| 1. |
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| 2. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 3. |
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| 4. |
- Wahlund, Martina, et al.
(författare)
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The Role of TPMT, ITPA, and NUDT15 Variants during Mercaptopurine Treatment of Swedish Pediatric Patients with Acute Lymphoblastic Leukemia
- 2020
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Ingår i: The Journal of Pediatrics. - : MOSBY-ELSEVIER. - 0022-3476 .- 1097-6833. ; 216, s. 150-
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Tidskriftsartikel (refereegranskat)abstract
- Objective To evaluate the roles of thiopurine methyltransferase (TPMT), inosine triphosphatase (ITPA), and Nudix hydrolase 15 (NUDT15) in 6-mercaptopurine (6-MP) sensitivity during treatment of pediatric patients with acute lymphoblastic leukemia (ALL). Study design The study included 102 pediatric patients with ALL subject to the Nordic society Of Paediatric Haematology and Oncology (NOPHO) ALL-2000 and ALL-2008 protocols. Episodes of neutropenia and febrile neutropenia, TPMT sequence variants, as well as 6-MP end doses, were collected retrospectively from medical records. TPMT, ITPA, and NUDT15 sequence variants were analyzed using pyrosequencing. Results TPMT variants were associated with a reduced risk of neutropenia and febrile neutropenia during the maintenance II period (P = .019 and P amp;lt; .0001, respectively). In addition, a NUDT15 variant was associated with a lower end dose of 6-MP (P = .0097), but not with neutropenia and febrile neutropenia. ITPA variants were not associated with an increased risk of neutropenia, febrile neutropenia, nor lower end dose of 6-MP. However, when analyzing the entire treatment period, ITPA variants were associated with a decreased risk of febrile neutropenia. Conclusions White blood cell count-based dose adjustments are regularly performed for known TPMT- deficient patients and results in a reduced risk of neutropenia and febrile neutropenia. Also in NUDT15-deficient patients dose adjustments are performed as indicated by low end dose of 6-MP. ITPA-deficient patients had a decreased risk of febrile neutropenia when analyzing the entire treatment period. Our data suggest that NUDT15 plays an important role in 6-MP treatment and the results should be confirmed in larger cohorts. Future studies should also follow up whether white blood cell count-based dose adjustments affect the risk of relapse.
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| 5. |
- Bachinger, Angelika, et al.
(författare)
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Systematic evaluation of bromine-free flame-retardant systems in acrylonitrile-butadiene-styrene
- 2022
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Ingår i: Journal of Applied Polymer Science. - : John Wiley & Sons, Ltd. - 0021-8995 .- 1097-4628. ; 139:13
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Tidskriftsartikel (refereegranskat)abstract
- A systematic investigation of phosphorus-based flame-retardant (PFR) systems in acrylonitrile-butadiene-styrene (ABS) is presented. The effect of various PFRs, combinations thereof and influence of different synergists is studied in terms of fire and mechanical performance, as well as toxicity of resulting ABS. Sustainable flame-retardant systems with a promising effect on the fire-retardant properties of ABS are identified: A combination of aluminum diethylphosphinate and ammonium polyphosphate is shown to exhibit superior flame-retardant properties in ABS compared to other studied PFRs and PFR combinations. Among a variety of studied potential synergists for this system, a grade of expandable graphite with a high-initiation temperature and a molybdenum-based smoke suppressant show the most promising effect, leading to a significant reduction of the peak heat release rate as well as the smoke production rate. Compared to current state-of-the-art brominated flame-retardant for ABS, the identified flame-retardant systems reduce the maximum smoke production rate by 70% and the peak heat release rate by 40%. However, a significant reduction of the impact performance of the resulting ABS is identified, which requires further investigation.
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| 6. |
- Berg, Hans ten, et al.
(författare)
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DN Debatt: Sluta skjutsa barnen till skolan - hälsa går före rädsla
- 2023
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Ingår i: Dagens Nyheter. (DN). - Stockholm : Bonnier. - 1101-2447. ; :2023-02-18
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Våra barn blir alltmer stillasittande, vilket får livslånga konsekvenser. En av de enklaste lösningarna står föräldrar i vägen för – på grund av rädsla. Föräldrarnas välvilja är i själva verket ett tydligt hot mot barnens hälsa, både i trafiken och genom livet. Sverige behöver en ny nationell rekommendation för aktiva skolresor, skriver åtta forskare och organisationer.
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| 7. |
- Ek, Anna, et al.
