| 1. |
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| 2. |
- Andersson, Elisabet, et al.
(författare)
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GSLG – Ett svenskt bibliotekskonsortium
- 2008
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Ingår i: BBL : Biblioteksbladet. - 0006-1867. ; 93:10, s. 22-24
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Andersson, Elisabet, et al.
(författare)
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GSLG – Ett svenskt bibliotekskonsortium
- 2008
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Ingår i: BBL : Biblioteksbladet. - 0006-1867. ; 93:10, s. 22-24
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- 1997 bildade fem högskolebibliotek ett ”konsortium” – ett samarbete kring ett gemensamt bibliotekssystem. Styrelsen för Guiding Star Library Group, gslg, summerar ett tioårigt projekt som har haft stor betydelse för samtliga inblandade parter och i hög grad bidragit till att öka kunskapen och kompetensen hos de medverkande.
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| 4. |
- Barbosa, Leo, et al.
(författare)
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Gold mineralization in the Lappberget deposit, Garpenberg mine, Sweden: towards a geometallurgical approach
- 2022
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Ingår i: Geological Society of Sweden, 150 year anniversary meeting: Abstract volume. ; , s. 116-117
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This study investigates the mineralogy and texture of gold-bearing phases in the Lappberget deposit, Garpenberg Mine, and how these characteristics affect gold recovery during mineral processing. Multiple methods such as optical microscopy, SEM-EDS, EPMA, LA-ICP-MS, and bulk chemical analysis were applied on drill core samples, and samples from the processing plant’s Knelson gravity concentrator. Electrum-type alloys were recognized as the most common gold hosts.
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| 6. |
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| 7. |
- Hong, Seung-Sun, et al.
(författare)
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TCPtransform : Property-Oriented TCP Traffic Transformation
- 2005
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Konferensbidrag (refereegranskat)abstract
- A TCPdump file captures not only packets but also various "properties" related to the live TCP sessions on the Internet. It is still an open problem to identify all the possible properties, if ever possible, and more importantly, which properties really matter for the consumers of this particular TCPdump file and how they are related to each other. However, it is quite clear that existing traffic replay tools, for the purpose of system evaluation, such as TCPreplay destroyed at least some of critical properties such as "ghost acknowledgment" (while the origin packet has never been delivered), which is a critical issue in conducting experimental evaluations for intrusion detection systems. In this paper, we present a software tool to transform an existing TCPdump file into another traffic file with different "properties". For instance, if the original traffic is being captured in a laboratory environment, the new file might "appear" to be captured in between US and Sweden. The transformation we have done here is "heuristically consistent" as there might be some hidden properties still being destroyed in the transformation process. One interesting application of our tool is to build long-term profiles to detect anomalous TCP attacks without really running the target application over the Internet. While, in this paper, we only focus on property-oriented traffic transformation, we have built and evaluated an interactive version of this tool, called TCPopera, to evaluate commercial intrusion prevention systems.
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| 8. |
- Högberg, Cecilia, et al.
(författare)
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Diagnosing colorectal cancer in primary care : cohort study in Sweden of qualitative faecal immunochemical tests, haemoglobin levels, and platelet counts
- 2020
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Ingår i: British Journal of General Practice. - London : Royal College of General Practitioners. - 0960-1643 .- 1478-5242. ; 70:701, s. E843-E851
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Tidskriftsartikel (refereegranskat)abstract
- Background Colorectal cancer (CRC) diagnostics are challenging in primary care and reliable diagnostic aids are desired. Qualitative faecal immunochemical tests (FITs) have been used for suspected CRC in Sweden since the mid-2000s, but evidence regarding their effectiveness is scarce. Anaemia and thrombocytosis are both associated with CRC. Aim To evaluate the usefulness of qualitative FITs requested for symptomatic patients in primary care, atone and combined with findings of anaemia and thrombocytosis, in the diagnosis of CRC. Design and setting A population-based cohort study using electronic health records and data from the Swedish Cancer Register, covering five Swedish regions. Method Patients aged >= 18 years in the five regions who had provided FITs requested by primary care practitioners from 1 January 2015 to 31 December 2015 were identified. FIT and blood-count data were registered and all CRC diagnoses made within 2 years were retrieved. Diagnostic measurements were calculated. Results In total, 15 789 patients provided FITs (four different brands); of these patients, 304 were later diagnosed with CRC. Haemoglobin levels were available for 13 863 patients, and platelet counts for 10 973 patients. Calculated for the different FIT brands only, the sensitivities for CRC were 81.6%-100%; specificities 65.7%-79.5%: positive predictive values 4.7%-8.1%; and negative predictive values 99.5%-100%. Calculated for the finding of either a positive FIT or anaemia, the sensitivities increased to 88.9-100%. Adding thrombocytosis did not further increase the diagnostic performance. Conclusion Qualitative FITs requested in primary care seem to be useful as rule in tests for referral when CRC is suspected. A negative FIT and no anaemia indicate a low risk of CRC.
