| 1. |
- Murray, Christopher J. L., et al.
(författare)
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Population and fertility by age and sex for 195 countries and territories, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017
- 2018
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Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 392:10159, s. 1995-2051
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Tidskriftsartikel (refereegranskat)abstract
- Background: Population estimates underpin demographic and epidemiological research and are used to track progress on numerous international indicators of health and development. To date, internationally available estimates of population and fertility, although useful, have not been produced with transparent and replicable methods and do not use standardised estimates of mortality. We present single-calendar year and single-year of age estimates of fertility and population by sex with standardised and replicable methods. Methods: We estimated population in 195 locations by single year of age and single calendar year from 1950 to 2017 with standardised and replicable methods. We based the estimates on the demographic balancing equation, with inputs of fertility, mortality, population, and migration data. Fertility data came from 7817 location-years of vital registration data, 429 surveys reporting complete birth histories, and 977 surveys and censuses reporting summary birth histories. We estimated age-specific fertility rates (ASFRs; the annual number of livebirths to women of a specified age group per 1000 women in that age group) by use of spatiotemporal Gaussian process regression and used the ASFRs to estimate total fertility rates (TFRs; the average number of children a woman would bear if she survived through the end of the reproductive age span [age 10–54 years] and experienced at each age a particular set of ASFRs observed in the year of interest). Because of sparse data, fertility at ages 10–14 years and 50–54 years was estimated from data on fertility in women aged 15–19 years and 45–49 years, through use of linear regression. Age-specific mortality data came from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 estimates. Data on population came from 1257 censuses and 761 population registry location-years and were adjusted for underenumeration and age misreporting with standard demographic methods. Migration was estimated with the GBD Bayesian demographic balancing model, after incorporating information about refugee migration into the model prior. Final population estimates used the cohort-component method of population projection, with inputs of fertility, mortality, and migration data. Population uncertainty was estimated by use of out-of-sample predictive validity testing. With these data, we estimated the trends in population by age and sex and in fertility by age between 1950 and 2017 in 195 countries and territories. Findings: From 1950 to 2017, TFRs decreased by 49·4% (95% uncertainty interval [UI] 46·4–52·0). The TFR decreased from 4·7 livebirths (4·5–4·9) to 2·4 livebirths (2·2–2·5), and the ASFR of mothers aged 10–19 years decreased from 37 livebirths (34–40) to 22 livebirths (19–24) per 1000 women. Despite reductions in the TFR, the global population has been increasing by an average of 83·8 million people per year since 1985. The global population increased by 197·2% (193·3–200·8) since 1950, from 2·6 billion (2·5–2·6) to 7·6 billion (7·4–7·9) people in 2017; much of this increase was in the proportion of the global population in south Asia and sub-Saharan Africa. The global annual rate of population growth increased between 1950 and 1964, when it peaked at 2·0%; this rate then remained nearly constant until 1970 and then decreased to 1·1% in 2017. Population growth rates in the southeast Asia, east Asia, and Oceania GBD super-region decreased from 2·5% in 1963 to 0·7% in 2017, whereas in sub-Saharan Africa, population growth rates were almost at the highest reported levels ever in 2017, when they were at 2·7%. The global average age increased from 26·6 years in 1950 to 32·1 years in 2017, and the proportion of the population that is of working age (age 15–64 years) increased from 59·9% to 65·3%. At the national level, the TFR decreased in all countries and territories between 1950 and 2017; in 2017, TFRs ranged from a low of 1·0 livebirths (95% UI 0·9–1·2) in Cyprus to a high of 7·1 livebirths (6·8–7·4) in Niger. The TFR under age 25 years (TFU25; number of livebirths expected by age 25 years for a hypothetical woman who survived the age group and was exposed to current ASFRs) in 2017 ranged from 0·08 livebirths (0·07–0·09) in South Korea to 2·4 livebirths (2·2–2·6) in Niger, and the TFR over age 30 years (TFO30; number of livebirths expected for a hypothetical woman ageing from 30 to 54 years who survived the age group and was exposed to current ASFRs) ranged from a low of 0·3 livebirths (0·3–0·4) in Puerto Rico to a high of 3·1 livebirths (3·0–3·2) in Niger. TFO30 was higher than TFU25 in 145 countries and territories in 2017. 33 countries had a negative population growth rate from 2010 to 2017, most of which were located in central, eastern, and western Europe, whereas population growth rates of more than 2·0% were seen in 33 of 46 countries in sub-Saharan Africa. In 2017, less than 65% of the national population was of working age in 12 of 34 high-income countries, and less than 50% of the national population was of working age in Mali, Chad, and Niger. Interpretation: Population trends create demographic dividends and headwinds (ie, economic benefits and detriments) that affect national economies and determine national planning needs. Although TFRs are decreasing, the global population continues to grow as mortality declines, with diverse patterns at the national level and across age groups. To our knowledge, this is the first study to provide transparent and replicable estimates of population and fertility, which can be used to inform decision making and to monitor progress. Funding: Bill & Melinda Gates Foundation.
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| 2. |
- Lozano, Rafael, et al.
