require surgical intervention, and over 8000 abdominal hernia repairs are performed each year in Sweden. While most hernia patients undergo successful hernia repair, some types of hernia are associated with high recurrence rates and considerable risk for complications, that in some cases prove fatal. This thesis is based on repair of two such types - giant incisional hernia and parastomal hernia. In many cases, the complications associated with repair of giant incisional hernia and parastomal hernia can be linked to the introduction of foreign mesh material placed in the abdominal wall as reinforcement. Our hypothesis was that the use of autologous full-thickness skin graft instead of synthetic mesh commonly used today would improve the outcome of these repairs.Aim: The overall aim of this thesis was to investigate the use of autologous full-thickness skin grafts as reinforcement material in the repair of complicated types of hernia.Results: No significant differences regarding recurrence rate, abdominal muscle strength, and quality-of-life were seen at the 12-month and long-term follow-ups of a randomised controlled multicentre trial comparing the use of full-thickness skin graft with synthetic mesh reinforcement in the repair of giant incisional hernia.Tensile strength and resistance to suture tearing of full-thickness skin were shown to be superior to conventional synthetic and biological meshes. This together with previously performed animal studies allowed us to proceed with the development of a method of parastomal hernia repair with full-thickness skin graft as reinforcement material. This novel method of repair was tested in four pilot patients without any major procedure-related complications. We present a study protocol for a larger randomised controlled multicentre trial to evaluate autologous full-thickness skin graft as reinforcement in parastomal hernia repair.Conclusions: Autologous full-thickness skin as reinforcement in giant incisional hernia repair produced outcomes similar to synthetic mesh. Its use in parastomal hernia repair is feasible and will be more thoroughly evaluated in a larger trial.
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| 4. |
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| 5. |
- Holmdahl, Viktor, et al.
(författare)
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Long-term follow-up of full-thickness skin grafting in giant incisional hernia repair : a randomised controlled trial
- 2022
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Ingår i: Hernia. - : Springer. - 1265-4906 .- 1248-9204. ; 26, s. 473-479
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Conventional repair of a giant incisional hernia often requires implantation of a synthetic mesh (SM). However, this surgical procedure can lead to discomfort, pain, and potentially serious complications. Full-thickness skin grafting (FTSG) could offer an alternative to SM, less prone to complications related to implantation of a foreign body in the abdominal wall. The aim of this study was to compare the use of FTSG to conventional SM in the repair of giant incisional hernia.Methods: Patients with a giant incisional hernia (> 10 cm width) were randomised to repair with either FTSG or SM. 3-month and 1-year follow-ups have already been reported. A clinical follow-up was performed 3 years after repair, assessing potential complications and recurrence. SF-36, EQ-5D and VHPQ questionnaires were answered at 3 years and an average of 9 years (long-term follow-up) after surgery to assess the impact of the intervention on quality-of-life (QoL).Results: Fifty-two patients were included. Five recurrences in the FTSG group and three in the SM group were noted at the clinical follow-up 3 years after surgery, but the difference was not significant (p = 0.313). No new procedure-related complication had occurred since the one-year follow-up. There were no relevant differences in QoL between the groups. However, there were significant improvemnts in both physical, emotional, and mental domains of the SF-36 questionnaire in both groups.Conclusion: The results of this long-term follow-up together with the results from previous follow-ups indicate that autologous FTSG as reinforcement in giant incisional hernia repair is an alternative to conventional repair with SM.
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| 6. |
- Holmdahl, Viktor, et al.
(författare)
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One-year outcome after repair of giant incisional hernia using synthetic mesh or full-thickness skin graft : a randomised controlled trial
- 2019
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Ingår i: Hernia. - : Springer. - 1265-4906 .- 1248-9204. ; 23:2, s. 355-361
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: Repair of giant incisional hernia often requires complex surgery and the results of conventional methods using synthetic mesh as reinforcement are unsatisfactory, with high recurrence and complication rates. Our hypothesis was that full-thickness skin graft (FTSG) provides an alternative reinforcement material for giant incisional hernia repair and that outcome is improved. The aim of this study was to compare FTSG with conventional materials currently used as reinforcement in the repair of giant incisional hernia.METHODS: A prospective randomised controlled trial was conducted, comparing FTSG with synthetic mesh as reinforcement in the repair of giant (> 10 cm minimum width) incisional hernia. One-year follow-up included a blinded clinical examination by a surgeon and objective measurements of abdominal muscle strength using the Biodex-4 system.RESULTS: 52 patients were enrolled in the study: 24 received FTSG and 28 synthetic mesh. Four recurrences (7.7%) were found at 1-year follow-up, two in each group. There were no significant differences regarding pain, patient satisfaction or aesthetic outcome between the groups. Strength in the abdominal wall was not generally improved in the study population and there was no significant difference between the groups.CONCLUSION: The outcome of repair of giant incisional hernia using FTSG as reinforcement is comparable with repair using synthetic mesh. This suggests that FTSG may have a future place in giant incisional hernia repair.
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| 7. |
- Holmdahl, Viktor, et al.
(författare)
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The Tensile Strength of Full-Thickness Skin : A Laboratory Study Prior to Its Use as Reinforcement in Parastomal Hernia Repair
- 2019
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Ingår i: Frontiers in Surgery. - : Frontiers Media S.A.. - 2296-875X. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Parastomal hernia is a common complication of an enterostoma. Current methods of repair have high recurrence rates and are associated with severe complications. Autologous full-thickness skin as reinforcement may reduce the recurrence and complication rates. This study aims to investigates the tensile strength of full-thickness skin; information that is essential if we are to proceed with clinical trials on humans.Methods: Full-thickness skin samples from 12 donors were tested for tensile strength, as well as the load tolerated by a suture through the skin. Strips of skin were cut out and stretched until breaking point. Sutures were made through skin samples and traction applied until either the tissue or the suture gave way. All done while recording the forces applied using a dynamometer. Identical tests were carried out on commercially available synthetic and biologic graft material for comparison.Results: The full-thickness skin strips had a median tensile strength of 604 N/cm. This tensile strength was significantly higher than that of the compared materials evaluated in this study. In full-thickness skin, the suture, or tissue endured a median force of 67 N before giving way, which was as high as, or higher than similar sutures through the compared materials.Conclusions: The tensile strength of full-thickness skin vastly exceeds the physiological forces affecting the abdominal wall, and sutures through skin endure high loads before giving way. The tensile strength of a full-thickness skin graft and the strength of sutures through this material will not limit its use for reinforcement in parastomal hernia repair.
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