(författare)
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Physical Activity and Mobile Phone Apps in the Preschool Age: Perceptions of Teachers and Parents
- 2019
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Ingår i: JMIR mhealth and uhealth. - : JMIR Publications. - 2291-5222. ; 7:4
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND:Physical activity (PA) is already beneficial at the preschool age. In many countries, young children spend most of their days in the preschool setting, making it a common arena for PA interventions. Mobile health tools are becoming increasingly popular to promote PA in different populations; however, little is known about the interest for and how the preschool setting could incorporate such a tool.OBJECTIVE:This study aimed to examine how teachers and parents perceive PA in preschool-aged children in general and their perceptions of how a mobile phone app could be used to promote PA in the preschool setting.METHODS:Semistructured interviews were conducted with 15 teachers (93%, [14/15] women, mean age 43.5 years, 47%, [7/15] with a university degree and 10 parents [91%, 9/10] women, mean age 38.9 years, all with a university degree) recruited from 2 urban preschools in central Sweden. The interviews were recorded, fully transcribed, coded, and analyzed using thematic analysis by means of an inductive approach.RESULTS:The analysis revealed 4 themes: (1) children are physically active by nature, (2) the environment as a facilitator or a barrier, (3) prerequisites of the adult world, and (4) an app in the preschool setting-challenges and possibilities. Parents and teachers perceived preschoolers as being spontaneously physically active; however, high-intensity PA was perceived as low. The PA was specifically performed during the day in the preschool. Identified facilitators of PA were access to safe and engaging outdoor environments such as forests, spacious indoor areas, and adult involvement. Adult involvement was considered especially important for children preferring sedentary activities. Identified barriers for PA were restricted indoor and outdoor space, rules for indoor activities, and lack of adult involvement because of time constraints. The teachers perceived that they had limited skills and experiences using apps in general, although they also acknowledged the increasing role of technological tools in the curriculum. Thus, the teachers expressed an interest for an app designed as a support tool for them, especially for situations when PA was limited because of perceived barriers. They suggested the app to include accessible information regarding the health benefits of PA in children linked to a library of activities for different settings and seasons. Parents suggested interactive app features including problem-solving tasks and music and dance, but not video clips as they made children passive.CONCLUSIONS:Vigorous PA was perceived as low in preschool-aged children. Future tailoring of interventions in the preschool setting should work around barriers and support facilitators to PA, especially PA of high intensity. In such work, an app could serve as a source of inspiration for PA in different ages, settings, and seasons and thus reduce environmental and structural inequalities in the preschool setting.
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| 8. |
- Günther-Hanssen, Anna, 1979-, et al.
(författare)
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Teachers, researchers, children, friction, dance skirts, drawings, lamp posts and emotions : How different agents can affect the trajectory of a practice-based research project
- 2024
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Ingår i: Programme and Abstract Book. - Helsinki : University of Helsinki. ; , s. 144-144
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Konferensbidrag (refereegranskat)abstract
- This presentation elaborates on how different agents, human and nonhuman, enact participation in a practice-based research project about STEAM education in preschool. The project is carried out in two teams of four-six teachers and two researchers each. Researchers and teachers work in close collaboration with children (3-5-years old), spaces and materials in their preschools. Theoretically, the project employs a sociomaterial stance (eg. Barad, 2007), implying that the research process takes shape through collaboration between all the part-taking agents, both human and nonhuman. The presentation is built around a number of agential cuts (Barad, 2014) created at an early stage of a project. These cuts concern how different agents, such as teachers, researchers, children, materials and concepts, participate and how their participation affects the project. For example, we will elaborate on how the participation of a child, a lamp post, a researcher and physical phenomena (friction) affected the trajectory of the project. We will also discuss how different agents’ participation can increase or decrease the participation of other agents in the project.
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| 9. |
- Günther-Hanssen, Anna, et al.
(författare)
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Transdisciplinary STEAM education : opportunities for thinking, doing and being beyond the already known?
- 2024
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Ingår i: NERA 2024.
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Konferensbidrag (refereegranskat)abstract
- In this workshop, we welcome researchers interested in transdisciplinary learning and questions of traversing norms within education - from preschool to higher education. Together we will explore the potentialities of merging STEM (Science, Technology, Engineering, Mathematics) and Arts (dance, drama, music, visual arts) into STEAM. The concept of STEAM education has become increasingly influential in many parts of the world during the last years. STEAM education is promoted as an arena for developing transdisciplinary knowledge and fostering innovative thinkers who can meet the demands of the future in sustainable ways (Ingold, 2019). One additional argument behind STEAM education is to motivate underrepresented groups, particularly girls, to engage with STEM (European Committee of the Regions, 2019; Ng & Ferguson, 2020). According to research, gender norms connected to STEM and to the arts, imply that some students, thinkings and doings are recognised by teachers and peers, whereas others are not. For example, girls and women have a more narrow space for participating and being recognised as learners in STEM (e.g. Heeg & Avraamidou, 2021; Stephenson, Fleer & Fragkiadaki, 2022), while boys and men have a more narrow space for participating and being recognised as learners in Arts (e.g. Hentschel, 2018; Oliver & Risner, 2017). This implies that children and students face different kinds of normative constraints when they are expected to engage with the world through separate disciplines, that is scientifically, technologically, artistically, engineeringly or mathematically. As we see it, transdisciplinary STEAM education harbours the potential to form new and norm-challenging ways of teaching and learning (Areljung & Günther-Hanssen, 2022). The transdisciplinary explorations during the workshop will focus on verbs connected to STEM and Arts. You do not need any specific background in STEM or Arts to participate. Expected outcomes are that the workshop will open up to new ways of being and learning, beyond current gender norms connected to different disciplines in education.
