| 1. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 2. |
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Att studera funktionshinder och åldrande : en bok om metoderfarenheter
- 2015
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- Syftet med den här boken är att presentera och reflektera över metoder som tillämpades inom ett forskningsprogram där funktionshinder och åldrande studerades1 och som var förlagt till Nationella institutet för forskning om äldre och åldrande (NISAL) vid Linköpings universitet. Inom programmet tillämpades ett antal olika kvalitativa ansatser och metoder, inom ramen för varierande betingelser. Det är mot bakgrund av dessa metoderfarenheter som vi skrivit denna bok. Fokus är inte i första hand på vad vi kommit fram till genom våra studier utan hur vi gjort det och på de erfarenheter, möjligheter och utmaningar som olika metoder varit förknippade med. Våra diskussioner handlar också om vilka praktiska och metodologiska slutsatser som kan dras av våra erfarenheter och iakttagelser. Vi reflekterar över kvalitativa metoder, med exempel från frågor om urval, intervjumetoder, forskarrollen och teoriskapande.Vad innebär det att leva ett långt liv och åldras med en fysisk eller intellektuell funktionsnedsättning som man haft i många år? Det var den övergripande frågan som studerades inom olika delstudier i det forskningsprogram inom vilket vi gjort våra erfarenheter och som belyses i bokens kapitel. Programmet tillämpade ett livsloppsperspektiv, vilket betyder att innebörden i funktionshinder och åldrande förstås och tolkas utifrån hela livets dynamik, och där åldrandet ses som en livslång process. Tidsbegreppet är centralt i denna ansats och det är ett mångdimensionellt begrepp där både individens tid och den historiska tiden tas i beaktande (Jeppsson Grassman 2008a; Jeppsson Grassman & Whitaker 2013). Det betyder också att vi i boken diskuterar livsloppet som metodologiskt verktyg, både dess möjligheter och svårigheter, med utgångspunkt från våra erfarenheter.Idag finns det stort antal metodböcker som behandlar kvalitativa metoder (se till exempel Gubrium & Holstein 2002; Denzin & Lincoln 2011; Silverman 2011). Det kan vara fråga om allmänt inriktade handböcker, men numera inte så sällan också böcker som fokuserar på speciella discipliner inom samhällsvetenskap eller omvårdnadsforskning, etc. Det kan också handla om metodböcker, kapitel eller artiklar, som knyter an till speciella grupper och de metodfrågor som därigenom kan aktualiseras (se till exempel Nind 2008; Wenger 2002 ). Det har hittills inte funnits någon speciell metodbok inom just vårt studerade område. De perspektiv vi har tillämpat har hittills också varit ganska outforskade. Men ett lika viktigt argument är att de flesta metodböcker beskriver hur man gör och inte, som i vårt fall, betingelserna kring – möjligheterna och utmaningarna – och konsekvenserna av att använda olika metoder. För att ta del av forskning om de sistnämnda frågorna får man som regel gå till metodkapitel i avhandlingar, vilka ibland, men inte alltid, belyser de här frågorna. Det finns naturligtvis också vetenskapliga artiklar som tar upp metodologiska erfarenheter på olika sätt. Men här saknas ofta en mer övergripande bild.Krävs det egentligen några speciella metoder för att studera funktionshinder och åldrande? Nej, det kan vara svårt att hävda. Men vårt område är förknippat med speciella betingelser, vilka får betydelse för den forskning man vill genomföra. Det handlar om ett etiskt känsligt område. Frågor som berör funktionshinder och livet för människor med funktionsnedsättningar är också påtagligt ”normativt impregnerat” när det gäller vilka perspektiv som anses vara politiskt korrekta för forskningen och beträffande vem som ”har rätt” att forska inom området överhuvudtaget. I flera av bokens kapitel reflekterar författarna över den här typen av frågor. Men ”det speciella” är inte vårt syfte i sig. Istället menar vi att vi, genom att belysa våra frågor och perspektiv mot bakgrund av vårt speciella område och dess betingelser och våra studerade grupper, illustrerar allmänna metodfrågor och deras praktiska implikationer. Det specifika kan ofta tydliggöra allmängiltiga mönster. Samtidigt – och det är viktigt att understryka – är de metodologiska frågor vi tar upp sådana som sällan diskuteras överhuvudtaget och de grupper som intervjuats kommer sällan till tals.Boken riktar sig främst till högskolestudenter inom samhälls- och beteendevetenskap, liksom till omsorgsutbildningar och vårdvetenskap, mer specifikt i samband med metodutbildning och uppsatsskrivande. Men även doktorander och mer etablerade forskare hoppas och tror vi kan ha användning av våra metodologiska reflektioner. Vår bedömning är också att de erfarenheter som redovisas kan vara av praktisk nytta för yrkesverksamma inom områden som socialt arbete, vård och omsorg.
