| 1. |
- Abazov, V. M., et al.
(författare)
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The upgraded DO detector
- 2006
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 565:2, s. 463-537
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Tidskriftsartikel (refereegranskat)abstract
- The DO experiment enjoyed a very successful data-collection run at the Fermilab Tevatron collider between 1992 and 1996. Since then, the detector has been upgraded to take advantage of improvements to the Tevatron and to enhance its physics capabilities. We describe the new elements of the detector, including the silicon microstrip tracker, central fiber tracker, solenoidal magnet, preshower detectors, forward muon detector, and forward proton detector. The uranium/liquid -argon calorimeters and central muon detector, remaining from Run 1, are discussed briefly. We also present the associated electronics, triggering, and data acquisition systems, along with the design and implementation of software specific to DO.
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| 2. |
- Abazov, V. M., et al.
(författare)
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Measurement of the t(t)over-bar production cross section in p(p)over-bar collisions at root s=1.96 TeV using secondary vertex b tagging
- 2006
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Ingår i: Physical Review D - Particles, Fields, Gravitation and Cosmology. - 1550-7998 .- 1550-2368. ; 74:11, s. 112004-
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Tidskriftsartikel (refereegranskat)abstract
- We report a new measurement of the t (t) over bar production cross section in p (beta) over bar collisions at a center-of-mass energy of 1.96 TeV using events with one charged lepton (electron or muon), missing transverse energy, and jets. Using 425 pb(-1) of data collected using the D0 detector at the Fermilab Tevatron Collider, and enhancing the t (t) over bar content of the sample by tagging b jets with a secondary vertex tagging algorithm, the t (t) over bar production cross section is measured to be sigma(p (t) over bar -> t (t) over bar +X)=6.6 +/- 0.9(stat+syst) +/- 0.4(lum) pb. This cross section is the most precise D0 measurement to date for t (t) over bar production and is in good agreement with standard model expectations.
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| 3. |
- Went, M, et al.
(författare)
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Author Correction: Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma
- 2019
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 213-
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Tidskriftsartikel (refereegranskat)abstract
- The original version of this Article contained an error in the spelling of a member of the PRACTICAL Consortium, Manuela Gago-Dominguez, which was incorrectly given as Manuela Gago Dominguez. This has now been corrected in both the PDF and HTML versions of the Article. Furthermore, in the original HTML version of this Article, the order of authors within the author list was incorrect. The PRACTICAL consortium was incorrectly listed after Richard S. Houlston and should have been listed after Nora Pashayan. This error has been corrected in the HTML version of the Article; the PDF version was correct at the time of publication.
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| 4. |
- Went, M, et al.
(författare)
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Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma
- 2018
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1, s. 3707-
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous GWAS and a replication series, totalling 9974 MM cases and 247,556 controls of European ancestry. Collectively, these data provide evidence for six new MM risk loci, bringing the total number to 23. Integration of information from gene expression, epigenetic profiling and in situ Hi-C data for the 23 risk loci implicate disruption of developmental transcriptional regulators as a basis of MM susceptibility, compatible with altered B-cell differentiation as a key mechanism. Dysregulation of autophagy/apoptosis and cell cycle signalling feature as recurrently perturbed pathways. Our findings provide further insight into the biological basis of MM.
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| 5. |
- Berman, F., et al.
(författare)
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New grid scheduling and rescheduling methods in the GrADS Project
- 2005
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Ingår i: International journal of parallel programming. - : Springer Science and Business Media LLC. - 0885-7458 .- 1573-7640. ; 33:3-Feb, s. 209-229
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Tidskriftsartikel (refereegranskat)abstract
- The goal of the Grid Application Development Software (GrADS) Project is to provide programming tools and an execution environment to ease program development for the Grid. This paper presents recent extensions to the GrADS software framework: a new approach to scheduling workflow computations, applied to a 3-D image reconstruction application; a simple stop/migrate/restart approach to rescheduling Grid applications, applied to a QR factorization benchmark; and a process-swapping approach to rescheduling, applied to an N-body simulation. Experiments validating these methods were carried out on both the GrADS MacroGrid (a small but functional Grid) and the MicroGrid (a controlled emulation of the Grid).