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| 10. |
- Günther-Hanssen, Anna, et al.
(författare)
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Transdisciplinary STEAM education – opportunities for thinking, doing and being beyond the already known?
- 2024
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Konferensbidrag (refereegranskat)abstract
- In this workshop, we welcome researchers interested in transdisciplinary learning and questions of traversing norms within education - from preschool to higher education. Together we will explore the potentialities of merging STEM (Science, Technology, Engineering, Mathematics) and Arts (dance, drama, music, visual arts) into STEAM. The concept of STEAM education has become increasingly influential in many parts of the world during the last years. STEAM education is promoted as an arena for developing transdisciplinary knowledge and fostering innovative thinkers who can meet the demands of the future in sustainable ways (Ingold, 2019). One additional argument behind STEAM education is to motivate underrepresented groups, particularly girls, to engage with STEM (European Committee of the Regions, 2019; Ng & Ferguson, 2020). According to research, gender norms connected to STEM and to the arts, imply that some students, thinkings and doings are recognised by teachers and peers, whereas others are not. For example, girls and women have a more narrow space for participating and being recognised as learners in STEM (e.g. Heeg & Avraamidou, 2021; Stephenson, Fleer & Fragkiadaki, 2022), while boys and men have a more narrow space for participating and being recognised as learners in Arts (e.g. Hentschel, 2018; Oliver & Risner, 2017). This implies that children and students face different kinds of normative constraints when they are expected to engage with the world through separate disciplines, that is scientifically, technologically, artistically, engineeringly or mathematically. As we see it, transdisciplinary STEAM education harbours the potential to form new and norm-challenging ways of teaching and learning (Areljung & Günther-Hanssen, 2022). The transdisciplinary explorations during the workshop will focus on verbs connected to STEM and Arts. You do not need any specific background in STEM or Arts to participate. Expected outcomes are that the workshop will open up to new ways of being and learning, beyond current gender norms connected to different disciplines in education.
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| 11. |
- Günther-Hanssen, Anna, 1979-, et al.
(författare)
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Transdisciplinary STEAM education – opportunities for thinking, doing and beingbeyond the already known?
- 2024
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Ingår i: NERA 2024. - Malmö.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- In this workshop, we welcome researchers interested in transdisciplinary learning and questions oftraversing norms within education - from preschool to higher education. Together we will explore thepotentialities of merging STEM (Science, Technology, Engineering, Mathematics) and Arts (dance,drama, music, visual arts) into STEAM.The concept of STEAM education has become increasingly influential in many parts of the world duringthe last years. STEAM education is promoted as an arena for developing transdisciplinary knowledgeand fostering innovative thinkers who can meet the demands of the future in sustainable ways (Ingold,2019). One additional argument behind STEAM education is to motivate underrepresented groups,particularly girls, to engage with STEM (European Committee of the Regions, 2019; Ng & Ferguson,2020). According to research, gender norms connected to STEM and to the arts, imply that somestudents, thinkings and doings are recognised by teachers and peers, whereas others are not. Forexample, girls and women have a more narrow space for participating and being recognised as learnersin STEM (e.g. Heeg & Avraamidou, 2021; Stephenson, Fleer & Fragkiadaki, 2022), while boys and menhave a more narrow space for participating and being recognised as learners in Arts (e.g. Hentschel,2018; Oliver & Risner, 2017). This implies that children and students face different kinds of normativeconstraints when they are expected to engage with the world through separate disciplines, that isscientifically, technologically, artistically, engineeringly or mathematically. As we see it, transdisciplinarySTEAM education harbours the potential to form new and norm-challenging ways of teaching andlearning (Areljung & Günther-Hanssen, 2022).The transdisciplinary explorations during the workshop will focus on verbs connected to STEM and Arts.You do not need any specific background in STEM or Arts to participate. Expected outcomes are thatthe workshop will open up to new ways of being and learning, beyond current gender norms connectedto different disciplines in education.
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| 12. |
- Gustavsson, Simon T., et al.