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| 3. |
- Austeng, Dordi, et al.
(författare)
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Incidence of and risk factors for neonatal morbidity after active perinatal care : extremely preterm infants study in Sweden (EXPRESS)
- 2010
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Ingår i: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 99:7, s. 978-992
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Tidskriftsartikel (refereegranskat)abstract
- Aims: The aim of this study was to determine the incidence of neonatal morbidity in extremely preterm infants and to identify associated risk factors. Methods: Population based study of infants born before 27 gestational weeks and admitted for neonatal intensive care in Sweden during 2004-2007. Results: Of 638 admitted infants, 141 died. Among these, life support was withdrawn in 55 infants because of anticipation of poor long-term outcome. Of 497 surviving infants, 10% developed severe intraventricular haemorrhage (IVH), 5.7% cystic periventricular leucomalacia (cPVL), 41% septicaemia and 5.8% necrotizing enterocolitis (NEC); 61% had patent ductus arteriosus (PDA) and 34% developed retinopathy of prematurity (ROP) stage >= 3. Eighty-five per cent needed mechanical ventilation and 25% developed severe bronchopulmonary dysplasia (BPD). Forty-seven per cent survived to one year of age without any severe IVH, cPVL, severe ROP, severe BPD or NEC. Tocolysis increased and prolonged mechanical ventilation decreased the chances of survival without these morbidities. Maternal smoking and higher gestational duration were associated with lower risk of severe ROP, whereas PDA and poor growth increased this risk. Conclusion: Half of the infants surviving extremely preterm birth suffered from severe neonatal morbidities. Studies on how to reduce these morbidities and on the long-term health of survivors are warranted.
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| 4. |
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| 5. |
- Blom, Johannes, et al.
(författare)
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A 9-year follow-up study of participants and nonparticipants in sigmoidoscopy screening : importance of self-selection
- 2008
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Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - 1055-9965 .- 1538-7755. ; 17:5, s. 1163-1168
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Self-selection may compromise cost-effectiveness of screening programs. We hypothesized that nonparticipants have generally higher morbidity and mortality than participants. METHODS: A Swedish population-based random sample of 1,986 subjects ages 59 to 61 years was invited to sigmoidoscopy screening and followed up for 9 years by means of multiple record linkages to health and population registers. Gender-adjusted cancer incidence rate ratio (IRR) and overall and disease group-specific and mortality rate ratio (MRR) with 95% confidence intervals (95% CI) were estimated for nonparticipants relative to participants. Cancer and mortality rates were also estimated relative to the age-matched, gender-matched, and calendar period-matched Swedish population using standardized incidence ratios and standardized mortality ratios. RESULTS: Thirty-nine percent participated. The incidence of colorectal cancer (IRR, 2.2; 95% CI, 0.8-5.9), other gastrointestinal cancer (IRR, 2.7; 95% CI, 0.6-12.8), lung cancer (IRR, 2.2; 95% CI, 0.8-5.9), and smoking-related cancer overall (IRR, 1.4; 95% CI, 0.7-2.5) tended to be increased among nonparticipants relative to participants. Standardized incidence ratios for most of the studied cancers tended to be >1.0 among nonparticipants and <1.0 among participants. Mortality from all causes (MRR, 2.4; 95% CI, 1.7-3.4), neoplastic diseases (MRR, 1.9; 95% CI, 1.1-3.5), gastrointestinal cancer (MRR, 4.7; 95% CI, 1.1-20.7), and circulatory diseases (MRR, 2.3; 95% CI, 1.2-4.2) was significantly higher among nonparticipants than among participants. Standardized mortality ratio for the studied outcomes tended to be increased among nonparticipants and was generally decreased among participants. CONCLUSION: Individuals who might benefit most from screening are overrepresented among nonparticipants. This self-selection may attenuate the cost-effectiveness of screening programs on a population level.
