| 1. |
- Cabaleiro-Lago, Celia, et al.
(författare)
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Inhibition of IAPP and IAPP(20-29) fibrillation by polymeric nanoparticles
- 2010
-
Ingår i: Langmuir. - : The American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 26:5, s. 3453-3461
-
Tidskriftsartikel (refereegranskat)abstract
- The fibrillation process of the islet amyloid polypeptide (IAPP) and its fragment (IAPP(20-29)) was studied by means of Thioflavin T (ThT) fluorescence and transmission electron microscopy in the absence and presence of N-isopropylacrylamide:N-tert-butylacrylamide (NiPAM:BAM) copolymeric nanoparticles. The process was found to be strongly affected by the presence of the nanoparticles, which retard protein fibrillation as a function of the chemical surface properties of the nanoparticles. The NiPAM:BAM ratio was varied from 50:50 to 100:0. The nanoparticles with higher fraction of NiPAM imposed the strongest retardation of IAPP and IAPP(20-29) fibrillation. These particles have the strongest hydrogen bonding capacity due to the less bulky N-isopropyl group and thus less steric hindrance of the hydrogen-bonding groups of the nanoparticle polymer backbone. Kinetic fibrillation data, as monitored by ThT fluorescence and supported by surface plasmon resonance experiments, suggest that the peptide is strongly absorbed onto the surface of the nanoparticles. This interaction reduces the concentration of peptide free in solution available to proceed to fibrillation which results in an increased lag time of fibrillation, observed as a delayed onset of ThT fluorescence increase, plus a reduction of the amount of fibrils formed as indicated by the equilibrium values at the end of the fibrillation reaction. For the fragment (IAPP(20-29)), the presence of nanoparticles changes the mechanism of association from monomers to fibrils, by interfering with early oligomeric species along the fibrillation pathway.
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| 2. |
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| 3. |
- Ackesjö, Helena, 1973-, et al.
(författare)
-
Förskoleklassen i en brytningstid. Konsekvenser av positionsförskjutningar i ett reformerat utbildningslandskap.
- 2019
-
Konferensbidrag (refereegranskat)abstract
- 2016 tillkom ett nytt läroplanskapitel för förskoleklassen. 2018 blev förskoleklassen obligatorisk när skolstartsåldern sänktes och skolplikt för sexåringarna infördes. 2019 införs en åtgärdsgaranti för tidiga insatser, vilket bland annat innebär obligatorisk kartläggning av alla sexåringars kunskaper. Förändringarna i läroplanen indikerar att förskoleklassen befinner sig i en brytningstid - en tid av positionsförskjutning i det svenska utbildningslandskapet från en tydligt lek- och förskoleorienterad till en mer kunskapsorienterad och skolförberedande verksamhet.I projektet undersöker vi betydelsen av denna positionsförskjutning och vilka konsekvenser förändringarna får för lärares och skolledares förståelse av uppdraget samt för den pedagogiska praktiken och undervisningen. Teoretiskt belyser projektet konsekvenserna av positionsförskjutningen genom att analysera aspekter av och förändringar i undervisningen som policyhändelser. Mer specifikt ställer vi teoretiska frågor om hur policy blir pedagogisk praktik, samtidigt som den pedagogiska praktiken formerar nya innebörder av policy.Betydelsen av att söka kunskap om konsekvenser av förskoleklassens positionsförskjutning i det svenska utbildningsväsendet är både empirisk och teoretisk. Empiriskt behövs ny kunskap om en delvis marginaliserad skolforms verksamhet i ett utbildningspolitiskt gränsland under stark förändring. Teoretiskt behöver vi förstå hur policy och pedagogisk praktik påverkar varandra ömsesidigt som en del av en historisk utbildningspolitik process. Projektet baseras på policyetnografi vilket innebär en bred ansats med flera olika metoder; bland annat intervjuer, observationer och dokumentanalys.
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| 4. |
- Ackesjö, Helena, 1973-, et al.
(författare)
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Images of the child in the educational landscape.
