| 1. |
- Andrén, Mats, et al.
(författare)
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Att lära sig språk
- 2013
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Ingår i: Språket, människan och världen : människans språk 1-2 - människans språk 1-2. - Lund : Studentlitteratur AB. - 9789144083391 ; , s. 73-89
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Bokkapitel (populärvet., debatt m.m.)
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| 7. |
- Johansson, Victoria, et al.
(författare)
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Att undersöka språk
- 2013
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Ingår i: Språket, människan och världen : människans språk 1-2. - Lund : Studentlitteratur AB. - 9789144083391 ; , s. 315-334
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Bokkapitel (populärvet., debatt m.m.)
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| 8. |
- Johansson, Victoria, et al.
(författare)
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Människan och språket
- 2013
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Ingår i: Språket, människan och världen : människans språk 1-2. - Lund : Studentlitteratur AB. - 9789144083391 ; , s. 41-52
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Bokkapitel (populärvet., debatt m.m.)
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| 9. |
- Johansson, Victoria, et al.
(författare)
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Om den här boken
- 2013
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Ingår i: Språket, människan och världen : människans språk 1-2. - 9789144083391 ; , s. 7-14
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Bokkapitel (populärvet., debatt m.m.)
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| 10. |
- Johansson, Victoria, et al.
(författare)
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Språk och hjärna
- 2013
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Ingår i: Språket, människan och världen : människans språk 1-2. - 9789144083391 ; , s. 225-241
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Bokkapitel (populärvet., debatt m.m.)
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| 11. |
- Johansson, Victoria, et al.
(författare)
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Språk och hjärna
- 2013
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Ingår i: Språket, människan och världen. - Lund : Studentlitteratur AB.
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 12. |
- Barkarmo, Sargon, et al.
(författare)
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Inflammatory cytokine release from human peripheral blood mononuclear cells exposed to polyetheretherketone and titanium-6 aluminum-4 vanadium in vitro.
- 2018
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Ingår i: Journal of biomaterials applications. - : SAGE Publications. - 1530-8022 .- 0885-3282. ; 33:2, s. 245-258
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Tidskriftsartikel (refereegranskat)abstract
- Objective To investigate the cytokine expression profiles of blood cells exposed to polyetheretherketone and titanium-6 aluminum-4 vanadium materials in vitro. Materials and methods Coin-shaped samples composed of titanium-6 aluminum-4 vanadium, polyetheretherketone, and blasted polyetheretherketone were manufactured. The surfaces of the coins were characterized using optical interferometry, scanning electron microscopy, and contact angle measurements. Peripheral blood mononuclear cells collected from 10 blood donors were cultured for one, three, and six days in the presence or absence of the coins, and then assayed for cytokine production. Quantification of the peripheral blood mononuclear cells attached to the coins was performed using confocal microscopy after immunofluorescence staining. Results The machined titanium-6 aluminum-4 vanadium coins had a smoother surface topography compared to the machined polyetheretherketone and blasted polyetheretherketone. The highest mean contact angle was noted for the blasted polyetheretherketone, followed by the machined polyetheretherketone and titanium-6 aluminum-4 vanadium. The peripheral blood mononuclear cells produced significantly more proinflammatory cytokines when exposed to the polyetheretherketone surface compared to the titanium-6 aluminum-4 vanadium surface, while the blasted polyetheretherketone induced the highest level of proinflammatory cytokine release from the peripheral blood mononuclear cells. Significantly more cells attached to both polyetheretherketone surfaces, as compared to the titanium-6 aluminum-4 vanadium surface. Conclusion Polyetheretherketone induces a stronger inflammatory response from peripheral blood mononuclear cells than does titanium-6 aluminum-4 vanadium. Surface topography has an impact on cytokine release from peripheral blood mononuclear cells.
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| 13. |
- Bosse, Yohan, et al.
