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| 2. |
- Bott, Lukas Thomas, et al.
(författare)
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Coulomb dissociation of O-16 into He-4 and C-12
- 2023
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Ingår i: NUCLEAR PHYSICS IN ASTROPHYSICS - X, NPA-X 2022. - : EDP Sciences. - 2100-014X. ; 279
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Konferensbidrag (refereegranskat)abstract
- We measured the Coulomb dissociation of O-16 into He-4 and C-12 within the FAIR Phase-0 program at GSI Helmholtzzentrum fur Schwerionenforschung Darmstadt, Germany. From this we will extract the photon dissociation cross section O-16(alpha,gamma)C-12, which is the time reversed reaction to C-12(alpha,gamma)O-16. With this indirect method, we aim to improve on the accuracy of the experimental data at lower energies than measured so far. The expected low cross section for the Coulomb dissociation reaction and close magnetic rigidity of beam and fragments demand a high precision measurement. Hence, new detector systems were built and radical changes to the (RB)-B-3 setup were necessary to cope with the high-intensity O-16 beam. All tracking detectors were designed to let the unreacted O-16 ions pass, while detecting the C-12 and He-4.
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| 4. |
- Koch, Christian, 1958, et al.
(författare)
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Information standards - A hinder or an enabler for innovation?
- 2018
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Ingår i: Proceeding of the 34th Annual ARCOM Conference, ARCOM 2018. - 9780995546325 ; , s. 27-36
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Konferensbidrag (refereegranskat)abstract
- © Proceeding of the 34th Annual ARCOM Conference, ARCOM 2018. The potential of cost reduction by efficient digital communication in building processes in Sweden has been investigated to be 15-25% of the building sum. An important part of this potential is by using building information standards, such as Omniclass and IFC. This research has aimed at evaluating the use of building information standards and its impact on innovation. Standards are understood as classification of information and rules for building processes. Selected literature help reveal the multiple character of relevant standardization in building and the effects on innovation. Ten types of effect are identified. Three national longitudinal case studies of hospital projects in Scandinavia were carried out. Many barriers for innovation when using standards were found. The regional public authorities can decide to adopt standards locally and in two out of three cases they did not. For the companies this is a business consideration: In the Norwegian case, the proactive adoption of the architect, meant benefits for the client and contractor. However, other actors did not follow. In the Swedish case, BIM coordination was hampered by incompatible design systems. In the Danish case, the client demanded use of Cuneco Classification System, a Danish information standard, but the classification was done in a reactive manner at a late stage. The Danish and the Norwegian case were innovative, but the Swedish less so. Nine out of ten types of effects were found in the cases. Standard-enabled innovations were mixed with other innovations. The two most remarkable were the Danish reverse innovation, and the Norwegian shift of structural concept. The information standards and BIM are closely intertwined in practice. A common database of coded objects in the Danish case is a strong innovation enabled by standards. The use of TFM, in the Norwegian architect project and its subsequent use in site BIM is remarkable.
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| 5. |
- Koch, Christian, 1958, et al.
(författare)
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Missed opportunities: two case studies of digitalization of FM in hospitals
- 2019
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Ingår i: Facilities. - 0263-2772. ; 37:7-8, s. 381-394
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Digital practices of facility management (FM) are undergoing transformation. Several Nordic countries have ambitious hospital-building projects, driven by large public clients with long-term experience of operating complex building campuses. There is thus an opportunity for creating state-of-the-art digital FM. This paper aims to investigate the role of digital FM in new hospital projects in Scandinavia. Design/methodology/approach: Based on a literature review, a framework of understanding of digital FM in hospital operation is established. Two longitudinal cases are presented and analysed, one for a Greenfield hospital and the other for an extension of an existing hospital. Findings: The literature highlights the importance of integration between technical digitalization, competences, organization and management of digital FM. The projects are in different phases and represent quite advanced preparations for digital FM. State-of-the-art computer-aided FM systems are prepared before operation. External consultants are involved, posing a dilemma of in-house/outsourced human resources in the future digital FM operation. Research limitations/implications: Two case studies provide insights, but they have limited generalizability. Practical implications: The study underscores the importance of preparation of management, organization and competences for digitalization. Originality/value: Documented research on building information modelling (BIM) integrations in FM is still scarce. This article adds to the few empirical studies in the area. The findings illustrate that real estate administrators investing in FM software for new hospital buildings face challenges of aligning BIM models from design and construction to the FM system.
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| 6. |
- Koch, Christian, et al.
