| 1. |
- Bouyoucef, S E, et al.
(author)
-
Poster Session 2 : Monday 4 May 2015, 08
- 2015
-
In: European Heart Journal Cardiovascular Imaging. - : Oxford University Press (OUP). - 2047-2404 .- 2047-2412. ; 16 Suppl 1
-
Journal article (peer-reviewed)
|
|
| 2. |
- Delios, A., et al.
(author)
-
Examining the generalizability of research findings from archival data
- 2022
-
In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 119:30
-
Journal article (peer-reviewed)abstract
- This initiative examined systematically the extent to which a large set of archival research findings generalizes across contexts. We repeated the key analyses for 29 original strategic management effects in the same context (direct reproduction) as well as in 52 novel time periods and geographies; 45% of the reproductions returned results matching the original reports together with 55% of tests in different spans of years and 40% of tests in novel geographies. Some original findings were associated with multiple new tests. Reproducibility was the best predictor of generalizability-for the findings that proved directly reproducible, 84% emerged in other available time periods and 57% emerged in other geographies. Overall, only limited empirical evidence emerged for context sensitivity. In a forecasting survey, independent scientists were able to anticipate which effects would find support in tests in new samples.
|
|
| 3. |
- Ferreira, Mjv, et al.
(author)
-
Poster Session 3 : Tuesday 5 May 2015, 08
- 2015
-
In: European Heart Journal Cardiovascular Imaging. - : Oxford University Press (OUP). - 2047-2404 .- 2047-2412. ; 16 Suppl 1
-
Journal article (peer-reviewed)
|
|
| 4. |
- Sugai, H., et al.
(author)
-
Updated Design of the CMB Polarization Experiment Satellite LiteBIRD
- 2020
-
In: Journal of Low Temperature Physics. - : Springer Science and Business Media LLC. - 0022-2291 .- 1573-7357. ; 199:3-4, s. 1107-1117
-
Journal article (peer-reviewed)abstract
- Recent developments of transition-edge sensors (TESs), based on extensive experience in ground-based experiments, have been making the sensor techniques mature enough for their application on future satellite cosmic microwave background (CMB) polarization experiments. LiteBIRD is in the most advanced phase among such future satellites, targeting its launch in Japanese Fiscal Year 2027 (2027FY) with JAXA's H3 rocket. It will accommodate more than 4000 TESs in focal planes of reflective low-frequency and refractive medium-and-high-frequency telescopes in order to detect a signature imprinted on the CMB by the primordial gravitational waves predicted in cosmic inflation. The total wide frequency coverage between 34 and 448 GHz enables us to extract such weak spiral polarization patterns through the precise subtraction of our Galaxy's foreground emission by using spectral differences among CMB and foreground signals. Telescopes are cooled down to 5 K for suppressing thermal noise and contain polarization modulators with transmissive half-wave plates at individual apertures for separating sky polarization signals from artificial polarization and for mitigating from instrumental 1/f noise. Passive cooling by using V-grooves supports active cooling with mechanical coolers as well as adiabatic demagnetization refrigerators. Sky observations from the second Sun-Earth Lagrangian point, L2, are planned for 3 years. An international collaboration between Japan, the USA, Canada, and Europe is sharing various roles. In May 2019, the Institute of Space and Astronautical Science, JAXA, selected LiteBIRD as the strategic large mission No. 2.
|
|
| 5. |
- Andersson, Per A., et al.
(author)
-
Anger and disgust shape judgments of social sanctions across cultures, especially in high individual autonomy societies
- 2024
-
In: Scientific Reports. - : Nature Research. - 2045-2322. ; 14:1
-
Journal article (peer-reviewed)abstract
- When someone violates a social norm, others may think that some sanction would be appropriate. We examine how the experience of emotions like anger and disgust relate to the judged appropriateness of sanctions, in a pre-registered analysis of data from a large-scale study in 56 societies. Across the world, we find that individuals who experience anger and disgust over a norm violation are more likely to endorse confrontation, ostracism and, to a smaller extent, gossip. Moreover, we find that the experience of anger is consistently the strongest predictor of judgments of confrontation, compared to other emotions. Although the link between state-based emotions and judgments may seem universal, its strength varies across countries. Aligned with theoretical predictions, this link is stronger in societies, and among individuals, that place higher value on individual autonomy. Thus, autonomy values may increase the role that emotions play in guiding judgments of social sanctions.
|
|
| 6. |
- Chapman, I. T., et al.