(författare)
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Nicotinamide prevents retinal vascular dropout in a rat model of ocular hypertension and supports ocular blood supply in glaucoma patients
- 2023
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Ingår i: Investigative Ophthalmology and Visual Science. - : Association for Research in Vision and Ophthalmology (ARVO). - 0146-0404 .- 1552-5783. ; 64
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE. To investigate whether nicotinamide (NAM) modulates retinal vasculature in glaucoma.METHODS. This was a prospective controlled clinical trial investigating animal and human histopathology. Participants included normotensive and ocular hypertensive rats, postmortem human ocular tissue, glaucoma patients (n = 90), and healthy controls (n = 30). The study utilized histopathology, computer-assisted retinal vasculature analysis, optical coherence tomography angiography (OCTA), and NAM treatment. The main outcome measures included retinal vascular parameters in rats as assessed by AngioTool; retinal vasculature integrity in rats and humans as assessed by histopathology, antibody-staining, and ImageJ-based measurements; and retinal perfusion density (PD) and flux index in humans as assessed by OCTA.RESULTS. A number of vessel parameters were altered in ocular hypertension/glaucoma compared to healthy controls. NAM treatment improved the retinal vasculature in ocular hypertensive rats, with an increase in mean vessel area, percentage area covered by vessels, total vessel length, total junctions, and junction density as assessed by AngioTool (all P < 0.05); vessel wall integrity as assessed by VE-cadherin antibody staining was also improved (P < 0.01). In humans, as assessed by OCTA, increases in PD in the optic nerve head and macula complete image (0.7%, P = 0.04 and 1.0%, P = 0.002, respectively) in healthy controls, and an increase in the temporal quadrant of the macula (0.7%, P = 0.02) in glaucoma patients was seen after NAM treatment.CONCLUSIONS. NAM can prevent retinal vascular damage in an animal model of glaucoma. After NAM treatment, glaucoma patients and healthy controls demonstrated a small increase in retinal vessel parameters as assessed by OCTA.
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| 13. |
- Henningsson, Anna, et al.
(författare)
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Human tick-borne encephalitis and characterization of virus from biting tick
- 2016
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Ingår i: Emerging Infectious Diseases. - : Centers for Disease Control and Prevention (CDC). - 1080-6040 .- 1080-6059. ; 22:8, s. 1485-1487
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Tidskriftsartikel (refereegranskat)abstract
- We report a case of human tick-borne encephalitis (TBE) in which the TBE virus was isolated from the biting tick. Viral growth and sequence were characterized and compared with those of a reference strain. Virus isolation from ticks from patients with TBE may offer a new approach for studies of epidemiology and pathogenicity. © 2016, Centers for Disease Control and Prevention (CDC). All rights reserved.
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| 14. |
- Hetland, M. L., et al.
(författare)
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Active conventional treatment and three different biological treatments in early rheumatoid arthritis: phase IV investigator initiated, randomised, observer blinded clinical trial
- 2020
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Ingår i: Bmj-British Medical Journal. - : BMJ. - 1756-1833. ; 371
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE To evaluate and compare benefits and harms of three biological treatments with different modes of action versus active conventional treatment in patients with early rheumatoid arthritis. DESIGN Investigator initiated, randomised, open label, blinded assessor, multiarm, phase IV study. SETTING Twenty nine rheumatology departments in Sweden, Denmark, Norway, Finland, the Netherlands, and Iceland between 2012 and 2018. PARTICIPANTS Patients aged 18 years and older with treatment naive rheumatoid arthritis, symptom duration less than 24 months, moderate to severe disease activity, and rheumatoid factor or anti-citrullinated protein antibody positivity, or increased C reactive protein. INTERVENTIONS Randomised 1:1:1:1, stratified by country, sex, and anti-citrullinated protein antibody status. All participants started methotrexate combined with (a) active conventional treatment (either prednisolone tapered to 5 mg/day, or sulfasalazine combined with hydroxychloroquine and intraarticular corticosteroids), (b) certolizumab pegol, (c) abatacept, or (d) tocilizumab. MAIN OUTCOME MEASURES The primary outcome was adjusted clinical disease activity index remission (CDAI <= 2.8) at 24 weeks with active conventional treatment as the reference. Key secondary outcomes and analyses included CDAI remission at 12 weeks and over time, other remission criteria, a non-inferiority analysis, and harms. RESULTS 812 patients underwent randomisation. The mean age was 54.3 years (standard deviation 14.7) and 68.8% were women. Baseline disease activity score of 28 joints was 5.0 (standard deviation 1.1). Adjusted 24 week CDAI remission rates were 42.7% (95% confidence interval 36.1% to 49.3%) for active conventional treatment, 46.5% (39.9% to 53.1%) for certolizumab pegol, 52.0% (45.5% to 58.6%) for abatacept, and 42.1% (35.3% to 48.8%) for tocilizumab. Corresponding absolute differences were 3.9% (95% confidence interval -5.5% to 13.2%) for certolizumab pegol, 9.4% (0.1% to 18.7%) for abatacept, and -0.6% (-10.1% to 8.9%) for tocilizumab. Key secondary outcomes showed no major differences among the four treatments. Differences in CDAI remission rates for active conventional treatment versus certolizumab pegol and tocilizumab, but not abatacept, remained within the prespecified non-inferiority margin of 15% (per protocol population). The total number of serious adverse events was 13 (percentage of patients who experienced at least one event 5.6%) for active conventional treatment, 20 (8.4%) for certolizumab pegol, 10 (4.9%) for abatacept, and 10 (4.9%) for tocilizumab. Eleven patients treated with abatacept stopped treatment early compared with 20-23 patients in the other arms. CONCLUSIONS All four treatments achieved high remission rates. Higher CDAI remission rate was observed for abatacept versus active conventional treatment, but not for certolizumab pegol or tocilizumab versus active conventional treatment. Other remission rates were similar across treatments. Non-inferiority analysis indicated that active conventional treatment was non-inferior to certolizumab pegol and tocilizumab, but not to abatacept. The results highlight the efficacy and safety of active conventional treatment based on methotrexate combined with corticosteroids, with nominally better results for abatacept, in treatment naive early rheumatoid arthritis.