(författare)
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Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017
- 2018
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Ingår i: The Lancet. - : Elsevier. - 1474-547X .- 0140-6736. ; 392:10159, s. 2091-2138
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Tidskriftsartikel (refereegranskat)abstract
- Background: Efforts to establish the 2015 baseline and monitor early implementation of the UN Sustainable Development Goals (SDGs) highlight both great potential for and threats to improving health by 2030. To fully deliver on the SDG aim of “leaving no one behind”, it is increasingly important to examine the health-related SDGs beyond national-level estimates. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017), we measured progress on 41 of 52 health-related SDG indicators and estimated the health-related SDG index for 195 countries and territories for the period 1990–2017, projected indicators to 2030, and analysed global attainment. Methods: We measured progress on 41 health-related SDG indicators from 1990 to 2017, an increase of four indicators since GBD 2016 (new indicators were health worker density, sexual violence by non-intimate partners, population census status, and prevalence of physical and sexual violence [reported separately]). We also improved the measurement of several previously reported indicators. We constructed national-level estimates and, for a subset of health-related SDGs, examined indicator-level differences by sex and Socio-demographic Index (SDI) quintile. We also did subnational assessments of performance for selected countries. To construct the health-related SDG index, we transformed the value for each indicator on a scale of 0–100, with 0 as the 2·5th percentile and 100 as the 97·5th percentile of 1000 draws calculated from 1990 to 2030, and took the geometric mean of the scaled indicators by target. To generate projections through 2030, we used a forecasting framework that drew estimates from the broader GBD study and used weighted averages of indicator-specific and country-specific annualised rates of change from 1990 to 2017 to inform future estimates. We assessed attainment of indicators with defined targets in two ways: first, using mean values projected for 2030, and then using the probability of attainment in 2030 calculated from 1000 draws. We also did a global attainment analysis of the feasibility of attaining SDG targets on the basis of past trends. Using 2015 global averages of indicators with defined SDG targets, we calculated the global annualised rates of change required from 2015 to 2030 to meet these targets, and then identified in what percentiles the required global annualised rates of change fell in the distribution of country-level rates of change from 1990 to 2015. We took the mean of these global percentile values across indicators and applied the past rate of change at this mean global percentile to all health-related SDG indicators, irrespective of target definition, to estimate the equivalent 2030 global average value and percentage change from 2015 to 2030 for each indicator. Findings: The global median health-related SDG index in 2017 was 59·4 (IQR 35·4–67·3), ranging from a low of 11·6 (95% uncertainty interval 9·6–14·0) to a high of 84·9 (83·1–86·7). SDG index values in countries assessed at the subnational level varied substantially, particularly in China and India, although scores in Japan and the UK were more homogeneous. Indicators also varied by SDI quintile and sex, with males having worse outcomes than females for non-communicable disease (NCD) mortality, alcohol use, and smoking, among others. Most countries were projected to have a higher health-related SDG index in 2030 than in 2017, while country-level probabilities of attainment by 2030 varied widely by indicator. Under-5 mortality, neonatal mortality, maternal mortality ratio, and malaria indicators had the most countries with at least 95% probability of target attainment. Other indicators, including NCD mortality and suicide mortality, had no countries projected to meet corresponding SDG targets on the basis of projected mean values for 2030 but showed some probability of attainment by 2030. For some indicators, including child malnutrition, several infectious diseases, and most violence measures, the annualised rates of change required to meet SDG targets far exceeded the pace of progress achieved by any country in the recent past. We found that applying the mean global annualised rate of change to indicators without defined targets would equate to about 19% and 22% reductions in global smoking and alcohol consumption, respectively; a 47% decline in adolescent birth rates; and a more than 85% increase in health worker density per 1000 population by 2030. Interpretation: The GBD study offers a unique, robust platform for monitoring the health-related SDGs across demographic and geographic dimensions. Our findings underscore the importance of increased collection and analysis of disaggregated data and highlight where more deliberate design or targeting of interventions could accelerate progress in attaining the SDGs. Current projections show that many health-related SDG indicators, NCDs, NCD-related risks, and violence-related indicators will require a concerted shift away from what might have driven past gains—curative interventions in the case of NCDs—towards multisectoral, prevention-oriented policy action and investments to achieve SDG aims. Notably, several targets, if they are to be met by 2030, demand a pace of progress that no country has achieved in the recent past. The future is fundamentally uncertain, and no model can fully predict what breakthroughs or events might alter the course of the SDGs. What is clear is that our actions—or inaction—today will ultimately dictate how close the world, collectively, can get to leaving no one behind by 2030.
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| 3. |
- Stanaway, Jeffrey D., et al.
(författare)
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Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017
- 2018
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Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 392:10159, s. 1923-1994
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Tidskriftsartikel (refereegranskat)abstract
- Background The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk-outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk-outcome pairs, and new data on risk exposure levels and risk- outcome associations. Methods We used the CRA framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or groups of risks from 1990 to 2017. This study included 476 risk-outcome pairs that met the GBD study criteria for convincing or probable evidence of causation. We extracted relative risk and exposure estimates from 46 749 randomised controlled trials, cohort studies, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. Using the counterfactual scenario of theoretical minimum risk exposure level (TMREL), we estimated the portion of deaths and DALYs that could be attributed to a given risk. We explored the relationship between development and risk exposure by modelling the relationship between the Socio-demographic Index (SDI) and risk-weighted exposure prevalence and estimated expected levels of exposure and risk-attributable burden by SDI. Finally, we explored temporal changes in risk-attributable DALYs by decomposing those changes into six main component drivers of change as follows: (1) population growth; (2) changes in population age structures; (3) changes in exposure to environmental and occupational risks; (4) changes in exposure to behavioural risks; (5) changes in exposure to metabolic risks; and (6) changes due to all other factors, approximated as the risk-deleted death and DALY rates, where the risk-deleted rate is the rate that would be observed had we reduced the exposure levels to the TMREL for all risk factors included in GBD 2017.
