| 1. |
- Andraos, Rama, et al.
(författare)
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Autoantibodies associated with systemic sclerosis in three autoimmune diseases imprinted by type I interferon gene dysregulation: a comparison across SLE, primary Sjogrens syndrome and systemic sclerosis
- 2022
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Ingår i: Lupus Science and Medicine. - : BMJ PUBLISHING GROUP. - 2053-8790. ; 9:1
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Tidskriftsartikel (refereegranskat)abstract
- ObjectiveSLE, primary Sjogrens syndrome (pSS) and systemic sclerosis (SSc) are heterogeneous autoimmune diseases with a dysregulated type I interferon (IFN) system. The diseases often show overlapping clinical manifestations, which may result in diagnostic challenges. We asked to which extent SSc-associated autoantibodies are present in SLE and pSS, and whether these link to serum IFN-alpha, clinical phenotypes and sex. Samples with clinical data from patients with SSc and healthy blood donors (HBDs) served as controls. Finally, the diagnostic performance of SSc-associated autoantibodies was evaluated.MethodsSamples from well-characterised subjects with SLE (n=510), pSS (n=116), SSc (n=57) and HBDs (n=236) were analysed using a commercially available immunoassay (EuroLine Systemic Sclerosis Profile (IgG)). IFN-alpha was quantified by ELISA. Self-reported data on Raynauds phenomenon (RP) were available.ResultsWith exceptions for anti-Ro52/SSA and anti-Th/To, SSc-associated autoantibodies were more frequent in SSc than in SLE, pSS and HBDs regardless of sex. IFN-alpha levels correlated with the number of positive SSc-associated autoantibodies (r=0.29, p<0.0001) and associated with Ro52/SSA positivity (p<0.0001). By using data from SLE, SSc and HBDs, RP was significantly associated with topoisomerase I, centromere protein (CENP)-B, RNA polymerase III 11 kDa, RNA polymerase III 155 kDa and PM-Scl100 whereas Ro52/SSA associated inversely with RP. In SLE, CENP-A was associated with immunological disorder, CENP-B with serositis and Ku with lupus nephritis. By combining analysis of ANA (immunofluorescence) with SSc-associated autoantibodies, the diagnostic sensitivity reached 98% and the specificity 33%.ConclusionsThe 13 specificities included in the EuroLine immunoassay are commonly detected in SSc, but they are also frequent among individuals with other diseases imprinted by type I IFNs. These findings are valuable when interpreting serological data on patients with suspected SSc, especially as patients may present with disease manifestations overlapping different rheumatological diseases. In SLE, we observed associations between manifestations and SSc-associated autoantibodies which have not previously been reported.
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| 2. |
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| 3. |
- Frodlund, Martina, et al.
(författare)
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Glucocorticoid treatment in SLE is associated with infections, comorbidities and mortality-a national cohort study
- 2024
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Ingår i: Rheumatology. - : OXFORD UNIV PRESS. - 1462-0324 .- 1462-0332. ; 63:4, s. 1104-1112
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Tidskriftsartikel (refereegranskat)abstract
- Objectives Patients with SLE have an increased risk of comorbidities and impaired survival. We aimed to assess whether various thresholds of oral CS (OCS) can predict development of infections, comorbidities, malignancies and survival in SLE using data from national health registries in Sweden. Methods All incident SLE cases, age >18 years, in Sweden (n = 5309) between 2005 and 2020 and matched population controls (n = 26 545) were included and followed until 2020, a total of 257 942 patient years. Data from national registers were retrieved including information from the National Prescribed Drug Register. Risk factors were analysed using time-dependent Cox regression models. Results Compared with no OCS, >0 to <5.0 mg/day, 5.0-7.5 mg/day as well as >7.5 mg/day OCS predicted development of infections (pneumonia, influenza, herpes zoster and urinary tract infection), osteoporosis, osteonecrosis, gastroduodenal ulcers, cataracts, hypertension and mortality (all P < 0.05). OCS >0 to <5.0 mg/day was associated with lower hazard ratios for these comorbidities than higher doses of OCS. Fifteen years after diagnosis, 48% of patients were taking OCS at a median dose of 5.7 mg/day. A small reduction of OCS treatment 5 years after diagnosis in patients diagnosed with SLE 2006-10 compared with 2011-15 was observed, 49% vs 46% respectively (P = 0.039). Conclusion Results highlight the potential harm associated with even low OCS dose treatment in SLE and the need to judiciously use OCS at the lowest possible dose to maximize efficacy and minimize harm.