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| 15. |
- Hulander, Erik, et al.
(författare)
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Diet intervention improves cardiovascular profile in patients with rheumatoid arthritis: results from the randomized controlled cross-over trial ADIRA.
- 2021
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Ingår i: Nutrition journal. - : Springer Science and Business Media LLC. - 1475-2891. ; 20:1
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Tidskriftsartikel (refereegranskat)abstract
- The chronic inflammation in patients with rheumatoid arthritis (RA) increases the risk for cardiovascular diseases (CVD). The contribution of diet as a risk factor for CVD among these patients is however not fully understood. The aim of this study is to investigate if a proposed anti-inflammatory diet improves cardiovascular profile in weight stable patients with RA.Patients (n=50) with RA were included in a cross-over trial. They were randomized to either a diet rich in whole grain, fatty fish, nuts, vegetables and fruit and supplemented with probiotics, or a control diet resembling average nutritional intake in Sweden, for ten weeks. After a 4-month washout they switched diet. Participants received food bags and dietary guidelines. Primary outcome was triglyceride (TG) concentration. Secondary outcomes were total-, high density lipoprotein- (HDL) and low density lipoprotein- (LDL) cholesterol, Apolipoprotein-B100 and -A1, lipoprotein composition, plasma phospholipid fatty acids and blood pressure.Forty-seven patients completed at least one period and they remained weight stable. There was a significant between-dietary treatment effect in TG and HDL-cholesterol concentration in favor of intervention (p=0.007 and p=0.049, respectively). Likewise, Apolipoprotein-B100/A1 ratio shifted toward a less atherogenic profile in favor of the intervention (p=0.007). Plasma fatty acids increased in polyunsaturated- and decreased in monounsaturated- and saturated fatty acids between diet periods in favor of the intervention period.Blood lipid profile improved indicating cardioprotective effects from an anti-inflammatory dietary intervention in patients with RA.This trial is registered at ClinicalTrials.gov as NCT02941055 .
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| 16. |
- Hulander, Erik, et al.
(författare)
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Improvements in Body Composition after a Proposed Anti-Inflammatory Diet Are Modified by Employment Status in Weight-Stable Patients with Rheumatoid Arthritis, a Randomized Controlled Crossover Trial
- 2022
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Ingår i: Nutrients. - : MDPI AG. - 2072-6643. ; 14:5
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Tidskriftsartikel (refereegranskat)abstract
- Rheumatoid Arthritis (RA) is an autoimmune disease affecting peripheral joints. Chronic activation of inflammatory pathways results in decreased function and the development of comorbidities, such as loss of lean mass while retaining total body mass. The objective of this report was to assess whether dietary manipulation affects body composition in patients with RA as a secondary outcome. Fifty patients were included in a randomized controlled crossover trial testing a proposed anti-inflammatory Mediterranean-style diet compared to a Western diet. Body composition was measured by bioelectrical impedance spectroscopy in patients without implants (n = 45). Regardless of treatment, fat-free mass increased and fat mass percentage decreased during weight stability, but no differences between intervention and control in the whole group (n = 42, all p > 0.20) were found. Interaction analysis revealed that participants who were non-employed (n = 15) significantly decreased in fat mass (-1.767 kg; 95% CI: -3.060, -0.475, p = 0.012) and fat mass percentage (-1.805%; 95% CI: -3.024, -0.586, p = 0.008) from the intervention compared to the control period. A Mediterranean-style diet improved body composition in non-employed participants (n = 15). The group as a whole improved regardless of dietary allocation, indicating a potential to treat rheumatoid cachexia by dietary manipulation.
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| 17. |
- Hulander, Erik, et al.