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| 4. |
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| 5. |
- Griswold, Max G., et al.
(författare)
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Alcohol use and burden for 195 countries and territories, 1990-2016 : a systematic analysis for the Global Burden of Disease Study 2016
- 2018
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Ingår i: The Lancet. - : Elsevier. - 0140-6736 .- 1474-547X. ; 392:10152, s. 1015-1035
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Tidskriftsartikel (refereegranskat)abstract
- Background: Alcohol use is a leading risk factor for death and disability, but its overall association with health remains complex given the possible protective effects of moderate alcohol consumption on some conditions. With our comprehensive approach to health accounting within the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we generated improved estimates of alcohol use and alcohol-attributable deaths and disability-adjusted life-years (DALYs) for 195 locations from 1990 to 2016, for both sexes and for 5-year age groups between the ages of 15 years and 95 years and older.Methods: Using 694 data sources of individual and population-level alcohol consumption, along with 592 prospective and retrospective studies on the risk of alcohol use, we produced estimates of the prevalence of current drinking, abstention, the distribution of alcohol consumption among current drinkers in standard drinks daily (defined as 10 g of pure ethyl alcohol), and alcohol-attributable deaths and DALYs. We made several methodological improvements compared with previous estimates: first, we adjusted alcohol sales estimates to take into account tourist and unrecorded consumption; second, we did a new meta-analysis of relative risks for 23 health outcomes associated with alcohol use; and third, we developed a new method to quantify the level of alcohol consumption that minimises the overall risk to individual health.Findings: Globally, alcohol use was the seventh leading risk factor for both deaths and DALYs in 2016, accounting for 2.2% (95% uncertainty interval [UI] 1.5-3.0) of age-standardised female deaths and 6.8% (5.8-8.0) of age-standardised male deaths. Among the population aged 15-49 years, alcohol use was the leading risk factor globally in 2016, with 3.8% (95% UI 3.2-4-3) of female deaths and 12.2% (10.8-13-6) of male deaths attributable to alcohol use. For the population aged 15-49 years, female attributable DALYs were 2.3% (95% UI 2.0-2.6) and male attributable DALYs were 8.9% (7.8-9.9). The three leading causes of attributable deaths in this age group were tuberculosis (1.4% [95% UI 1. 0-1. 7] of total deaths), road injuries (1.2% [0.7-1.9]), and self-harm (1.1% [0.6-1.5]). For populations aged 50 years and older, cancers accounted for a large proportion of total alcohol-attributable deaths in 2016, constituting 27.1% (95% UI 21.2-33.3) of total alcohol-attributable female deaths and 18.9% (15.3-22.6) of male deaths. The level of alcohol consumption that minimised harm across health outcomes was zero (95% UI 0.0-0.8) standard drinks per week.Interpretation: Alcohol use is a leading risk factor for global disease burden and causes substantial health loss. We found that the risk of all-cause mortality, and of cancers specifically, rises with increasing levels of consumption, and the level of consumption that minimises health loss is zero. These results suggest that alcohol control policies might need to be revised worldwide, refocusing on efforts to lower overall population-level consumption.
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| 6. |
- Feigin, Valery L., et al.
(författare)
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Global, regional, and national burden of neurological disorders, 1990–2016 : a systematic analysis for the Global Burden of Disease Study 2016
- 2019
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Ingår i: Lancet Neurology. - : Elsevier. - 1474-4422 .- 1474-4465. ; 18:5, s. 459-480
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Tidskriftsartikel (refereegranskat)abstract
- Background: Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders.Methods: We estimated prevalence, incidence, deaths, and disability-adjusted life-years (DALYs; the sum of years of life lost [YLLs] and years lived with disability [YLDs]) by age and sex for 15 neurological disorder categories (tetanus, meningitis, encephalitis, stroke, brain and other CNS cancers, traumatic brain injury, spinal cord injury, Alzheimer's disease and other dementias, Parkinson's disease, multiple sclerosis, motor neuron diseases, idiopathic epilepsy, migraine, tension-type headache, and a residual category for other less common neurological disorders) in 195 countries from 1990 to 2016. DisMod-MR 2.1, a Bayesian meta-regression tool, was the main method of estimation of prevalence and incidence, and the Cause of Death Ensemble model (CODEm) was used for mortality estimation. We quantified the contribution of 84 risks and combinations of risk to the disease estimates for the 15 neurological disorder categories using the GBD comparative risk assessment approach.Findings: Globally, in 2016, neurological disorders were the leading cause of DALYs (276 million [95% UI 247–308]) and second leading cause of deaths (9·0 million [8·8–9·4]). The absolute number of deaths and DALYs from all neurological disorders combined increased (deaths by 39% [34–44] and DALYs by 15% [9–21]) whereas their age-standardised rates decreased (deaths by 28% [26–30] and DALYs by 27% [24–31]) between 1990 and 2016. The only neurological disorders that had a decrease in rates and absolute numbers of deaths and DALYs were tetanus, meningitis, and encephalitis. The four largest contributors of neurological DALYs were stroke (42·2% [38·6–46·1]), migraine (16·3% [11·7–20·8]), Alzheimer's and other dementias (10·4% [9·0–12·1]), and meningitis (7·9% [6·6–10·4]). For the combined neurological disorders, age-standardised DALY rates were significantly higher in males than in females (male-to-female ratio 1·12 [1·05–1·20]), but migraine, multiple sclerosis, and tension-type headache were more common and caused more burden in females, with male-to-female ratios of less than 0·7. The 84 risks quantified in GBD explain less than 10% of neurological disorder DALY burdens, except stroke, for which 88·8% (86·5–90·9) of DALYs are attributable to risk factors, and to a lesser extent Alzheimer's disease and other dementias (22·3% [11·8–35·1] of DALYs are risk attributable) and idiopathic epilepsy (14·1% [10·8–17·5] of DALYs are risk attributable).Interpretation: Globally, the burden of neurological disorders, as measured by the absolute number of DALYs, continues to increase. As populations are growing and ageing, and the prevalence of major disabling neurological disorders steeply increases with age, governments will face increasing demand for treatment, rehabilitation, and support services for neurological disorders. The scarcity of established modifiable risks for most of the neurological burden demonstrates that new knowledge is required to develop effective prevention and treatment strategies.Funding: Bill & Melinda Gates Foundation.