(författare)
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Understanding the dialectics in consumer legitimacy judgments : The case of the dairy industry
- 2023
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Konferensbidrag (refereegranskat)abstract
- We explore consumer’s interpretive strategies developed in response to the dairy industry’s efforts to maintain and repair legitimacy. Our findings suggest that consumers may judge pragmatic legitimacy strongly, which ultimately leads them to perceive the dairy industry as legitimate enough to consume dairy despite rejecting the industry’s normative or cognitive legitimacy.
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| 7. |
- Koch, Christian, 1958, et al.
(författare)
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Yet another Trojan horse? Is Facility Management Ready for Digitalisation?
- 2017
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Ingår i: Ruddock, L, Van-Dijk, H and Houghton, CAM, (eds.) 2017, International Research Conference 2017: Shaping Tomorrow's Built Environment - conference proceedings, University of Salford, Salford, UK. - 9781912337040
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Konferensbidrag (refereegranskat)abstract
- Digital practices of facility management (FM) are still rare. Several Nordic countries have ambitious hospital building projects, driven by large public clients with long term experience of operating complex building campuses. There is thus an opportunity of creating state of art regarding digital FM. However, a recurrent problem is that a technically focused implementation leads to prolonged learning and practice development in the involved organization and never get operational. Hence members of organisations successfully resist the perceived Trojan horse entering. This paper aims at investigating the role of digital FM in new hospital projects in Scandinavia. Based on a literature review, a framework of understanding of digital FM in hospital operation is established. This highlight the importance of integration between technical digitalization, competences, organization and management of digital FM. Two longitudinal cases are presented and analysed. A greenfield hospital and an extension of an existing hospital. The projects are in different phases and represent quite advanced preparations for digital FM. State of the art software FM system are prepared before operation. External consultants are involved, posing a dilemma of inhouse/outsource human resources in the future digital FM operation. The importance of managerial, organizational and competence preparation is highlighted as implication.
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| 8. |
- Martins, Leila R., et al.
(författare)
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Stk33 is required for spermatid differentiation and male fertility in mice
- 2018
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Ingår i: Developmental Biology. - : Academic Press. - 0012-1606 .- 1095-564X. ; 433:1, s. 84-93
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Tidskriftsartikel (refereegranskat)abstract
- Spermiogenesis is the final phase during sperm cell development in which round spermatids undergo dramatic morphological changes to generate spermatozoa. Here we report that the serine/threonine kinase Stk33 is essential for the differentiation of round spermatids into functional sperm cells and male fertility. Constitutive Stk33 deletion in mice results in severely malformed and immotile spermatozoa that are particularly characterized by disordered structural tail elements. Stk33 expression first appears in primary spermatocytes, and targeted deletion of Stk33 in these cells recapitulates the defects observed in constitutive knockout mice, confirming a germ cell-intrinsic function. Stk33 protein resides in the cytoplasm and partially co-localizes with the caudal end of the manchette, a transient structure that guides tail elongation, in elongating spermatids, and loss of Stk33 leads to the appearance of a tight, straight and elongated manchette. Together, these results identify Stk33 as an essential regulator of spermatid differentiation and male fertility.
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| 9. |
- Noddeland, Heidi Kyung, et al.
(författare)
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Matrix metalloproteinase landscape in the imiquimod-induced skin inflammation mouse model
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Ingår i: Biochimie. - 0300-9084.
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Tidskriftsartikel (refereegranskat)abstract
- Inflammation and autoimmunity are known as central processes in many skin diseases, including psoriasis. It is therefore important to develop pre-clinical models that describe disease-related aspects to enable testing of pharmaceutical drug candidates and formulations. A widely accepted pre-clinical model of psoriasis is the imiquimod (IMQ)-induced skin inflammation mouse model, where topically applied IMQ provokes local skin inflammation. In this study, we investigated the abundance of a subset of matrix metalloproteinases (MMPs) in skin from mice with IMQ-induced skin inflammation and skin from naïve mice using targeted proteomics. Our findings reveal a significant increase in the abundance of MMP-2, MMP-7, MMP-8, and MMP-13 after treatment with IMQ compared to the control skin, while MMP-3, MMP-9, and MMP-10 were exclusively detected in the IMQ-treated skin. The increased abundance and broader representation of MMPs in the IMQ-treated skin provide valuable insight into the pathophysiology of skin inflammation in the IMQ model, adding to previous studies on cytokine levels using conventional immunochemical methods. Specifically, the changes in the MMP profiles observed in the IMQ-treated skin resemble the MMP patterns found in skin lesions of individuals with psoriasis. Ultimately, the differences in MMP abundance under IMQ-induced inflammation as compared to non-inflamed control skin can be exploited as a model to investigate drug efficacy or performance of drug delivery systems.
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