| 1. |
- Buchanan, E. M., et al.
(författare)
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The Psychological Science Accelerator's COVID-19 rapid-response dataset
- 2023
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Ingår i: Scientific Data. - : Springer Science and Business Media LLC. - 2052-4463. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- In response to the COVID-19 pandemic, the Psychological Science Accelerator coordinated three large-scale psychological studies to examine the effects of loss-gain framing, cognitive reappraisals, and autonomy framing manipulations on behavioral intentions and affective measures. The data collected (April to October 2020) included specific measures for each experimental study, a general questionnaire examining health prevention behaviors and COVID-19 experience, geographical and cultural context characterization, and demographic information for each participant. Each participant started the study with the same general questions and then was randomized to complete either one longer experiment or two shorter experiments. Data were provided by 73,223 participants with varying completion rates. Participants completed the survey from 111 geopolitical regions in 44 unique languages/dialects. The anonymized dataset described here is provided in both raw and processed formats to facilitate re-use and further analyses. The dataset offers secondary analytic opportunities to explore coping, framing, and self-determination across a diverse, global sample obtained at the onset of the COVID-19 pandemic, which can be merged with other time-sampled or geographic data.
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| 2. |
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| 5. |
- Jones, Benedict C, et al.
(författare)
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To which world regions does the valence-dominance model of social perception apply?
- 2021
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Ingår i: Nature Human Behaviour. - : Springer Science and Business Media LLC. - 2397-3374. ; 5:1, s. 159-169
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Tidskriftsartikel (refereegranskat)abstract
- Over the past 10 years, Oosterhof and Todorov's valence-dominance model has emerged as the most prominent account of how people evaluate faces on social dimensions. In this model, two dimensions (valence and dominance) underpin social judgements of faces. Because this model has primarily been developed and tested in Western regions, it is unclear whether these findings apply to other regions. We addressed this question by replicating Oosterhof and Todorov's methodology across 11 world regions, 41 countries and 11,570 participants. When we used Oosterhof and Todorov's original analysis strategy, the valence-dominance model generalized across regions. When we used an alternative methodology to allow for correlated dimensions, we observed much less generalization. Collectively, these results suggest that, while the valence-dominance model generalizes very well across regions when dimensions are forced to be orthogonal, regional differences are revealed when we use different extraction methods and correlate and rotate the dimension reduction solution. PROTOCOL REGISTRATION: The stage 1 protocol for this Registered Report was accepted in principle on 5 November 2018. The protocol, as accepted by the journal, can be found at https://doi.org/10.6084/m9.figshare.7611443.v1 .
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| 6. |
- Tsiantoulas, D., et al.
(författare)
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APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans
- 2021
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 597, s. 92-96
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Tidskriftsartikel (refereegranskat)abstract
- Atherosclerotic cardiovascular disease causes heart attacks and strokes, which are the leading causes of mortality worldwide(1). The formation of atherosclerotic plaques is initiated when low-density lipoproteins bind to heparan-sulfate proteoglycans (HSPGs)(2) and become trapped in the subendothelial space of large and medium size arteries, which leads to chronic inflammation and remodelling of the artery wall(2). A proliferation-inducing ligand (APRIL) is a cytokine that binds to HSPGs(3), but the physiology of this interaction is largely unknown. Here we show that genetic ablation or antibody-mediated depletion of APRIL aggravates atherosclerosis in mice. Mechanistically, we demonstrate that APRIL confers atheroprotection by binding to heparan sulfate chains of heparan-sulfate proteoglycan 2 (HSPG2), which limits the retention of low-density lipoproteins, accumulation of macrophages and formation of necrotic cores. Indeed, antibody-mediated depletion of APRIL in mice expressing heparan sulfate-deficient HSPG2 had no effect on the development of atherosclerosis. Treatment with a specific anti-APRIL antibody that promotes the binding of APRIL to HSPGs reduced experimental atherosclerosis. Furthermore, the serum levels of a form of human APRIL protein that binds to HSPGs, which we termed non-canonical APRIL (nc-APRIL), are associated independently of traditional risk factors with long-term cardiovascular mortality in patients with atherosclerosis. Our data reveal properties of APRIL that have broad pathophysiological implications for vascular homeostasis.
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| 7. |
- Leloudas, G., et al.