(författare)
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Proposed Anti-Inflammatory Diet Reduces Inflammation in Compliant, Weight-Stable Patients with Rheumatoid Arthritis in a Randomized Controlled Crossover Trial
- 2021
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Ingår i: Journal of Nutrition. - : Elsevier BV. - 0022-3166. ; 151:12, s. 3856-3864
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Tidskriftsartikel (refereegranskat)abstract
- Background: It is unclear to what extent adjuvant dietary intervention can influence inflammation in rheumatoid arthritis (RA). Objectives: The objective was to assess the effects of dietary manipulation on inflammation in patients with RA. Methods: In a crossover design, participants [n = 50, 78% females, median BMI (in kg/m2) 27, median age 63 y] were randomly assigned to begin with either a 10-wk portfolio diet of proposed anti-inflammatory foods (i.e., a high intake of fatty fish, whole grains, fruits, nuts, and berries) or a control diet resembling a Western diet with a 4-mo washout in between. This report evaluates the secondary outcome markers of inflammation among participants with stable medication. Analyses were performed using a linear mixed ANCOVA model. Results: There were no significant effects on CRP or ESR in the group as a whole. In those with high compliance (n = 29), changes in ESR within the intervention diet period differed significantly compared with changes within the control diet period (mean: -5.490; 95% CI: -10.310, -0.669; P = 0.027). During the intervention diet period, there were lowered serum concentrations of C-X-C motif ligand 1 (CXCL1) (mean: -0.268; 95% CI: -0.452, -0.084;P = 0.006), CXCL5 (mean: -0.278; 95% CI: -0.530, -0.026 P = 0.031), CXCL6 (mean: -0.251; 95% CI: -0.433, -0.069; P = 0.009), and tumor necrosis factor ligand superfamily member 14 (TNFSF14) (mean: -0.139; 95% CI: -0.275, -0.002; P = 0.047) compared with changes within the control diet period. Conclusion: A proposed anti-inflammatory diet likely reduced systemic inflammation, as indicated by a decreased ESR in those who completed the study with high compliance (n = 29). These findings warrant further studies to validate our results, and to evaluate the clinical relevance of changes in CXCL1, CXCL5, CXCL6, and TNFSF14 in patients with RA. © 2021 The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.
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| 18. |
- Lindqvist, Anna-Karin, et al.
(författare)
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Active School Transportation in Winter Conditions: Biking Together Is Warmer
- 2019
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Ingår i: International Journal of Environmental Research and Public Health. - : MDPI. - 1661-7827 .- 1660-4601. ; 16:2
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Tidskriftsartikel (refereegranskat)abstract
- There has been a decline in children’s use of active school transportation (AST) while there is also limited research concerning AST in winter conditions. This study aimed to explore the prerequisites and experiences of schoolchildren and parents participating in an empowerment- and gamification-inspired intervention to promote students’ AST in winter conditions. Methods: Thirty-five students, who were aged 12–13 years, and 34 parents from the north of Sweden participated in the study. Data were collected using photovoice and open questions in a questionnaire and analyzed using qualitative content analysis. Results: The results show that involvement and togetherness motivated the students to use AST. In addition, during the project, the parents changed to have more positive attitudes towards their children’s use of AST. The students reported that using AST during wintertime is strenuous but rewarding and imparts a sense of pride. Conclusion: Interventions for increasing students’ AST in winter conditions should focus on the motivational aspects for both children and parents. For overcoming parental hesitation with regards to AST during winter, addressing their concerns and empowering the students are key factors. To increase the use of AST all year around, targeting the challenges perceived during the winter is especially beneficial.
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| 19. |
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| 20. |
- Lindqvist, Anna-Karin, et al.
(författare)
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Backcross and partial advanced intercross analysis of nonobese diabetic gene-mediated effects on collagen-induced arthritis reveals an interactive effect by two major loci.
- 2006
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Ingår i: Journal of Immunology. - Rockville, MD : American Association of Immunologists. - 1550-6606 .- 0022-1767. ; 177:6, s. 3952-3959
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Tidskriftsartikel (refereegranskat)abstract
- Genetic segregation analysis between NOD and C57BL strains have been used to identify loci associated with autoimmune disease. Only two loci (Cia2 and Cia9) had earlier been found to control development of arthritis, whereas none of the previously identified diabetes loci was of significance for arthritis. We have now made a high-powered analysis of a backcross of NOD genes on to the B10.Q strain for association with collagen-induced arthritis. We could confirm relevance of both Cia2 and Cia9 as well as the interaction between them, but we did not identify any other significant arthritis loci. Immune cellular subtyping revealed that Cia2 was also associated with the number of blood macrophages. Congenic strains of the Cia2 and Cia9 loci on the B10.Q background were made and used to establish a partial advanced intercross (PAI). Testing the PAI mice for development of collagen-induced arthritis confirmed the loci and the interactions and also indicated that at least two genes contribute to the Cia9 locus. Furthermore, it clearly showed that Cia2 is dominant protective but that the protection is not complete. Because these results may indicate that the Cia2 effect on arthritis is not only due to the deficiency of the complement C5, we analyzed complement functions in the Cia2 congenics as well as the PAI mice. These data show that not only arthritis but also C5-dependent complement activity is dominantly suppressed, confirming that C5 is one of the major genes explaining the Cia2 effect.
