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- Nelander, Sven, 1974, et al.
(författare)
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Predictive screening for regulators of conserved functional gene modules (gene batteries) in mammals
- 2005
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Ingår i: BMC genomics. - : Springer Science and Business Media LLC. - 1471-2164. ; 6:1
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The expression of gene batteries, genomic units of functionally linked genes which are activated by similar sets of cis- and trans-acting regulators, has been proposed as a major determinant of cell specialization in metazoans. We developed a predictive procedure to screen the mouse and human genomes and transcriptomes for cases of gene-battery-like regulation. RESULTS: In a screen that covered approximately 40 percent of all annotated protein-coding genes, we identified 21 co-expressed gene clusters with statistically supported sharing of cis-regulatory sequence elements. 66 predicted cases of over-represented transcription factor binding motifs were validated against the literature and fell into three categories: (i) previously described cases of gene battery-like regulation, (ii) previously unreported cases of gene battery-like regulation with some support in a limited number of genes, and (iii) predicted cases that currently lack experimental support. The novel predictions include for example Sox 17 and RFX transcription factor binding sites that were detected in approximately 10% of all testis specific genes, and HNF-1 and 4 binding sites that were detected in approximately 30% of all kidney specific genes respectively. The results are publicly available at http://www.wlab.gu.se/lindahl/genebatteries. CONCLUSION: 21 co-expressed gene clusters were enriched for a total of 66 shared cis-regulatory sequence elements. A majority of these predictions represent novel cases of potential co-regulation of functionally coupled proteins. Critical technical parameters were evaluated, and the results and the methods provide a valuable resource for future experimental design.
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- Sobron, Alejandro, 1990-, et al.
(författare)
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Methods for efficient flight testing and modelling of remotely piloted aircraft within visual line-of-sight
- 2018
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Ingår i: Proceedings of the 31st Congress of The International Council of the Aeronautical Sciences (ICAS), September 9-14 2018, Belo Horizonte, Brazil.. - Bohn : International Council of the Aeronautical Sciences. - 9783932182884
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Konferensbidrag (refereegranskat)abstract
- Remotely piloted scaled models not only serve as convenient low-risk flying test-beds but also can provide useful data and increase confidence in an eventual full-scale design. Nevertheless, performing advanced flight tests in a safe and cost-effective manner is often a challenge for organizations with limited resources. A typical scenario is testing within visual line-of-sight at very low altitude, a type of operation that offers major cost advantages at the expense of a reduced available airspace. This paper describes some of the authors' work towards efficient performance evaluation and system identification of fixed-wing, remotely piloted aircraft under these challenging conditions. Results show that certain techniques, manoeuvre automation, and platform-optimised multisine input signals can improve the flight test efficiency and the modelling process. It is also probable that some of the benefits observed here could be extrapolated to flight testing beyond visual line-of-sight or even to full-scale flight testing.
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- Wehlin, Joakim, 1982-, et al.
(författare)
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Hunter-gatherer farming during the first millennium bce in inland, boreal landscapes : new pollen analytical and archaeological evidence from Dalarna, central Sweden
- 2023
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Ingår i: Vegetation History and Archaeobotany. - : Springer Nature. - 0939-6314 .- 1617-6278. ; 32:6, s. 615-633
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Tidskriftsartikel (refereegranskat)abstract
- The archaeological evidence of a sedentary hunter-gatherer society during the early metal ages, i.e. the frst and second millennia bce, in the central Scandinavian boreal inlands has previously been overlooked. In order to gain a deeper understandingof these past societies we have combined archaeological data with landscape-scale changes based on pollen records. Thecombined record clearly indicates landscape use characterized by domestication strategies that started during the Late BronzeAge ca. 1000 bce and further intensifed during the Early Iron Age. Indications of cultivation of plants, as well as possibleburning practices to clear shrub and forest, clearly show that arable farming and grazing were practiced in the area earlierthan had previously been assumed. The farming economy seems to have involved mainly small scale arable farming. Fishingand hunting continued to be important, but the investment in the landscape shown by both pitfall systems and agriculturealso express a domestication that would have required settled presence.
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