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| 7. |
- Ashkarran, Ali Akbar, et al.
(författare)
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Conformation- and phosphorylation-dependent electron tunnelling across self-assembled monolayers of tau peptides
- 2022
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Ingår i: Journal of Colloid and Interface Science. - : Elsevier BV. - 0021-9797. ; 606, s. 2038-2050
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Tidskriftsartikel (refereegranskat)abstract
- We report on charge transport across self-assembled monolayers (SAMs) of short tau peptides by probing the electron tunneling rates and quantum mechanical simulation. We measured the electron tunneling rates across SAMs of carboxyl-terminated linker molecules (C6H12O2S) and short cis-tau (CT) and trans-tau (TT) peptides, supported on template-stripped gold (AuTS) bottom electrode, with Eutectic Gallium-Indium (EGaIn)(EGaIn) top electrode. Measurements of the current density across thousands of AuTS/linker/tau//Ga2O3/EGaIn single-molecule junctions show that the tunneling current across CT peptide is one order of magnitude lower than that of TT peptide. Quantum mechanical simulation demonstrated a wider energy bandgap of the CT peptide, as compared to the TT peptide, which causes a reduction in its electron tunneling current. Our findings also revealed the critical role of phosphorylation in altering the charge transport characteristics of short peptides; more specifically, we found that the presence of phosphate groups can reduce the energy band gap in tau peptides and alter their electrical properties. Our results suggest that conformational and phosphorylation of short peptides (e.g., tau) can significantly change their charge transport characteristics and energy levels.
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| 8. |
- Nakhaei, Maryam, et al.
(författare)
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Impact of disaster on women in Iran and implication for emergency nurses volunteering to provide urgent humanitarian aid relief : A qualitative study
- 2015
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Ingår i: Australasian emergency nursing journal : AENJ. - : Elsevier. - 1574-6267 .- 1839-2776. ; 18:3, s. 165-172
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Men and women are equally affected by disasters, but they experience disaster in different ways. To provide new knowledge and promote women's involvement in all phases of the disaster management, we decided to capture the perspectives and experiences of the women themselves; and to explore the conditions affecting Iranian women after recent earthquake disasters.METHODS: The study was designed as a qualitative content analysis. Twenty individuals were selected by purposeful sampling and data collected by in-depth, semi-structured interviews analysed qualitatively.RESULTS: Three main themes were evident reflecting women's status after disaster: individual impacts of disaster, women and family, and women in the community. Participants experienced the emotional impact of loss, disorganisation of livelihood and challenges due to physical injuries. Women experienced changes in family function due to separation and conflicts which created challenges and needed to be managed after the disaster. Their most urgent request was to be settled in their own permanent home. This motivated the women to help reconstruction efforts.CONCLUSIONS: Clarification of women's need after a disaster can help to mainstream gender-sensitive approaches in planning response and recovery efforts.
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| 9. |
- Ataei, Mohammad A., et al.
(författare)
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Fuzzy analytical hierarchy process approach for ranking the sawability of carbonate rock
- 2012
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Ingår i: International Journal of Rock Mechanics And Mining Sciences. - : Elsevier BV. - 1365-1609 .- 1873-4545. ; 50, s. 83-93
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Tidskriftsartikel (refereegranskat)abstract
- A new classification system is presented to evaluate and ranking the sawability of carbonate rock. The sawability of carbonate rock is classified into five categories: excellent, good, fair, poor and very poor. The sawability is assumed to depend on the uniaxial compressive strength, Young's modulus, Mohs hardness, and a new abrasivity index. The FAHP approach is used to determine the weights of the above-mentioned parameters by decision makers. Moreover, in this paper, a new classification system was developed to modify Schimazek's F-abrasiveness factor. In this new abrasivity classification, each parameter has a different importance coefficient. The new abrasivity index of carbonate rocks can be obtained from this new abrasivity classification system. The calculated sawability index of developed classification is applied for Iranian carbonate rocks to evaluation the energy consumption in rock sawing process. A variety of two groups of carbonate rocks (seven types) were saw using a fully instrumented laboratory sawing rig at different feed rates, peripheral speeds, and depth of cut. Then, a new statistical model was obtained using multiple regression method based on operating parameters and rock sawability index
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| 10. |
- Beal, Jacob, et al.
