| 1. |
- Elyouncha, Anis, 1978, et al.
(författare)
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COMPARISON OF THE SEA SURFACE VELOCITY DERIVED FROM SENTINEL-1 AND TANDEM-X
- 2021
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Ingår i: International Geoscience and Remote Sensing Symposium (IGARSS). ; , s. 7354-7357
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Konferensbidrag (refereegranskat)abstract
- This paper presents a direct comparison of the sea surface radial velocity (RVL) derived from the two satellite SAR systems Sentinel-1 and TanDEM-X, operating at different frequencies and imaging modes. The RVL is derived from the Doppler centroid (Dc) provided in the Sentinel-1 OCN product and from the along-track interferometric phase of the TanDEM-X, respectively. The comparison is performed using an opportunistic collocated acquisition over the Pentland Firth strait, known for its strong tidal stream. This comparison shows that the two SAR systems observe similar sea surface circulation patterns with high spatial correlation coefficient (r ~0.8). It is also shown that, provided a common calibration reference is available, the two independently derived RVL are quantitatively in good agreement with a negligible bias and reasonable RMSE (~0.3 m/s). This encourages use of the synergy between different C- and X-band SAR systems, measuring sea surface velocity.
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| 2. |
- Elyouncha, Anis, 1978, et al.
(författare)
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Direct comparison of sea surface velocity estimated from Sentinel-1 and TanDEM-X SAR data
- 2022
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Ingår i: IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing. - 2151-1535 .- 1939-1404. ; 15, s. 2425-2436
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents the first direct comparison of the sea surface radial velocity (RVL) derived from the two satellite SAR systems Sentinel-1 and TanDEM-X, operating at different frequencies and imaging modes. The RVL is derived from the Doppler centroid (Dc) provided in the Sentinel-1 OCN product and from the along-track interferometric phase of the TanDEM-X. The comparison is carried out using opportunistic acquisitions, collocated in space and time, over three different sites. First, it is observed that the RVL derived from both satellites is biased, thus calibration is applied using the land as a reference. The comparison shows that the correlation and the mean RVL bias between the two datasets depend on the differences in acquisition time, incidence angle and azimuth angle, and on wind and current speed and direction. It is found that, given a time difference of < 20 min, the spatial correlation coefficient is relatively high (between 0.7 and 0.93), which indicates that the two SAR systems observe similar sea surface current fields. The spatial correlation degrades primarily due to increasing time difference and decreasing current magnitudes. The mean RVL bias increases primarily with the radial wind speed, which suggests that the RVL bias is mainly due to the wave-induced Doppler shift. This study shows that under certain conditions, i.e. similar acquisition geometry and short time delay, a good agreement between the two independently derived RVL is achieved. This encourages a synergistic use of the sea surface velocity estimated from different C- and X-band SAR systems.
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| 3. |
- Elyouncha, Anis, 1978, et al.
(författare)
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Using Sentinel-1 Ocean Data for Mapping Sea Surface Currents Along the Southern Norwegian Coast
- 2019
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Ingår i: International Geoscience and Remote Sensing Symposium (IGARSS). - 9781538691540 ; , s. 8058-8061
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Konferensbidrag (refereegranskat)abstract
- In this paper, the capability of Sentinel-1 data to map ocean surface currents in the Skagerrak Sea, with a focus on the Norwegian Coastal Current (NCC), is investigated. Post-processing methods for removing artefacts in the data and improving of the geophysical interpretation are suggested. Scalloping is one major artefact, which significantly degrades the quality of the velocity maps. Two methods, in spatial and spectral domain, for correcting this effect are proposed. It is also found that the radial velocity provided in the Sentinel-1 ocean data is biased, hence land is used as a reference to correct for the absolute and inter-beam bias. Finally, the retrieved (corrected) velocity is compared to a regional ocean circulation model (ROMS). It is shown that there is a good agreement between the ocean model and the retrieved velocity with values of ≈ 0.8 m/s in the core of the NCC.