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| 6. |
- Blom, Johannes, et al.
(författare)
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Toward understanding non participation in sigmoidoscopy screening for colorectal cancer
- 2008
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 122:7, s. 1618-1623
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Tidskriftsartikel (refereegranskat)abstract
- Understanding the reasons for nonparticipation in cancer screening may give clues about how to improve compliance. However, limited cooperation has hampered research on nonparticipant profiles. We took advantage of Sweden's comprehensive demographic and health care registers to investigate characteristics of all participants and nonparticipants in a pilot program for colorectal cancer screening with sigmoidoscopy. A population-based sample of 1986 Swedish residents 59-61 years old was invited. Registers provided information on each individual's gender, country of birth, marital status, education, income, hospital contacts, place of residence, distance to screening center and cancer within the family. Odds ratios (ORs) with 95% confidence intervals (CIs), modeled with multivariable logistic regression, estimated the independent associations between each background factor and the propensity for nonparticipation after control for the effects of other factors. All statistical tests were 2-sided. Being male (OR = 1.27, 95% CI = 1.03-1.57, relative to female), unmarried or divorced (OR = 1.69, 95% CI = 1.23-2.30 and OR = 1.49, 95% CI = 1.14-1.95, respectively, relative to married) and having an income in the lowest tertile (OR = 1.68, 95% CI = 1.27-2.23, relative to highest tertile) was associated with increased nonparticipation. Living in the countryside or in small communities and having a documented family history of colorectal cancer was associated with better participation. Distance to the screening center did not significantly affect participation, nor did recent hospital care consumption or immigrant status. To increase compliance, invitations must appeal to men, unmarried or divorced people and people with low socioeconomic status.
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| 7. |
- Blomqvist, Lennart, 1947, et al.
(författare)
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Arachidonic acid-induced platelet aggregation and acetylsalicylic acid treatment during pregnancy in women with recurrent miscarriage, a post hoc study
- 2022
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Ingår i: Platelets. - : Informa UK Limited. - 0953-7104 .- 1369-1635. ; 33:2, s. 278-284
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Tidskriftsartikel (refereegranskat)abstract
- In this post hoc study, arachidonic acid (AA)-induced platelet aggregation during pregnancy with and without acetylsalicylic acid (ASA) treatment was studied in 323 women with unexplained recurrent first-trimester miscarriage and in 59 healthy women with normal pregnancies. All women had normal AA-induced platelet aggregation in the non-pregnant state. Women with recurrent miscarriage were treated with 75 mg ASA or placebo daily. AA-induced platelet aggregation was measured with multiple electrode impedance aggregometry and presented in units (U), where 1 U = 10 aggregation units x minutes. There were no significant differences in platelet aggregation between placebo-treated women with recurrent miscarriage and healthy women. The mean differences were -0.7 (95%CI; -7.0; 5.6) U in the non-pregnant state, 3.8 (95%CI; -4.6; 12.2) U during the late first trimester and 1.7 (95%CI; -6.7; 10.3) U and 4.1 (95%CI; -3.9; 12.0) U during the early and late third trimester, respectively. ASA reduced platelet aggregation by median -84.0% (Q1; Q3; -89.8; -76.3), -79.9% (-84.7; -69.2) and -75.7% (-83.5; -49.5), respectively, during pregnancy. The degree of inhibition by ASA decreased during the third trimester (p < .0001). There were two (1.9%) complete non-responders to ASA and 32.1% with a partial response. The rate of subsequent miscarriage was not affected by ASA, which did not seem to influence the rate of early miscarriage if treatment was initiated when a viable pregnancy was detectable by ultrasound.
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| 8. |
- Claesson, Ing-Marie, et al.
