| 1. |
- Czub, Joanna, et al.
(författare)
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Biological effects of mixed-ion beams. Part 1 : Effect of irradiation of the CHO-K1 cells with a mixed-ion beam containing the carbon and oxygen ions
- 2018
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Ingår i: Applied Radiation and Isotopes. - : Elsevier BV. - 0969-8043 .- 1872-9800. ; 139, s. 304-309
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Tidskriftsartikel (refereegranskat)abstract
- Carbon and oxygen ions were accelerated simultaneously to estimate the effect of irradiation of living cells with the two different ions. This mixed ion beam was used to irradiate the CHO-K1 cells, and a survival test was performed. The type of the effect of the mixed ion beam on the cells was determined with the isobologram method, whereby survival curves for irradiations with individual ion beams were also used. An additive effect of irradiation with the two ions was found.
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| 2. |
- Czub, Joanna, et al.
(författare)
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Biological effects of mixed-ion beams. Part 2 : The relative biological effectiveness of CHO-K1 cells irradiated by mixed- and single-ion beams
- 2019
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Ingår i: Applied Radiation and Isotopes. - : Elsevier BV. - 0969-8043 .- 1872-9800. ; 150, s. 192-198
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Tidskriftsartikel (refereegranskat)abstract
- The relative biological effectiveness (RBE) values were determined for single- and mixed-ion beams containing carbon and oxygen ions. The CHO-K1 cells were irradiated with beams with the linear energy transfer (LET) values of 236-300 and 461-470 keV/mu m for C-12 and O-16 ions, respectively. The RBE was estimated as a function of dose, survival fraction (SF) and LET. The SF was not affected by varying contributions of the constituent ions to the total mixed dose. The RBE has the same value for single-ion exposures with ions with LET 300 (C-12) and 470 keV/mu m (O-16).
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| 3. |
- Carlborg, Carl Fredrik, et al.
(författare)
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A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips
- 2010
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Ingår i: Lab on a Chip. - : Royal Society of Chemistry (RSC). - 1473-0197 .- 1473-0189. ; 10:3, s. 281-290
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Tidskriftsartikel (refereegranskat)abstract
- We present the design, fabrication, and characterisation of an array of optical slot-waveguide ring resonator sensors, integrated with microfluidic sample handling in a compact cartridge, for multiplexed real-time label-free biosensing. Multiplexing not only enables high throughput, but also provides reference channels for drift compensation and control experiments. Our use of alignment tolerant surface gratings to couple light into the optical chip enables quick replacement of cartridges in the read-out instrument. Furthermore, our novel use of a dual surface-energy adhesive film to bond a hard plastic shell directly to the PDMS microfluidic network allows for fast and leak-tight assembly of compact cartridges with tightly spaced fluidic interconnects. The high sensitivity of the slot-waveguide resonators, combined with on-chip referencing and physical modelling, yields a volume refractive index detection limit of 5 x 10(-6) refractive index units (RIUs) and a surface mass density detection limit of 0.9 pg mm(-2), to our knowledge the best reported values for integrated planar ring resonators.
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| 4. |
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| 5. |
- Giannone, Domenico, et al.
(författare)
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High Performance Multichannel Photonic Biochip Sensors for Future Point of Care Diagnostics : an Overview on Two EU-Sponsored Projects
- 2010
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Ingår i: SPIE Proc. 7715 BIOPHOTONICS - PHOTONIC SOLUTIONS FOR BETTER HEALTH CARE II. - : SPIE. - 9780819481887 ; , s. 77150U-1-77150U-12
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Konferensbidrag (refereegranskat)abstract
- We present here research work on two optical biosensors which have been developed within two separate European projects (6(th) and 7(th) EU Framework Programmes). The biosensors are based on the idea of a disposable biochip, integrating photonics and microfluidics, optically interrogated by a multichannel interrogation platform. The objective is to develop versatile tools, suitable for performing screening tests at Point of Care or for example, at schools or in the field. The two projects explore different options in terms of optical design and different materials. While SABIO used Si(3)N(4)/SiO(2) ring resonators structures, P3SENS aims at the use of photonic crystal devices based on polymers, potentially a much more economical option. We discuss both approaches to show how they enable high sensitivity and multiple channel detection. The medium term objective is to develop a new detection system that has low cost and is portable but at the same time offering high sensitivity, selectivity and multiparametric detection from a sample containing various components (e. g. blood, serum, saliva, etc.). Most biological sensing devices already present on the market suffer from limitations in multichannel operation capability (either the detection of multiple analytes indicating a given pathology or the simultaneous detection of multiple pathologies). In other words, the number of different analytes that can be detected on a single chip is very limited. This limitation is a main issue addressed by the two projects. The excessive cost per test of conventional bio sensing devices is a second issue that is addressed.
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| 6. |
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| 7. |
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| 8. |
- Gylfason, Kristinn, 1978-, et al.