- 2019
-
Ingår i: 29th EECERA ANNUAL CONFERENCE, Early Years: Making it Count, Thessaloniki, Greece 20th – 23rd August 2019. ; , s. 240-
-
Konferensbidrag (refereegranskat)abstract
- This study is a part of a research project, which aims to analyse consequences of educational policy change in Sweden. The overall policy change in Sweden is related to economy (Heckman 2000), to increase quality in education and to qualify children for further studies (Riddersporre & Persson, 2010). These changes are related to a global knowledge economy that enhances education for the youngest (Persson, 2010). Policies can be seen as narratives about progress and salvation, about ‘finding the better life’ and about ‘making’ the new citizen through schooling (Lindblad & Popkewitz, 2004). The descriptions of the child in the selected policy documents has therefore been analysed from the point of view of creating a new citizen as well as good education for children using Biesta’s (2009) concepts of subjectification and qualification. In this study, focus is to examine descriptions of the child, the school start, school readiness and mandatory school attendance through analysing national policy documents from 1940-2017. Even if document analysis includes limited ethical issues, the results may implicate consequences in educational practice. The most prominent and recurring description of the child is school ready child vs the immature child. Descriptions of power and control over children and the obedient and silenced child appears in almost all policy texts. The process of learnification in an individual performative school culture is an overarching and still standing theme. Societal ideas of children and how these are expressed in policy can be assumed to influence educational practice.
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| 5. |
- Ackesjö, Helena, 1973-, et al.
(författare)
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Låt reformpennan vila!
- 2019
-
Annan publikation (populärvet., debatt m.m.)
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| 6. |
- Ackesjö, Helena, 1973-, et al.
(författare)
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Rektorers och skolhuvudmäns meningsskapande om förskoleklassens position i utbildningslandskapet.
- 2022
-
Ingår i: Utbildning och Lärande / Education and Learning. - Falun : Högskolan Dalarna. - 2001-4554. ; 16:2, s. 7-26
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Tidskriftsartikel (refereegranskat)abstract
- The preschool class has been subject to several policy reforms, which principals and local education authorities are responsible. for implementing and evaluating. The aim of this study is to contribute with knowledge about how principals and local education authorities make meaning of the position and organization of the preschool class in relation to these policy reforms and to the existing practices. The method used in the study is interviews with principals and local education authorities and shows how they reason about and relate to various regulatory, normative, and cultural-cognitive elements of governance. The analysis shows that the principals have arguments for three basic positions for the preschool class: a bridge between preschool and primary school, a knowledgeoriented position, and a socially oriented position. A key argument put forward by the principals is that the preschool class should be integrated into a continuous primary school organisation. The local education authorities, on their part, interpret the new policy as an ongoing qualification and homogenization process, which affects the preschool class’s position in the education system.
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| 7. |
- Ackesjö, Helena, 1973-, et al.
(författare)
-
Utbildning för barn i skolstartsålder
- 2022. - 1
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Det ligger något av ett magiskt skimmer över skolstarten. Många barn har längtat efter dagen då de får packa sin ryggsäck och träda in genom porten till det mytomspunna skolhuset där nya klasskamrater, lärare och utmaningar väntar.Denna bok handlar om hur utbildningen för barn i skolstartsåldern har förändrats under de senaste decennierna och hur man kan förstå mekanismerna bakom dessa förändringar. Idag råder ett starkt kunskaps- och lärandefokus, där huvudsyftet är att elever ska kvalificeras till nästa nivå i skolsystemet. Detta beskriver vi i boken som en skolarisering av utbildningen och dess konsekvenser berör alla aspekter av utbildning. Skolariseringen syns på policynivå. Den påverkar den pedagogiska praktiken och undervisningen; den förändrar synen på barnet och dess förmågor, och inte minst påverkar den vår syn på vad utbildning är till för. I denna bok används skolstarten och förskoleklassen som exempel, men analysen av skolariseringen är allmängiltig för utbildning och undervisning av barn i hela skolsystemet. Hur kan dessa förändringar beskrivas? Vad bidrar till skolariseringen? Vilken betydelse har denna utveckling? Detta är angelägna frågor för alla som är engagerade i utbildning. Därför är det viktigt att lärare och lärarstudenter får ett språk för att kritiskt kunna granska och diskutera vad skolariseringen innebär - både för dem själva och för deras profession.