(author)
-
Overview of MAST results
- 2015
-
In: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 55:10
-
Journal article (peer-reviewed)abstract
- The Mega Ampere Spherical Tokamak (MAST) programme is strongly focused on addressing key physics issues in preparation for operation of ITER as well as providing solutions for DEMO design choices. In this regard, MAST has provided key results in understanding and optimizing H-mode confinement, operating with smaller edge localized modes (ELMs), predicting and handling plasma exhaust and tailoring auxiliary current drive. In all cases, the high-resolution diagnostic capability on MAST is complemented by sophisticated numerical modelling to facilitate a deeper understanding. Mitigation of ELMs with resonant magnetic perturbations (RMPs) with toroidal mode number n(RMP) = 2, 3, 4, 6 has been demonstrated: at high and low collisionality; for the first ELM following the transition to high confinement operation; during the current ramp-up; and with rotating n(RMP) = 3 RMPs. n(RMP) = 4, 6 fields cause less rotation braking whilst the power to access H-mode is less with n(RMP) = 4 than n(RMP) = 3, 6. Refuelling with gas or pellets gives plasmas with mitigated ELMs and reduced peak heat flux at the same time as achieving good confinement. A synergy exists between pellet fuelling and RMPs, since mitigated ELMs remove fewer particles. Inter-ELM instabilities observed with Doppler backscattering are consistent with gyrokinetic simulations of micro-tearing modes in the pedestal. Meanwhile, ELM precursors have been strikingly observed with beam emission spectroscopy (BES) measurements. A scan in beta at the L-H transition shows that pedestal height scales strongly with core pressure. Gyro-Bohm normalized turbulent ion heat flux (as estimated from the BES data) is observed to decrease with increasing tilt of the turbulent eddies. Fast ion redistribution by energetic particle modes depends on density, and access to a quiescent domain with 'classical' fast ion transport is found above a critical density. Highly efficient electron Bernstein wave current drive (1 A W-1) has been achieved in solenoid-free start-up. A new proton detector has characterized escaping fusion products. Langmuir probes and a high-speed camera suggest filaments play a role in particle transport in the private flux region whilst coherence imaging has measured scrape-off layer (SOL) flows. BOUT++ simulations show that fluxes due to filaments are strongly dependent on resistivity and magnetic geometry of the SOL, with higher radial fluxes at higher resistivity. Finally, MAST Upgrade is due to begin operation in 2016 to support ITER preparation and importantly to operate with a Super-X divertor to test extended leg concepts for particle and power exhaust.
|
|
| 7. |
- Kirk, A., et al.
(author)
-
Overview of recent physics results from MAST
- 2017
-
In: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 57:10
-
Journal article (peer-reviewed)abstract
- New results from MAST are presented that focus on validating models in order to extrapolate to future devices. Measurements during start-up experiments have shown how the bulk ion temperature rise scales with the square of the reconnecting field. During the current ramp-up, models are not able to correctly predict the current diffusion. Experiments have been performed looking at edge and core turbulence. At the edge, detailed studies have revealed how filament characteristics are responsible for determining the near and far scrape off layer density profiles. In the core the intrinsic rotation and electron scale turbulence have been measured. The role that the fast ion gradient has on redistributing fast ions through fishbone modes has led to a redesign of the neutral beam injector on MAST Upgrade. In H-mode the turbulence at the pedestal top has been shown to be consistent with being due to electron temperature gradient modes. A reconnection process appears to occur during edge localized modes (ELMs) and the number of filaments released determines the power profile at the divertor. Resonant magnetic perturbations can mitigate ELMs provided the edge peeling response is maximised and the core kink response minimised. The mitigation of intrinsic error fields with toroidal mode number n > 1 has been shown to be important for plasma performance.
|
|
| 8. |
- Tierney, W., et al.
