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- Dicks, Lynn V., et al.
(författare)
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Farmland conservation
- 2015
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Ingår i: What works in conservation. - 9781783741571 - 9781783741588 - 9781783741595 - 9781783741601 - 9781783741618 ; , s. 245-284
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- This book is meant as a guide to the evidence available for different conservation interventions and as a starting point in assessing their effectiveness. The assessments are based on the available evidence for the target group of species for each intervention. The assessment may therefore refer to different species or habitat to the one(s) you are considering. Before making any decisions about implementing interventions it is vital that you read the more detailed accounts of the evidence in order to assess their relevance for your study species or system.Full details of the evidence are available at www.conservationevidence.comThere may also be significant negative side-effects on the target groups or other species or communities that have not been identified in this assessment.A lack of evidence means that we have been unable to assess whether or not an intervention is effective or has any harmful impacts.
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| 4. |
- Asche, F., et al.
(författare)
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Fisheries performance in Africa: An analysis based on data from 14 countries
- 2021
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Ingår i: Marine Policy. - : Elsevier BV. - 0308-597X. ; 125
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Tidskriftsartikel (refereegranskat)abstract
- The Fishery Performance Indicators is a data collection tool that allows collection of comparable fisheries data in the environmental, economic and community pillars even under data poor circumstances. In this paper, data collected for 35 fisheries in 14 African countries are analyzed and compared to global averages. Similar to a previous global analysis, the different pillars of sustainability were positively correlated. The results are even more pronounced for Africa than globally. The only exception is the relationship between environment and community pillars in Africa, which is statistically insignificant, and this is also the case for open access fisheries globally. The average scores in Africa are lower than global average scores in all dimensions, which is not unexpected given the high number of open access fisheries. However, factors that are not fisheries specific may be more important for this result, suggesting that a country's governance, economic conditions, and development status are important for fisheries performance. © 2020 Elsevier Ltd
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- Schellong, S. M., et al.
(författare)
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Ultrasound screening for asymptomatic deep vein thrombosis after major orthopaedic surgery: the VENUS study
- 2007
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Ingår i: J Thromb Haemost. - 1538-7933.
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Tidskriftsartikel (refereegranskat)abstract
- Background: Venography is currently used to assess the incidence of deep vein thrombosis (DVT) in dose-finding and confirmatory trials of new antithrombotic agents. Centrally adjudicated, complete compression ultrasound (CCUS) could be a non-invasive alternative to venography. Objectives: A substudy of two, similarly designed, phase IIb trials of a novel, oral anticoagulant for the prevention of venous thromboembolism after elective hip or knee arthroplasty was undertaken to validate CCUS against venography. Patients/Methods: Patients received study drugs until mandatory, bilateral venography was performed 7 +/- 2 days after surgery. CCUS was performed within 24 hours after venography by sonographers blinded to the venography result. Sonographers were trained and certified for the standardized examination and documentation procedure. Venograms and sonograms were adjudicated centrally at different sites by two independent readers; discrepancies between readers were resolved by consensus. Results: A total of 1104 matching pairs of evaluable venograms and sonograms were obtained from the participants of the two trials (n = 1435): 19% of venograms and 20% of sonograms were not evaluable. The observed frequency of any DVT was 18.9% with venography and 11.5% with CCUS. Sensitivity of CCUS compared with venography was 31.1% for any DVT (95% confidence interval 23.4, 38.9), 21.0% (2.7, 39.4) for proximal DVT, and 30.8% (23.1, 38.6) for distal DVT. The figures for specificity were 93.0% (91.0, 95.1), 98.7% (98.0, 99.5), and 93.3% (91.5, 95.3), respectively. Conclusions: Based on these results, centrally adjudicated CCUS will be unable to replace venography for DVT screening early after major orthopaedic surgery in studies evaluating anticoagulant drugs.
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| 6. |
- Dicks, Lynn V., et al.
(författare)
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Farmland Conservation : Evidence for the effects of interventions in northern and western Europe
- 2014
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- This synopsis covers evidence for the effects of conservation interventions for native farmland wildlife. It is restricted to evidence captured on the website www.conservationevidence.com. It includes papers published in the journal Conservation Evidence, evidence summarized on our database and systematic reviews collated by the Collaboration for Environmental Evidence. It is the thrid volume in the series Synopses of Conservation Evidence. Evidence was collected from all European countries west of Russia, but not those south of France, Switzerland, Austria, Hungary and Romania. A list of interventions to conserve wildlife on farmland was developed collaboratively by a team of thirteen experts. A number of interventions that are not currently agri-environment options were added during this process, such as 'Provide nest boxes for bees (solitary or bumblebees)' and 'Implement food labelling schemes relating to biodiversity-friendly farming'. Interventions relating to the creation or management of habitats not considered commercial farmland (such as lowland heath, salt marsh and farm woodland) were removed. The list of interventions was organized into categories based on the International Union for the Conservation of Nature (IUCN) classifications of direct threats and conservation actions. Interventions that fall under the threat category 'Agriculture' are grouped by farming system, with separate sections for interventions that apply to arable or livestock farms, or across all farming types.
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| 7. |
- Eriksson, Bengt I., 1946, et al.