(författare)
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The normal Type Ia SN 2003hv out to very late phases
- 2009
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 505:1, s. 265-279
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Tidskriftsartikel (refereegranskat)abstract
- Aims: We study a thermonuclear supernova (SN), emphasizing very late phases. Methods: An extensive dataset for SN 2003hv that covers the flux evolution from maximum light to day +786 is presented. This includes 82 epochs of optical imaging, 24 epochs of near-infrared (NIR) imaging, and 10 epochs of optical spectroscopy. These data are combined with published nebular-phase IR spectra, and the observations are compared to model light curves and synthetic nebular spectra. Results: SN 2003hv is a normal Type Ia supernova (SN Ia) with photometric and spectroscopic properties consistent with its rarely observed B-band decline-rate parameter, Δ m15(B) = 1.61 ± 0.02. The blueshift of the most isolated [Fe ii] lines in the nebular-phase optical spectrum appears consistent with those observed in the IR at similar epochs. At late times there is a prevalent color evolution from the optical toward the NIR bands. We present the latest-ever detection of a SN Ia in the NIR in Hubble Space Telescope images. The study of the ultraviolet/optical/infrared (UVOIR) light curve reveals that a substantial fraction of the flux is “missing” at late times. Between 300 and 700 days past maximum brightness, the UVOIR light curve declines linearly following the decay of radioactive 56Co, assuming full and instantaneous positron trapping. At 700 days we detect a possible slowdown of the decline in optical-bands, mainly in the V-band. Conclusions: The data are incompatible with a dramatic infrared catastrophe (IRC). However, the idea that an IRC occurred in the densest regions before 350 days can explain the missing flux from the UVOIR wavelengths and the flat-topped profiles in the NIR. We argue that such a scenario is possible if the ejecta are clumpy. The observations suggest that positrons are most likely trapped in the ejecta. Based on observations collected at the European Southern Observatory, Paranal, Chile (ESO Programmes 073.D-0294(AB), 074.D-0259(BC) and 075.D-0116(AB)), Cerro Tololo Inter-American Observatory, Lick Observatory, Las Campanas Observatory, Siding Spring Observatory, and the Hubble Space Telescope. Tables 3, 4, and Appendix A are only available in electronic form at http://www.aanda.org
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| 9. |
- Wang, Xiaofeng, et al.
(författare)
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Evidence for type ia supernova diversity from ultraviolet observations with the hubble space telescope
- 2012
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 749:2, s. 126-
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Tidskriftsartikel (refereegranskat)abstract
- We present ultraviolet (UV) spectroscopy and photometry of four Type Ia supernovae (SNe 2004dt, 2004ef, 2005M, and 2005cf) obtained with the UV prism of the Advanced Camera for Surveys on the Hubble Space Telescope. This data set provides unique spectral time series down to 2000 angstrom. Significant diversity is seen in the near-maximum-light spectra (similar to 2000-3500 angstrom) for this small sample. The corresponding photometric data, together with archival data from Swift Ultraviolet/Optical Telescope observations, provide further evidence of increased dispersion in the UV emission with respect to the optical. The peak luminositiesmeasured in the uvw1/F250W filter are found to correlate with the B-band light-curve shape parameter Delta m(15)(B), but with much larger scatter relative to the correlation in the broadband B band (e.g., similar to 0.4 mag versus similar to 0.2 mag for those with 0.8 mag < Delta m(15)(B) < 1.7 mag). SN 2004dt is found as an outlier of this correlation (at > 3 sigma), being brighter than normal SNe Ia such as SN 2005cf by similar to 0.9 mag and similar to 2.0 mag in the uvw1/F250W and uvm2/F220W filters, respectively. We show that different progenitor metallicity or line-expansion velocities alone cannot explain such a large discrepancy. Viewing-angle effects, such as due to an asymmetric explosion, may have a significant influence on the flux emitted in the UV region. Detailed modeling is needed to disentangle and quantify the above effects.
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| 10. |
- Chalermsook, P., et al.