(author)
-
A creative destruction approach to replication : Implicit work and sex morality across cultures
- 2021
-
In: Journal of Experimental Social Psychology. - : Elsevier BV. - 0022-1031 .- 1096-0465. ; 93
-
Journal article (peer-reviewed)abstract
- How can we maximize what is learned from a replication study? In the creative destruction approach to replication, the original hypothesis is compared not only to the null hypothesis, but also to predictions derived from multiple alternative theoretical accounts of the phenomenon. To this end, new populations and measures are included in the design in addition to the original ones, to help determine which theory best accounts for the results across multiple key outcomes and contexts. The present pre-registered empirical project compared the Implicit Puritanism account of intuitive work and sex morality to theories positing regional, religious, and social class differences; explicit rather than implicit cultural differences in values; self-expression vs. survival values as a key cultural fault line; the general moralization of work; and false positive effects. Contradicting Implicit Puritanism's core theoretical claim of a distinct American work morality, a number of targeted findings replicated across multiple comparison cultures, whereas several failed to replicate in all samples and were identified as likely false positives. No support emerged for theories predicting regional variability and specific individual-differences moderators (religious affiliation, religiosity, and education level). Overall, the results provide evidence that work is intuitively moralized across cultures.
|
|
| 9. |
- Ramilowski, JA, et al.
(author)
-
Functional annotation of human long noncoding RNAs via molecular phenotyping
- 2020
-
In: Genome research. - : Cold Spring Harbor Laboratory. - 1549-5469 .- 1088-9051. ; 30:7, s. 1060-1072
-
Journal article (peer-reviewed)abstract
- Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project, we systematically knocked down the expression of 285 lncRNAs in human dermal fibroblasts and quantified cellular growth, morphological changes, and transcriptomic responses using Capped Analysis of Gene Expression (CAGE). Antisense oligonucleotides targeting the same lncRNAs exhibited global concordance, and the molecular phenotype, measured by CAGE, recapitulated the observed cellular phenotypes while providing additional insights on the affected genes and pathways. Here, we disseminate the largest-to-date lncRNA knockdown data set with molecular phenotyping (over 1000 CAGE deep-sequencing libraries) for further exploration and highlight functional roles for ZNF213-AS1 and lnc-KHDC3L-2.
|
|
| 10. |
- Meyer, H., et al.
(author)
-
Overview of physics results from MAST towards ITER/DEMO and the MAST Upgrade
- 2013
-
In: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 53:10, s. 104008-
-
Journal article (peer-reviewed)abstract
- New diagnostic, modelling and plant capability on the Mega Ampere Spherical Tokamak (MAST) have delivered important results in key areas for ITER/DEMO and the upcoming MAST Upgrade, a step towards future ST devices on the path to fusion currently under procurement. Micro-stability analysis of the pedestal highlights the potential roles of micro-tearing modes and kinetic ballooning modes for the pedestal formation. Mitigation of edge localized modes (ELM) using resonant magnetic perturbation has been demonstrated for toroidal mode numbers n = 3, 4, 6 with an ELM frequency increase by up to a factor of 9, compatible with pellet fuelling. The peak heat flux of mitigated and natural ELMs follows the same linear trend with ELM energy loss and the first ELM-resolved T-i measurements in the divertor region are shown. Measurements of flow shear and turbulence dynamics during L-H transitions show filaments erupting from the plasma edge whilst the full flow shear is still present. Off-axis neutral beam injection helps to strongly reduce the redistribution of fast-ions due to fishbone modes when compared to on-axis injection. Low-k ion-scale turbulence has been measured in L-mode and compared to global gyro-kinetic simulations. A statistical analysis of principal turbulence time scales shows them to be of comparable magnitude and reasonably correlated with turbulence decorrelation time. T-e inside the island of a neoclassical tearing mode allow the analysis of the island evolution without assuming specific models for the heat flux. Other results include the discrepancy of the current profile evolution during the current ramp-up with solutions of the poloidal field diffusion equation, studies of the anomalous Doppler resonance compressional Alfven eigenmodes, disruption mitigation studies and modelling of the new divertor design for MAST Upgrade. The novel 3D electron Bernstein synthetic imaging shows promising first data sensitive to the edge current profile and flows.
