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- Ferreiro-Iglesias, Aida, et al.
(författare)
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Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity
- 2018
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Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- Lung cancer has several genetic associations identified within the major histocompatibility complex (MHC); although the basis for these associations remains elusive. Here, we analyze MHC genetic variation among 26,044 lung cancer patients and 20,836 controls densely genotyped across the MHC, using the Illumina Illumina OncoArray or Illumina 660W SNP microarray. We impute sequence variation in classical HLA genes, fine-map MHC associations for lung cancer risk with major histologies and compare results between ethnicities. Independent and novel associations within HLA genes are identified in Europeans including amino acids in the HLA-B*0801 peptide binding groove and an independent HLA-DQB1*06 loci group. In Asians, associations are driven by two independent HLA allele sets that both increase risk in HLA-DQB1*0401 and HLA-DRB1*0701; the latter better represented by the amino acid Ala-104. These results implicate several HLA-tumor peptide interactions as the major MHC factor modulating lung cancer susceptibility.
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- Trovik, Clement, et al.
(författare)
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The Scandinavian Sarcoma Group Central Register: 6,000 patients after 25 years of monitoring of referral and treatment of extremity and trunk wall soft-tissue sarcoma
- 2017
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Ingår i: Acta Orthopaedica. - : TAYLOR & FRANCIS LTD. - 1745-3674 .- 1745-3682. ; 88:3, s. 341-347
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Tidskriftsartikel (refereegranskat)abstract
- Purpose - We wanted to examine the potential of the Scandinavian Sarcoma Group (SSG) Central Register, and evaluate referral and treatment practice for soft-tissue sarcomas in the extremities and trunk wall (STS) in the Nordic countries. Background - Based on incidence rates from the literature, 8,150 (7,000-9,300) cases of STS of the extremity and trunk wall should have been diagnosed in Norway, Finland, Iceland, and Sweden from 1987 through 2011. The SSG Register has 6,027 cases registered from this period, with 5,837 having complete registration of key variables. 10 centers have been reporting to the Register. The 5 centers that consistently report treat approximately 90% of the cases in their respective regions. The remaining centers have reported all the patients who were treated during certain time periods, but not for the entire 25-year period. Results - 59% of patients were referred to a sarcoma center untouched, i.e. before any attempt at open biopsy. There was an improvement from 52% during the first 5 years to 70% during the last 5 years. 50% had wide or better margins at surgery. Wide margins are now achieved less often than 20 years ago, in parallel with an increase in the use of radiotherapy. For the centers that consistently report, 97% of surviving patients are followed for more than 4 years. Metastasis-free survival (MFS) increased from 67% to 73% during the 25-year period. Interpretation - The Register is considered to be representative of extremity and trunk wall sarcoma disease in the population of Scandinavia, treated at the reporting centers. There were no clinically significant differences in treatment results at these centers.
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- Gråsjö, Johan, et al.
(författare)
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Electronic structure of water molecules confined in a micelle lattice
- 2009
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Ingår i: Journal of Physical Chemistry B. - : American Chemical Society (ACS). - 1520-6106 .- 1520-5207. ; 113:24, s. 8201-8205
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Tidskriftsartikel (refereegranskat)abstract
- Oxygen K absorption and emission spectra of water molecules confined in dodecyltrimethyl ammonium chloride micelle structures are presented. The local electronic structure of the water molecules is found to be dramatically different from the electronic structure of water molecules in the gas-phase as well as in liquid water. Hybridization with states of the ions in the surrounding ions is directly observed, and evidence for stabilization of the water molecules relative to molecules in bulk water is found.
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- Johansson, Egil
(författare)
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Literacy campaigns in Sweden
- 2008. - 1
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Ingår i: National literacy campaigns and movements. - New York : Routledge. - 9781315125077 - 9781138528628 ; , s. 65-98
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Bokkapitel (refereegranskat)abstract
- It has been difficult in the past to make an accurate history of Swedish literacy known in other countries. To make a population literate requires some form of organized instruction and a number of literacy campaigns. In Denmark and Sweden, the population remained nearly steady, the increase being spread over the rest of Scandinavia. The most noteworthy was Scandinavian popular poetry and, in particular, the oral and written popular literature of Iceland. Politics, through war and peace, has drawn its dramatic lines over the Swedish and Scandinavian map. The traditional form of popular education, conducted under the auspices of the Swedish Church, was relieved of a good share of its responsibilities by the system of school education decreed in 1842. If the Swedish model of popular education is accepted, it also means that the Swedish material can be used for setting up new models for literacy campaigns in the developing countries.
