| 1. |
- Lind, Lars, et al.
(författare)
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Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC)
- 2021
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Ingår i: eLife. - : eLife Sciences Publications Ltd. - 2050-084X. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions.
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| 2. |
- Mishra, A, et al.
(författare)
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Diminishing benefits of urban living for children and adolescents' growth and development
- 2023
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 615:7954, s. 874-883
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Tidskriftsartikel (refereegranskat)abstract
- Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.
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| 12. |
- Andersson, Joel B.H., et al.
(författare)
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U-Pb zircon-titanite-apatite age constraints on basin development and basin inversion in the Kiruna mining district, Sweden
- 2022
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Ingår i: Precambrian Research. - : Elsevier. - 0301-9268 .- 1872-7433. ; 372
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Tidskriftsartikel (refereegranskat)abstract
- To constrain the tectonothermal evolution of the type locality for iron oxide-apatite deposits, we have obtained U-Pb zircon, titanite, and apatite age data for the Kiruna mining district in northernmost Sweden. The results indicate that the host basin initiated in an overall extensional regime as indicated by the deposition of alluvial conglomerates and greywackes. A volcanic intercalation in a conglomerate unit northwest of the Luossavaara iron oxide-apatite deposit yields a U-Pb zircon age of 1887 ± 3 Ma representing the timing of the earliest Orosirian volcanism in the central Kiruna mining district coinciding with the onset of basin development. In-situ analysis of titanite on hydrothermally altered fracture planes within a cataclastic fault damage zone (c. 270 m from the fault core system associated to the Luossavaara iron oxide-apatite deposit) yields complex U-Pb data. Applying a strict discordance filter yields a 207Pb/206Pb age of 1889 ± 26 Ma. The age implies that the fault probably has a syn-volcanic origin and that syn-volcanic faults may have played an important role during iron ore emplacement. The mineralized basin was subsequently buried and metamorphosed under upper greenschist-facies conditions and later tectonically exhumed and cooled below the apatite closure temperature at 1805 ± 26 Ma indicated by apatite from the Nukutus iron oxide-apatite deposit. Basin inversion is temporally constrained by syn-tectonic titanite as part of sodic-calcic + Fe + Cl hydrothermal alteration along a brittle-ductile reverse shear zone to the east of the study area. Titanite grains that show sector and oscillatory zoning yield an age of 1812 ± 3 Ma, which we interpret as the onset of basin inversion. Homogeneous (relatively unzoned) titanite in the same sample yields an age of 1802 ± 8 Ma, tentatively indicating that the tectonothermal activity lasted up to c. 20 m.y.
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| 13. |
- Bauer, Tobias E., Associate professor, 1982-, et al.
(författare)
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Analysis of data from Unmanned Aerial Systems (UAS) in a Virtual Reality environment
- 2019
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Ingår i: Proceedings of the Visual3D conference 2019, 1–2 October 2019, Uppsala, Sweden: Visualization of 3D/4D models in geosciences, exploration and mining. - : Luleå University of Technology. ; , s. 19-19
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Konferensbidrag (refereegranskat)abstract
- The use of Unmanned Aerial Systems (UAS) is getting increasingly popular for many different types of applications. The field of geology is slowly catching up resulting in new and innovative UAS solutions for various kinds of airborne measurement techniques. These techniques comprise a wide range of geophysical and remote sensing methods used to investigate the sub-surface. At Luleå University of Technology two different types of UAS are used in combination with a Virtual Reality environment in order to analyze geological structures and related ore deposits and mineralizations. The two UAS comprise a) a custom made quadrocopter (HUGIN) with a pay load of approx. 3.5 kg and an operational time of 5 times (batteries) maximum 35 minutes depending on payload, ambient temperatures and wind speed; and b) a foldable DJI Mavic Pro with an operational time of 3 times 30 minutes. The HUGIN system can be operated with a high-resolution optical camera for photogrammetry surveys and a 3-axial fluxgate magnetometer for measuring magnetic anomalies within bedrock and ultimately delineating geological structures. The system is highly flexible and a thermal camera is currently added to the system in order detect water fluxes in relation to geological structures or exothermal mineral processes. The DJI system is equipped with an optical camera for photogrammetric surveying and is a highly valuable tool in remote areas due to its lightweight and compact construction.Data acquired from both UAS is subsequently analysed in a Virtual Reality lab utilizing a 6m wide screen with active stereo functions. Photogrammetry data is first processed using the Aigsoft software package following a Structure for Motion (SfM) workflow where dense point cloud models and subsequently meshed and textured 3D surface models are produced. These models are then converted and transferred to the GeoVisionary software package that allows visualization of models in stereo 3D view. This allows digitizing geological structures such as foliation, fractures, and faults among others in an immersive 3D environment and provides an efficient tool complimentary to traditional field mapping. In particular, this makes it possible to capture and analyse data from hardly accessible and dangerous areas such as rock faces in open pits. Another complimentary method of data analysis comprises SCAT analysis of the meshed surfaces using the MOVE software package.
