| 1. |
- Villa, Luisa L., et al.
(författare)
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Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions
- 2007
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Ingår i: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 356:19, s. 1915-1927
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Human papillomavirus types 16 (HPV-16) and 18 (HPV-18) cause approximately 70% of cervical cancers worldwide. A phase 3 trial was conducted to evaluate a quadrivalent vaccine against HPV types 6, 11, 16, and 18 (HPV-6/11/16/18) for the prevention of high-grade cervical lesions associated with HPV-16 and HPV-18. METHODS: In this randomized, double-blind trial, we assigned 12,167 women between the ages of 15 and 26 years to receive three doses of either HPV-6/11/16/18 vaccine or placebo, administered at day 1, month 2, and month 6. The primary analysis was performed for a per-protocol susceptible population that included 5305 women in the vaccine group and 5260 in the placebo group who had no virologic evidence of infection with HPV-16 or HPV-18 through 1 month after the third dose (month 7). The primary composite end point was cervical intraepithelial neoplasia grade 2 or 3, adenocarcinoma in situ, or cervical cancer related to HPV-16 or HPV-18. RESULTS: Subjects were followed for an average of 3 years after receiving the first dose of vaccine or placebo. Vaccine efficacy for the prevention of the primary composite end point was 98% (95.89% confidence interval [CI], 86 to 100) in the per-protocol susceptible population and 44% (95% CI, 26 to 58) in an intention-to-treat population of all women who had undergone randomization (those with or without previous infection). The estimated vaccine efficacy against all high-grade cervical lesions, regardless of causal HPV type, in this intention-to-treat population was 17% (95% CI, 1 to 31). CONCLUSIONS: In young women who had not been previously infected with HPV-16 or HPV-18, those in the vaccine group had a significantly lower occurrence of high-grade cervical intraepithelial neoplasia related to HPV-16 or HPV-18 than did those in the placebo group.
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| 2. |
- Johannisson, Jenny, et al.
(författare)
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Vetenskap på tvären : akademiska värden, friheter och gränser
- 2013
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Ingår i: Vetenskap för profession. - : Högskolan i Borås. - 1654-6520. ; :26, s. 11-19
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Texten utgör en inledning till antologin Vetenskap på tvären; den tredje volymen som dokumenterar seminarieserien Från Högskolan i Borås till Humboldt. Texten sätter den tredje seminarieseriens innehåll i förhållande till de två tidigare, diskuterar i korthet några aspekter på begreppet och företeelsen tvärvetenskap samt introducerar de nio övriga uppsatser som ingår i volymen.
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| 3. |
- Björnelius, E, et al.
(författare)
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Antibiotic treatment of symptomatic Mycoplasma genitalium infection in Scandinavia: a controlled clinical trial.
- 2008
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Ingår i: Sexually transmitted infections. - : BMJ. - 1472-3263 .- 1368-4973. ; 84:1, s. 72-6
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To evaluate the microbiological cure rate after treatment with tetracyclines or azithromycin in patients infected with M genitalium. METHODS: One hundred and fifty-two men and 60 women positive for M genitalium were recruited. Patients treated either with doxycyline for 9 days or with azithromycin 1 g stat. were compared. Those still positive for M genitalium after primary doxycycline treatment received an extended course of azithromycin 500 mg on day 1 followed by 250 mg daily for the following 4 days, whereas those with treatment failure after azithromycin received doxycycline 100 mg twice daily for 15 days. RESULTS: The eradication rate after azithromycin 1 g stat. was 85% (95% CI 69 to 94) in men (n = 39) and 88% (95% CI 64 to 99) in women (n = 17) and after doxycycline 17% (95% CI 9 to 27) in men (n = 76) and 37% (95% CI 19 to 58) in women (n = 27). Extended azithromycin eradicated M genitalium from 96% (95% CI 85 to 99) of the men (n = 47) and from all six women who failed on doxycycline. Extended doxycycline treatment was insufficient. Persistent urethral inflammation was seen in a substantial portion of the men after eradication of M genitalium regardless of the antibiotic drug, indicating a poor predictive value of urethral smears in evaluation of persistent or recurrent infection. CONCLUSIONS: Azithromycin was more effective than doxycycline in treating patients infected with M genitalium. The extended course of azithromycin was highly effective but was given after the initial treatment with doxycycline. Randomised clinical trials are needed to compare the different dosages of azithromycin.
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| 6. |
- Erikson, Martin G, et al.