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| 4. |
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| 5. |
- Hanly, John G., et al.
(författare)
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Cerebrovascular Events in Systemic Lupus Erythematosus : Results From an International Inception Cohort Study
- 2018
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Ingår i: Arthritis Care and Research. - : Wiley. - 2151-464X .- 2151-4658. ; 70:10, s. 1478-1487
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To determine the frequency, characteristics, and outcomes of cerebrovascular events (CerVEs), as well as clinical and autoantibody associations in a multiethnic/racial inception cohort of patients with systemic lupus erythematosus (SLE). Methods: A total of 1,826 patients were assessed annually for 19 neuropsychiatric (NP) events, including 5 types of CerVEs: 1) stroke, 2) transient ischemia, 3) chronic multifocal ischemia, 4) subarachnoid/intracranial hemorrhage, and 5) sinus thrombosis. Global disease activity (Systemic Lupus Erythematosus Disease [SLE] Activity Index 2000), damage scores (SLE International Collaborating Clinics/American College of Rheumatology Damage Index), and Short Form 36 (SF-36) scores were collected. Time to event, linear and logistic regressions, and multistate models were used as appropriate. Results: CerVEs were the fourth most frequent NP event: 82 of 1,826 patients had 109 events; of these events, 103 were attributed to SLE, and 44 were identified at the time of enrollment. The predominant events were stroke (60 of 109 patients) and transient ischemia (28 of 109 patients). CerVEs were associated with other NP events attributed to SLE, non–SLE-attributed NP events, African ancestry (at US SLICC sites), and increased organ damage scores. Lupus anticoagulant increased the risk of first stroke and sinus thrombosis and transient ischemic attack. Physician assessment indicated resolution or improvement in the majority of patients, but patients reported sustained reduction in SF-36 summary and subscale scores following a CerVE. Conclusion: CerVEs, the fourth most frequent NP event in SLE, are usually attributable to lupus. In contrast to good physician-reported outcomes, patients reported a sustained reduction in health-related quality of life following a CerVE.
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| 6. |
- Hanly, John G., et al.
(författare)
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Neuropsychiatric Events in Systemic Lupus Erythematosus : Predictors of Occurrence and Resolution in a Longitudinal Analysis of an International Inception Cohort
- 2021
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Ingår i: Arthritis and Rheumatology. - : Wiley. - 2326-5191 .- 2326-5205. ; 73:12, s. 2293-2302
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To determine predictors of change in neuropsychiatric (NP) event status in a large, prospective, international inception cohort of patients with systemic lupus erythematosus (SLE). Methods: Upon enrollment and annually thereafter, NP events attributed to SLE and non-SLE causes and physician-determined resolution were documented. Factors potentially associated with the onset and resolution of NP events were determined by time-to-event analysis using a multistate modeling structure. Results: NP events occurred in 955 (52.3%) of 1,827 patients, and 593 (31.0%) of 1,910 unique events were attributed to SLE. For SLE-associated NP (SLE NP) events, multivariate analysis revealed a positive association with male sex (P = 0.028), concurrent non-SLE NP events excluding headache (P < 0.001), active SLE (P = 0.012), and glucocorticoid use (P = 0.008). There was a negative association with Asian race (P = 0.002), postsecondary education (P = 0.001), and treatment with immunosuppressive drugs (P = 0.019) or antimalarial drugs (P = 0.056). For non-SLE NP events excluding headache, there was a positive association with concurrent SLE NP events (P < 0.001) and a negative association with African race (P = 0.012) and Asian race (P < 0.001). NP events attributed to SLE had a higher resolution rate than non-SLE NP events, with the exception of headache, which had comparable resolution rates. For SLE NP events, multivariate analysis revealed that resolution was more common in patients of Asian race (P = 0.006) and for central/focal NP events (P < 0.001). For non-SLE NP events, resolution was more common in patients of African race (P = 0.017) and less common in patients who were older at SLE diagnosis (P < 0.001). Conclusion: In a large and long-term study of the occurrence and resolution of NP events in SLE, we identified subgroups with better and worse prognosis. The course of NP events differs greatly depending on their nature and attribution.