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| 15. |
- Garcia Uriarte, Ainara, et al.
(författare)
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SUstainable management of PRIMary raw materials through a better approach in Life Cycle Sustainability Assessment (SUPRIM)
- 2019
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The project focuses on the assessment of the environmental impact of raw materials production and the development of services to better understand sustainability issues in the sector. The main objectives of the project are:• Development of a Life Cycle Impact Assessment (LCIA) method to address resource accessibility in sustainability assessment and testing and validatingthe method.• Development of Life Cycle Inventory (LCI) datasets through case studies in collaboration with the industrial partners from the mining sector and apply anenvironmental assessment with the aim to better understand the environmental impacts of the production of copper and the sources of these impacts.• Bring the service to a broader audience, including the LCIA community, mining companies and their downstream users, policy makers, academia.Two case studies have been performed, the Cobre las Cruces mine in Spain, operated by First Quantum Minerals Ltd, as well as the Aitik mining operation innorthern Sweden, operated by Boliden Mineral AB.
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| 17. |
- Kamal, H., et al.
(författare)
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Long-Term Study of Hepatitis Delta Virus Infection at Secondary Care Centers: The Impact of Viremia on Liver-Related Outcomes
- 2020
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Ingår i: Hepatology. - : Ovid Technologies (Wolters Kluwer Health). - 0270-9139 .- 1527-3350. ; 72:4, s. 1177-1190
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Tidskriftsartikel (refereegranskat)abstract
- Background and Aims Hepatitis delta virus (HDV) infection is associated with fast progression to liver cirrhosis and liver complications. Previous studies have, however, been mainly from tertiary care centers, with risk for referral bias toward patients with worse outcomes. Furthermore, the impact of HDV viremiaper seon liver-related outcomes is not really known outside the human immunodeficiency virus co-infection setting. We have therefore evaluated the long-term impact of HDV viremia on liver-related outcomes in a nationwide cohort of patients with hepatitis B and D co-infection, cared for at secondary care centers in Sweden. Approach and Results In total, 337 patients with anti-HDV positivity, including 233 patients with HDV RNA viremia and 91 without HDV viremia at baseline, were retrospectively studied, with a mean follow-up of 6.5 years (range, 0.5-33.1). The long-term risks for liver-related events (i.e., hepatocellular carcinoma [HCC], hepatic decompensation, or liver-related death/transplantation) were assessed, using Cox regression analysis. The risk for liver-related events and HCC was 3.8-fold and 2.6-fold higher, respectively, in patients with HDV viremia compared with those without viremia, although the latter was not statistically significant. Among patients with HDV viremia with no baseline cirrhosis, the cumulative risk of being free of liver cirrhosis or liver-related events was 81.9% and 64.0% after 5 and 10 years of follow-up, respectively. This corresponds to an incidence rate of 0.04 cases per person-year. Conclusions HDV RNA viremia is associated with a 3.8-fold higher risk for liver-related outcomes. The prognosis was rather poor for patients with HDV viremia without cirrhosis at baseline, but it was nevertheless more benign than previous estimates from tertiary centers. Our findings may be of importance when making decisions about treatment and evaluating potential outcomes of upcoming antivirals against HDV.