(författare)
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Transcriptome-wide association study reveals candidate causal genes for lung cancer
- 2020
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Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 146:7, s. 1862-1878
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Tidskriftsartikel (refereegranskat)abstract
- We have recently completed the largest GWAS on lung cancer including 29,266 cases and 56,450 controls of European descent. The goal of our study has been to integrate the complete GWAS results with a large‐scale expression quantitative trait loci (eQTL) mapping study in human lung tissues (n = 1,038) to identify candidate causal genes for lung cancer. We performed transcriptome‐wide association study (TWAS) for lung cancer overall, by histology (adenocarcinoma, squamous cell carcinoma and small cell lung cancer) and smoking subgroups (never‐ and ever‐smokers). We performed replication analysis using lung data from the Genotype‐Tissue Expression (GTEx) project. DNA damage assays were performed in human lung fibroblasts for selected TWAS genes. As expected, the main TWAS signal for all histological subtypes and ever‐smokers was on chromosome 15q25. The gene most strongly associated with lung cancer at this locus using the TWAS approach was IREB2 (pTWAS = 1.09E−99), where lower predicted expression increased lung cancer risk. A new lung adenocarcinoma susceptibility locus was revealed on 9p13.3 and associated with higher predicted expression of AQP3 (pTWAS = 3.72E−6). Among the 45 previously described lung cancer GWAS loci, we mapped candidate target gene for 17 of them. The association AQP3‐adenocarcinoma on 9p13.3 was replicated using GTEx (pTWAS = 6.55E−5). Consistent with the effect of risk alleles on gene expression levels, IREB2 knockdown and AQP3 overproduction promote endogenous DNA damage. These findings indicate genes whose expression in lung tissue directly influences lung cancer risk.
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| 14. |
- Dai, Juncheng, et al.
(författare)
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Genome-wide association study of INDELs identified four novel susceptibility loci associated with lung cancer risk
- 2020
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Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 146:10, s. 2855-2864
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) have identified 45 susceptibility loci associated with lung ncer. Only less than SNPs, small insertions and deletions (INDELs) are the second most abundant netic polymorphisms in the human genome. INDELs are highly associated with multiple human seases, including lung cancer. However, limited studies with large-scale samples have been available to stematically evaluate the effects of INDELs on lung cancer risk. Here, we performed a large-scale meta- alysis to evaluate INDELs and their risk for lung cancer in 23,202 cases and 19,048 controls. Functional notations were performed to further explore the potential function of lung cancer risk INDELs. nditional analysis was used to clarify the relationship between INDELs and SNPs. Four new risk loci re identified in genome-wide INDEL analysis (1p13.2: rs5777156, Insertion, OR = 0.92, p = 9.10 x 10(- ; 4q28.2: rs58404727, Deletion, OR = 1.19, p = 5.25 x 10(-7); 12p13.31: rs71450133, Deletion, OR = 09, p = 8.83 x 10(-7); and 14q22.3: rs34057993, Deletion, OR = 0.90, p = 7.64 x 10(-8)). The eQTL alysis and functional annotation suggested that INDELs might affect lung cancer susceptibility by gulating the expression of target genes. After conducting conditional analysis on potential causal SNPs, e INDELs in the new loci were still nominally significant. Our findings indicate that INDELs could be tentially functional genetic variants for lung cancer risk. Further functional experiments are needed to tter understand INDEL mechanisms in carcinogenesis.
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| 15. |
- Fanidi, Anouar, et al.
(författare)
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Circulating Folate, Vitamin B6, and Methionine in Relation to Lung Cancer Risk in the Lung Cancer Cohort Consortium (LC3)
- 2018
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Ingår i: Journal of the National Cancer Institute. - : Oxford University Press. - 0027-8874 .- 1460-2105. ; 110:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Circulating concentrations of B vitamins and factors related to one-carbon metabolism have been found to be strongly inversely associated with lung cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The extent to which these associations are present in other study populations is unknown.Methods: Within 20 prospective cohorts from the National Cancer Institute Cohort Consortium, a nested case-control study was designed including 5364 incident lung cancer case patients and 5364 control subjects who were individually matched to case patients by age, sex, cohort, and smoking status. Centralized biochemical analyses were performed to measure circulating concentrations of vitamin B6, folate, and methionine, as well as cotinine as an indicator of recent tobacco exposure. The association between these biomarkers and lung cancer risk was evaluated using conditional logistic regression models.Results: Participants with higher circulating concentrations of vitamin B6 and folate had a modestly decreased risk of lung cancer risk overall, the odds ratios when comparing the top and bottom fourths (OR 4vs1 ) being 0.88 (95% confidence interval [CI] = 0.78 to 1.00) and 0.86 (95% CI = 0.74 to 0.99), respectively. We found stronger associations among men (vitamin B6: OR 4vs1 = 0.74, 95% CI = 0.62 to 0.89; folate: OR 4vs1 = 0.75, 95% CI = 0.61 to 0.93) and ever smokers (vitamin B6: OR 4vs1 = 0.78, 95% CI = 0.67 to 0.91; folate: OR 4vs1 = 0.87, 95% CI = 0.73 to 1.03). We further noted that the association of folate was restricted to Europe/Australia and Asia, whereas no clear association was observed for the United States. Circulating concentrations of methionine were not associated with lung cancer risk overall or in important subgroups.Conclusions: Although confounding by tobacco exposure or reverse causation cannot be ruled out, these study results are compatible with a small decrease in lung cancer risk in ever smokers who avoid low concentrations of circulating folate and vitamin B6.