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| 8. |
- Aguado, M. T., et al.
(författare)
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Species delimitation in Amblyosyllis (Annelida, Syllidae)
- 2019
-
Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 14:4
-
Tidskriftsartikel (refereegranskat)abstract
- Amblyosyllis is a worldwide distributed group of annelids mainly found in coastal environments. It is well known among the polychaete specialists mostly because of its notable beauty, showing bright colourful patterns and outstanding long and coiled appendices. Amblyosyllis is a monophyletic genus easy to identify due to its distinct diagnostic features; however, the species and their boundaries are, in most cases, not well defined. Herein, we provide an extensive sample of Amblyosyllis material (115 specimens) from several world geographic areas. We have studied the morphological features of each specimen and photographed them alive. Two mitochondrial DNA markers (COI and 16S) and one nuclear gene fragment (28S, D1 region) were sequenced. We performed phylogenetic analyses based on each DNA partition, as well as the combined data sets, obtaining congruent results. Species delimitation methods such as distance analyses, statistical parsimony networks and multi-rate Poisson tree processes were also applied. The combined results obtained from different methodologies and data sets are used to differentiate between, at least, 19 lineages compatible with the separately evolving meta-populations species concept. Four of these lineages are identified as nominal species, including the type species of Amblyosyllis, A. rhombeata. For three other lineages previously synonymized names are recovered, and seven lineages are described as new species. All of these species are described and supported by appropriate iconography. We recognize several morphological characters useful to identify species of Amblyosyllis, which in some cases should also be combined with molecular methods for species delineation. The genetic divergence in the genus is high, contrary to the morphological homogeneity observed. Two species show a wide geographical distribution, while the rest have a more restricted distribution. There are several examples of species with overlapping distribution patterns.
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| 9. |
- Anand, Kanwlajeet J. S., et al.
(författare)
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Assessment of continuous pain in newborns admitted to NICUs in 18 European countries
- 2017
-
Ingår i: Acta Paediatrica. - : John Wiley & Sons. - 0803-5253 .- 1651-2227. ; 106:8, s. 1248-1259
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Tidskriftsartikel (refereegranskat)abstract
- Aim: Continuous pain occurs routinely, even after invasive procedures, or inflammation and surgery, but clinical practices associated with assessments of continuous pain remain unknown.Methods: A prospective cohort study in 243 Neonatal Intensive Care Units (NICUs) from 18 European countries recorded frequency of pain assessments, use of mechanical ventilation, sedation, analgesia, or neuromuscular blockade for each neonate upto 28 days after NICU admission.Results: Only 2113/6648 (31·8%) of neonates received assessments of continuous pain, occurring variably among tracheal ventilation (TrV, 46·0%), noninvasive ventilation (NiV, 35·0%), and no ventilation (NoV, 20·1%) groups (p<0·001). Daily assessments for continuous pain occurred in only 10·4% of all neonates (TrV: 14·0%, NiV: 10·7%, NoV: 7·6%; p<0·001). More frequent assessments of continuous pain occurred in NICUs with pain guidelines, nursing champions, and surgical admissions prompted (all p<0·01), and for newborns <32 weeks gestational age, those requiring ventilation, or opioids, sedatives-hypnotics, general anesthetics (O-SH-GA) (all p<0·001), or surgery (p=0·028). Use of O-SH-GA drugs increased the odds for pain assessment in the TrV (OR:1·60, p<0·001) and NiV groups (OR:1·40, p<0·001).Conclusion: Assessments of continuous pain occurred in less than one-third of NICU admissions, and daily in only 10% of neonates. NICU clinical practices should consider including routine assessments of continuous pain in newborns.
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| 10. |
- Andrikopoulos, Vasilios, et al.