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| 18. |
- Kampmann, Tobias Christoph, 1987-
(författare)
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Age, origin and tectonothermal modification of the Falun pyritic Zn-Pb-Cu-(Au-Ag) sulphide deposit, Bergslagen, Sweden
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The Falun pyritic Zn-Pb-Cu-(Au-Ag) sulphide deposit, situated in the Palaeoproterozoic (1.9–1.8 Ga) Bergslagen lithotectonic unit in the south-western part of the Fennoscandian Shield, is one of the major base and precious metal sulphide deposits in Sweden. Felsic volcanic rocks and limestone hosting the deposit, as well as their hydrothermally altered equivalents and the mineralization, were affected by heterogeneous ductile strain and metamorphism under low-pressure, lower amphibolite-facies conditions during the Svecokarelian orogeny (2.0–1.8 Ga). These processes reworked the mineral assemblages of the original hydrothermal system and the mineralization, and also reshaped the structural geometry of the deposit.A three-dimensional modelling approach has been used in order to evaluate geometric relationships between lithologies at the deposit. The polyphase character (D1 and D2) of the strong ductile deformation at Falun is apparent. The main rock-forming minerals in the altered silicate-rich rocks are quartz, biotite and anthophyllite with porphyroblasts of cordierite and garnet, as well as retrogressive chlorite. Major static grain growth occurred between D1 and D2, inferred to represent the peak of metamorphism, as well as after D2 with growth (or recrystallization) of anthophyllite. A major shear zone with chlorite, talc and disseminated sulphides bounds the pyritic Zn-Pb-Cu-rich massive sulphide mineralization to the north, the latter being surrounded elsewhere by disseminated to semi-massive Cu-Au mineralization. F2 sheath folding along axes plunging steeply to the south-south-east is suggested as a key deformation mechanism, accounting for the cone-shaped mineralized bodies, which pinch out at depth, and explaining the similar character of intensely altered rocks on all sides of the massive sulphide mineralization. Immobile-element lithogeochemistry suggests that they share a common volcanic precursor. These relationships are consistent with a model in which the pyritic massive sulphide mineralization is located in the core of a sheath fold structure, surrounded by the same altered stratigraphic footwall rocks with Cu-Au mineralization.The geological evolution in the metavolcanic inlier that hosts the Falun deposit, constrained by secondary ion mass spectrometry (SIMS) U–Pb (zircon) geochronology, involved emplacement of a felsic volcanic and sub-volcanic rock suite at 1894±3 Ma, followed by hydrothermal alteration and mineralization. Subsequent burial and intrusion of late- to post-mineralization dykes occurred between 1896±3 Ma and 1891±3 Ma, followed by further burial and emplacement of plutons with variable composition during the time span 1894±3 Ma to 1893±3 Ma. The age determinations for all these magmatic suites overlap within their uncertainties, indicating a rapid sequence of continuous burial and different magmatic pulses. A metamorphic event, herein dated at 1831±8 Ma and 1822±5 Ma (SIMS U–Pb monazite), falls in the age range of a younger Svecokarelian metamorphic episode (M2). U-Th-Pb isotope systematics in monazite was completely reset during this event.During hydrothermal alteration and mineralization, a hot, reducing and acidic fluid carrying metals and sulphur together flowed upward along syn-volcanic faults, leading to intense chloritization, sericitization and silicification of calc-alkaline volcanic rocks in the stratigraphic footwall to the deposit. This resulted in proximal siliceous associations including Fe-rich chlorite, and dominant Mg-rich chlorite and sericite in more peripheral parts. Cu-Au stockwork mineralization formed in the siliceous core of the hydrothermal system as result of fluid cooling. Neutralization of the metal-bearing fluids upon carbonate interaction stratigraphically higher in the sub-seafloor regime led to formation of Zn-Pb-Cu-rich massive sulphide mineralization, the space for which was created by a combination of carbonate dissolution, primary porosity in the overlying volcanic rocks and secondary porosity produced during syn-volcanic faulting. A hybrid model for mineralization is suggested by alteration styles, metal zoning