(författare)
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Consumer satisfaction with a weight-gain intervention programme for obese pregnant women
- 2008
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Ingår i: Midwifery. - : Elsevier. - 0266-6138 .- 1532-3099. ; 24:2, s. 163-167
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Tidskriftsartikel (refereegranskat)abstract
- Objective: to investigate women's attitudes and satisfaction with a weight-gain intervention programme during pregnancy.Design: exploratory, descriptive study. Data were collected via interviews.Setting: University hospital.Participants: 56 obese pregnant women who attended antenatal care at the University Hospital of Linkoping's obstetrical department and took part in an intervention programme aimed at reducing weight gain during pregnancy, between November 2003 and August 2004.Findings: the interviews comprised several questions concerning attitudes and opinions of the programme. Most of the women expressed positive experiences with the treatment and would attend the programme if they became pregnant again. Most of the women stated that they had changed their eating and exercise habits during pregnancy, and almost all of them had continued with these new habits. Even though the weight gain goal of a maximum 6.9 kg was reached by less than half of the participants, most of the women were satisfied with their weight gain. A total of 71.4% of the women participated in aqua aerobics classes. They stated that they were most satisfied with this form of exercise, and that it also was a good social experience.Key conclusions and implications for practice: a pregnant woman herself must be actively involved in setting her own goals to prevent excessive weight gain during pregnancy. Considerable effort and support must be placed on discussing strategies, pitfalls and risks. In order for the woman to maintain the change in attitude and habits, she must probably be given continuous feedback and reinforcement over the long term.
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| 9. |
- Claesson, Ing-Marie, 1953-, et al.
(författare)
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Weight after childbirth : A 2-year follow-up of obese women in a weight-gain restriction program
- 2011
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Ingår i: Acta Obstetricia et Gynecologica Scandinavica. - : Informa Healthcare. - 0001-6349 .- 1600-0412. ; 90:1, s. 103-110
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Objective: To investigate the effects of a weight gain restriction program on weight development or weight maintenance two years after childbirth. Methods: The intervention group consisted of 155 obese pregnant women who participated in a weight gain restriction program with weekly support duringpregnancy. The control group consisted of 193 obese pregnant women. Follow-up weight measurements were done at 12 and 24 months postpartum. Results: The mean value of weight change in the intervention group was -2.2 kg compared to + 0.4 kg in the control group from early pregnancy to the follow-up 12 months after childbirth (p = .046). A greater percentage of women in the intervention group showed a weight loss 24 months after delivery than did women in the control group at that same time (p = .034). Women in the intervention group who gained less than 7 kg during pregnancy had a significantly lower weight than the controls at the 24 months follow-up (p = .018). Conclusion: An intervention program with weekly motivational support visits during pregnancy and every 6 months after childbirth seems to have an impact on weight gain up to 24 months after childbirth for those women in the intervention group who succeeded in restricting their gestational weight gain to less than 7 kg.
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| 10. |
- Claesson, Ing-Marie, et al.
(författare)
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Weight gain restriction during pregnancy is safe for both the mother and neonate
- 2009
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Ingår i: Acta Obstetricia et Gynecologica Scandinavica. - : John Wiley & Sons. - 0001-6349 .- 1600-0412. ; 88:10, s. 1158-1162
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Tidskriftsartikel (refereegranskat)abstract
- The objective of this study was to investigate whether pregnancy, delivery, and neonatal outcome among obese pregnant women who took part in an intervention study for weight restriction differed from a group of obese pregnant women attending regular antenatal care. The intervention group consisted of 155 obese pregnant women and 193 obese pregnant women who formed a control group. We found that a weight gain restriction of less than 7 kg during pregnancy is safe for both the mother and the neonate.
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| 11. |
- Claesson, Ing-Marie, 1953-, et al.
(författare)
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Weight gain restriction for obese pregnant women : A case-control intervention study
- 2008
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Ingår i: British Journal of Obstetrics and Gynecology. - : Wiley. - 1470-0328 .- 1471-0528. ; 115:1, s. 44-50
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To minimise obese women's total weight gain during pregnancy to less than 7 kg and to investigate the delivery and neonatal outcome. Design: A prospective case-control intervention study. Setting: Antenatal care clinics in the southeast region of Sweden. Population: One hundred fifty-five pregnant women in an index group and one hundred ninety-three women in a control group. Methods: An intervention programme with weekly motivational talks and aqua aerobic classes for obese pregnant women. Main outcome measures: Weight gain in kilograms, delivery and neonatal outcome. Results: The index group had a significantly lower weight gain during pregnancy compared with the control group (P < 0.001). The women in the index group weighed less at the postnatal check-up compared with the weight registered in early pregnancy (P < 0.001). The percentage of women in the index group who gained less than 7 kg was greater than that of women in the control group who gained less than 7 kg (P = 0.003). The percentage of nulliparous women in this group was greater than that in the control group (P = 0.018). In addition, the women in the index group had a significantly lower body mass index at the postnatal check-up, compared with the control group (P < 0.001). There were no differences between the index group and the control group regarding birthweight, gestational age and mode of delivery. Conclusion: The intervention programme was effective in controlling weight gain during pregnancy and did not affect delivery or neonatal outcome.