(författare)
-
Software Sustainability in the Age of Everything as a Service
- 2021
-
Ingår i: Next-Gen Digital Services. A Retrospective and Roadmap for Service Computing of the Future: Essays Dedicated to Michael Papazoglou on the Occasion of His 65th Birthday and His Retirement. - Cham : Springer International Publishing. - 9783030732035 ; , s. 35-47
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The need for acknowledging and managing sustainability as an essential quality of software systems has been steadily increasing over the past few years, in part as a reaction to the implications of ``software eating the world''. Especially the widespread adoption of the Everything as a Service (*aaS) model of delivering software and (virtualized) hardware through cloud computing has put two sustainability dimensions upfront and center. On the one hand, services must be sustainable on a technical level by ensuring continuity of operations for both providers and consumers despite, or even better, while taking into account their evolution. On the other hand, the prosuming of services must also be financially sustainable for the involved stakeholders.
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| 11. |
- Apriliyanto, Yusuf Bramastya, et al.
(författare)
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Toward a Generalized Hückel Rule : The Electronic Structure of Carbon Nanocones
- 2021
-
Ingår i: Journal of Physical Chemistry A. - : American Chemical Society (ACS). - 1089-5639 .- 1520-5215. ; 125:45, s. 9819-9825
-
Tidskriftsartikel (refereegranskat)abstract
- In this work, we investigate a particular class of carbon nanocones, which we name graphannulenes, and present a generalized Hückel rule (GHR) that predicts the character of their ground state based on simply the three topological indices that uniquely define them. Importantly, this rule applies to both flat and curved systems, encompassing a wide variety of known structures that do not satisfy the “classic” 4n + 2 rule such as coronene, corannulene, and Kekulene. We test this rule at the Hückel level of theory for a large number of systems, including structures that are convex and flat, with a saddle-like geometry, and at the CASSCF level of theory for a selected representative subset. All the performed calculations support the GHR that we propose in this work.
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| 12. |
- Aslund, Ingrid, et al.
(författare)
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Diffusion NMR for determining the homogeneous length-scale in lamellar phases.
- 2008
-
Ingår i: Journal of Physical Chemistry B. - : The American Chemical Society (ACS). - 1520-6106 .- 1520-5207. ; 112:10, s. 2782-2794
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Tidskriftsartikel (refereegranskat)abstract
- The size of the anisotropic domains in a lyotropic liquid crystal is estimated using a new protocol for diffusion NMR. Echo attenuation decays are recorded for different durations of the displacement-encoding gradient pulses, while keeping the effective diffusion time and the range of the wave vectors constant. Deviations between the sets of data appear if there are non-Gaussian diffusion processes occurring on the time-scale defined by the gradient pulse duration and the length-scale defined by the wave vector. The homogeneous length-scale is defined as the minimum length-scale for which the diffusion appears to be Gaussian. Simulations are performed to show that spatial variation of the director orientation in an otherwise homogeneous system is sufficient to induce non-Gaussian diffusion. The method is demonstrated by numerical solutions of the Bloch-Torrey equation and experiments on a range of lamellar liquid crystals with different domain sizes.
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| 13. |
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| 14. |
- Assarsson, Anna, et al.
(författare)
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Charge dependent retardation of amyloid β aggregation by hydrophilic proteins
- 2014
-
Ingår i: ACS Chemical Neuroscience. - 1948-7193 .- 1948-7193. ; 5:4, s. 266-74
-
Tidskriftsartikel (refereegranskat)abstract
- The aggregation of amyloid β peptides (Aβ) into amyloid fibrils is implicated in the pathology of Alzheimer's disease. In light of the increasing number of proteins reported to retard Aβ fibril formation, we investigated the influence of small hydrophilic model proteins of different charge on Aβ aggregation kinetics and their interaction with Aβ. We followed the amyloid fibril formation of Aβ40 and Aβ42 using thioflavin T fluorescence in the presence of six charge variants of calbindin D9k and single-chain monellin. The formation of fibrils was verified with transmission electron microscopy. We observe retardation of the aggregation process from proteins with net charge +8, +2, -2, and -4, whereas no effect is observed for proteins with net charge of -6 and -8. The single-chain monellin mutant with the highest net charge, scMN+8, has the largest retarding effect on the amyloid fibril formation process, which is noticeably delayed at as low as a 0.01:1 scMN+8 to Aβ40 molar ratio. scMN+8 is also the mutant with the fastest association to Aβ40 as detected by surface plasmon resonance, although all retarding variants of calbindin D9k and single-chain monellin bind to Aβ40.