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| 7. |
- Hanly, John G., et al.
(författare)
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Peripheral Nervous System Disease in Systemic Lupus Erythematosus : Results From an International Inception Cohort Study
- 2020
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Ingår i: Arthritis and Rheumatology. - : Wiley. - 2326-5191 .- 2326-5205. ; 72:1, s. 67-77
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To determine the frequency, clinical characteristics, associations, and outcomes of different types of peripheral nervous system (PNS) disease in a multiethnic/multiracial, prospective inception cohort of systemic lupus erythematosus (SLE) patients. Methods: Patients were evaluated annually for 19 neuropsychiatric (NP) events including 7 types of PNS disease. SLE disease activity, organ damage, autoantibodies, and patient and physician assessment of outcome were measured. Time to event and linear regressions were used as appropriate. Results: Of 1,827 SLE patients, 88.8% were female, and 48.8% were white. The mean ± SD age was 35.1 ± 13.3 years, disease duration at enrollment was 5.6 ± 4.2 months, and follow-up was 7.6 ± 4.6 years. There were 161 PNS events in 139 (7.6%) of 1,827 patients. The predominant events were peripheral neuropathy (66 of 161 [41.0%]), mononeuropathy (44 of 161 [27.3%]), and cranial neuropathy (39 of 161 [24.2%]), and the majority were attributed to SLE. Multivariate Cox regressions suggested longer time to resolution in patients with a history of neuropathy, older age at SLE diagnosis, higher SLE Disease Activity Index 2000 scores, and for peripheral neuropathy versus other neuropathies. Neuropathy was associated with significantly lower Short Form 36 (SF-36) physical and mental component summary scores versus no NP events. According to physician assessment, the majority of neuropathies resolved or improved over time, which was associated with improvements in SF-36 summary scores for peripheral neuropathy and mononeuropathy. Conclusion: PNS disease is an important component of total NPSLE and has a significant negative impact on health-related quality of life. The outcome is favorable for most patients, but our findings indicate that several factors are associated with longer time to resolution.
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| 8. |
- Hanly, John G., et al.
(författare)
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Psychosis in Systemic Lupus Erythematosus : Results From an International Inception Cohort Study
- 2019
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Ingår i: Arthritis and Rheumatology. - : Wiley. - 2326-5191 .- 2326-5205. ; 71:2, s. 281-289
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To determine, in a large, multiethnic/multiracial, prospective inception cohort of patients with systemic lupus erythematosus (SLE), the frequency, attribution, clinical, and autoantibody associations with lupus psychosis and the short- and long-term outcomes as assessed by physicians and patients. Methods: Patients were evaluated annually for 19 neuropsychiatric (NP) events including psychosis. Scores on the Systemic Lupus Erythematosus Disease Activity Index 2000, the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index, and the Short Form 36 (SF-36) were recorded. Time to event and linear regressions were used as appropriate. Results: Of 1,826 SLE patients, 88.8% were female and 48.8% were Caucasian. The mean ± SD age was 35.1 ± 13.3 years, the mean ± SD disease duration was 5.6 ± 4.2 months, and the mean ± SD follow-up period was 7.4 ± 4.5 years. There were 31 psychotic events in 28 of 1,826 patients (1.53%), and most patients had a single event (26 of 28 [93%]). In the majority of patients (20 of 25 [80%]) and events (28 of 31 [90%]), psychosis was attributed to SLE, usually either in the year prior to or within 3 years of SLE diagnosis. Positive associations (hazard ratios [HRs] and 95% confidence intervals [95% CIs]) with lupus psychosis were previous SLE NP events (HR 3.59 [95% CI 1.16–11.14]), male sex (HR 3.0 [95% CI 1.20–7.50]), younger age at SLE diagnosis (per 10 years) (HR 1.45 [95% CI 1.01–2.07]), and African ancestry (HR 4.59 [95% CI 1.79–11.76]). By physician assessment, most psychotic events resolved by the second annual visit following onset, in parallel with an improvement in patient-reported SF-36 summary and subscale scores. Conclusion: Psychosis is an infrequent manifestation of NPSLE. Generally, it occurs early after SLE onset and has a significant negative impact on health status. As determined by patient and physician report, the short- and long-term outlooks are good for most patients, although careful follow-up is required.