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| 6. |
- Cooper, K., et al.
(författare)
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New Grid Scheduling and Rescheduling Methods in the GrADS Project
- 2004
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Konferensbidrag (refereegranskat)abstract
- Summary form only given. The goal of the Grid Application Development Software (GrADS) project is to provide programming tools and an execution environment to ease program development for the grid. We present recent extensions to the GrADS software framework: 1. A new approach to scheduling workflow computations, applied to a 3D image reconstruction application; 2. A simple stop/migrate/restart approach to rescheduling grid applications, applied to a QR 3. A process-swapping approach to rescheduling, applied to an N-body simulation. Experiments validating these methods were carried out on both the GrADS MacroGrid (a small but functional grid) and the MicroGrid (a controlled emulation of the grid) and the results were demonstrated at the SC2003 conference.
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| 7. |
- Haugen, H.A., et al.
(författare)
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Infrastructure for CCS in the Skagerrak/Kattegat region, Southern Scandinavia: A feasibility study
- 2013
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Ingår i: Energy Procedia. - : Elsevier BV. - 1876-6102. ; 37, s. 2562-2569
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Konferensbidrag (refereegranskat)abstract
- This paper gives an overview of results from a project which explored the feasibility of establishing a CO2 Capture and Storage infrastructure in the Skagerrak/Kattegat region of Southern Scandinavia. This involves assessment of the technical and economic parameters of the complete CCS chain and, in particular, identification of possible storage locations. The project ran from June 2009 to December 2011. Emissions from three major industrial clusters in the Skagerrak/Kattegat region - Gothenburg in Sweden, Grenland in Telemark County, southern Norway and Aalborg in Denmark - were targeted. Both emissions from process industries as well as power plants were included.
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| 8. |
- Sanchez-Gonzalez, A., et al.
(författare)
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Auger electron and photoabsorption spectra of glycine in the vicinity of the oxygen K-edge measured with an X-FEL
- 2015
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Ingår i: Journal of Physics B-Atomic Molecular and Optical Physics. - : IOP Publishing. - 0953-4075 .- 1361-6455. ; 48:23
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Tidskriftsartikel (refereegranskat)abstract
- We report the first measurement of the near oxygen K-edge auger spectrum of the glycine molecule. Our work employed an x-ray free electron laser as the photon source operated with input photon energies tunable between 527 and 547 eV. Complete electron spectra were recorded at each photon energy in the tuning range, revealing resonant and non-resonant auger structures. Finally ab initio theoretical predictions are compared with the measured above the edge auger spectrum and an assignment of auger decay channels is performed.
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| 9. |
- Ali, Mina, et al.
(författare)
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The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression
- 2018
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1, s. 1649-
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Tidskriftsartikel (refereegranskat)abstract
- Recently, we identified ELL2 as a susceptibility gene for multiple myeloma (MM). To understand its mechanism of action, we performed expression quantitative trait locus analysis in CD138+ plasma cells from 1630 MM patients from four populations. We show that the MM risk allele lowers ELL2 expression in these cells (Pcombined = 2.5 × 10−27; βcombined = −0.24 SD), but not in peripheral blood or other tissues. Consistent with this, several variants representing the MM risk allele map to regulatory genomic regions, and three yield reduced transcriptional activity in plasmocytoma cell lines. One of these (rs3777189-C) co-locates with the best-supported lead variants for ELL2 expression and MM risk, and reduces binding of MAFF/G/K family transcription factors. Moreover, further analysis reveals that the MM risk allele associates with upregulation of gene sets related to ribosome biogenesis, and knockout/knockdown and rescue experiments in plasmocytoma cell lines support a cause–effect relationship. Our results provide mechanistic insight into MM predisposition.