(författare)
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Robust estimation of bacterial cell count from optical density
- 2020
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Ingår i: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
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Tidskriftsartikel (refereegranskat)abstract
- Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
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| 11. |
- Choobineh, Alireza, et al.
(författare)
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Editorial
- 2007
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Ingår i: Norma. - 1890-2138 .- 1890-2146. ; 2:1, s. 1-7
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 12. |
- Choobineh, Alireza, et al.
(författare)
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Musculoskeletal symptoms as related to ergonomic factors in Iranian hand-woven carpet industry and general guidelines for workstation design
- 2004
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Ingår i: International Journal of Occupational Safety and Ergonomics. - : Informa UK Limited. - 1080-3548 .- 2376-9130. ; 10:2, s. 157-168
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Tidskriftsartikel (refereegranskat)abstract
- Carpet weaving is a high risk occupation for developing musculoskeletal disorders (MSDs). The objectives of the present study, which was carried out in the Iranian hand-woven carpet industry, were determination of the prevalence of MSD symptoms, identification of major factors associated with MSD symptoms and development of guidelines for workstation design. 1,439 randomly selected weavers participated in this study. A questionnaire was used to collect data on MSD symptoms. The results revealed that the prevalence rates for symptoms in different body regions were high as compared to the general Iranian population (for neck, back and large joints, both p < .0001). The results of multivariate analyses showed that major ergonomic factors associated with musculoskeletal symptoms were loom type, working posture, daily working time and seat type. Based on the results, some general guidelines for designing weaving workstations were developed. A prototype test showed that the new workstation was acceptable for subject tests and that it improved working posture.
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| 13. |
- Choobineh, Alireza, et al.
(författare)
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Workstation design in carpet hand-weaving operation : Guidelines for prevention of musculoskeletal disorders
- 2004
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Ingår i: International Journal of Occupational Safety and Ergonomics. - : Informa UK Limited. - 1080-3548 .- 2376-9130. ; 10:4, s. 411-424
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Tidskriftsartikel (refereegranskat)abstract
- Carpet weavers suffer from musculoskeletal problems mainly attributed to poor working postures. Their posture is mostly constrained by the design of workstations. This study was conducted to investigate the effects of 2 design parameters (weaving height and seat type) on postural variables and subjective experience, and to develop guidelines for workstation adjustments. At an experimental workstation, 30 professional weavers worked in 9 different conditions. Working posture and weavers' perceptions were measured. It was shown that head, neck and shoulder postures were influenced by weaving height. Both design parameters influenced trunk and elbows postures. The determinant factor for weavers' perception on the neck, shoulders and elbows was found to be weaving height, and on the back and knees it was seat type. Based on the results, the following guidelines were developed: (a) weaving height should be adjusted to 20 cm above elbow height; (b) a 10º forward-sloping high seat is to be used at weaving workstations.
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| 14. |
- Firouzabadi, Elahe Dehghani, et al.
(författare)
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Detection of novel PPP1R1B::STARD3 fusion transcript in acute myeloid leukemia : a case report
- 2024
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Ingår i: Journal of Medical Case Reports. - 1752-1947. ; 18
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Tidskriftsartikel (refereegranskat)abstract
- Background Acute myeloid leukemia (AML) is the second most common type of leukemia in children. Although prognostic and diagnostic tests of AML patients have improved, there is still a great demand for new reliable clinical biomarkers for AML. Read-through fusion transcripts (RTFTs) are complex transcripts of adjacent genes whose molecular mechanisms are poorly understood. This is the first report of the presence of the PPP1R1B::STARD3 fusion transcript in an AML patient. Here, we investigated the presence of PPP1R1B::STARD3 RTFT in a case of AML using paired-end RNA sequencing (RNA-seq).Case presentation A Persian 12-year-old male was admitted to Dr. Sheikh Hospital of Mashhad, Iran, in September 2019 with the following symptoms, including fever, convulsions, hemorrhage, and bone pain. The patient was diagnosed with AML (non-M3-FAB subtype) based on cell morphologies and immunophenotypical features. Chromosomal analysis using the G-banding technique revealed t (9;22) (q34;q13).Conclusions Single-cell RNA sequencing (scRNA-seq) analysis suggested that the PPP1R1B promoter may be responsible for the PPP1R1B::STARD3 expression. Alterations in the level of lipid metabolites implicate cancer development, and this fusion can play a crucial role in the cholesterol movement in cancer cells. PPP1R1B::STARD3 may be considered a candidate for targeted therapies of the cholesterol metabolic and the PI3K/AKT signaling pathways involved in cancer development and progression.
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| 15. |
- Ghajarnia, Navid, et al.