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| 9. |
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| 10. |
- Jonsén, Pär, 1971-, et al.
(författare)
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A Novel Method for Modelling of Cold Cutting of Microstructurally Tailored Hot Formed Components
- 2019
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Ingår i: Hot sheet metal forming of high-performance steel. - : Wissenschaftliche Scripten. ; , s. 645-652
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Konferensbidrag (refereegranskat)abstract
- In the last decade, hot metal forming of advanced high strength steel (AHSS) have improved passenger safety and open possibilities for lightweight design. Hot metal forming can be applied to locally tailor the microstructure of components and gradual vary mechanical properties to improve crash resistance behaviour and optimized weight for e.g. safety related parts. Sometimes post punching or trimming must be done on hardened parts. Such conditions induce damage and fractures in the trimmed edge. Another issue is that high pressures are required in cutting operations due to the high yield stress of press hardened parts, which accelerate wear and produce premature fracture in tools. Optimizing cutting operations to minimize damage and wear are essentials and numerical simulations of cutting operations can be of good assistance. One of the main challenges in the numerical modelling consists of numerically be able to treat the extremely large deformation occurring in the cutting zone. A second challenge is to find suitable failure models. In this work, the punching process of soft and hard microstructures obtained by press hardening is experimentally studied, but also modelled with a combination of smoothed particle Galerkin (SPG) method and finite element method (FEM). Laboratory punching tests with different clearance values were carried out using sheets of different fracture strengths. All experimental cases are numerically modelled. Validation is conducted by comparing numerical results with experimental measurements of punch force and displacement. In addition, morphology of the final cutting edges from both real and virtual are compared. Numerical results show good agreement against experimental measurements. Furthermore, the combined method gives robust-ness and stability as it can handle large deformations efficiently.
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| 11. |
- Jonsén, Pär, et al.
(författare)
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Charge and structure behaviour in a tumbling mill
- 2010
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Ingår i: The Fifth International Conference on Discrete Element Methods. - London : Research Publishing Services. - 9780955117985 ; , s. 490-495
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Konferensbidrag (refereegranskat)abstract
- The grinding process in tumbling mills is complex and to include all phenomena that occur in a single numerical model is today not possi-ble. This paper presents the results of a study in which the deflection of a lifter bar in a pilot ball mill is measured by an embedded strain gauge sensor and compared to deflections predicted from finite ele-ment (FE) simulations. The flexible rubber lifter and the lining in a tumbling mill are modelled with the finite element method (FEM) and the grinding medium modelled with the distinct element method (DEM). The deflection profile obtained from DEM-FE simulation shows a reasonably good correspondence to pilot mill measurements. The approach presented here is a contribution to the validation of DEM-FE simulations and an introduction to the description of a bend-able rubber lifter implemented in a DEM-FEM mill model. It opens up the possibility to predict contact forces for varying mill dimensions and liner combinations. FEM is especially valuable in this case, since there are readily available libraries with material models. This is a fol-low-up work to previous preliminary result from a mono-size ball charge interaction study
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| 12. |
- Jonsén, Pär, et al.
(författare)
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Development of physically based tumbling mill models
- 2014
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Ingår i: Proceedings of XXIII International Mineral Processing Congress. - Santiago : IMPC. - 9789569393150
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Konferensbidrag (refereegranskat)abstract
- Numerical modelling of grinding in tumbling mills is traditionally done with the discrete element method (DEM). The grinding balls are then represented by DEM particles and the mill structure is considered rigid. To include more physical phenomena several numerical methods can be combined. One important improvement is to include the mill structure response, using the finite element method (FEM). The interaction between charge and lining can then be studied in detail. The pulp can also be included using a particle-based continuum method e.g. smoothed particle method (SPH). The strength of SPH lies in modelling of free surface flows and very large deformations and it is suited to model simultaneous fluid and granular flow. Still, the coarse particles (grinding balls) in the charge are suitable to be model using DEM. Each of these methods has their strength and weaknesses, but combined they can successfully mimic the main features of the charge movement. With these numerical tools the complex interaction between the different components of the grinding process; pulp, charge, lining and the mechanical behaviour of the mill, can be studied together. This work will present novel numerical approaches to model, simulate and validate charge behaviour in tumbling mills. These numerical models give possibilities to better understand the physical and mechanical behaviour of particulate material systems during grinding in a tumbling mill. This is important in order to develop and optimise future high-capacity grinding circuits and save energy.