(författare)
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Greedy is an almost optimal deque
- 2015
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Ingår i: 14th International Symposium on Algorithms and Data Structures, WADS 2015. - Cham : Springer. - 9783319218397 ; , s. 152-165
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Konferensbidrag (refereegranskat)abstract
- In this paper we extend the geometric binary search tree (BST) model of Demaine, Harmon, Iacono, Kane, and Pătraşcu (DHIKP) to accommodate for insertions and deletions. Within this extended model, we study the online GREEDY BST algorithm introduced by DHIKP. GREEDY BST is known to be equivalent to a maximally greedy (but inherently offline) algorithm introduced independently by Lucas in 1988 and Munro in 2000, conjectured to be dynamically optimal. With the application of forbidden-submatrix theory, we prove a quasilinear upper bound on the performance of GREEDY BST on deque sequences. It has been conjectured (Tarjan, 1985) that splay trees (Sleator and Tarjan, 1983) can serve such sequences in linear time. Currently neither splay trees, nor other general-purpose BST algorithms are known to fulfill this requirement. As a special case, we show that GREEDY BST can serve output-restricted deque sequences in linear time. A similar result is known for splay trees (Tarjan, 1985; Elmasry, 2004). As a further application of the insert-delete model, we give a simple proof that, given a set U of permutations of [n], the access cost of any BST algorithm is Ω(log |U| + n) on “most” of the permutations from U. In particular, this implies that the access cost for a random permutation of [n] is Ω(n log n) with high probability. Besides the splay tree noted before, GREEDY BST has recently emerged as a plausible candidate for dynamic optimality. Compared to splay trees, much less effort has gone into analyzing GREEDY BST. Our work is intended as a step towards a full understanding of GREEDY BST, and we remark that forbidden-submatrix arguments seem particularly well suited for carrying out this program.
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| 11. |
- Chalermsook, P., et al.
(författare)
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Multi-finger binary search trees
- 2018
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Ingår i: Leibniz International Proceedings in Informatics, LIPIcs. - : Schloss Dagstuhl- Leibniz-Zentrum fur Informatik GmbH, Dagstuhl Publishing. - 9783959770941 ; , s. 55:1-55:26
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Konferensbidrag (refereegranskat)abstract
- We study multi-finger binary search trees (BSTs), a far-reaching extension of the classical BST model, with connections to the well-studied k-server problem. Finger search is a popular technique for speeding up BST operations when a query sequence has locality of reference. BSTs with multiple fingers can exploit more general regularities in the input. In this paper we consider the cost of serving a sequence of queries in an optimal (offline) BST with k fingers, a powerful benchmark against which other algorithms can be measured. We show that the k-finger optimum can be matched by a standard dynamic BST (having a single root-finger) with an O(log k) factor overhead. This result is tight for all k, improving the O(k) factor implicit in earlier work. Furthermore, we describe new online BSTs that match this bound up to a (log k) O (1) factor. Previously only the “one-finger” special case was known to hold for an online BST (Iacono, Langerman, 2016; Cole et al., 2000). Splay trees, assuming their conjectured optimality (Sleator and Tarjan, 1983), would have to match our bounds for all k. Our online algorithms are randomized and combine techniques developed for the k-server problem with a multiplicative-weights scheme for learning tree metrics. To our knowledge, this is the first time when tools developed for the k-server problem are used in BSTs. As an application of our k-finger results, we show that BSTs can efficiently serve queries that are close to some recently accessed item. This is a (restricted) form of the unified property (Iacono, 2001) that was previously not known to hold for any BST algorithm, online or offline.
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| 12. |
- Chalermsook, P., et al.
(författare)
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Pattern-Avoiding Access in Binary Search Trees
- 2015
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Ingår i: Proceedings - Annual IEEE Symposium on Foundations of Computer Science, FOCS. - : Institute of Electrical and Electronics Engineers (IEEE). - 9781467381918 ; , s. 410-423
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Konferensbidrag (refereegranskat)abstract
- The dynamic optimality conjecture is perhaps the most fundamental open question about binary search trees (BST). It postulates the existence of an asymptotically optimal online BST, i.e. One that is constant factor competitive with any BST on any input access sequence. The two main candidates for dynamic optimality in the literature are splay trees [Sleator and Tarjan, 1985], and Greedy [Lucas, 1988, Munro, 2000, Demaine et al. 2009]. Despite BSTs being among the simplest data structures in computer science, and despite extensive effort over the past three decades, the conjecture remains elusive. Dynamic optimality is trivial for almost all sequences: the optimum access cost of most length-n sequences is Theta(n log n), achievable by any balanced BST. Thus, the obvious missing step towards the conjecture is an understanding of the 'easy' access sequences, and indeed the most fruitful research direction so far has been the study of specific sequences, whose 