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| 9. |
- Högberg, Cecilia, et al.
(författare)
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Qualitative faecal immunochemical tests (FITs) for diagnosing colorectal cancer in patients with histories of rectal bleeding in primary care : a cohort study
- 2020
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Ingår i: International Journal of Colorectal Disease. - : Springer. - 0179-1958 .- 1432-1262. ; 35, s. 2035-2040
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Tidskriftsartikel (refereegranskat)abstract
- Background Rectal bleeding is considered an alarm symptom for colorectal cancer (CRC) but it is common and mostly caused by benign conditions. Qualitative faecal immunochemical tests (FITs) for occult blood have been used as diagnostic aids for many years in Sweden when CRC is suspected. The study aimed to evaluate the usefulness of FITs requested by primary care physicians for patients with and without histories of rectal bleeding, in the diagnosis of CRC. Methods Results of all FITs requested in primary care for symptomatic patients in the orebro region during 2015 were retrieved. Data on each patient's history of rectal bleeding was gathered from electronic health records. Patients diagnosed with CRC within 2 years were identified from the Swedish Cancer Register. The analysis focused on three-sample FITs, the customary FIT in Sweden. Results A total of 4232 patients provided three-sample FITs. Information about the presence/absence of rectal bleeding was available for 2027 patients, of which 59 were diagnosed with CRC. For 606 patients with the presence of rectal bleeding, the FIT showed sensitivity 96.2%, specificity 60.2%, positive predictive value 9.8% (95% CI 6.1-13.4) and negative predictive value 99.7% (95% CI 99.2-100) for CRC. For 1421 patients without rectal bleeding, the corresponding figures were 100%, 73.6%, 8.3% (95% CI 5.6-10.9) and 100% (95% CI 99.6-100). Conclusion The diagnostic performance of a qualitative three-sample FIT provided by symptomatic patients in primary care was similar for those with and without a history of rectal bleeding. FITs seem useful for prioritising patients also with rectal bleeding for further investigation.
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| 10. |
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| 11. |
- Högberg, Cecilia, et al.
(författare)
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Use of faecal immunochemical tests common in patients with suspected colorectal cancer but unrelated to travel distance to secondary care : a population-based study from Swedish primary care
- 2022
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Ingår i: Scandinavian Journal of Primary Health Care. - : Taylor & Francis Group. - 0281-3432 .- 1502-7724. ; 40:4, s. 459-465
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Tidskriftsartikel (refereegranskat)abstract
- Background Evidence is increasing for the use of faecal immunochemical tests (FITs) for occult blood as diagnostic tools when colorectal cancer can be suspected. FITs have been used for this purpose in Swedish primary care since around 2005 despite absence of supporting guidelines. To our knowledge, the extent of this use has not been studied. Objective To investigate the use of FITs as diagnostic tools, and if the use was related to patient age, sex and travel time from primary care to diagnostic facilities in secondary care. Design Population-based retrospective study using data from electronic health records. Setting and subjects Patients >= 18 years that provided FITs in primary care in five Swedish health care regions during 2015. Driving times from their primary care centres to secondary care were calculated. Main outcome measures The proportion of patients that provided FITs was calculated for each region, different age intervals and grouped driving times. Results 18,913 patients provided FITs. The proportion of listed patients in the five regions that provided FITs increased with age: 0.86-1.2% for ages <65 years, 3.6-4.1% for ages 65-79 years and 3.8-6.1% for ages >= 80 years. Differences between the regions were small. There was no overall correlation between the proportion of patients that provided FITs and driving time to secondary care. Conclusion FITs were used extensively in Swedish primary care with a higher use in older age groups. There was no tendency towards a higher use of FITs at primary care centres with longer driving times to secondary care.