and textures indicating replacement of carbonate rock or highly porous pumice breccia by pyritic massive sulphide. Aspects of a sub-seafloor volcanogenic massive sulphide (VMS) system and carbonate replacement are both present. Partly Zn-Pb-(Ag) mineralized skarns comprise a separate and subordinate type of mineralization, probably formed after burial of the hydrothermal system to the contact-metasomatic regime.Textures and microstructures in the massive sulphide mineralization indicate that the ductile deformation and metamorphism resulted in internal mechanical and chemical remobilization of sulphide minerals. Laser ablation inductively coupled mass spectrometry (LA-ICP-MS) analysis of the main sulphide minerals suggests, for example, that trace elements (including Au) were liberated from pyrite during metamorphism. A system of auriferous quartz veins, affected by D2 ductile strain, occurs in intensely altered and mineralized rocks on the eastern side of the deposit. It is suggested that they formed after the peak of metamorphism and prior to the completion of the D2 tectonic event, as a result of fluid-assisted remobilization of sulphides and Au in the disseminated to semi-massive Cu-Au mineralization and possibly also the massive sulphide mineralization.
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| 19. |
- Kampmann, Tobias Christoph, et al.
(författare)
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Structural investigation and 3D modelling of the Falun pyritic Zn-Pb-Cu-(Au-Ag) sulphide deposit, Bergslagen region, south-central Sweden
- 2013
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Konferensbidrag (refereegranskat)abstract
- One of the prominent ore deposits of the Bergslagen region in south-central Sweden is located in Falun in the northern part of this mining district. A belt of 1.91-1.89 Ga metavolcanic rocks hosts both the ores and an alteration aureole of several hundreds to thousands of metres in extent at the ground surface. Analysis of the structures in the area reveals a polyphase ductile deformational history and a major, steeply plunging F2 reclined fold. 3D modelling of the boundary surface to the pyritic Zn-Pb-Cu sulphide ore has been used to visualize the geometry of this ore body at depth, constraining its steeply plunging rod-like and NW-SE elongate shape and a geometric control by the F2 fold structure.
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| 20. |
- Kampmann, Tobias Christoph, 1987-, et al.
(författare)
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Syn-tectonic sulphide remobilization and trace element redistribution at the Falun pyritic Zn-Pb-Cu-(Au-Ag) sulphide deposit, Bergslagen, Sweden
- 2018
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Ingår i: Ore Geology Reviews. - : Elsevier. - 0169-1368 .- 1872-7360. ; 96, s. 48-71
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Tidskriftsartikel (refereegranskat)abstract
- Mineralization types at the Palaeoproterozoic Falun base metal sulphide deposit are predominantly pyritic Zn-Pb-Cu-rich massive sulphide mineralization, disseminated to semi-massive Cu-Au mineralization, auriferous quartz veins, and mineralized shear zones of talc-chlorite-dominated schist. The massive and disseminated to semi-massive sulphide mineralization types were subject to polyphase ductile deformation (D1 and D2) and metamorphism under low-P, lower-amphibolite facies conditions, which led to the development of ore textures and paragenetic relationships indicating both mechanical and chemical remobilization of sulphides. In the massive sulphide mineralization, rare inclusion-rich pyrite occurs as relic cores inside inclusion-poor metamorphosed pyrite. Imaging and spot analysis using multielement laser ablation inductively-coupled plasma mass spectrometry (LA-ICP-MS) reveal that inclusion-poor pyrite was depleted in trace elements, which were originally present as non-stoichiometric lattice substitutions or in mineral inclusions. The inclusion-rich pyrite was shielded from depletion and, at least partly, retained its initially higher trace element concentrations, including Au.Gold is also associated with chalcopyrite in the disseminated to semi-massive Cu-Au mineralization and in the system of auriferous quartz veins hosted therein, the latter being also affected by the D2 ductile strain. It is inferred that emplacement of the vein system took place after the peak of metamorphism, which occurred between D1 and