(författare)
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Evaluating the Evolution of ECMWF Precipitation Products Using Observational Data for Iran : From ERA40 to ERA5
- 2022
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Ingår i: Earth and Space Science. - : American Geophysical Union (AGU). - 2333-5084. ; 9:10
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Tidskriftsartikel (refereegranskat)abstract
- European Center for Medium-Range Weather Forecasts Reanalysis (ERA), one of the most widely used precipitation products, has evolved from ERA-40 to ERA-20CM, ERA-20C, ERA-Interim, and ERA5. Studies evaluating the performance of individual ERA products cannot adequately assess the evolution of the products. We compared the performance of all ERA precipitation products at daily, monthly, and annual data (1980-2018) using more than 2100 Iran precipitation gauges. Results indicated that ERA-40 performed worst, followed by ERA-20CM, which showed only minor improvements over ERA-40. ERA-20C considerably outperformed its predecessors, benefiting from the assimilation of observational data. Although several previous studies have reported full superiority of ERA5 over ERA-Interim, our results revealed several shortcomings in ERA5 compared with the ERA-Interim estimates. Both ERA-Interim and ERA5 performed best overall, with ERA-Interim showing better statistical and categorical skill scores, and ERA5 performing better in estimating extreme precipitations. These results suggest that the accuracy of ERA precipitation products has improved from ERA-40 to ERA-Interim, but not consistently from ERA-Interim to ERA5. This study employed a grid-grid comparison approach by first creating a gridded reference data set through the spatial aggregation of point source observations, however, the results from a point-grid approach showed no change in the overall ranking of products (despite the slight changes in the error index values). These findings are useful for model development at a global scale and for hydrological applications in Iran.
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| 16. |
- Hosseini, Atiyeh Najla, et al.
(författare)
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A modified Jarzynski free-energy estimator to eliminate non-conservative forces and its application in nanoparticle-membrane interactions
- 2022
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Ingår i: Physical Chemistry Chemical Physics. - : Royal Society of Chemistry (RSC). - 1463-9076 .- 1463-9084. ; 24:6, s. 3647-3654
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Tidskriftsartikel (refereegranskat)abstract
- Computational methods to understand interactions in bio-complex systems are however limited to time-scales typically much shorter than in Nature. For example, on the nanoscale level, interactions between nanoparticles (NPs)/molecules/peptides and membranes are central in complex biomolecular processes such as membrane-coated NPs or cellular uptake. This can be remedied by the application of e.g. Jarzynski's equality where thermodynamic properties are extracted from non-equilibrium simulations. Although, the out of equilibrium work leads to non-conservative forces. We here propose a correction Pair Forces method, that removes these forces. Our proposed method is based on the calculation of pulling forces in backward and forward directions for the Jarzynski free-energy estimator using steered molecular dynamics simulation. Our results show that this leads to much improvement for NP-membrane translocation free energies. Although here we have demonstrated the application of the method in molecular dynamics simulation, it could be applied for experimental approaches.
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| 17. |
- Hosseini, Hadis, et al.
(författare)
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Nutrient Use in Vertical Farming : Optimal Electrical Conductivity of Nutrient Solution for Growth of Lettuce and Basil in Hydroponic Cultivation
- 2021
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Ingår i: Horticulturae. - : MDPI. - 2311-7524. ; 7:9
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Tidskriftsartikel (refereegranskat)abstract
- During the past few decades, vertical farming has attracted a lot of interest as an alternative food production method. Vertical farms use engineered growth environments and hydroponic cultivation techniques for growing plants indoors. One of the important factors in vertical farming for the cultivation of different plants is the amount of nutrients, which can be measured as electrical conductivity (EC). Studying the optimal EC is important for avoiding nutrient loss and deficiency in vertical farms. In this study, we investigated the effect of five EC levels (2, 1.2, 0.9, 0.7, and 0.5 dS m(-1)) of Hoagland nutrient solution on the growth and development of basil cultivar Emily and lettuce cultivar Batavia-Caipira. During the study, the environmental parameters were kept fixed using an automatic dosing machine. The experiment was done in automatic vertical farms using the hydroponic ebb-flow cultivation technique with a temperature of 20 +/- 1 degrees C, relative humidity of 50-60%, CO2 concentration of 450 ppm, pH = 6, the PPFD (photosynthetic photon flux density) of 215 +/- 5.5 mu mol m(-2) s(-1), and the photoperiod of 16:8 h (day/night). Each treatment was replicated four times. We studied the effects on several growth parameters (including the dry and fresh weight of leaves and roots, number of leaves, and leaf area) as well as the chlorophyll and nitrogen concentration of the leaves. According to the results, the basil and lettuce growth parameters among the five treatments have been significantly higher in the treatment with EC of 1.2 and 0.9 dS m(-1). These EC values are lower than the recommended EC value given as the optimum in the previous studies. However, the concentration of chlorophyll and nitrogen show different trends and were higher in full strength of nutrient solution with EC = 2 dS m(-1).
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| 18. |
- Hosseini, Maryam, et al.
(författare)
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Game theory-based radio resource allocation in NOMA vehicular communication networks supported by UAV
- 2022
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Ingår i: Physical Communication. - : Elsevier BV. - 1874-4907 .- 1876-3219. ; 52, s. 101681-
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Tidskriftsartikel (refereegranskat)abstract
- Vehicular communication networks are emerging as a promising technology to provide high-quality internet service such as entertainment for road users via infrastructure-to-vehicle (I2V) communication, and to guarantee road users' safety via vehicle-to-vehicle (V2V) communication. Some technical issues that impact the performance of these networks are the lack of or poor communication paths between vehicles, and the limitation of radio resources. Unmanned aerial vehicles (UAVs) as promising solutions for supporting vehicular networks could provide communication coverage in hazardous environments and areas with no capacities for installation or maintenance of ground base stations (BSs). Also, non-orthogonal multiple access (NOMA) methods can improve spectral and energy efficiency and thereby allow more users to be connected to the desired network. In this paper, exploring the NOMA, we develop a scheme for optimum resource allocation in presence of a UAV that supports vehicular communications. Resource allocation for this scenario is formulated as a mixed-integer non-linear programming (MINLP) problem. Due to the high complexity of such problems, we propose two low-complexity near-optimal methods. First, we apply difference-of-concave-functions (DC) approximations to solve the problem in an iterative process. Next, we use Stackelberg game-based method for efficient solving, and then, closed-form expressions of optimal power allocations using KKT-conditions are derived. Simulations illustrate the effectiveness of the proposed scheme along with the Stackelberg game-based method.
