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- Prakash, A, et al.
(author)
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Deliverable D6.3 : Trials and experimentation (cycle 3)
- 2022
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Reports (peer-reviewed)abstract
- This deliverable presents the third and final cycle of trials and experimentation activities executed over 5GENESIS facilities. The document is the continuation of deliverables D6.1 and D6.2, in the sense that it captures tests carried out over the evolved infrastructures hosting 5GENESIS facilities following the methodology defined in the previous editions of this deliverable. The tests reported in this document focus on i) the final 5G infrastructure deployments that includes radio and core elements mostly in Stand-Alone (SA) deployment configurations based on commercial and open implementations, and ii) the various use cases/applications, some of them also involving field trials. Most of the tests described herein, especially the generic/lab ones are performed using the Open5GENESIS experimentation suite.
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- Laj, P., et al.
(author)
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Measuring Atmospheric Composition Change
- 2009
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In: Atmospheric Environment. - : Elsevier BV. - 1873-2844 .- 1352-2310. ; 43:33, s. 5351-5414
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Journal article (peer-reviewed)abstract
- Scientific findings from the last decades have clearly highlighted the need for a more comprehensive approach to atmospheric change processes. In fact, observation of atmospheric composition variables has been an important activity of atmospheric research that has developed instrumental tools (advanced analytical techniques) and platforms (instrumented passenger aircrafts, ground-based in-situ and remote sensing stations, earth observation satellite instruments) providing essential information on the composition of the atmosphere. The variability of the atmospheric system and the extreme complexity of the atmospheric cycles for short-lived gaseous and aerosol species have led to the development of complex models to interpret observations, test our theoretical understanding of atmospheric chemistry and predict future atmospheric composition. The validation of numerical models requires accurate information concerning the variability of atmospheric composition for targeted species via comparison with observations and measurements. In this paper, we provide an overview of recent advances in instrumentation and methodologies for measuring atmospheric composition changes from space, aircraft and the surface as well as recent improvements in laboratory techniques that permitted scientific advance in the field of atmospheric chemistry. Emphasis is given to the most promising and innovative technologies that will become operational in the near future to improve knowledge of atmospheric composition. Our current observation capacity, however, is not satisfactory to understand and predict future atmospheric composition changes, in relation to predicted climate warming. Based on the limitation of the current European observing system, we address the major gaps in a second part of the paper to explain why further developments in current observation strategies are still needed to strengthen and optimise an observing system not only capable of responding to the requirements of atmospheric services but also to newly open scientific questions.
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- Moore, K. L. F., et al.
(author)
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Improved survival in myeloma patients-a nationwide registry study of 4,647 patients=75 years treated in Denmark and Sweden
- 2023
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In: Haematologica. - : Ferrata Storti Foundation (Haematologica). - 0390-6078 .- 1592-8721. ; 108:6, s. 1640-1651
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Journal article (peer-reviewed)abstract
- The prevalence of multiple myeloma (MM) is increasing in Nordic countries and the rest of the western world. Patients aged =75 years at diagnosis constitute an increasing proportion of all MM patients, but are underrepresented in randomized clinical trials. There is an urgent need for studies of the characteristics, treatment and outcome in this cohort. We present data from two nationwide population-based registries of all MM patients diagnosed in Denmark from January 1, 2005 until February 18, 2020, and in Sweden from January 1, 2008 until December 31, 2019, including treatment data for patients diagnosed until 2018 (Denmark) and 2019 (Sweden). In total 4,647 patients were =75 years at diagnosis, compared to 7,378 younger patients. Patients =75 years, accounting for approximately 40% of all MM patients, are a distinct cohort with more advanced disease at diagnosis, reflected by higher International Staging System (ISS) stage, and a higher proportion have renal failure and anemia. We found a more gradual introduction of modern medications in the older cohort than in the younger, despite simultaneous changes in guidelines. Compared to the cohorts in randomized controlled trials that guide the treatment of non-transplant eligible patients, we found a higher proportion of patients =75 years and presenting with ISS III in the real-world populations. Nevertheless, response rates and survival are increasing, indicating that modern treatment regimens are effective and well tolerated also in elderly MM patients in real-world populations.