|
|
| 11. |
|
|
| 12. |
- Nannya, Y, et al.
(author)
-
Postazacitidine clone size predicts long-term outcome of patients with myelodysplastic syndromes and related myeloid neoplasms
- 2023
-
In: Blood advances. - : American Society of Hematology. - 2473-9537 .- 2473-9529. ; 7:14, s. 3624-3636
-
Journal article (peer-reviewed)abstract
- Azacitidine is a mainstay of therapy for MDS-related diseases. The purpose of our study is to elucidate the effect of gene mutations on hematological response and overall survival (OS), particularly focusing on their post-treatment clone size. We enrolled a total of 449 patients with MDS or related myeloid neoplasms. They were analyzed for gene mutations in pre- (n=449) and post- (n=289) treatment bone marrow samples using targeted-capture sequencing to assess the impact of gene mutations and their post-treatment clone size on treatment outcomes. In Cox proportional hazard modeling, multi-hit TP53 mutation (HR, 2.03; 95% CI, 1.42-2.91; P<.001), EZH2 mutation (HR, 1.71; 95% CI, 1.14-2.54; P=.009), and DDX41 mutations (HR, 0.33; 95% CI, 0.17-0.62; P<.001), together with age, high-risk karyotypes, low platelet, and high blast counts, independently predicted OS. Post-treatment clone size accounting for all drivers significantly correlated with International Working Group (IWG)-response (P<.001, trend test), except for that of DDX41-mutated clones, which did not predict IWG-response. Combined, IWG-response and post-treatment clone size further improved the prediction of the original model and even that of a recently proposed molecular prediction model, IPSS-M (c-index, 0.653 vs 0.688; P<.001, likelihood ratio test). In conclusion, evaluation of post-treatment clone size, together with pre-treatment mutational profile as well as IWG-response have a role in better prognostication of azacitidine-treated myelodysplasia patients.
|
|
| 13. |
|
|
| 14. |
- Adithya, H. N., et al.
(author)
-
Solar Soft X-ray Irradiance Variability, I : Segmentation of Hinode/XRT Full-Disk Images and Comparison with GOES (1-8 angstrom) X-Ray Flux
- 2021
-
In: Solar Physics. - : Springer Nature. - 0038-0938 .- 1573-093X. ; 296:4
-
Journal article (peer-reviewed)abstract
- It is of great interest and importance to study the variabilities of solar EUV, UV and X-ray irradiance in heliophysics, in Earth's climate, and space weather applications. A careful study is required to identify, track, monitor and segment the different coronal features such as active regions (ARs), coronal holes (CHs), the background regions (BGs) and the X-ray bright points (XBPs) from spatially resolved full-disk images of the Sun. Variability of solar soft X-ray irradiance is studied for a period of 13 years (February 2007-March 2020, covers Solar Cycle 24), using the X-Ray Telescope on board the Hinode (Hinode/XRT) and GOES (1 - 8 angstrom). The full-disk X-ray images observed in Al_mesh filter from XRT are used, for the first time, to understand the solar X-ray irradiance variability measured, Sun as a star, by GOES instrument. An algorithm in Python has been developed and applied to identify and segment coronal X-ray features (ARs, CHs, BGs, and XBPs) from the full-disk soft X-ray observations of Hinode/XRT. The segmentation process has been carried out automatically based on the intensity level, morphology and sizes of the X-ray features. The total intensity, area, and contribution of ARs/CHs/BGs/XBPs features were estimated and compared with the full-disk integrated intensity (FDI) and GOES (1 - 8 angstrom) X-ray irradiance measurements. The XBPs have been identified and counted automatically over the full disk to investigate their relation to solar magnetic cycle. The total