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| 12. |
- Fellman, Vineta, et al.
(författare)
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One-year survival of extremely preterm infants after active perinatal care in Sweden.
- 2009
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Ingår i: JAMA : the journal of the American Medical Association. - : American Medical Association (AMA). - 1538-3598 .- 0098-7484. ; 301:21, s. 2225-33
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Tidskriftsartikel (refereegranskat)abstract
- Up-to-date information on infant survival after extremely preterm birth is needed for assessing perinatal care services, clinical guidelines, and parental counseling.
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| 13. |
- Gad, Helge, et al.
(författare)
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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
- 2014
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Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 508:7495, s. 215-221
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Tidskriftsartikel (refereegranskat)abstract
- Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA replication. Although MTH1 is non-essential in normal cells, we show that cancer cells require MTH1 activity to avoid incorporation of oxidized dNTPs, resulting in DNA damage and cell death. We validate MTH1 as an anticancer target in vivo and describe small molecules TH287 and TH588 as first-in-class nudix hydrolase family inhibitors that potently and selectively engage and inhibit the MTH1 protein in cells. Protein co-crystal structures demonstrate that the inhibitors bindin the active site of MTH1. The inhibitors cause incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts. This study exemplifies the non-oncogene addiction concept for anticancer treatment and validates MTH1 as being cancer phenotypic lethal.
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| 14. |
- Grothérus, Annika, 1972-, et al.
(författare)
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Formative Scaffolding : how to alter the level and strength of self-efficacy and foster self-regulation in a mathematics test situation
- 2018
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Ingår i: Educational action research. - : Taylor & Francis Group. - 0965-0792 .- 1747-5074. ; 27:5, s. 667-690
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Tidskriftsartikel (refereegranskat)abstract
- The aim of the present study is to advocate the use of a participatory action research programme, the Formative Scaffolding Programme (FSP), in mathematics. The FSP’s main structure is presented as well as an implementation of a class intervention, with the aim of exploring the FSP test cycle’s virtues in a social science class in a Swedish upper-secondary school. The motivations for the FSP’s development were to enhance students’ awareness of their mathematical proficiency, alter the level and strength of their self-efficacy, foster self-regulated learning (SRL), reduce and prevent mathematics-related anxiety, and visualise the learning process in mathematics. The primary findings of the study were there was a resemblance between the FSP setting and SRL phases, and that participation in the test cycle altered the level and strength of students’ self-efficacy and fostered self-regulation in a mathematics test situation. The benefits of working in a formative scaffolding manner indicate that it is worth implementing the FSP on a larger scale. The study is an example of how students can engage in transforming classroom practice and be radical agents of change.
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| 15. |
- Hardell, Christian, et al.
(författare)
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A relational database for general mechanical systems
- 1995
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Ingår i: Computational Dynamics in Multibody Systems. - Dordrecht : Encyclopedia of Global Archaeology/Springer Verlag. - 792333047 ; , s. 49-59
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Konferensbidrag (refereegranskat)abstract
- This paper provides a specification of a relational data base structure for mechanical systems. Through the example provided, a robot gripping device, it is demonstrated how the initial development of the data-base structure has successfully led to an implementation in a practical software environment. The data base is accessible to multiple engineering application programs and supports a flexible environment for the continuing development of new applications
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| 16. |
- Hermansson, Cecilia, et al.
(författare)
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Reduced expression of NLRP3 and MEFV in human ischemic heart tissue.