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| 19. |
- Hosseini, M. Reza, et al.
(författare)
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A qualitative investigation of perceived impacts of virtuality on effectiveness of hybrid construction project teams
- 2018
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Ingår i: Construction Innovation. - 1477-0857 .- 1471-4175. ; 18:1, s. 109-131
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Tidskriftsartikel (refereegranskat)abstract
- Purpose – The “virtuality” of a team collaborative interaction is the extent to which it is accomplished in the same place, in fully distributed virtual teams, or in a hybrid combination of the two. However, existence, strength and process of potential association between virtuality and effectiveness in construction project teams have remained elusive. This paper aims to address this gap in the literature. Design/methodology/approach – In this study, a conceptual model demonstrating the association between virtuality and effectiveness of teams was developed through integrating the input-process-output (IPO) model and the “Big Five” theory. This conceptual model was contextualised for the construction industry drawing upon conducting 17 semi-structured interviews with hybrid team experts. Findings – The findings provide the first model mapping the associations between virtuality and dimensions of team effectiveness for the construction context. Practical implications – The discovered patterns of associations between virtuality and dimensions of effectiveness for hybrid construction project teams (HCPTs) will assist managers in designing and running more effective teams. In addition, the findings help construction practitioners better understand how virtuality influence the performance and satisfaction of team members in HCPTs. The present study concludes with outlining a set of recommendations based on the findings of the study. Originality/value – As the first study in its kind, the present study offers a new insight into the concept and impacts of virtuality for construction teams and provides instructions and guidelines for designing and maintaining the effectiveness of such teams on construction projects.
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| 20. |
- Hosseini, Payam, et al.
(författare)
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Effect of nano-particles and aminosilane interaction on the performances of cement-based composites : An experimental study
- 2014
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Ingår i: Construction and Building Materials. - : Elsevier BV. - 0950-0618 .- 1879-0526. ; 66, s. 113-124
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Tidskriftsartikel (refereegranskat)abstract
- The aim of the present study was to experimentally investigate the interaction between a low replacement ratio of different nano-particles (SiO2, Al2O3, clay, and CaCO3) and aminosilane in the matrices of cement paste and mortar. Results showed that the optimum content of aminosilane for improving the 28-day compressive strength of cement mortar was 0.75% (by weight of the total binder). The utilization of nano-SiO2 and nano-clay particles improved the strengths of the cement mortar containing hybrid systems of nano-particles/aminosilane at early (7 days) and middle curing ages (28 and 91 days). The 28-day compressive strength enhancement of cement mortar with hybrid systems of nano-SiO2/aminosilane and nano-clay/aminosilane was about 19% and 20%, respectively. Additionally, the application of aminosilane with nano-CaCO3 and nano-Al2O3 particles showed lower efficacy on mechanical performance of the cement-based composites in comparison with nano-clay and nano-SiO2. Despite the fact that the utilization of aminosilane with and without different nano-particles enhanced the flowability of the cement paste and mortar, it reduced the electrical resistivity of the cement mortar. In this regard, the minimum electrical resistivity was achieved for specimens with only aminosilane. This reduction was about 19.5% for samples containing 0.75% aminosilane for a curing time of 28 days.
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| 21. |
- Hosseini, Reza, et al.
(författare)
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A Novel Method for Extracting and Analyzing the Geometry Properties of the Shortest Pedestrian Paths Focusing on Open Geospatial Data
- 2023
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Ingår i: ISPRS International Journal of Geo-Information. - : MDPI AG. - 2220-9964. ; 12:7
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Tidskriftsartikel (refereegranskat)abstract
- Unlike car navigation, where almost all vehicles can traverse every route, one route might not be optimal or even suitable for all pedestrians. Route geometry information, including tortuosity, twists and turns along roads, junctions, and road slopes, among others, matters a great deal for specific types of pedestrians, particularly those with limited mobility, such as wheelchair users and older adults. Offering practical routing services to these users requires that pedestrian navigation systems provide further information on route geometry. Therefore, this article proposes a novel method for extracting and analyzing the geometry properties of the shortest pedestrian paths, with a focus on open geospatial data across four aspects: (a) similarity, (b) route curviness,
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| 22. |
- Hosseini, Zahra Sadat Javadi, et al.
(författare)
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Structured Multidisciplinary work Evaluation Tool (SMET) questionnaire : Translation, cultural adaptation and psychometric evaluation of the Persian version.