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| 16. |
- Fanidi, Anouar, et al.
(författare)
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Is high vitamin B12 status a cause of lung cancer?
- 2019
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Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 145:6, s. 1499-1503
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Tidskriftsartikel (refereegranskat)abstract
- Vitamin B supplementation can have side effects for human health, including cancer risk. We aimed to elucidate the role of vitamin B12 in lung cancer etiology via direct measurements of pre‐diagnostic circulating vitamin B12 concentrations in a nested case–control study, complemented with a Mendelian randomization (MR) approach in an independent case–control sample. We used pre‐diagnostic biomarker data from 5183 case–control pairs nested within 20 prospective cohorts, and genetic data from 29,266 cases and 56,450 controls. Exposures included directly measured circulating vitamin B12 in pre‐diagnostic blood samples from the nested case–control study, and 8 single nucleotide polymorphisms associated with vitamin B12 concentrations in the MR study. Our main outcome of interest was increased risk for lung cancer, overall and by histological subtype, per increase in circulating vitamin B12 concentrations. We found circulating vitamin B12 to be positively associated with overall lung cancer risk in a dose response fashion (odds ratio for a doubling in B12 [ORlog2B12] = 1.15, 95% confidence interval (95%CI) = 1.06–1.25). The MR analysis based on 8 genetic variants also indicated that genetically determined higher vitamin B12 concentrations were positively associated with overall lung cancer risk (OR per 150 pmol/L standard deviation increase in B12 [ORSD] = 1.08, 95%CI = 1.00–1.16). Considering the consistency of these two independent and complementary analyses, these findings support the hypothesis that high vitamin B12 status increases the risk of lung cancer.
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| 17. |
- Feng, Xiaoshuang, et al.
(författare)
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Evaluation of pre-diagnostic blood protein measurements for predicting survival after lung cancer diagnosis
- 2023
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Ingår i: EBioMedicine. - : Elsevier. - 2352-3964. ; 92
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Tidskriftsartikel (refereegranskat)abstract
- Background: To evaluate whether circulating proteins are associated with survival after lung cancer diagnosis, and whether they can improve prediction of prognosis.Methods: We measured up to 1159 proteins in blood samples from 708 participants in 6 cohorts. Samples were collected within 3 years prior to lung cancer diagnosis. We used Cox proportional hazards models to identify proteins associated with overall mortality after lung cancer diagnosis. To evaluate model performance, we used a round-robin approach in which models were fit in 5 cohorts and evaluated in the 6th cohort. Specifically, we fit a model including 5 proteins and clinical parameters and compared its performance with clinical parameters only.Findings: There were 86 proteins nominally associated with mortality (p < 0.05), but only CDCP1 remained statistically significant after accounting for multiple testing (hazard ratio per standard deviation: 1.19, 95% CI: 1.10–1.30, unadjusted p = 0.00004). The external C-index for the protein-based model was 0.63 (95% CI: 0.61–0.66), compared with 0.62 (95% CI: 0.59–0.64) for the model with clinical parameters only. Inclusion of proteins did not provide a statistically significant improvement in discrimination (C-index difference: 0.015, 95% CI: −0.003 to 0.035).Interpretation: Blood proteins measured within 3 years prior to lung cancer diagnosis were not strongly associated with lung cancer survival, nor did they importantly improve prediction of prognosis beyond clinical information.
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| 18. |
- Feng, Xiaoshuang, et al.