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| 4. |
- Gommenginger, Christine, et al.
(författare)
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SEASTAR: A mission to study ocean submesoscale dynamics and small-scale atmosphere-ocean processes in coastal, shelf and polar seas
- 2019
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Ingår i: Frontiers in Marine Science. - : Frontiers Media SA. - 2296-7745. ; 6:JUL
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- High-resolution satellite images of ocean color and sea surface temperature reveal an abundance of ocean fronts, vortices and filaments at scales below 10 km but measurements of ocean surface dynamics at these scales are rare. There is increasing recognition of the role played by small scale ocean processes in ocean-atmosphere coupling, upper-ocean mixing and ocean vertical transports, with advanced numerical models and in situ observations highlighting fundamental changes in dynamics when scales reach 1 km. Numerous scientific publications highlight the global impact of small oceanic scales on marine ecosystems, operational forecasts and long-term climate projections through strong ageostrophic circulations, large vertical ocean velocities and mixed layer re-stratification. Small-scale processes particularly dominate in coastal, shelf and polar seas where they mediate important exchanges between land, ocean, atmosphere and the cryosphere e.g. freshwater, pollutants. As numerical models continue to evolve towards finer spatial resolution and increasingly complex coupled atmosphere-wave-ice-ocean systems, modern observing capability lags behind, unable to deliver the high-resolution synoptic measurements of total currents, wind vectors and waves needed to advance understanding, develop better parameterizations and improve model validations, forecasts and projections. SEASTAR is a satellite mission concept that proposes to directly address this critical observational gap with synoptic two-dimensional imaging of total ocean surface current vectors and wind vectors at 1 km resolution and coincident directional wave spectra. Based on major recent advances in squinted along-track Synthetic Aperture Radar interferometry, SEASTAR is an innovative, mature concept with unique demonstrated capabilities, seeking to proceed towards spaceborne implementation within Europe and beyond.
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| 5. |
- Lorenz, Matthias W., et al.
(författare)
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Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project
- 2010
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Ingår i: American Heart Journal. - : Elsevier BV. - 1097-6744 .- 0002-8703. ; 159:5, s. 25-730
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Tidskriftsartikel (refereegranskat)abstract
- Carotid intima media thickness (IMT) progression is increasingly used as a surrogate for vascular risk. This use is supported by data from a few clinical trials investigating statins, but established criteria of surrogacy are only partially fulfilled. To provide a valid basis for the use of IMT progression as a study end point, we are performing a 3-step meta-analysis project based on individual participant data. Objectives of the 3 successive stages are to investigate (1) whether IMT progression prospectively predicts myocardial infarction, stroke, or death in population-based samples; (2) whether it does so in prevalent disease cohorts; and (3) whether interventions affecting IMT progression predict a therapeutic effect on clinical end points. Recruitment strategies, inclusion criteria, and estimates of the expected numbers of eligible studies are presented along with a detailed analysis plan. (Am Heart J 2010; 159: 730-736.e2.)
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| 6. |
- Palmer, Nicholette D, et al.
(författare)
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A genome-wide association search for type 2 diabetes genes in African Americans.
- 2012
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Ingår i: PloS one. - San Francisco : Public Library of Science (PLoS). - 1932-6203. ; 7:1, s. e29202-
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Tidskriftsartikel (refereegranskat)abstract
- African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P<0.0071), were directionally consistent in the Replication cohort and were associated with T2DM in subjects without nephropathy (P<0.05). Meta-analysis in all cases and controls revealed a single SNP reaching genome-wide significance (P<2.5×10(-8)). SNP rs7560163 (P = 7.0×10(-9), OR (95% CI) = 0.75 (0.67-0.84)) is located intergenically between RND3 and RBM43. Four additional loci (rs7542900, rs4659485, rs2722769 and rs7107217) were associated with T2DM (P<0.05) and reached more nominal levels of significance (P<2.5×10(-5)) in the overall analysis and may represent novel loci that contribute to T2DM. We have identified novel T2DM-susceptibility variants in the African-American population. Notably, T2DM risk was associated with the major allele and implies an interesting genetic architecture in this population. These results suggest that multiple loci underlie T2DM susceptibility in the African-American population and that these loci are distinct from those identified in other ethnic populations.