(författare)
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Från Högskolan i Borås till Humboldt, volym 3
- 2013
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Denna rapport är den tredje i ordningen som har sin upprinnelse i Humboldtuniversitetets 200-årsjubileum och i ambitionen att föra en kvalificerad diskussion om vilka roller som högskolor och universitet spelar idag. Rapporten ägnar särskild uppmärksamhet åt fenomenet tvärvetenskap och de utmaningar som en sådan ansats innebär, men den för också upp grundläggande principfrågor om akademiska friheter och värden till diskussion.
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| 7. |
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| 8. |
- Gisslén, Magnus, 1962, et al.
(författare)
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Sexuellt överförbara sjukdomar
- 2005
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Ingår i: Läkemedelsboken 2005/2006. ; , s. 387-398
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 9. |
- Gisslén, Magnus, 1962, et al.
(författare)
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Sexuellt överförbara sjukdomar
- 2007
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Ingår i: Läkemedelsboken 2007/2008. ; , s. 399-408
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 10. |
- Gisslén, Magnus, 1962, et al.
(författare)
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Sexuellt överförbara sjukdomar
- 2009
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Ingår i: Läkemedelsboken 2009/2010. ; , s. 427-438
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 17. |
- Löwhagen, Gun-Britt, 1942, et al.
(författare)
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Recurrent genital herpes in a population attending a clinic for sexually transmitted diseases.
- 2001
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Ingår i: Acta dermato-venereologica. - 0001-5555. ; 81:1, s. 35-7
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Tidskriftsartikel (refereegranskat)abstract
- Patients with recurrent genital herpes attending a sexually transmitted disease clinic were studied and transmission of the infection was elucidated by evaluating serostatus in their partners. Of 84 patients attending for recurrent genital herpes, 94% had a herpes simplex virus type 2 (HSV-2) infection and only 6% (5 patients) a type 1 infection. The mean age of the patients was 36 years and the duration of their infection was up to 37 years (median 4 years). In most patients the number of recurrences had not decreased between the first year and the last year. About half had experienced a more severe first episode infection. Of the patients, 64% were not aware of asymptomatic shedding and the risk of sexual transmission without clinical symptoms. Of 67 steady partners of patients with genital HSV-2, 15% had a history of genital herpes. By HSV serology, HSV-2 antibodies (indicating subclinical genital herpes) were demonstrated in more than half of the partners. The duration of the relationship or condom use did not seem to influence the frequency of transmission to the partner, which may indicate an individual susceptibility for acquiring a genital HSV-2 infection. Eleven per cent of the patients were on suppressive antiviral therapy, while 39% had no experience of antiviral therapy. Type-specific HSV serology was found to be of value in counselling partners of patients with genital herpes.
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| 18. |
- Malmgren Fänge, Agneta, et al.
(författare)
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Min bostad och jag.
- 2005
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Konferensbidrag (refereegranskat)
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| 19. |
- Nazari, Mohammad Ali, 1987, et al.
(författare)
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MmWave 6D Radio Localization with a Snapshot Observation from a Single BS
- 2023
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Ingår i: IEEE Transactions on Vehicular Technology. - 0018-9545 .- 1939-9359. ; 72:7, s. 8914-8928
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Tidskriftsartikel (refereegranskat)abstract
- Accurate and ubiquitous localization is crucial for a variety of applications such as logistics, navigation, intelligent transport, monitoring, control, and also for the benefit of communications. Exploiting millimeter-wave (mmWave) signals in 5G and Beyond 5G systems can provide accurate localization with limited infrastructure. We consider the single base station (BS) localization problem and extend it to 3D position and 3D orientation estimation of an unsynchronized multi-antenna user equipment (UE), using downlink multiple-input multiple-output orthogonal frequency-division multiplexing (MIMO-OFDM) signals. Through a Fisher information analysis, we show that the problem is often identifiable, provided that there is at least one multipath component in addition to the line-of-sight (LoS), even if the position of corresponding incidence point (IP) is a priori unknown. Subsequently, we pose a maximum likelihood (ML) estimation problem, to jointly estimate the 3D position and 3D orientation of the UE as well as several nuisance parameters (the UE clock offset and the positions of IPs corresponding to the multipath). The ML problem is a high-dimensional nonconvex optimization problem over a product of Euclidean and non-Euclidean manifolds. To avoid complex exhaustive search procedures, we propose a geometric initial estimate of all parameters, which reduces the problem to a 1-dimensional search over a finite interval. Numerical results show the efficiency of the proposed ad-hoc estimation, whose gap to the Cramér-Rao bound (CRB) is tightened using the ML estimation.
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