(författare)
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Oral rivaroxaban for the prevention of symptomatic venous thromboembolism after elective hip and knee replacement
- 2009
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Ingår i: Journal of Bone and Joint Surgery. - 0301-620X. ; 91:5, s. 636-44
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Tidskriftsartikel (refereegranskat)abstract
- A once-daily dose of rivaroxaban 10 mg, an oral, direct Factor Xa inhibitor, was compared with enoxaparin 40 mg subcutaneously once daily for prevention of venous thromboembolism in three studies of patients undergoing elective hip and knee replacement (RECORD programme). A pooled analysis of data from these studies (n = 9581) showed that rivaroxaban was more effective than enoxaparin in reducing the incidence of the composite of symptomatic venous thromboembolism and all-cause mortality at two weeks (0.4% vs 0.8%, respectively, odds ratio 0.44; 95% confidence interval 0.23 to 0.79; p = 0.005), and at the end of the planned medication period (0.5% vs 1.3%, respectively; odds ratio 0.38; 95% confidence interval 0.22 to 0.62; p < 0.001). The rate of major bleeding was similar at two weeks (0.2% for both) and at the end of the planned medication period (0.3% vs 0.2%). Rivaroxaban started six to eight hours after surgery was more effective than enoxaparin started the previous evening in preventing symptomatic venous thromboembolism and all-cause mortality, without increasing major bleeding.
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| 8. |
- Francis, C. W., et al.
(författare)
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Treatment of venous thromboembolism in cancer patients with dalteparin for up to 12months : the DALTECAN Study
- 2015
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Ingår i: Journal of Thrombosis and Haemostasis. - : Elsevier BV. - 1538-7933 .- 1538-7836. ; 13:6, s. 1028-1035
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundTreatment of venous thromboembolism (VTE) in patients with cancer has a high rate of recurrence and bleeding complications. Guidelines recommend low-molecular-weight heparin (LMWH) for at least 3-6months and possibly indefinitely for patients with active malignancy. There are, however, few data supporting treatment with LMWH beyond 6months. The primary aim of the DALTECAN study (NCT00942968) was to determine the safety of dalteparin between 6 and 12months in cancer-associated VTE. MethodsPatients with active cancer and newly diagnosed VTE were enrolled in a prospective, multicenter study and received subcutaneous dalteparin for 12months. The rates of bleeding and recurrent VTE were evaluated at months 1, 2-6 and 7-12. FindingsOf 334 patients enrolled, 185 and 109 completed 6 and 12months of therapy; 49.1% had deep vein thrombosis (DVT); 38.9% had pulmonary embolism (PE); and 12.0% had both on presentation. The overall frequency of major bleeding was 10.2% (34/334). Major bleeding occurred in 3.6% (12/334) in the first month, and 1.1% (14/1237) and 0.7% (8/1086) per patient-month during months 2-6 and 7-12, respectively. Recurrent VTE occurred in 11.1% (37/334); the incidence rate was 5.7% (19/334) for month 1, 3.4% (10/296) during months 2-6, and 4.1% (8/194) during months 7-12. One hundred and sixteen patients died, four due to recurrent VTE and two due to bleeding. ConclusionMajor bleeding was less frequent during dalteparin therapy beyond 6months. The risk of developing major bleeding complications or VTE recurrence was greatest in the first month of therapy and lower over the subsequent 11 months.
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| 9. |
- Lee, A. Y., et al.
(författare)
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Bilateral vs. ipsilateral venography as the primary efficacy outcome measure in thromboprophylaxis clinical trials: a systematic review
- 2004
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Ingår i: J Thromb Haemost. - 1538-7933. ; 2:10, s. 1752-9
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Tidskriftsartikel (refereegranskat)abstract
- Contrast venography, in combination with symptomatic venous thromboembolism (VTE), is the standard efficacy outcome measure in clinical trials of thromboprophylaxis in major orthopedic surgery. It is uncertain whether performing bilateral venography offers any real advantage over venography of the operated leg alone. This study was undertaken to determine the risk of isolated contralateral deep vein thrombosis (DVT) following major orthopedic surgery and to evaluate whether bilateral venography, rather than venography on the operated leg alone, offers any gain in DVT detection and, thereby, improves efficiency in clinical study design. A systematic review of prospective studies that reported DVT incidence as the primary efficacy outcome based on mandatory bilateral venography in patients undergoing elective hip or knee arthroplasty or hip fracture repair was conducted. Based on the use of bilateral venography as a primary efficacy outcome measure, the incidence of any DVT is 16.7% following total hip replacement, 18.8% after hip fracture repair, and 33.8% after total knee replacement. While DVT risk in the operated leg varies depending on the type of surgery, the risk of isolated DVT in the non-operated leg is approximately 4% to 5% in all three procedures. By increasing the detection of any DVT, the use of bilateral venography reduces required sample size by 16% to 25% compared to ipsilateral venography. In clinical trials evaluating the efficacy of thromboprophylaxis in major orthopedic surgery, bilateral venography reduces the risk of undiagnosed DVT in the non-operated leg and improves the efficiency of study design by substantially reducing the sample size requirement.
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