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| 7. |
- Roaldsen, M.B., et al.
(författare)
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Safety and efficacy of tenecteplase in patients with wake-up stroke assessed by non-contrast CT (TWIST): a multicentre, open-label, randomised controlled trial
- 2023
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Ingår i: The Lancet Neurology. - 1474-4422 .- 1474-4465. ; 22:2, s. 117-126
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Tidskriftsartikel (refereegranskat)abstract
- Background: Current evidence supports the use of intravenous thrombolysis with alteplase in patients with wake-up stroke selected with MRI or perfusion imaging and is recommended in clinical guidelines. However, access to advanced imaging techniques is often scarce. We aimed to determine whether thrombolytic treatment with intravenous tenecteplase given within 4·5 h of awakening improves functional outcome in patients with ischaemic wake-up stroke selected using non-contrast CT. Methods: TWIST was an investigator-initiated, multicentre, open-label, randomised controlled trial with blinded endpoint assessment, conducted at 77 hospitals in ten countries. We included patients aged 18 years or older with acute ischaemic stroke symptoms upon awakening, limb weakness, a National Institutes of Health Stroke Scale (NIHSS) score of 3 or higher or aphasia, a non-contrast CT examination of the head, and the ability to receive tenecteplase within 4·5 h of awakening. Patients were randomly assigned (1:1) to either a single intravenous bolus of tenecteplase 0·25 mg per kg of bodyweight (maximum 25 mg) or control (no thrombolysis) using a central, web-based, computer-generated randomisation schedule. Trained research personnel, who conducted telephone interviews at 90 days (follow-up), were masked to treatment allocation. Clinical assessments were performed on day 1 (at baseline) and day 7 of hospital admission (or at discharge, whichever occurred first). The primary outcome was functional outcome assessed by the modified Rankin Scale (mRS) at 90 days and analysed using ordinal logistic regression in the intention-to-treat population. This trial is registered with EudraCT (2014–000096–80), ClinicalTrials.gov (NCT03181360), and ISRCTN (10601890). Findings: From June 12, 2017, to Sept 30, 2021, 578 of the required 600 patients were enrolled (288 randomly assigned to the tenecteplase group and 290 to the control group [intention-to-treat population]). The median age of participants was 73·7 years (IQR 65·9–81·1). 332 (57%) of 578 participants were male and 246 (43%) were female. Treatment with tenecteplase was not associated with better functional outcome, according to mRS score at 90 days (adjusted OR 1·18, 95% CI 0·88–1·58; p=0·27). Mortality at 90 days did not significantly differ between treatment groups (28 [10%] patients in the tenecteplase group and 23 [8%] in the control group; adjusted HR 1·29, 95% CI 0·74–2·26; p=0·37). Symptomatic intracranial haemorrhage occurred in six (2%) patients in the tenecteplase group versus three (1%) in the control group (adjusted OR 2·17, 95% CI 0·53–8·87; p=0·28), whereas any intracranial haemorrhage occurred in 33 (11%) versus 30 (10%) patients (adjusted OR 1·14, 0·67–1·94; p=0·64). Interpretation: In patients with wake-up stroke selected with non-contrast CT, treatment with tenecteplase was not associated with better functional outcome at 90 days. The number of symptomatic haemorrhages and any intracranial haemorrhages in both treatment groups was similar to findings from previous trials of wake-up stroke patients selected using advanced imaging. Current evidence does not support treatment with tenecteplase in patients selected with non-contrast CT. Funding: Norwegian Clinical Research Therapy in the Specialist Health Services Programme, the Swiss Heart Foundation, the British Heart Foundation, and the Norwegian National Association for Public Health. © 2023 Elsevier Ltd
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| 8. |
- Saxena, Richa, et al.