- 2013
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Ingår i: Biochemical and biophysical research communications. - : Elsevier BV. - 1090-2104 .- 0006-291X. ; 430:1, s. 425-428
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Tidskriftsartikel (refereegranskat)abstract
- The innate immune system and, in particular, activation of the multi-protein complex known as the inflammasome complex are involved in ischemic injury in myocardial cells. The nucleotide-binding leucine-rich repeat-containing pyrin receptor 3 (NLRP3) inflammasome has been linked to inflammation and NLRP3 is especially important for increased inflammation in atherosclerosis, which may lead to myocardial infarction. Here we investigated how inflammasome molecules are affected in human ischemic heart tissue. Surprisingly the important member of the inflammasome complex, NLRP3, displayed markedly decreased levels in human ischemic heart tissue compared with non ischemic control heart tissue. However, subsequent gene analysis revealed mutations in NLRP3 in human ischemic heart tissues but not in non-ischemic control tissue. Gene polymorphisms in the NLRP3 inflammasome have been shown to be associated with increased IL-1β and IL-18 production and severe inflammation. The autoinflammatory disorder familial Mediterranean fever (FMF) is associated with decreased expression of the Mediterranean fever gene (MEFV) and increased inflammation. We also observed reduced expression of MEFV in ischemic versus non-ischemic heart tissue. Further analyses showed a mutation in MEFV in human ischemic heart tissue but not in non-ischemic control tissue. Our data show that defects in the inflammasome and associated proteins may be involved in promoting ischemic heart disease.
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| 17. |
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| 18. |
- Jeppsson, Annika, 1958-
(författare)
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The significance of placental and placental-like alkaline phosphatases in tumor biology and their potential use in clinical practice
- 1984
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Placental alkaline phosphatase (PLAP) is a membrane bound enzyme normally synthesized by the syncytiotrophoblasts in the human placenta. Recent studies have indicated that trace amounts of placental-like alkaline phosphatases also are present in several normal organs like testes and endocervix. PLAP and PLAP-1ike enzymes are furthermore synthesized by some tumors and can be detected in sera of approximately 12 % of patients with any type of cancer, more often in patients with genital tumors. This synthesis has been considered to be ectopic.PLAP is known to be electrophoretically highly polymorphic. Both poly- and monoclonal antibodies were used to study this enzyme. One of the monoclonal antibodies was able to discriminate between different phenotypes of PLAP and thus immunochemical approaches to elucidate enzyme polymorphism were established.To evaluate the potential clinical use of PLAP as a tumor marker serum levels of the enzyme were measured by a radioimmunoassay in 100 patients with the testicular tumor seminoma. Elevated levels of PLAP were found in 43 % of the patients with primary tumors and in 75 % of the patients with recurrent or metastatic disease. After successful treatment of seminoma the PLAP levels decreased. This indicates that measuring PLAP give useful information during follow up of treatment of seminomas.The content of PLAP-like enzymes in seminoma tumors was determined in 13 typical seminomas. The levels, of enzyme found in the tumor tissue ranged from 870-13 404 ng/g wet weight, which should be compared to around 100 ng/g in normal testes. Analysis using monoclonal antibodies and enzyme inhibitors showed the PLAP-like enzymes present in seminomas to be similar to the enzymes in normal testes. This suggests that the increased expression of PLAP-like enzymes in seminomas results from an enhanced eutopic expression of enzymes found in normal testis.A sensitive catalytic assay was used to quantify enzyme levels in sera from women with malignant gynaecological tumors. In the group of patients with cervical carcinoma 68 % had values exceeding the normal limit. For patients with ovarian cancer and carcinoma of the breast the percentages were 35 and 23 respectively.Monoclonal and polyclonal antibodies against PLAP were evaluated for tumor immunolocalization of human PLAP-producing tumors in nude mice.The antibodies were labeled with "125j and injected into mice with tumors. The distribution of 25j_an-ti-PLAP in various tissues showed that the labeled antibodies were enriched in the tumors, with a mean concentration ratio of 7. This indicates that there is a potential use of PLAP in localizing tumors in humans.
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| 19. |
- Jeppsson-Grassman, Eva, et al.
