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  • Aries, Myriam, et al. (författare)
  • Particulate matter and the health effects on human living lung cells
  • 2009
  • Ingår i: 9th International Conference and Exhibition - Healthy Buildings 2009, HB 2009.
  • Konferensbidrag (refereegranskat)abstract
    • Predominant sources of personal particulate matter exposure are residential indoor and road-traffic or soil-borne outdoor respirable particles. Candles are an important source of indoor particulate matter. Therefore a pilot study was conducted in a specially built research facility for a fixed period of time. Fine and ultrafine particle concentrations were continuously sampled and the likelihood for potential health effects was studied using the CULTEX® system in which human lung cells were directly exposed to air samples. A high concentration of ultrafine particles was registered during the candle burning; a control condition recorded a much lower concentration and larger particle diameters. First results indicate that unhealthy situations due to candle burning in the indoor environment are very well possible.
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  • Raaschou-Nielsen, O., et al. (författare)
  • Particulate matter air pollution components and risk for lung cancer
  • 2016
  • Ingår i: Environment International. - : Elsevier BV. - 0160-4120 .- 1873-6750. ; 87, s. 66-73
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Particulate matter (PM) air pollution is a human lung carcinogen; however, the components responsible have not been identified. We assessed the associations between PM components and lung cancer incidence. Methods: We used data from 14 cohort studies in eight European countries. We geocoded baseline addresses and assessed air pollution with land-use regression models for eight elements (Cu, Fe, K, Ni, S, Si, V and Zn) in size fractions of PM2.5 and PM10. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effect models for meta-analysis. Results: The 245,782 cohort members contributed 3,229,220 person-years at risk. During follow-up (mean, 13.1 years), 1878 incident cases of lung cancer were diagnosed. In the meta-analyses, elevated hazard ratios (HRs) for lung cancer were associated with all elements except V; none was statistically significant In analyses restricted to participants who did not change residence during follow-up, statistically significant associations were found for PM2.5 Cu (HR, 125; 95% Cl, 1.01-1.53 per 5 ng/m(3)), PM10 Zn (1.28; 1.02-1.59 per 20 ng/m3), PMio S (1.58; 1.03-2.44 per 200 ng/m(3)), PM10 Ni (1.59; 1.12-2.26 per 2 ng/m(3)) and PM10K (1.17; 1.02-1.33 per 100 ng/m(3)). In two-pollutant models, associations between PMio and PM2.5 and lung cancer were largely explained by PM2.5 S. Conclusions: This study indicates that the association between PM in air pollution and lung cancer can be attributed to various PM components and sources. PM containing S and Ni might be particularly important.
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