intensity of ARs/CHs/BGs/XBPs/FD regions are compared with the GOES (1 - 8 angstrom) X-ray irradiance variations. We present the results obtained from Hinode/XRT full-disk images (in Al_mesh filter) and compare the resulting integrated full-disk intensity (FDI) with GOES X-ray irradiance. The X-ray intensity measured over ARs/CHs/BGs/XBPs/FD is well correlated with GOES X-ray flux. The contributions of the segmented X-ray features to FDI and X-ray irradiance variations are determined. It is found that the background and active regions have a greater impact on the X-ray irradiance fluctuations. The mean contribution estimated for the whole observed period of the background regions (BGs) will be around 65 +/- 10.97%, whereas the ARs, XBPs and CHs are 30 +/- 11.82%, 4 +/- 1.18% and 1 +/- 0.52%, respectively, to total solar X-ray flux. We observed that the area and contribution of ARs and CHs varies with the phase of the solar cycle, whereas the BGs and XBPs show an anti-correlation. We find that the area of the coronal features is highly variable suggesting that their area has to be taken into account in irradiance models, in addition to their intensity variations. The time series results of XBPs suggest for an existence of anti-correlation between the number of XBPs and the sunspot numbers. It is also important to consider both the number variation and the contribution of XBPs in the reconstruction of total solar X-ray irradiance variability.
|
|
| 15. |
- Belitsky, Victor, 1955, et al.
(author)
-
ALMA Band 2 Cold Cartridge Assembly Design
- 2022
-
In: 32nd International Symposium of Space Terahertz Technology, ISSTT 2022.
-
Conference paper (peer-reviewed)abstract
- As part of the ALMA development, we present the design of the ALMA Band 2 Cold Cartridge Assembly (CCA). The Band 2 is the last band that completes the suit of the 10 receiver channels of ALMA. The originally planned ALMA Band 2 receiver cartridge should cover the RF band of 67 - -90 GHz. The recent progress in technology, optics, OMT design and mm-wave amplifiers, however allowed to implement receiver that has an extended RF band up to 116 GHz. Furthermore, the Band 2 receiver pursues 2SB layout and provides 4-18 GHz IF band for two sidebands in a dual-polarization configuration. Here, we describe the design of the Band 2 CCA that includes optics, amplifier assembly, internal RF transport, mechanics and cryogenics. The downconverter part and performances are described elsewhere.
|
|
| 16. |
- Chen, Li-Jen, et al.
(author)
-
Observation of energetic electrons within magnetic islands
- 2008
-
In: Nature Physics. - : Nature Publishing Group. - 1745-2473 .- 1745-2481. ; 4:1, s. 19-23
-
Journal article (peer-reviewed)abstract
- Magnetic reconnection is the underlying process that releases impulsively an enormous amount of magnetic energy(1) in solar flares(2,3), flares on strongly magnetized neutron stars(4) and substorms in the Earth's magnetosphere(5). Studies of energy release during solar flares, in particular, indicate that up to 50% of the released energy is carried by accelerated 20-100 keV suprathermal electrons(6-8). How so many electrons can gain so much energy during reconnection has been a long-standing question. A recent theoretical study suggests that volume-filling contracting magnetic islands formed during reconnection can produce a large number of energetic electrons(9). Here we report the first evidence of the link between energetic electrons and magnetic islands during reconnection in the Earth's magnetosphere. The results indicate that energetic electron fluxes peak at sites of compressed density within islands, which imposes a new constraint on theories of electron acceleration.
|
|