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| 13. |
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| 14. |
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| 15. |
- Jonsén, Pär, et al.
(författare)
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Novel simulation methods for mill charges
- 2011
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Ingår i: Conference in minerals engineering. - Luleå : Luleå tekniska universitet. - 9789174392203
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 16. |
- Jonsén, Pär, et al.
(författare)
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Prediction of mill structure behaviour in a tumbling mill
- 2010
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Ingår i: Conference in Minerals Engineering. - Luleå : Luleå tekniska universitet. - 9789174390971 ; , s. 85-98
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Computational demands and the lack of detailed experimental verification have limited the value of Distinct Element Method (DEM) modelling approaches in mill simulation studies. This paper presents the results of a study in which the deflection of a lifter bar in a pilot ball mill is measured by an embedded strain gauge sensor and compared to deflections predicted from finite element (FE) simulations. The flexible rubber lifter and the lining in a tumbling mill are modelled with the finite element method (FEM) and the grinding medium modelled with DEM. The deflection profile obtained from DEM-FE simulation shows a reasonably good correspondence to pilot mill measurements. To study the charge impact on the mill structure two different charges are used in the simulations. The approach presented here is a contribution to the validation of DEM-FE simulations and an introduction to the description of a bendable rubber lifter implemented in a DEM-FEM mill model. It opens up the possibility to predict contact forces for varying mill dimensions and liner combinations. FEM is especially valuable in this case, since there are readily available libraries with material models. This is a follow-up work to previous preliminary result from a mono-size ball charge interaction study.
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| 17. |
- Jonsén, Pär, et al.
(författare)
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Prediction of mill structure behaviour in a tumbling mill
- 2011
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Ingår i: Minerals Engineering. - : Elsevier BV. - 0892-6875 .- 1872-9444. ; 24:3-4, s. 236-244
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Tidskriftsartikel (refereegranskat)abstract
- Computational demands and the lack of detailed experimental verification have limited the value of distinct element method (DEM) modelling approaches in mill simulation studies. This paper presents the results of a study in which the deflection of a lifter bar in a pilot ball mill is measured by an embedded strain gauge sensor and compared to deflections predicted from finite element (FE) simulations. The flexible rubber lifter and the lining in a tumbling mill are modelled with the finite element method (FEM) and the grinding medium is modelled with DEM. The deflection profile obtained from DEM-FE simulation shows a reasonably good correspondence to pilot mill measurements. To study the charge impact on the mill structure two different charges are used in the simulations. The approach is a contribution to the validation of DEM-FE simulations and an introduction to the description of a bendable rubber lifter implemented in a DEM-FEM mill model. It opens up the possibility to predict contact forces for varying mill dimensions and liner combinations. FEM is especially valuable in this case, since there are readily available libraries with material models.
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| 18. |
- Jonsén, Pär, et al.
(författare)
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Simulation of charge and structure behaviour in a tumbling mill
- 2011
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Ingår i: 8th European LD-DYNA Users Conference May 23-24, 2011, Strasbourg.
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Konferensbidrag (refereegranskat)abstract
- For a long time discrete element methods (DEM) has been used as simulation tools to gain insight into particulate flow processes. The mechanical behaviour in tumbling mills is complex. To include all phenomena that occur in a single numerical model is today not possible. A common approach is to model milling charges using the DEM assuming a rigid mill structure. To close the gap between reality and numerical models in milling, more physically realistic methods have to be used. In this work, the finite element method (FEM) and the smoothed particle hydrodynamic (SPH) method are used together to model a ball mill charge in a tumbling mill. The mesh free formulation and the adaptive nature of the SPH method result in a method that handles extremely large deformations and thereby suits for modelling of grinding charges. The flexible rubber lifter and the lining are modelled with the finite element method. The mill structure consists of rubber lifter and liners and a mantel made of solid steel. For the elastic behaviour of the rubber, a Blatz-Ko hyper-elastic model is used. The supplier of the lining provided experimental data for the rubber. The deflection profile of the lifters obtained from SPH-FEM simulation shows a reasonably good correspondence to pilot mill measurements as measured by an embedded strain gauge sensor. This computational model makes it possible to predict charge pressure and shear stresses within the charge. It is also possible to predict contact forces for varying mill dimensions and liner combinations.