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- Blimark, Cecilie, et al.
(author)
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Outcome data from >10 000 multiple myeloma patients in the Danish and Swedish national registries
- 2022
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In: European Journal of Haematology. - : Wiley. - 0902-4441 .- 1600-0609. ; 108:2, s. 99-108
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Journal article (peer-reviewed)abstract
- Objective We describe real-world evidence (RWE) from the nationwide Swedish and Danish registries that provide important information on incidence and outcome in multiple myeloma (MM). Method First line treatment data on more than 10.000 MM patients from Denmark and Sweden between 2005-2018 are presented. Key results from research conducted within the Swedish and Danish myeloma registries are summarized, describing subgroups of patients with comorbidity, myeloma complications, and early relapse. Results We show that national guidelines, generated on results from randomized clinical trials (RCTs) are rapidly implemented and improve overall survival (OS). We find that both the incidence of MM and the median age at diagnosis is higher in national registries compared to results from referral centres, indicating a more complete coverage. This highlights the need of validation of prognostic scoring systems and indices in e.g., SMM and high-risk MM in a real- world-population. We show that these subgroups are unlikely to be captured in RCTs with narrow inclusion and exclusion criteria, that they have worse survival, and are in need of new treatment approaches. Conclusion National registries that include all MM patients are an important source of knowledge on epidemiology, treatment and outcome with implications for the planning of MM care. Despite the introduction of new and better treatments, rapidly implemented in our countries, our registries uncover subgroups of patients that still have inferior outcome. Our RWE can help to identify important research questions to be studied in further clinical trials also in patients currently not included in RCTs.
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- Salminen, Johanna, et al.
(author)
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Congo-São Francisco craton in Paleoproterozoic-Mesoproterozoic supercontinent Nuna
- 2024
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In: Precambrian Research. - 0301-9268. ; 406
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Journal article (peer-reviewed)abstract
- The location of the Congo-São Francisco (CSF) craton, one of the largest cratons in Proterozoic paleogeography, has been poorly constrained for the supercontinent Nuna interval (ca. 1800–1300 Ma). Initial models of Nuna suggested that the CSF craton was part of the Atlantica continent, together with Amazonia, West Africa, and perhaps Río de la Plata, as a separate continental block from other Nuna constituents. In other Nuna models the CSF craton has been placed adjacent to Baltica and Siberia, the core of Nuna, based mainly on ages of mafic magmatism and sparse paleomagnetic data. Through a geochemical, geochronological and paleomagnetic study of the WNW-trending Virei mafic dykes, which extend outward from the Mesoproterozoic Kunene Igneous Complex in southwest Angola, we provide a U-Pb baddeleyite age of 1385 ± 5 Ma, geochemical signatures, and a robust Mesoproterozoic paleomagnetic pole to test the CSF craton's placement within Nuna. Including our new pole with quality-filtered poles from the other cratons during the Nuna interval, we propose a refined Nuna model with (1) southwest Congo / west Siberia cratonic connection at 1700–1500 Ma, (2) proximity of Amazonia and West Africa cratons, and (3) connection of southwest Congo craton with northwest West Africa at 1380 Ma. Our proposed 1500–1380 Ma reconstructions are further supported by matching large igneous province (LIP) records from these crustal blocks. The new 1385 Ma Virei pole, when considered relative to an earlier CSF pole at ca. 1500 Ma, requires substantial azimuthal rotation (∼85°) of CSF in the intervening time interval. To accommodate both the matching LIP records and paleomagnetic data from CSF and neighboring cratons in Nuna, we propose an interval of transform motion near the supercontinent's periphery prior to more widespread mid-Mesoproterozoic supercontinental breakup.
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