(författare)
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Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:2, s. 142-148
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Tidskriftsartikel (refereegranskat)abstract
- Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance used in the diagnosis of type 2 diabetes. We report a meta-analysis of nine genome-wide association studies (n = 15,234 nondiabetic individuals) and a follow-up of 29 independent loci (n = 6,958–30,620). We identify variants at the GIPR locus associated with 2-h glucose level (rs10423928, β (s.e.m.) = 0.09 (0.01) mmol/l per A allele, P = 2.0 × 10−15). The GIPR A-allele carriers also showed decreased insulin secretion (n = 22,492; insulinogenic index, P = 1.0 × 10−17; ratio of insulin to glucose area under the curve, P = 1.3 × 10−16) and diminished incretin effect (n = 804; P = 4.3 × 10−4). We also identified variants at ADCY5 (rs2877716, P = 4.2 × 10−16), VPS13C (rs17271305, P = 4.1 × 10−8), GCKR (rs1260326, P = 7.1 × 10−11) and TCF7L2 (rs7903146, P = 4.2 × 10−10) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies (n = 35,869 cases, 89,798 controls, OR = 1.12, 95% CI 1.09–1.15, P = 4.8 × 10−18).
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| 9. |
- Skaret, Georg, et al.
(författare)
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Diel vertical movements determine spatial interactions between cod, pelagic fish and krill on an Arctic shelf bank
- 2020
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Ingår i: Marine Ecology Progress Series. - : Inter-Research Science Center. - 0171-8630 .- 1616-1599. ; 638, s. 13-23
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Tidskriftsartikel (refereegranskat)abstract
- Predator-prey spatial interactions are essential to understand ecosystem processes like predation rates and trophic interaction strength. In marine systems, such spatial interactions are highly dynamic and difficult to observe, as predators, prey and resources are mobile and responsive to each other, and also since shifting vertical light gradients strongly affect the space use of visual predators and their prey. We visited a bank area in the northern Barents Sea with cold bottom waters (similar to 1 degrees C), and combined conventional trawl and acoustic sampling with broad-band hydroacoustics to obtain long-range, fine-scale observations of interactions between cod, their planktivore prey (capelin and polar cod) and krill. We caught cod in demersal trawl hauls but could not detect them with the vessel acoustics. However, broadband acoustics mounted on a submersible probe allowed us to track individual cod, revealing that they remained mostly within 10 m of the bottom throughout the diel cycle. In the morning, cod lifted slightly from the seabed indicating feeding activity, which corresponded with more fresh prey in cod stomachs in the morning. During daylight, krill pushed towards the bottom, sharing habitat with cod, while the planktivores aggregated in pelagic schools at the cost of lost feeding opportunities, overlapping with their hill prey only during twilight hours. The diel light cycle was an important driver of the spatial movements and aggregations, and krill appear to hide from capelin among the cod near bottom, while cod take advantage of descending pelagic fish after dawn to feed with a minimum of effort.
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| 10. |
- Zeggini, Eleftheria, et al.
(författare)
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Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
- 2008
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 40:5, s. 638-645
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D)(1-11). Established associations to common and rare variants explain only a small proportion of the heritability of T2D. As previously published analyses had limited power to identify variants with modest effects, we carried out meta-analysis of three T2D GWA scans comprising 10,128 individuals of European descent and similar to 2.2 million SNPs (directly genotyped and imputed), followed by replication testing in an independent sample with an effective sample size of up to 53,975. We detected at least six previously unknown loci with robust evidence for association, including the JAZF1 (P=5.0 x 10(-14)), CDC123-CAMK1D (P=1.2 x 10(-10)), TSPAN8-LGR5 (P=1.1 x 10(-9)), THADA (P=1.1 x 10(-9)), ADAMTS9 (P=1.2 x 10(-8)) and NOTCH2 (P=4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D.
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