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| 10. |
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| 11. |
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| 12. |
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| 13. |
- Bernhardt, H., et al.
(författare)
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Debris flow recurrence periods and multi-temporal observations of colluvial fan evolution in central Spitsbergen (Svalbard)
- 2017
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Ingår i: Geomorphology. - : Elsevier BV. - 0169-555X. ; 296, s. 132-141
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Tidskriftsartikel (refereegranskat)abstract
- Fan-shaped accumulations of debris flow deposits are common landforms in polar regions such as Svalbard. Although depositional processes in these environments are of high interest to climate as well as Mars-analog research, several parameters, e.g., debris flow recurrence periods, remain poorly constrained. Here, we present an investigation based on remote sensing as well as in situ data of a similar to 0.4 km(2) large colluvial fan in Hanaskogdalen, central Spitsbergen. We analyzed high resolution satellite and aerial images covering five decades from 1961 to 2014 and correlated them with lichenometric dating as well as meteorological data. Image analyses and lichenometry deliver consistent results and show that the recurrence period of large debris flows (>= 400 m(3)) is about 5 to 10 years, with smaller flows averaging at two per year in the period from 2008 to 2013. While this is up to two orders of magnitude shorter than previous estimates for Svalbard (80 to 500 years), we found the average volume of -220 m(3) per individual flow to be similar to previous estimates for the region. Image data also reveal that an avulsion took place between 1961 and 1976, when the active part of the fan moved from its eastern to its western portion. A case study of the effects of a light rain event (similar to 5 mm/day) in the rainy summer of 2013, which triggered a large debris flow, further shows that even light precipitation can trigger major flows. This is made possible by multiple light rain events or gradual snow melt pre-saturating the permafrost ground and has to be taken into account when predicting the likelihood of potentially hazardous mass wasting in polar regions. Furthermore, our findings imply a current net deposition rate on the colluvial fan of similar to 480 m(3)/year, which is slightly less than the integrated net deposition rate of 576 to 720 m(3)/year resulting from the current fan volume divided by the 12,500 to 10,000 years since the onset of fan build-up after the area's deglaciation. However, the actual deposition rate, which should increase in a warmer climate including more rain, cannot be constrained due to effects like ongoing toe-cutting of the debris fan and some flows only causing internal redistributions.
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| 14. |
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| 15. |
- Eremina, R. M., et al.
(författare)
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Magnetization and specific heat of the dimer system CuTe(2)O(5)
- 2011
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Ingår i: European Physical Journal B. - : Springer Science and Business Media LLC. - 1434-6028 .- 1434-6036. ; 84:3, s. 391-395
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Tidskriftsartikel (refereegranskat)abstract
- We report on magnetization and specific heat measurements on single-crystalline CuTe(2)O(5). The experimental data are directly compared to theoretical results for two different spin structures, namely an alternating spin-chain and a two-dimensional (2D) coupled dimer model, obtained by Das et al. [Phys. Rev. B 77, 224437 (2008)]. While the analysis of the specific heat does not allow to distinguish between the two models, the magnetization data is in good agreement with the 2D coupled dimer model.
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| 16. |
- Faergemann, Jan, 1948, et al.