(författare)
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Lung cancer risk discrimination of prediagnostic proteomics measurements compared with existing prediction tools
- 2023
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Ingår i: Journal of the National Cancer Institute. - : Oxford University Press. - 0027-8874 .- 1460-2105. ; 115:9, s. 1050-1059
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: We sought to develop a proteomics-based risk model for lung cancer and evaluate its risk-discriminatory performance in comparison with a smoking-based risk model (PLCOm2012) and a commercially available autoantibody biomarker test.METHODS: We designed a case-control study nested in 6 prospective cohorts, including 624 lung cancer participants who donated blood samples at most 3 years prior to lung cancer diagnosis and 624 smoking-matched cancer free participants who were assayed for 302 proteins. We used 470 case-control pairs from 4 cohorts to select proteins and train a protein-based risk model. We subsequently used 154 case-control pairs from 2 cohorts to compare the risk-discriminatory performance of the protein-based model with that of the Early Cancer Detection Test (EarlyCDT)-Lung and the PLCOm2012 model using receiver operating characteristics analysis and by estimating models' sensitivity. All tests were 2-sided.RESULTS: The area under the curve for the protein-based risk model in the validation sample was 0.75 (95% confidence interval [CI] = 0.70 to 0.81) compared with 0.64 (95% CI = 0.57 to 0.70) for the PLCOm2012 model (Pdifference = .001). The EarlyCDT-Lung had a sensitivity of 14% (95% CI = 8.2% to 19%) and a specificity of 86% (95% CI = 81% to 92%) for incident lung cancer. At the same specificity of 86%, the sensitivity for the protein-based risk model was estimated at 49% (95% CI = 41% to 57%) and 30% (95% CI = 23% to 37%) for the PLCOm2012 model.CONCLUSION: Circulating proteins showed promise in predicting incident lung cancer and outperformed a standard risk prediction model and the commercialized EarlyCDT-Lung.
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| 19. |
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| 20. |
- Gullberg, Kajsa, et al.
(författare)
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In Scriptura Veritas? : Exploring Measures for Identifying Increased Cognitive Load in Speaking and Writing
- 2024
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Ingår i: Languages. - : MDPI AG. - 2226-471X. ; 9:3, s. 85
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Tidskriftsartikel (refereegranskat)abstract
- This study aims to establish a methodological framework for investigating deception in both spoken and written language production. A foundational premise is that the production of deceitful narratives induces a heightened cognitive load that has a discernable influence on linguistic processes during real-time language production. This study includes meticulous analysis of spoken and written data from two participants who told truthful and deceitful narratives. Spoken processes were captured through audio recordings and subsequently transcribed, while written processes were recorded using keystroke logging, resulting in final texts and corresponding linear representations of the writing activity. By grounding our study in a linguistic approach for understanding cognitive load indicators in language production, we demonstrate how linguistic processes, such as text length, pauses, fluency, revisions, repetitions, and reformulations can be used to capture instances of deception in both speaking and writing. Additionally, our findings underscore that markers of cognitive load are likely to be more discernible and more automatically measured in the written modality. This suggests that the collection and examination of writing processes have substantial potential for forensic applications. By highlighting the efficacy of analyzing both spoken and written modalities, this study provides a versatile methodological framework for studying deception during language production, which significantly enriches the existing forensic toolkit.
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| 21. |
- Gullberg, Kajsa, et al.
(författare)
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In scriptura veritas: ett metodologiskt förslag för att jämföra att skriva och att tala för forensiska ändamål
- 2024
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Konferensbidrag (populärvet., debatt m.m.)abstract
- Can language production processes in writing and speaking facilitate identification of fabrications? If so, are fabrications easier to detect in the written modality compared to the spoken modality? The aim of this study is to examine how language production processes manifest across truthful and fabricated narrative accounts of witnessed events. Specifically, the study asks if and how differences and similarities are manifested across written and spoken modalities, and if/how these differences/similarities can be analyzed within and across modalities. Linguistic processes in written and spoken language production are subject to working memory constraints (Goldman Eisler, 1970; McCutchen, 1996), and this can be seen in for example increased pause duration, frequency, and other disfluencies (Heldner & Edlund, 2010; Matsuhashi, 1981). It has also been found that lying leads to increased cognitive load (Williams, Bott, Patrick, & Lewis, 2013), leading to the hypothesis that fabrication would be visible in the production patterns in both modalities. Due to the synchronous nature of speaking, where the production process is overt, compared to the asynchronous nature of writing, where the process is covert, another hypothesis is that it will be easier to detect fabrication during writing.Two truthful and two fabricated narratives (whereof two spoken and two written) from a corpus of written and spoken narratives were used to qualitatively examine how pauses and disfluencies manifest in the two conditions across modalities. Written data consisted of a keystroke logging file and spoken as an audio file and transcription. Cognitive load was analyzed through text length, pause analyses and revisions (in writing) and reformulations (in speaking). The results show that, taking the difference in production speed across modalities into consideration, cognitive load can meaningfully be operationalized as pause frequency in relation to text length. Further, when measuring text length, the number of written/transcribed charactersis proposed as a way of measuring this while taking repetitions (in speaking) and fragments (in writing) into consideration. In conclusion, the study suggests that comparable results in the modalities can be reached by making informed analytical choices.