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| 15. |
- Assarsson, Anna, et al.
(författare)
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Effects of polyamino acids and polyelectrolytes on amyloid β fibril formation
- 2014
-
Ingår i: Langmuir. - : The American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 30:29, s. 8812-8
-
Tidskriftsartikel (refereegranskat)abstract
- The fibril formation of the neurodegenerative peptide amyloid β (Aβ42) is sensitive to solution conditions, and several proteins and peptides have been found to retard the process. Aβ42 fibril formation was followed with ThT fluorescence in the presence of polyamino acids (poly-glutamic acid, poly-lysine, and poly-threonine) and other polymers (poly(acrylic acid), poly(ethylenimine), and poly(diallyldimethylammonium chloride). An accelerating effect on the Aβ42 aggregation process is observed from all positively charged polymers, while no effect is seen from the negative or neutral polymers. The accelerating effect is dependent on the concentration of positive polymer in a highly reproducible manner. Acceleration is observed from a 1:500 polymer to Aβ42 weight ratio and up. Polyamino acids and the other polymers exert quantitatively the same effect at the same concentrations based on weight. Fibrils are formed in all cases as verified by transmission electron microscopy. The concentrations of polymers required for acceleration are too low to affect the Aβ42 aggregation process through increased ionic strength or molecular crowding effects. Instead, the acceleration seems to arise from the locally increased Aβ42 concentration near the polymers, which favors association and affects the electrostatic environment of the peptide.
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| 16. |
- Assarsson, Anna, et al.
(författare)
-
Effects of Polyamino Acids and Polyelectrolytes on Amyloid β Fibril Formation.
- 2014
-
Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 30:29, s. 8812-8818
-
Tidskriftsartikel (refereegranskat)abstract
- The fibril formation of the neurodegenerative peptide amyloid β (Aβ42) is sensitive to solution conditions, and several proteins and peptides have been found to retard the process. Aβ42 fibril formation was followed with ThT fluorescence in the presence of polyamino acids (poly-glutamic acid, poly-lysine, and poly-threonine) and other polymers (poly(acrylic acid), poly(ethylenimine), and poly(diallyldimethylammonium chloride). An accelerating effect on the Aβ42 aggregation process is observed from all positively charged polymers, while no effect is seen from the negative or neutral polymers. The accelerating effect is dependent on the concentration of positive polymer in a highly reproducible manner. Acceleration is observed from a 1:500 polymer to Aβ42 weight ratio and up. Polyamino acids and the other polymers exert quantitatively the same effect at the same concentrations based on weight. Fibrils are formed in all cases as verified by transmission electron microscopy. The concentrations of polymers required for acceleration are too low to affect the Aβ42 aggregation process through increased ionic strength or molecular crowding effects. Instead, the acceleration seems to arise from the locally increased Aβ42 concentration near the polymers, which favors association and affects the electrostatic environment of the peptide.
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| 17. |
- Assarsson, Anna, et al.
(författare)
-
Inactivation and adsorption of human carbonic anhydrase II by nanoparticles
- 2014
-
Ingår i: Langmuir. - : The American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 30:31, s. 9448-56
-
Tidskriftsartikel (refereegranskat)abstract
- The enzymatic activity of human carbonic anhydrase II (HCAII) was studied in the presence of nanoparticles of different nature and charge. Negatively charged nanoparticles inhibit HCAII whereas no effect is seen for positively charged particles. The kinetic effects were correlated with the strength of binding of the enzyme to the particle surface as measured by ITC and adsorption assays. Moreover, conformational changes upon adsorption were observed by circular dichroism. The main initial driving force for the adsorption of HCAII to nanoparticles is of electrostatic nature whereas the hydrophobic effect is not strong enough to drive the initial binding. This is corroborated by the fact that HCAII do not adsorb on positively charged hydrophobic polystyrene nanoparticles. Furthermore, the dehydration of the particle and protein surface seems to play an important role in the inactivation of HCAII by carboxyl-modified polystyrene nanoparticles. On the other hand, the inactivation by unmodified polystyrene nanoparticles is mainly driven by intramolecular interactions established between the protein and the nanoparticle surface upon conformational changes in the protein.