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| 19. |
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| 20. |
- Kang, Shaojie, et al.
(författare)
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Deformation in silicon compressed by a steel ball
- 2013
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Most of the studies dealing with contact mechanics are focused on the pressure and the deformation at the surfaces of the contacting bodies. However, the stress and deformation in the material underneath the actual surface are also important to study. In this work, the elastic deformations arising in a silicon block that is compressed by a steel ball is studied. More precisely, an optical metrology technique is employed to obtain the deformation in the substrate at a fixed depth. A finite element based model, is also developed in order to numerically estimate the elastic deformation of the silicon block. Moreover, the deformation and corresponding stress fields are also analysed with closed form analytical solutions. Comparisons of the results obtained from the experiments, the numerical simulations and analytical solution show that a good prediction of the deformation can be obtained by the finite element model.
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| 21. |
- Legge, Alexandra, et al.
(författare)
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Construction of a frailty index as a novel health measure in systemic lupus erythematosus
- 2020
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Ingår i: Journal of Rheumatology. - : The Journal of Rheumatology. - 0315-162X .- 1499-2752. ; 47:1, s. 72-81
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Tidskriftsartikel (refereegranskat)abstract
- Objective. To construct a Frailty Index (FI) as a measure of vulnerability to adverse outcomes among patients with systemic lupus erythematosus (SLE), using data from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort. Methods. The SLICC inception cohort consists of recently diagnosed patients with SLE followed annually with clinical and laboratory assessments. For this analysis, the baseline visit was defined as the first study visit at which sufficient information was available for construction of an FI. Following a standard procedure, variables from the SLICC database were evaluated as potential health deficits. Selected health deficits were then used to generate a SLICC-FI. The prevalence of frailty in the baseline dataset was evaluated using established cutpoints for FI values. Results. The 1683 patients with SLE (92.1% of the overall cohort) eligible for inclusion in the baseline dataset were mostly female (89%) with mean (SD) age 35.7 (13.4) years and mean (SD) disease duration 18.8 (15.7) months at baseline. Of 222 variables, 48 met criteria for inclusion in the SLICC-FI. Mean (SD) SLICC-FI was 0.17 (0.08) with a range from 0 to 0.51. At baseline, 27.1% (95% CI 25.0-29.2) of patients were classified as frail, based on SLICC-FI values > 0.21. Conclusion. The SLICC inception cohort permits feasible construction of an FI for use in patients with SLE. Even in a relatively young cohort of patients with SLE, frailty was common. The SLICC-FI may be a useful tool for identifying patients with SLE who are most vulnerable to adverse outcomes, but validation of this index is required prior to its use.
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| 22. |
- Legge, Alexandra, et al.
(författare)
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Prediction of Damage Accrual in Systemic Lupus Erythematosus Using the Systemic Lupus International Collaborating Clinics Frailty Index
- 2020
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Ingår i: Arthritis and Rheumatology. - : Wiley. - 2326-5191 .- 2326-5205. ; 72:4, s. 658-666
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The Systemic Lupus International Collaborating Clinics (SLICC) frailty index (FI) has been shown to predict mortality, but its association with other important outcomes is unknown. We examined the association of baseline SLICC FI values with damage accrual in the SLICC inception cohort. Methods: The baseline visit was defined as the first visit at which both organ damage (SLICC/American College of Rheumatology Damage Index [SDI]) and health-related quality of life (Short Form 36) were assessed. Baseline SLICC FI scores were calculated. Damage accrual was measured by the increase in SDI between the baseline assessment and the last study visit. Multivariable negative binomial regression was used to estimate the association between baseline SLICC FI values and the rate of increase in the SDI during follow-up, adjusting for relevant demographic and clinical characteristics. Results: The 1,549 systemic lupus erythematosus (SLE) patients eligible for this analysis were mostly female (88.7%) with a mean ± SD age of 35.7 ± 13.3 years and a median disease duration of 1.2 years (interquartile range 0.9–1.5 years) at baseline. The mean ± SD baseline SLICC FI was 0.17 ± 0.08. Over a mean ± SD follow-up of 7.2 ± 3.7 years, 653 patients (42.2%) had an increase in SDI. Higher baseline SLICC FI values (per 0.05 increase) were associated with higher rates of increase in the SDI during follow-up (incidence rate ratio [IRR] 1.19 [95% confidence interval 1.13–1.25]), after adjusting for age, sex, ethnicity/region, education, baseline SLE Disease Activity Index 2000, baseline SDI, and baseline use of glucocorticoids, antimalarials, and immunosuppressive agents. Conclusion: Our findings indicate that the SLICC FI predicts damage accrual in incident SLE, which further supports the SLICC FI as a valid health measure in SLE.