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| 22. |
- Gullberg, Kajsa, et al.
(författare)
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Using keystroke logging to explore differences in written language production processes between self-experienced and invented narrative accounts : A forensic linguistic approach
- 2024
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Konferensbidrag (populärvet., debatt m.m.)abstract
- This study aims at investigating if/how writing processes, such as planning and revision, differ between accounts of self-experienced and invented narratives. The underlying assumption is that cognitive load will increase for the writer when s/he is is changing or inventing parts of an otherwise self-experienced series of events. This builds on theories of how limited working memory capacity leads to increased pausing behavior in accordance with increased cognitive demands (Kellogg, 1996; McCutchen 2000), and that the need for revisions will increase when the writer wants to meet the goal of convincing the reader that something is true (cf. the relation between planning, translating and revision described in e.g. the writing model of Hayes and Flower, 1980). This presentation primarily focusses on comparing written accounts, collected with an experimental design. Participants (n=45) were presented with 4 elicitation videos, depicting misdemeanors (e.g., cheating on an exam, stealing a bike). Each participant performed 4 accounts across the 4 films: two written, and two spoken. For one account in each modality the participant is asked to lie and alter “who did it”. Modality, films and invented/self-experienced accounts are balanced for order. The written data was collected online through keystroke logging (ScriptLog). The participants repeated the experiment 4 times with 2 weeks apart, to allow for comparisons of consecutive accounts of both invented and self-experienced narratives. The first results showed no differences between time on task between invented and self-experienced narratives, but the invented narratives required overall more pause time. In addition, time on task and overall pause time decreased over the consecutive accounts, indicating that the retelling task became easier independent of condition. There were no overall differences in the amounts of deleted text between the conditions, but during the writing of the invented narratives, less characters were written between pauses, indicating theneed to pause (and plan?) more often. The general picture is that there are many individual differences, and that individual baselines may need to be established, as well as including comparisons within subjects in the further explorations of the data. Continuing analyses will look more closer at the linguistic contexts where the writers need to pause and revise, and will also compare the written accounts to spoken equivalents. The overall picture is however that using keystroke logging to investigate “true” and “false” narratives may be a rewarding avenue for forensic linguistics, and could be used (in addition to other tools) to identify instances where information needs to be further investigated.
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| 23. |
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| 25. |
- Huang, Joyce Y., et al.
(författare)
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Circulating markers of cellular immune activation in prediagnostic blood sample and lung cancer risk in the Lung Cancer Cohort Consortium (LC3)
- 2020
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Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 146:9, s. 2394-2405
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Tidskriftsartikel (refereegranskat)abstract
- Cell-mediated immune suppression may play an important role in lung carcinogenesis. We investigated the associations for circulating levels of tryptophan, kynurenine, kynurenine:tryptophan ratio (KTR), quinolinic acid (QA) and neopterin as markers of immune regulation and inflammation with lung cancer risk in 5,364 smoking-matched case-control pairs from 20 prospective cohorts included in the international Lung Cancer Cohort Consortium. All biomarkers were quantified by mass spectrometry-based methods in serum/plasma samples collected on average 6 years before lung cancer diagnosis. Odds ratios (ORs) and 95% confidence intervals (CIs) for lung cancer associated with individual biomarkers were calculated using conditional logistic regression with adjustment for circulating cotinine. Compared to the lowest quintile, the highest quintiles of kynurenine, KTR, QA and neopterin were associated with a 20-30% higher risk, and tryptophan with a 15% lower risk of lung cancer (all p(trend) < 0.05). The strongest associations were seen for current smokers, where the adjusted ORs (95% CIs) of lung cancer for the highest quintile of KTR, QA and neopterin were 1.42 (1.15-1.75), 1.42 (1.14-1.76) and 1.45 (1.13-1.86), respectively. A stronger association was also seen for KTR and QA with risk of lung squamous cell carcinoma followed by adenocarcinoma, and for lung cancer diagnosed within the first 2 years after blood draw. This study demonstrated that components of the tryptophan-kynurenine pathway with immunomodulatory effects are associated with risk of lung cancer overall, especially for current smokers. Further research is needed to evaluate the role of these biomarkers in lung carcinogenesis and progression.
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