(författare)
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On-chip temperature compensation in an integrated slot-waveguide ring resonator refractive index sensor array
- 2010
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Ingår i: Optics Express. - 1094-4087. ; 18:4, s. 3226-3237
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Tidskriftsartikel (refereegranskat)abstract
- We present an experimental study of an integrated slot-waveguide refractive index sensor array fabricated in silicon nitride on silica. We study the temperature dependence of the slot-waveguide ring resonator sensors and find that they show a low temperature dependence of -16.6 pm/K, while at the same time a large refractive index sensitivity of 240 nm per refractive index unit. Furthermore, by using on-chip temperature referencing, a differential temperature sensitivity of only 0.3 pm/K is obtained, without individual sensor calibration. This low value indicates good sensor-to-sensor repeatability, thus enabling use in highly parallel chemical assays. We demonstrate refractive index measurements during temperature drift and show a detection limit of 8.8 x 10(-6) refractive index units in a 7 K temperature operating window, without external temperature control. Finally, we suggest the possibility of athermal slot-waveguide sensor design.
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| 9. |
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| 10. |
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| 11. |
- Kazmierczak, Andrzej, et al.
(författare)
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High quality optical microring resonators in Si3N 4/SiO2
- 2008
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Ingår i: Proceedings of the 14th European Conference on Integrated Optics - ECIO'08 Eindhoven. - 9789038613178 ; , s. 313-316
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Konferensbidrag (refereegranskat)abstract
- We have experimentally demonstrated high Q-factors strip waveguide resonators using the Si3N4/SiO2 material platform at the wavelength of 1.31μm. The analyzed filters demonstrate high quality factors reaching 133,000. The dependence on resonator radii and coupling gap is also discussed.
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| 12. |
- Kazmierczak, Andrzej, et al.
(författare)
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Light coupling and distribution for Si3N4/SiO2 integrated multichannel single-mode sensing system
- 2009
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Ingår i: Optical Engineering. - : SPIE-Intl Soc Optical Eng. - 0091-3286 .- 1560-2303. ; 48:1
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Tidskriftsartikel (refereegranskat)abstract
- We present an efficient and highly alignment-tolerant light coupling and distribution system for a multichannel Si3N4/SiO2 single-mode photonics sensing chip. The design of the input and output couplers and the distribution splitters is discussed. Examples of multichannel data obtained with the system are given.
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| 13. |
- Maire, Guillaume, et al.
(författare)
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High efficiency silicon nitride surface grating couplers
- 2008
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Ingår i: Optics Express. - 1094-4087. ; 16:1, s. 328-333
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Tidskriftsartikel (refereegranskat)abstract
- High efficiency surface grating couplers for silicon nitride waveguides have been designed, fabricated, and characterized. Coupling efficiencies exceeding 60 % are reported at a wavelength of 1.31 mu m, as well as angular and wavelength -3 dB tolerances of 4 and 50 nm, respectively. When the wavelength is increased from 1310 nm to 1450 nm the coupling efficiency progressively decreases but remains above 20 % at 1450 nm. The influence of the duty ratio of the grating has also been investigated: maximum coupling efficiency was obtained at 50 % duty ratio.
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| 14. |
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| 15. |
- Płódowska, Magdalena, et al.
(författare)
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Small is beautiful : low activity alpha and gamma sources for small-scale radiation protection research experiments
- 2021
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Ingår i: International Journal of Radiation Biology. - : Informa UK Limited. - 0955-3002 .- 1362-3095. ; 97:4, s. 541-552
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Uncertainties regarding the magnitude of health effects following exposure to low dosesof ionizing radiation remain a matter of concern both for professionals and for the public. There isconsensus within the international radiation research community that more research is requiredon biological effects of radiation doses below 100 mGy applied at low dose rates. Moreover, thereis a demand for increasing education and training of future radiation researchers and regulators.Research, education and training is primarily carried out at universities but university-based radiationresearch is often hampered by limited access to radiation sources. The aim of the presentreport is to describe small and cost-effective low activity gamma and alpha sources that can easilybe installed and used in university laboratories.Methods and results: A gamma radiation source was made from an euxenite-(Y) rock(Y,Ca,Ce,U,Th)(Nb,Ta,Ti)2O6) that was found in an abandoned mine in Sweden. It allows exposingcells grown in culture dishes to radiation at a dose rate of 50 μGy/h and lower. Three alpha sourceswere custom-made and yield a dose rate of 1 mGy/h each. The construction, dosimetry andcellular effects of the sources are described.Conclusions: We hope that the report will stimulate research and training activities in the lowdose field by facilitating access to radiation sources.
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| 16. |
- Vivien, Laurent, et al.
(författare)
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A high efficiency silicon nitride grating coupler
- 2007
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Ingår i: 2007 4th IEEE International Conference on Group IV Photonics. - : IEEE. - 9781424409341 ; , s. 157-159
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Konferensbidrag (refereegranskat)abstract
- The experimental demonstration of a high efficiency silicon nitride grating coupler is reported for wavelengths from lambda=1.25 to 1.45 mu m for TE polarization. At the resonant angle, a coupling efficiency higher than 60% has been measured.
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