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| 12. |
- Jaervinen, Elina, et al.
(författare)
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Cultured lymphocytes' mitochondrial genome integrity is not altered by cladribine
- 2023
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Ingår i: Clinical and Experimental Immunology. - 0009-9104 .- 1365-2249. ; 214:3, s. 304-313
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Tidskriftsartikel (refereegranskat)abstract
- Cladribine tablets are a treatment for multiple sclerosis with effects on lymphocytes, yet its mode of action has not been fully established. Here, we analyzed the effects of cladribine on mitochondrial DNA integrity in lymphocytes. We treated cultured human T-cell lines (CCRF-CEM and Jurkat) with varying concentrations of cladribine to mimic the slow cell depletion observed in treated patients. The CCRF-CEM was more susceptible to cladribine than Jurkat cells. In both cells, mitochondrial protein synthesis, mitochondrial DNA copy number, and mitochondrial cytochrome-c oxidase-I mRNA mutagenesis was not affected by cladribine, while caspase-3 cleavage was detected in Jurkat cells at 100 nM concentration. Cladribine treatment at concentrations up to 10 nM in CCRF-CEM and 100 nM in Jurkat cells did not induce significant increase in mitochondrial DNA mutations. Peripheral blood mononuclear cells from eight multiple sclerosis patients and four controls were cultured with or without an effective dose of cladribine (5 nM). However, we did not find any differences in mitochondrial DNA somatic mutations in lymphocyte subpopulations (CD4+, CD8+, and CD19+) between treated versus nontreated cells. The overall mutation rate was similar in patients and controls. When different lymphocyte subpopulations were compared, greater mitochondrial DNA mutation levels were detected in CD8+ (P = 0.014) and CD4+ (P = 0.038) as compared to CD19+ cells, these differences were independent of cladribine treatment. We conclude that T cells have more detectable mitochondrial DNA mutations than B cells, and cladribine has no detectable mutagenic effect on lymphocyte mitochondrial genome nor does it impair mitochondrial function in human T-cell lines. Cultured leukemic human T-cell lines and cultured ex vivo human peripheral mononuclear cells from patients with multiple sclerosis and controls were treated with cladribine in vitro . In the T-cell lines mitochondrial protein synthesis, DNA copy number and mutagenesis were not affected by cladribine. In the ex vivo lymphocyte subpopulations (CD4+, CD8+, and CD19+), there were no significant differences in mitochondrial DNA mutations between treated versus nontreated cells. Graphical Abstract
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| 13. |
- Jansson, T, et al.
(författare)
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Positron emission tomography studies in patients with locally advanced and/or metastatic breast cancer : a method for early therapy evaluation?
- 1995
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Ingår i: Journal of Clinical Oncology. - 0732-183X .- 1527-7755. ; 13:6, s. 1470-1477
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To investigate if sequential positron emission tomographic (PET) scans with the glucose analog 18F-2-fluoro-2-deoxy-D-glucose (18FDG) and/or L-methyl-11C-methionine (11C-methionine) in patients with breast cancer could provide early information on the efficacy of polychemotherapy. PATIENTS AND METHODS: Sixteen patients with breast cancer (11 with locally advanced tumors, three with recurrent disease in the contralateral breast, two of them with distant and regional metastases, and two with distant metastases) underwent a baseline and two follow-up PET scans after the first and third/fourth polychemotherapy course. Tumor response was determined clinically/radiographically after three/four polychemotherapy courses. RESULTS: Five patients were investigated with 18FDG, seven with both 11C-methionine and 18FDG, and four with only 11C-methionine before polychemotherapy. 11C-methionine presented a more distinct visualization of primary/contralateral breast cancers in five of seven patients when compared with 18FDG. Twelve of 16 patients demonstrated a response using conventional methods after the third/fourth course of polychemotherapy. Eight of these 12 clinical responders had a significant decrease in tracer uptake at the first PET scan performed 6 to 13 days after the first polychemotherapy course, and these reductions were further augmented after the third/fourth course and corresponded to the conventional therapy evaluation (clinical examination, computed tomography [CT], ultrasonography, and mammography). CONCLUSION: Our data indicate that PET may be of clinical value in predicting response to chemotherapy in patients with locally advanced breast cancer and/or metastatic disease earlier than any other method used.