(författare)
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“A home away from home” : The role of the Church of Sweden Abroad for Swedish migrants
- 2013
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Ingår i: New Religiosity in Migration. ; , s. 38-41
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Konferensbidrag (refereegranskat)abstract
- According to some studies, Sweden is one of the most secularized countries in the world. with low church attendance. For most Swedes, their contact with the church is limited to traditional rites. How are we then to understand that quite a few Swedes seem to act much like immigrant groups from less secularized nations, by turning to the ethnic church and to religious practices while moving – fully or part time – to foreign countries?The aim of the presentation is to discuss this question, based on results from a project in which the role of the Church of Sweden Abroad has been explored. The Church of Sweden has a long traditions of creating parishes abroad, mainly in the larger European cities and in connection with harbors, as Seaman`s Churches. Since some decades, however, the Church has started to follow the streams of tourists and elderly migrants and parishes have been established, mainly in Southern Europe and, lately in Asian countries.The presentation will be based on a project consisting of three studies: 1) A qualitative case study, 2) A mapping of the web sites of all 45 parishes, and 3) An internet-based survey of all parishes. An interesting pattern turned out to be that many church visitors who initially seemed to be attracted by the (Swedish) “home away from home” that the parish offered through e.g. “Swedish coffee”, eventually began to participate regularly in the church services, even in Holy Communion.
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| 20. |
- Jeppsson-Grassman, Eva, 1944-, et al.
(författare)
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A long life with a particular signature : life course and ageing for people with disabilities
- 2012
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Ingår i: Journal of gerontological social work. - : Routledge. - 0163-4372 .- 1540-4048. ; 55:2, s. 95-111
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Tidskriftsartikel (refereegranskat)abstract
- What does it mean to live a long life and grow old with disabilities? Or to be an aging parent and still be a caregiver to a disabled adult child? These are questions discussed in this article, the aim of which is to show how a life course perspective adds insight to the lived experience of disability and ageing of adults with disabilities. It is argued that the time concept is fundamental to the understanding of the lives of disabled people. Results are presented which challenge established knowledge regarding disability policies, autonomy, body, biographical disruption and prerequisites of active aging.
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| 21. |
- Jeppsson-Grassman, Eva, 1944-, et al.
(författare)
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Att reflektera över forskningsmetoder : en bakgrund
- 2015
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Ingår i: Att studera funktionshinder och åldrande. - Norrköping : Nationella institutet för forskning och äldre och åldrande (NISAL), Linköpings unversitet. - 9789175191591 ; , s. 15-27
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 22. |
- Jeppsson Grassman, Eva, et al.
(författare)
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Ett långt liv med särskilda förtecken : Livslopp och åldrande hos människor med funktionsnedsättningar
- 2011
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Ingår i: Socialvetenskaplig tidskrift. - 1104-1420 .- 2003-5624. ; 18:2, s. 107-125
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Vad innebär det att åldras med funktionsnedsättningar som man fått redan i tidig ålder eller som yngre vuxen? På vilket sätt formar funktionshinder livet över tid? Och hur är det att vara en till åren kommen förälder och fortfarande vara central som hjälpgivare till ett vuxet, funktionshindrat barn? Vilken betydelse har epoken och reformerna? I artikeln diskuteras dessa frågor med utgångspunkt i ett brett upplagt forskningsprojekt ”Funktionshinder, livslopp och åldrande”
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| 23. |
- Jeppsson Grassman, Eva, 1944-, et al.
(författare)
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Family as failure? The role of informal help-givers to disabled people in Sweden.
- 2009
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Ingår i: Scandinavian Journal of Disability Research. - : Stockholm University Press. - 1501-7419 .- 1745-3011. ; 11:1, s. 35-49
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Tidskriftsartikel (refereegranskat)abstract
- Based on a survey mapping all unpaid help and care work in the county of Stockholm, this article focuses on the informal help and care carried out for long-term ill and/or disabled people aged 64 or younger. The findings indicate that these forms of support are common and that the informal help-givers work many hours every month. Yet the impact of this work is quite invisible in texts on disability policy and there is a void of research addressing this issue. This article argues that, in spite of welfare state arrangements and reforms, families play a crucial role in providing resources, notably help and care for disabled family members. Their invisibility is interpreted as an expression of the fact that the care concept has become politically incorrect. In the light of modern disability policies, with its ideals of autonomy and empowerment, help and care provided by families to adults aged 64 or younger stand out as a dilemma and a contradiction. Making help and care provided by families invisible can be interpreted as one way of solving this contradiction.
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| 24. |
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| 25. |
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