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| 23. |
- Legge, Alexandra, et al.
(författare)
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Prediction of Hospitalizations in Systemic Lupus Erythematosus Using the Systemic Lupus International Collaborating Clinics Frailty Index
- 2022
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Ingår i: Arthritis Care and Research. - : Wiley. - 2151-464X .- 2151-4658. ; 74:4, s. 638-647
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The Systemic Lupus International Collaborating Clinics (SLICC) frailty index (FI) predicts mortality and damage accrual in systemic lupus erythematosus (SLE), but its association with hospitalizations has not been described. Our objective was to estimate the association of baseline SLICC-FI values with future hospitalizations in the SLICC inception cohort. Methods: Baseline SLICC-FI scores were calculated. The number and duration of inpatient hospitalizations during follow-up were recorded. Negative binomial regression was used to estimate the association between baseline SLICC-FI values and the rate of hospitalizations per patient-year of follow-up. Linear regression was used to estimate the association of baseline SLICC-FI scores with the proportion of follow-up time spent in the hospital. Multivariable models were adjusted for relevant baseline characteristics. Results: The 1,549 patients with SLE eligible for this analysis were mostly female (88.7%), with a mean ± SD age of 35.7 ± 13.3 years and a median disease duration of 1.2 years (interquartile range 0.9–1.5) at baseline. Mean ± SD baseline SLICC-FI was 0.17 ± 0.08. During mean ± SD follow-up of 7.2 ± 3.7 years, 614 patients (39.6%) experienced 1,570 hospitalizations. Higher baseline SLICC-FI values (per 0.05 increment) were associated with more frequent hospitalizations during follow-up, with an incidence rate ratio of 1.21 (95% confidence interval [95% CI] 1.13–1.30) after adjustment for baseline age, sex, glucocorticoid use, immunosuppressive use, ethnicity/location, SLE Disease Activity Index 2000 score, SLICC/American College of Rheumatology Damage Index score, and disease duration. Among patients with ≥1 hospitalization, higher baseline SLICC-FI values predicted a greater proportion of follow-up time spent hospitalized (relative rate 1.09 [95% CI 1.02–1.16]). Conclusion: The SLICC-FI predicts future hospitalizations among incident SLE patients, further supporting the SLICC-FI as a valid health measure in SLE.
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| 24. |
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| 25. |
- Resman, Lars, et al.
(författare)
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Components acting downstream of short day perception regulate differential cessation of cambial activity and associated responses in early and late clones of hybrid poplar
- 2010
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Ingår i: Plant Physiology. - : American Society of Plant Biologists. - 0032-0889 .- 1532-2548. ; 154:3, s. 1294-1303
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Tidskriftsartikel (refereegranskat)abstract
- Short days (SDs) in autumn induce growth cessation, bud set, cold acclimation, and dormancy in trees of boreal and temperate forests, and these responses occur earlier in northern than in southern genotypes. Nevertheless, we know little about whether this variation results from differential perception of SDs or differential downstream responses to the SD signal or a combination of the two. We compared global patterns of SD-regulated gene expression in the stems of hybrid poplar (Populus trichocarpa × Populus deltoides) clones that differ in their SD-induced growth cessation in order to address this question. The timing of cessation of cambial cell division caused by SDs differed between the clones and was coincident with the change in the pattern of expression of the auxin-regulated genes. The clones also differed in the timing of their SD-regulated changes in the transcript abundance of genes associated with cold tolerance, starch breakdown, and storage protein accumulation. By analyzing the expression of homologs of FLOWERING LOCUS T, we demonstrated that the clones differed little in their perception of SDs under the growth conditions applied but differed substantially in the downstream responses manifested in the timing and magnitude of gene expression after SD treatment. These results demonstrate the existence of factors that act downstream of SD perception and can contribute to variation in SD-regulated adaptive photoperiodic responses in trees.
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