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- Johansson, Pär, 1986, et al.
(författare)
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Interior Insulation Retrofit of a Brick Wall Using Vacuum Insulation Panels: Design of a Laboratory Study to Determine the Hygrothermal Effect on Existing Structure and Wooden Beam Ends
- 2013
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Ingår i: 12th International Conference on Thermal Performance of the Exterior Envelopes of Whole Buildings, Clearwater, United States, 1-5 December 2013.
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Konferensbidrag (refereegranskat)abstract
- The increasing demand on energy-efficient buildings requires energy retrofitting measures in the existing building stock. Conventional thermal insulation materials, such as mineral wool and expanded polystyrene (EPS), demand a thick layer of insulation to reach the energy targets. Vacuum insulation panels (VIPs) are a novel thermal insulation component with 5-10 times lower thermal conductivity than the conventional insulation materials, depending on the VIP ageing state. The thermal transmittance of the building envelope can thereby be substantially reduced using a limited additional insulation thickness. Previous research has shown that interior energy retrofitting of exterior walls may increase the moisture content of the walls and increases the risk of freeze-thaw damages at the surface. This study analyzes the hygrothermal consequences on a 250 mm (9.8 in.) thick brick wall retrofitted with 20 mm (0.8 in.) interior VIP (glued directly on the plastered brick wall). Hygrothermal simulations in WUFI 2D are used to study the hygrothermal effects by different material properties and boundary conditions. Apart from the material properties, the amount of driving rain available at the surface is the most important influential parameter in the simulations. The conclusions from this study are used to plan a measurement study in a climate simulator where driving rain and solar radiation will be simulated.
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| 22. |
- Johansson, Pär, 1986, et al.
(författare)
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Interior insulation retrofit of a historical brick wall using vacuum insulation panels: Hygrothermal numerical simulations and laboratory investigations
- 2014
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Ingår i: Building and Environment. - : Elsevier BV. - 0360-1323. ; 79, s. 31-45
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Tidskriftsartikel (refereegranskat)abstract
- Old listed buildings need to be retrofitted to reduce the energy use for heating. The possible thickness of the insulation layer is limited by the existing construction. Vacuum insulation panels (VIPs) require less thickness than conventional insulation materials to reach the same thermal resistance. Therefore, it could be more appropriate to use VIPs than conventional insulation materials when retrofitting the building envelope of listed buildings. The aim of this study is to investigate the hygrothermal performance of a brick wall with wooden beam ends after it was insulated on the interior with VIPs. One- and two-dimensional hygrothermal numerical simulations were used to design a laboratory study in a large-scale building envelope climate simulator. The wall was exposed to driving rain on the exterior surface and a temperature gradient. The relative humidity in the wall increased substantially when exposed to driving rain. The moisture content in the wooden beams also increased. There was no significant difference between the relative humidity in the wooden beam ends for the cases with and without VIPs. However, it was found that the reduced temperature in the brick after the VIPs were added led to a higher relative humidity in the wooden beams. It was also clear that when VIPs were added to the interior, the drying capacity to that side of the wall was substantially reduced. Finally, calculations of the U-value showed a large potential to reduce the energy use using VIPs on the interior of brick walls.
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| 23. |
- Johansson, Pär, 1986, et al.
(författare)
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Retrofitting a brick wall using vacuum insulation panels: measured hygrothermal effect on the existing structure
- 2014
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Ingår i: Proceedings of the 10th Nordic Symposium on Building Physics, June 15-19, 2014, Lund, Sweden.
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Konferensbidrag (refereegranskat)abstract
- Old listed buildings need to be retrofitted to reduce the energy use for heating. Vacuum insulation panels (VIPs) require less thickness than conventional insulation materials to reach the same thermal resistance. The aim of this paper is to investigate the hygrothermal performance of a brick wall with wooden beam ends after it was insulated on the interior with VIPs. The paper presents the first part of a laboratory study where a brick wall was built in the laboratory and exposed to simulated driving rain. Different measurement techniques of the relative humidity in the construction have been used. The relative humidity in the wall increased substantially when exposed to driving rain. The moisture content in the wooden beams also increased. However, it has not been possible to fully determine the influence by the added insulation layer. It is clear that the drying capacity to the interior side is substantially reduced. These investigations are ongoing and will be reported in future publications.
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