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| 21. |
- Lindqvist, Anna-Karin, et al.
(författare)
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One should really be more worried about too little physical activity than injuries while walking or cycling to school. Parents’ perception of risk concerning active school transportation.
- 2023
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Ingår i: Journal of Transport & Health. - : Elsevier. - 2214-1405 .- 2214-1413. ; 29
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Tidskriftsartikel (refereegranskat)abstract
- IntroductionActive school transportation (AST) can be a powerful strategy to promote physical activity and improve children's health. Parents' perceptions of traffic risks are an important factor in their decision concerning their child's transport mode to school and addressing discordances between the percieved risks and actual incidents might contribute to promote children's AST. This study adopted a game originally designed for the context of information security to resonate with the context of Swedish AST and the aim of the study was to describe parent's experience of playing the game.MethodsA qualitative approach was chosen and data was collected using focus groups with 16 parents for totally 29 children aged 7–12. The collected data were analyzed using qualitative content analysis.ResultsThe results formed one main theme “Playing promotes parents' awareness and consideration of active school transportation” and three subthemes; “Fast, fun, and functional; Experiences from playing the game” showing that the parents perceived the game to be fun, easy, and time efficient to play. “Then and now. Own childhood experience vs being a parent” showing that parents' perception of risk can sometimes be barriers to their children's opportunity to use AST. “Personal perceptions vs statistical risk” showing that playing the game addressed the discordance between the parents' perceived risks and actual incidents, as well as promoted parents' awareness and consideration of AST.ConclusionsIncluding an intervention component such as a game for parents and using schools as the arena for implementing projects promoting AST to improve children's physical activity levels, might be a fruitful avenue.
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| 22. |
- Lindqvist, Anna-Karin, et al.
(författare)
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User Perception of a Smartphone App to Promote Physical Activity through Active Transportation : An Inductive Qualitative Content Analysis within the Smart City Active Mobile Phone Intervention (SCAMPI) Study
- 2020
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Ingår i: JMIR mhealth and uhealth. - : JMIR Publications. - 2291-5222. ; 8:8
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Tidskriftsartikel (refereegranskat)abstract
- Background: Physical inactivity is globally recognized as a major risk factor for morbidity, particularly the incidence of non-communicable diseases, and mortality. Engaging in active transportation (AT) is a viable approach toward increasing physical activity (PA) on a daily basis. Mobile (mHealth) interventions enable promoting AT to a larger population. The Smart City Active Mobile Phone Intervention (SCAMPI) study is a randomized controlled trial designed to evaluate a smartphone application (app)’s ability to motivate participants to increase their PA by engaging in AT.Objective: This qualitative study examines the acceptance and usability of the SCAMPI app from the participants’ perspectives.Methods: Seventeen residents of Stockholm county (13 women; age range 25-61 years), who had completed the three-month, app-based behavioral change program in the SCAMPI randomized controlled trial during 2018 agreed to participate in a semi-structured telephone-based interview. These 17 participants were well representative of the whole intervention group (n = 127) in terms of baseline characteristics such as age, sex, and area of residence. The interviews were audio-recorded, transcribed verbatim, and analyzed using inductive qualitative content analysis.Results: The content analysis revealed two themes and four subcategories. The first theme “Main motivators: monitoring and messages” highlighted that monitoring AT and being able to set weekly goals using the app were the primary motivators reported among study participants. The second theme “Acceptable but modifiable” reflects that the app was well accepted and effectively encouraged many participants to use more AT. Nevertheless, there were functions in the app that require modification. For example, while the automated travel tracking feature was appreciated, participants found it time-consuming and unreliable at times.Conclusions: This study contributes novel insight into healthy adults’ experiences of using a mobile app to promote the use of AT. The results showed that the app was well-accepted and that self-monitoring and goal setting were the main motivators to engage in more AT. The automated tracking of AT was appreciated; however, it was also reported to be energy- and time-consuming when it failed to work. Thus, this feature should be improved going forward.
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| 23. |
- Nilsson, Magnus, et al.
(författare)
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Discovery of 4 '-azido-2 '-deoxy-2 '-C-methyl cytidine and prodrugs thereof : A potent inhibitor of Hepatitis C virus replication
- 2012
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Ingår i: Bioorganic & Medicinal Chemistry Letters. - : Elsevier BV. - 0960-894X .- 1464-3405. ; 22:9, s. 3265-3268
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Tidskriftsartikel (refereegranskat)abstract
- 4'-Azido-2'-deoxy-2'-methylcytidine (14) is a potent nucleoside inhibitor of the HCV NS5B RNA-dependent RNA polymerase, displaying an EC50 value of 1.2 mu M and showing moderate in vivo bioavailability in rat (F = 14%). Here we describe the synthesis and biological evaluation of 4'-azido-2'-deoxy-2'-methylcytidine and prodrug derivatives thereof. (C) 2012 Elsevier Ltd. All rights reserved.