'easiness' is captured by a parameter of interest. For instance, splay provably achieves the bound of O(nd) when d roughly measures the distances between consecutive accesses (dynamic finger), the average entropy (static optimality), or the delays between multiple accesses of an element(working set). The difficulty of proving dynamic optimality is witnessed by other highly restricted special cases that remain unresolved, one prominent example is the traversal conjecture [Sleator and Tarjan, 1985], which states that preorder sequences (whose optimum is linear) are linear-time accessed by splay trees, no online BST is known to satisfy this conjecture. In this paper, we prove two different relaxations of the traversal conjecture for Greedy: (i) Greedy is almost linear for preorder traversal, (ii) if a linear-time preprocessing is allowed, Greedy is in fact linear. These statements are corollaries of our more general results that express the complexity of access sequences in terms of a pattern avoidance parameter k. Pattern avoidance is a well-established concept in combinatorics, and the classes of input sequences thus defined are rich, e.g. The k = 3 case includes preorder sequences. For any sequence X with parameter k, our most general result shows that Greedy achieves the cost n2α(n)O(k) where α is the inverse Ackermann function. Furthermore, a broad subclass of parameter-k sequences has a natural combinatorial interpretation as k-decomposable sequences. For this class of inputs, we obtain an n∗2O(k) bound for Greedy when preprocessing is allowed. For k = 3, these results imply (i) and (ii). To our knowledge, these are the first upper bounds for Greedy that are not known to hold for any other online BST. To obtain these results we identify an input-revealing property of Greedy. Informally, this means that the execution log partially reveals the structure of the access sequence. This property facilitates the use of rich technical tools from forbidden sub matrix theory. Further studying the intrinsic complexity of k-decomposable sequences, we make several observations. First, in order to obtain an offline optimal BST, it is enough to bound Greedy on non-decomposable access sequences. Furthermore, we show that the optimal cost for k-decomposable sequences is Theta(n log k), which is well below the proven performance of all known BST algorithms. Hence, sequences in this class can be seen as a 'candidate counterexample' to dynamic optimality.
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| 15. |
- Gumaelius, Lena, et al.
(författare)
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Outreach initiatives operated by universities for increasing interest in science and technology
- 2016
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Ingår i: European Journal of Engineering Education. - : Taylor & Francis Group. - 0304-3797 .- 1469-5898. ; , s. 1-34
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Tidskriftsartikel (refereegranskat)abstract
- Since the 1990s, the low number of students choosing to study science and technology in higher education has been on the societal agenda and many initiatives have been launched to promote awareness regarding career options. The initiatives particularly focus on increasing enrolment in the engineering programmes. This article describes and compares eight European initiatives that have been established and operated by universities (and in some cases through collaboration with other actors in society). Each initiative is summarised in a short essay that discusses motivation, organisation, pedagogical approach, and activities. The initiatives are characterised by comparing the driving forces behind their creation, how the initiative activities relate to the activities at the university, size based on the number of participants and cost per participant and pedagogical framework. There seem to be two main tracks for building outreach activities, one where outreach activities are based on the university's normal activities, and one where outreach activities are designed specifically for the visiting students.
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| 16. |
- Larsson, Josefin, et al.
(författare)
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X-ray illumination of the ejecta of supernova 1987A
- 2011
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 474:7352, s. 484-486
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Tidskriftsartikel (refereegranskat)abstract
- When a massive star explodes as a supernova, substantial amounts of radioactive elements-primarily (56)Ni, (57)Ni and (44)Ti-are produced(1). After the initial flash of light from shock heating, the fading light emitted by the supernova is due to the decay of these elements(2). However, after decades, the energy powering a supernova remnant comes from the shock interaction between the ejecta and the surrounding medium(3). The transition to this phase has hitherto not been observed: supernovae occur too infrequently in the Milky Way to provide a young example, and extragalactic supernovae are generally too faint and too small. Here we report observations that show this transition in the supernova SN 1987A in the Large Magellanic Cloud. From 1994 to 2001, the ejecta faded owing to radioactive decay of (44)Ti as predicted. Then the flux started to increase, more than doubling by the end of 2009. We show that this increase is the result of heat deposited by X-rays produced as the ejecta interacts with the surrounding material. In time, the X-rays will penetrate farther into the ejecta, enabling us to analyse the structure and chemistry of the vanished star.
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| 17. |
- Lundqvist, Peter, et al.