- 2024
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Ingår i: Work. - : IOS Press. - 1051-9815 .- 1875-9270. ; 77:2, s. 659-669
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: To assess relevant environmental conditions in any work-setting requires a multidisciplinary perspective that is practical, valid, and reliable. This includes the physical, environmental, and psychosocial risk-factors. The Structured Multidisciplinary work Evaluation Tool (SMET) questionnaire simultaneously considers multiple work-related demands.OBJECTIVE: This study translated and culturally adapted the SMET into Persian and evaluated its psychometric properties in Persian industrial workers.METHODS: Cross-sectional translation and cross-cultural adaptation in five standardized phases. A convenience sample (n = 211) recruited from an industrial-occupation setting completed: the SMET; and the Rapid Upper Limb Assessment (RULA), and National Aeronautics and Space Administration Task Load Index (NASA-TLX) criteria; plus light and noise levels were concurrently assessed. Psychometric properties included: validity, with face (from confirmed language clarity, simplicity, and readability), content (via the content validity index, CVI, for equivalency and relevancy), criterion (through Pearson's r correlation with relevant criteria), and construct (through known group validity between participants with/without work-related musculoskeletal disorders, WMSDs); internal consistency (Cronbach's α); and test-retest reliability (intraclass correlation coefficient, ICC2.1).RESULTS: Validity was confirmed with: face through the adaptation; content from suitable CVI values for items (CVI range = 0.78-1.0) and scale-total (CVI = 0.86); criterion from SMET associations with levels for light (r = - 0.42) and noise (r = 0.21), plus RULA (r = 0.42) and NASA-TLX (r = 0.39); and construct through participants with WMSD having significantly higher SMET total-scores (p = 0.01). Internal consistency (α= 0.89) and reliability (ICC2.1 = 0.87) were acceptable and strong.CONCLUSION: This study indicated that the SMET Persian version had acceptable psychometric properties in an industrial occupational setting. Further investigation in longitudinal populations is recommended.
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| 23. |
- Hosseinpourpia, Reza, 1983-, et al.
(författare)
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Effects of sulfite waste fibers incorporating silica nano-particles on mechanical and microstructural properties of cementitious composite
- 2010
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Ingår i: 2nd International Conference on Composites: Characterization, Fabrication and Application. ; , s. 431-436
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Konferensbidrag (refereegranskat)abstract
- Natural fibers are one of the most appropriate alternatives for designation and production of structural panels due to low final production cost. However a principal point is the strength loss caused by usage of these fibers in the matrix of cement based composites. Hence, a simple and cheap method should be applied to develop the properties of these fibers. Therefore, in this study by application of sulfite waste (along with waste management in the wood and paper industries) and usage of low-dosage silica nanoparticles (in order to enhance the interfacial transition zone of the cement-fiber paste), production of cement based sheets reinforced with natural fibers and silica nano-particles are investigated. Alongside, flexural strength and microstructure of sheets are examined by calculating the Modulus of Rupture (MOR) and Modulus of Elasticity (MOE), and applying the Scanning Electron Microscopy (SEM), respectively. Results show that mechanical performance and microstructure of cement based composites containing waste natural fibers and silica nano-particles can be improved.
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| 24. |
- Hosseinpourpia, Reza, 1983-, et al.
(författare)
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Influence of Nanosilica on Properties of Green Cementitious Composites Filled with Waste Sulfite Pulp Fiber and Aminosilane
- 2014
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Ingår i: Arabian Journal for Science and Engineering. - : Springer Science and Business Media LLC. - 2193-567X .- 2191-4281 .- 1319-8025. ; 39:4, s. 2631-2640
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Tidskriftsartikel (refereegranskat)abstract
- Developments in the field of green cement-based products are characterized as an important approach to sustainable development and are being devoted much attention by the construction industry. Numerous types of materials are utilized; however, based on other published studies, the use of waste material as a filler normally deteriorates the performance of cementitious products. Appropriate additives thus need to be employed to improve the performances and properties of green products. As a consequence, the aim of this study has been to investigate the properties of a novel green cement-based composite—a hybrid system composed of cement, waste natural fiber, silica nano-particles, and aminosilane. Experiments were performed to assess the physical properties (density and flowability), mechanical properties (compressive strength and bending performance), and microstructural properties (as determined by scanning electron microscopy) of the cement sheets. The results demonstrated an improvement in the mechanical and microstructural properties of green cement-based composites by using this hybrid system.
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| 25. |
- Hosseinpourpia, Reza, 1983-, et al.
(författare)
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Production of waste bio-fiber cement-based composites reinforced with nano-SiO2 particles as a substitute for asbestos cement composites
- 2012
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Ingår i: Construction and Building Materials. - : Elsevier BV. - 0950-0618 .- 1879-0526. ; 31, s. 105-111
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Tidskriftsartikel (refereegranskat)abstract
- The environmental impact of asbestos fibers on human health and their consequent safety-related problems indicate that there is a significant need to replace this material in all asbestos-containing products. Many different types of fibers have been introduced to replace asbestos fibers.In this study, the performance of silica nano-particles combined with waste paper pulp fibers (sulfite fibers) has been investigated. Different mechanical (compressive and flexural strengths and bending performance), durability (water absorption), physical (bulk density and flowability), and microstructural (scanning electron microscopy) tests were conducted to examine the properties of manufactured green composites.The results reveal that the mechanical properties of cement-based composites containing a ternary system of “natural waste fiber–silica nano-particle cement” have been enhanced. Adding silica nano-particles allows the development of green cement-based composites and movement toward sustainable development in the concrete industry.
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