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| 24. |
- Ostergaard, Mikkel, et al.
(författare)
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Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis : 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial
- 2023
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Ingår i: Annals of the Rheumatic Diseases. - : BMJ PUBLISHING GROUP. - 0003-4967 .- 1468-2060. ; 82:10, s. 1286-1295
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Tidskriftsartikel (refereegranskat)abstract
- Background The optimal first-line treatment in early rheumatoid arthritis (RA) is debated. We compared clinical and radiographic outcomes of active conventional therapy with each of three biological treatments with different modes of action. Methods Investigator-initiated, randomised, blinded-assessor study. Patients with treatment-naive early RA with moderate-severe disease activity were randomised 1:1:1:1 to methotrexate combined with (1) active conventional therapy: oral prednisolone (tapered quickly, discontinued at week 36) or sulfasalazine, hydroxychloroquine and intra-articular glucocorticoid injections in swollen joints; (2) certolizumab pegol; (3) abatacept or (4) tocilizumab. Coprimary endpoints were week 48 Clinical Disease Activity Index (CDAI) remission (CDAI <= 2.8) and change in radiographic van der Heijde-modified Sharp Score, estimated using logistic regression and analysis of covariance, adjusted for sex, anticitrullinated protein antibody status and country. Bonferroni's and Dunnet's procedures adjusted for multiple testing (significance level: 0.025). Results Eight hundred and twelve patients were randomised. Adjusted CDAI remission rates at week 48 were: 59.3% (abatacept), 52.3% (certolizumab), 51.9% (tocilizumab) and 39.2% (active conventional therapy). Compared with active conventional therapy, CDAI remission rates were significantly higher for abatacept (adjusted difference +20.1%, p<0.001) and certolizumab (+13.1%, p=0.021), but not for tocilizumab (+12.7%, p=0.030). Key secondary clinical outcomes were consistently better in biological groups. Radiographic progression was low, without group differences. Conclusions Compared with active conventional therapy, clinical remission rates were superior for abatacept and certolizumab pegol, but not for tocilizumab. Radiographic progression was low and similar between treatments.
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| 25. |
- Turesson Wadell, Anna, et al.
(författare)
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Dietary biomarkers and food records indicate compliance to study diets in the ADIRA (Anti-inflammatory Diet In Rheumatoid Arthritis) trial
- 2023
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Ingår i: FRONTIERS IN NUTRITION. - 2296-861X. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- Background: In the ADIRA (Anti-inflammatory Diet In Rheumatoid arthritis) trial, compliance to the study diets has previously been described primarily with a score based on reported intake of trial foods from telephone interviews. The aim of this study was to evaluate compliance using objective dietary biomarkers for whole grain, fruit and vegetables, margarine and oil, seafood and overall fat quality, as well as reported intake from food records of key components of the study diets. Methods: Fifty patients with rheumatoid arthritis were randomized to begin with the intervention diet (rich in whole grain, fruit and vegetables, margarine/oil and seafood) or the control diet (rich in meat and high-fat dairy) for 10 weeks, followed by a similar to 4 months wash-out period, and then switched diet. Compliance was evaluated using plasma alkylresorcinols (AR) as biomarkers for intake of whole grain wheat and rye, serum carotenoids for fruit and vegetables, plasma linoleic acid (LA, 18:2 n-6) and -alpha-linolenic acid (18:3, n-3) for margarine and cooking oil, plasma eicosapentaenoic acid (EPA, 20:5 n-3), -docosahexaenoic acid (DHA 22:6, n-3) and -docosapentaenoic acid (22:5 n-3) for seafood, and plasma fatty acid pattern for the overall dietary fat quality. Reported intake of whole grain, fruit, berries and vegetables, seafood, red meat, and fat quality was extracted from 3-d food records. Results: Plasma AR C21:0 and C23:0, LA, EPA, and DHA were higher while total serum carotenoids were lower after the intervention diet period compared to the control diet period (AR and carotenoids: p = <0.05, fatty acids: p = <0.001). Reported intake of whole grain, fruit, berries and vegetables, and seafood was higher and reported intake of red meat was lower during the intervention diet period compared to the control diet period (p = <0.001). Plasma- and reported fatty acid pattern differed as intended between the diet periods. Conclusion: This study indicates that the participants in the ADIRA trial were compliant to the study diets regarding intake of whole grain, cooking fat, seafood, and red meat, and the intended overall dietary fat quality. Compliance to instructions on fruit- and vegetable intake remains uncertain.
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