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| 18. |
- Assarsson, Anna, et al.
(författare)
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Inactivation and Adsorption of Human Carbonic Anhydrase II by Nanoparticles.
- 2014
-
Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 30:31, s. 9448-9456
-
Tidskriftsartikel (refereegranskat)abstract
- The enzymatic activity of human carbonic anhydrase II (HCAII) was studied in the presence of nanoparticles of different nature and charge. Negatively charged nanoparticles inhibit HCAII whereas no effect is seen for positively charged particles. The kinetic effects were correlated with the strength of binding of the enzyme to the particle surface as measured by ITC and adsorption assays. Moreover, conformational changes upon adsorption were observed by circular dichroism. The main initial driving force for the adsorption of HCAII to nanoparticles is of electrostatic nature whereas the hydrophobic effect is not strong enough to drive the initial binding. This is corroborated by the fact that HCAII do not adsorb on positively charged hydrophobic polystyrene nanoparticles. Furthermore, the dehydration of the particle and protein surface seems to play an important role in the inactivation of HCAII by carboxyl-modified polystyrene nanoparticles. On the other hand, the inactivation by unmodified polystyrene nanoparticles is mainly driven by intramolecular interactions established between the protein and the nanoparticle surface upon conformational changes in the protein.
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| 19. |
- Assarsson, A., et al.
(författare)
-
Kinetic and thermodynamic study of the interactions between human carbonic anhydrase variants and polystyrene nanoparticles of different size
- 2016
-
Ingår i: RSC Advances. - : Royal Society of Chemistry (RSC). - 2046-2069. ; 6:42, s. 35868-35874
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Tidskriftsartikel (refereegranskat)abstract
- The activity and adsorption of three variants of human carbonic anhydrase (HCA) with similar topology but variation in charge and stability were studied in the presence of carboxyl-modified polystyrene nanoparticles of different sizes ranging from 25 nm to 114 nm. The balance of forces driving the adsorption of carbonic anhydrase variants is affected by the physicochemical properties of the protein and the nanoparticle size. All enzymes are totally inhibited upon adsorption due to the transition towards a molten globule like state that lacks enzymatic activity. The size of the particle affects the adsorption of human carbonic anhydrase I and N-terminal truncated human carbonic anhydrase II. Investigations on pH effects indicate that the size of the particle modulates the lateral interactions at the protein layer for these particular variants whose adsorption is mainly driven by electrostatic forces. A third variant, human carbonic anhydrase II, instead shows no strong influence of nanoparticle size which supports an adsorption process mainly driven by the hydrophobic effect.
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| 20. |
-
Barn i fritidshem
- 2022. - 1
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- Boken fokuserar på barnens perspektiv på olika aspekter av fritidshem och på hur lärare i fritidshem arbetar med dem som utgångspunkt.I bokens första del Barns perspektiv på fritidshem berörs fritidshemmets fysiska miljö, övergångar och sociala relationer. Vidare berörs olikheter i barns erfarenheter i relation till fritidshemmets och familjers skilda förutsättningar. Andra delen Fritidshemmets arbete med barns perspektiv berör områden som media och delaktighet samt fritidshemmets roll i förhållande till bildning och trygghet.Boken vidgar bilden av fritidshem med fokus på barns egna perspektiv vilket är starkt framskrivet i läroplanen genom att aktiviteter i fritidshem ska formas på ett sätt som både utgår från och utmanar barn med utgångspunkt i deras faktiska erfarenheter. Dessa perspektiv är även en viktig utgångspunkt i FN:s barnkonvention.Boken vänder sig till grundlärarstudenter inriktning fritidshem och redan yrkesverksam personal i fritidshem.