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| 14. |
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| 15. |
- Johansson, Margareta, et al.
(författare)
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Freebirth, the only option for women who do not fit into common practice : A Swedish national interview study.
- 2023
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Ingår i: Sexual & Reproductive HealthCare. - : Elsevier BV. - 1877-5756 .- 1877-5764. ; 37
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To explore women's experience of freebirth, as giving birth without the presence of a skilled healthcare professional such as a midwife.METHODS: Online semi-structured interviews with nine multiparous women in Sweden. A qualitative experiential approach, as described by Burnard, was followed for data analysis.RESULTS: The five main categories explored were: (i) previous negative experiences of hospital care as a reason for freebirth; (ii) receiving support for the decision of freebirth was crucial; (iii) longing for individual midwifery-assisted home-birthing support; (iv) to give birth in peace and in self-control, in the safe home environment; and (v) helpful support during labor and birth was appreciated.CONCLUSIONS: The women in the study had a powerful and positive experience of freebirth, but individual midwifery birthing support was also requested. Easily available and respectful midwifery support should be offered to all childbearing women.
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| 16. |
- Lilja, Mikael, et al.
(författare)
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Diagnos och behandlingsmål vid diabetes typ 2
- 2018
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Ingår i: Läkartidningen. - : Sveriges läkarförbund. - 0023-7205 .- 1652-7518. ; 115
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Tidskriftsartikel (refereegranskat)abstract
- The article presents diagnostic criteria for diabetes and treatment goals for diabetes type 2.
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| 17. |
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| 18. |
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| 19. |
- Nicolas, Aude, et al.
(författare)
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Genome-wide Analyses Identify KIF5A as a Novel ALS Gene
- 2018
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Ingår i: Neuron. - : Cell Press. - 0896-6273 .- 1097-4199. ; 97:6, s. 1268-1283.e6
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Tidskriftsartikel (refereegranskat)abstract
- To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia (SPG10) and Charcot-Marie-Tooth type 2 (CMT2). In contrast, ALS-associated mutations are primarily located at the C-terminal cargo-binding tail domain and patients harboring loss-of-function mutations displayed an extended survival relative to typical ALS cases. Taken together, these results broaden the phenotype spectrum resulting from mutations in KIF5A and strengthen the role of cytoskeletal defects in the pathogenesis of ALS.
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| 20. |
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| 21. |
- Tiu, Glacialle, et al.
(författare)
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Ore mineralogy and trace element (re)distribution at the metamorphosed Lappberget Zn-Pb-Ag-(Cu-Au) deposit, Garpenberg, Sweden
- 2021
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Ingår i: Ore Geology Reviews. - : Elsevier. - 0169-1368 .- 1872-7360. ; 135
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Tidskriftsartikel (refereegranskat)abstract
- Qualitative and quantitative mineralogical and textural investigations were undertaken for the different sulfide minerals in the 1.89 Ga Lappberget deposit, with a focus on sphalerite and pyrite. Three sphalerite types were identified and associated with: (1) main massive sulfide mineralization, (2) Fe-Mn skarn ore, and (3) Ag-rich fissure veins. Sphalerite-1 contained a relatively higher amount of trace elements (Fe, Co, Ge, Cu, Sn, and Au) but is lower in Mn/Fe, Ga, and Hg compared to sphalerite-2. Evidence of tectono-metamorphic modification of sulfides is observed throughout the deposit, such as the formation of growth twins and deformation twins in sulfides, the development of high-angled triple-point junctions in recrystallized pyrite and sphalerite, and the formation of ‘ball ore’ or ‘durchbewegung’ textures within mineralized shear zones. The recrystallization of pyrite and galena may have led to the re-distribution of fluid-mobile elements (As, Cu, Zn, Pb, Ag, and Au), some of which were deposited in discordant Ag-rich fissure veins peripheral to the main massive sulfide lenses. Trace element signatures of sulfides in Lappberget are compatible with the other metamorphosed and deformed, subseafloor volcanogenic carbonate replacement (SVALS)-type deposits in the Bergslagen mining district.
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