D2, but prior to and possibly even shortly after completion of the D2 deformational event. Similarities in trace element signatures in chalcopyrite are compatible with the interpretation that the quartz veins formed by local chemical remobilization of components from the Cu-Au mineralization. Transport of liberated Au from pyrite during grain growth in the massive sulphide mineralization may have upgraded the Au endowment in the quartz veins, leading to the additional formation of native gold in the veins. A strong correspondence between elements liberated from pyrite (e.g. Pb, Bi, Se and Au) and those forming discrete and characteristic mineral phases in the quartz veins (Pb-Bi sulphosalts, native gold) supports this hypothesis.Trace element signatures for the main sulphide minerals pyrite, chalcopyrite, sphalerite and galena are similar to previously published data from other metamorphosed massive sulphide deposits. The association of the Falun mineralization with elevated Bi is reflected by its occurrence in sulphide minerals (e.g. galena) and in abundant mineral inclusions of Pb-Bi sulphosalts (e.g. weibullite), especially in the disseminated to semi-massive Cu-Au mineralization. Elevated Sn concentrations in the lattice and/or as cassiterite inclusions in chalcopyrite, sphalerite and galena are compatible with a hot, acidic and reducing fluid during formation of the syn-volcanic, base metal sulphide mineralization and associated host-rock alteration.
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| 21. |
- Kampmann, Tobias, et al.
(författare)
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Timing of magmatism and mineralisation at Falun, a major base metal sulphide deposit in the Fennoscandian Shield, Sweden
- 2015
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Ingår i: Mineral Resources in a Sustainable World. - 9782855550664 ; , s. 591-594
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Konferensbidrag (refereegranskat)abstract
- U-Pb (zircon) ion probe geochronology on key lithologies at the Palaeoproterozoic Falun Zn-Pb-Cu-(Au-Ag) sulphide deposit in the south-western part of the Fennoscandian Shield has been carried out. Results suggest that dominantly felsic sub-volcanic intrusion, hydrothermal alteration, ore formation and intrusion by dykes and plutons took place in a short time interval between 1894 ± 3 Ma and 1891 ± 3 Ma. Analogues to intra-arc VMS mineralisation in Peru are discussed.
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| 22. |
- Lange, C, et al.
(författare)
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Preventive chemotherapy for contacts of MDR-TB: is the proof in the pudding?
- 2014
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Ingår i: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. - : International Union Against Tuberculosis and Lung Disease. - 1815-7920. ; 18:11, s. 1262-1263
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 25. |
- Parra Bravo, Celeste, et al.
(författare)
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Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.
- 2024
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Ingår i: Cell. - 1097-4172. ; 187:10
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Tidskriftsartikel (refereegranskat)abstract
- Tauopathies are age-associated neurodegenerative diseases whose mechanistic underpinnings remain elusive, partially due to a lack of appropriate human models. Here, we engineered human induced pluripotent stem cell (hiPSC)-derived neuronal lines to express 4R Tau and 4R Tau carrying the P301S MAPT mutation when differentiated into neurons. 4R-P301S neurons display progressive Tau inclusions upon seeding with Tau fibrils and recapitulate features of tauopathy phenotypes including shared transcriptomic signatures, autophagic body accumulation, and reduced neuronal activity. A CRISPRi screen of genes associated with Tau pathobiology identified over 500 genetic modifiers of seeding-induced Tau propagation, including retromer VPS29 and genes in the UFMylation cascade. In progressive supranuclear palsy (PSP) and Alzheimer's Disease (AD) brains, the UFMylation cascade is altered in neurofibrillary-tangle-bearing neurons. Inhibiting the UFMylation cascade invitro and invivo suppressed seeding-induced Tau propagation. This model provides a robust platform to identify novel therapeutic strategies for 4R tauopathy.
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