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| 21. |
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| 22. |
- Bayani, Jane, et al.
(författare)
-
Evaluation of multiple transcriptomic gene risk signatures in male breast cancer
- 2021
-
Ingår i: npj Breast Cancer. - : Springer Science and Business Media LLC. - 2374-4677. ; 7:1
-
Tidskriftsartikel (refereegranskat)abstract
- Male breast cancer (BCa) is a rare disease accounting for less than 1% of all breast cancers and 1% of all cancers in males. The clinical management is largely extrapolated from female BCa. Several multigene assays are increasingly used to guide clinical treatment decisions in female BCa, however, there are limited data on the utility of these tests in male BCa. Here we present the gene expression results of 381 M0, ER+ve, HER2-ve male BCa patients enrolled in the Part 1 (retrospective analysis) of the International Male Breast Cancer Program. Using a custom NanoString™ panel comprised of the genes from the commercial risk tests Prosigna®, OncotypeDX®, and MammaPrint®, risk scores and intrinsic subtyping data were generated to recapitulate the commercial tests as described by us previously. We also examined the prognostic value of other risk scores such as the Genomic Grade Index (GGI), IHC4-mRNA and our prognostic 95-gene signature. In this sample set of male BCa, we demonstrated prognostic utility on univariate analysis. Across all signatures, patients whose samples were identified as low-risk experienced better outcomes than intermediate-risk, with those classed as high risk experiencing the poorest outcomes. As seen with female BCa, the concordance between tests was poor, with C-index values ranging from 40.3% to 78.2% and Kappa values ranging from 0.17 to 0.58. To our knowledge, this is the largest study of male breast cancers assayed to generate risk scores of the current commercial and academic risk tests demonstrating comparable clinical utility to female BCa.
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| 23. |
- Bischoff, Yassin, et al.
(författare)
-
A Taxonomy About Information Systems Complexity and Sustainability
- 2022
-
Ingår i: ADVANCES AND NEW TRENDS IN ENVIRONMENTAL INFORMATICS: A BOGEYMAN OR SAVIOUR FOR THE UN SUSTAINABILITY GOALS?. - Cham : Springer International Publishing. - 2196-8713 .- 2196-8705. - 9783030880637 ; , s. 17-33
-
Konferensbidrag (refereegranskat)abstract
- With the increasing digitalization of all industry sectors, information systems are becoming more and more complex. At the same time, thanks to their crucial societal role, they have the potential to help (or hinder) organizations in their ambition to contribute to sustainability goals. In our work, we aim at helping them by identifying the important concerns that shape their information systems and that are found to influence complexity in certain sustainability aspects. To this aim, we perform a study in a mid-sized bank, and build a taxonomy of concerns that emerge from real projects and experience, and blend both complexity and sustainability.
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| 24. |
- Blais, André, et al.
(författare)
-
What Kind of Electoral Outcome do People Think is Good for Democracy?
- 2021
-
Ingår i: Political Studies. - : Sage Publications. - 0032-3217 .- 1467-9248.
-
Tidskriftsartikel (refereegranskat)abstract
- There is perennial debate in comparative politics about electoral institutions, but what characterizes this debate is the lack of consideration for citizens’ perspective. In this paper, we report the results of an original survey conducted on representative samples in 15 West European countries (N = 15,414). We implemented an original instrument to elicit respondents’ views by asking them to rate “real but blind” electoral outcomes. With this survey instrument, we aimed to elicit principled rather than partisan preferences regarding the kind of electoral outcomes that citizens think is good for democracy. We find that West Europeans do not clearly endorse a majoritarian or proportional vision of democracy. They tend to focus on aspects of the government rather than parliament when they pass a judgment. They want a majority government that has few parties and enjoys wide popular support. Finally, we find only small differences between citizens of different countries.
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| 25. |
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