(författare)
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Pentane-1,5-diol as a percutaneous absorption enhancer
- 2005
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Ingår i: Arch Dermatol Res. - : Springer Science and Business Media LLC. ; 297:6, s. 261-5
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Tidskriftsartikel (refereegranskat)abstract
- Propylene glycol (propane-1,2-diol) is the only diol widely used in dermatology. Pentane-1,5-diol is mainly used as a plasticizer in cellulose products and adhesives, in dental composites and in brake fluid compositions and as a preservative for grain. However, pentane-1,5-diol is also an effective solvent, water-binding substance, antimicrobial agent and preservative and may therefore replace several ingredients in a skin composition. The release of tri-iodothyroacetic acid (TRIAC) and percutaneous absorption of hydrocortisone and mometasone furoate with either pentane-1,5-diol or propane-1,2-diol and 2-methyl-pentane-2,4-diol (hexylene glycol), respectively, as enhancers was compared. The release of TRIAC was 21% higher when pentane-1,5-diol was used as an enhancer instead of propane-1,2-diol. The percutaneous absorption of hydrocortisone through the skin was increased 12 times with propane-1,2-diol compared to 4.4 times with pentane-1,5-diol. However, the percutaneous absorption of hydrocortisone into the skin was 50% higher with pentane-1,5-diol compared to propane-1,2-diol. There was no significant difference, between the original mometasone furoate cream, with 2-methyl-pentane-2,4-diol, and the new cream with pentane-1,5-diol in the amount of mometasone furoate that was absorbed into the skin and through the skin. However, the cosmetic properties of the new mometasone furoate cream was superior to the original mometasone furoate cream, for examples, no bad odour, more even texture, goes better into the skin and has less greasiness. Pentane-1,5-diol can be used as a technology platform, which adds a series of desirable properties to dermatological preparations and enhances product usability. This will result in improved formulations for a series of major and commonly used dermatological drugs. When used in pharmaceutical topical preparations, pentane-1,5-diol will increase the percutaneous absorption of the active substance and it is an efficient antimicrobial agent that will act as an effective preservative in topical formulations. Pentane-1,5-diol is cosmetically attractive, has low risk for skin and eye irritation compared to other diols, low toxicity risk and no bad odour.
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| 17. |
- Fukuzawa, H., et al.
(författare)
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Deep Inner-Shell Multiphoton Ionization by Intense X-Ray Free-Electron Laser Pulses
- 2013
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Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 110:17
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Tidskriftsartikel (refereegranskat)abstract
- We have investigated multiphoton multiple ionization dynamics of xenon atoms using a new x-ray free-electron laser facility, SPring-8 Angstrom Compact free electron LAser (SACLA) in Japan, and identified that Xen+ with n up to 26 is produced at a photon energy of 5.5 keV. The observed high charge states (n >= 24) are produced via five-photon absorption, evidencing the occurrence of multiphoton absorption involving deep inner shells. A newly developed theoretical model, which shows good agreement with the experiment, elucidates the complex pathways of sequential electronic decay cascades accessible in heavy atoms. The present study of heavy-atom ionization dynamics in high-intensity hard-x-ray pulses makes a step forward towards molecular structure determination with x-ray free-electron lasers. DOI: 10.1103/PhysRevLett.110.173005
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| 18. |
- Fukuzawa, H., et al.
(författare)
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Electron spectroscopy of rare-gas clusters irradiated by x-ray free-electron laser pulses from SACLA
- 2016
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Ingår i: Journal of Physics B-Atomic Molecular and Optical Physics. - : IOP Publishing. - 0953-4075 .- 1361-6455. ; 49:3
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Tidskriftsartikel (refereegranskat)abstract
- We have measured electron energy spectra and asymmetry parameters of Ar clusters and Xe clusters illuminated by intense x-rays at 5 and 5.5 keV. A velocity map imaging spectrometer was developed for this purpose and employed at an x-ray free-electron laser facility, SACLA in Japan. The cluster size dependence and the peak fluence dependence of the electron spectra and asymmetry parameters are discussed.
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| 19. |
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| 20. |
- Gryzlova, E. V., et al.
(författare)
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Doubly resonant three-photon double ionization of Ar atoms induced by an EUV free-electron laser
- 2011
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Ingår i: Physical Review A (Atomic, Molecular and Optical Physics). - 1050-2947. ; 84:6
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Tidskriftsartikel (refereegranskat)abstract
- A mechanism for three-photon double ionization of atoms by extreme-ultraviolet free-electron laser pulses is revealed, where in a sequential process the second ionization step, proceeding via resonant two-photon ionization of ions, is strongly enhanced by the excitation of ionic autoionizing states. In contrast to the conventional model, the mechanism explains the observed relative intensities of photoelectron peaks and their angular dependence in three-photon double ionization of argon.
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