(författare)
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Hydrogen and helium in the spectra of Type Ia supernovae
- 2013
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 435:1, s. 329-345
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Tidskriftsartikel (refereegranskat)abstract
- We present predictions for hydrogen and helium emission line luminosities from circumstellar matter around Type Ia supernovae (SNe Ia) using time dependent photoionization modelling. Early high-resolution ESO/Very Large Telescope (VLT) optical echelle spectra of the SN Ia 2000cx were taken before and up to similar to 70 d after maximum to probe the existence of such narrow emission lines from the supernova. We detect no such lines, and from our modelling place an upper limit on the mass-loss rate for the putative wind from the progenitor system,. M less than or similar to 1.3 x 10(-5) M-circle dot yr(-1), assuming a speed of 10 km s(-1) and solar abundances for the wind. If the wind would be helium-enriched and/or faster, the upper limit on. M could be significantly higher. In the helium-enriched case, we show that the best line to constrain the mass-loss would be He I.10 830. In addition to confirming the details of interstellar Na I and Ca II absorption towards SN 2000cx as discussed by Patat et al., we also find evidence for 6613.56 angstrom diffuse interstellar band absorption in the Milky Way. We also discuss measurements of the X-ray emission from the interaction between the supernova ejecta and the wind and we re-evaluate observations of SN 1992A obtained similar to 16 d after maximum by Schlegel & Petre. We find an upper limit of. M less than or similar to 1.3 x 10(-5) M-circle dot yr(-1) which is significantly higher than that estimated by Schlegel & Petre. These results, together with the previous observational work on the normal SNe Ia 1994D and 2001el, disfavour a symbiotic star in the upper mass-loss rate regime (so-called Mira-type systems) from being the likely progenitor scenario for these SNe. Our model calculations are general, and can also be used for the subclass of SNe Ia that do show circumstellar interaction, e. g. the recent PTF 11kx. To constrain hydrogen in late-time spectra, we present ESO/VLT and ESO/New Technology Telescope optical and infrared observations of SNe Ia 1998bu and 2000cx in the nebular phase, 251-388 d after maximum. We see no signs of hydrogen line emission in SNe 1998bu and 2000cx at these epochs, and from the absence of Ha with a width of the order of similar to 10(3) km s(-1), we argue from modelling that the mass of such hydrogen-rich gas must be less than or similar to 0.03 M circle dot for both supernovae. Comparing similar upper limits with recent models of Pan et al., it seems that hydrogen-rich donors with a separation of less than or similar to 5 times the radius of the donor may be ruled out for the five SNe Ia 1998bu, 2000cx, 2001el, 2005am and 2005cf. Larger separation, helium-rich donors, or a double-degenerate origin for these supernovae seems more likely. Our models have also been used to put the limit on hydrogen-rich gas in the recent SN 2011fe, and for this supernova, a double-degenerate origin seems likely.
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| 18. |
- Meeuwsen, John A.L., et al.
(författare)
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High levels of (un)switched memory B cells are associated with better outcome in patients with advanced atherosclerotic disease
- 2017
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Ingår i: Journal of the American Heart Association. - 2047-9980. ; 6:9
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Tidskriftsartikel (refereegranskat)abstract
- Background--Atherosclerosis is an inflammatory lipid disorder and the main underlying pathology of acute ischemic events. Despite a vast amount of data from murine atherosclerosis models, evidence of B-cell involvement in human atherosclerotic disease is limited. We therefore investigated the association of circulating B-cell subtypes with the occurrence of secondary cardiovascular events in advanced atherosclerotic disease. Methods and Results--This cohort study consists of 168 patients who were included in the Athero-Express biobank between 2009 and 2011. Before surgery, peripheral blood mononuclear cells were isolated and stored in liquid nitrogen. After gentle thawing of the peripheral blood mononuclear cells, different B-cell subtypes including naïve, (un)switched memory, and CD27+CD43+ B1-like B cells, were analyzed by flow cytometry. Univariable and multivariable Cox proportional hazard models were used to analyze associations between B-cell subtypes, circulating antibodies and secondary cardiovascular manifestations during the 3-year follow-up period. Mean age was 70.1±9.6 years, males represented 62.8% of the population, and 54 patients had secondary manifestations during follow-up. High numbers of unswitched memory cells were protective against secondary outcome (hazard ratio, 0.30 [95% CI, 0.13-0.69]; P < 0.01). Similar results were obtained for the switched memory cells that also showed to be protective against secondary outcome (hazard ratio, 0.33 [95% CI, 0.14-0.77]; P = 0.01). Conclusions--A high number of (un)switched memory B cells is associated with better outcome following carotid artery endarterectomy. These findings suggest a potential role for B-cell subsets in prediction and prevention of secondary cardiovascular events in patients with atherosclerosis.
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