| 1. |
- Ljungvall, Ingrid, et al.
(författare)
-
Evaluation of post-operative complications after mastectomy performed without perioperative antimicrobial prophylaxis in dogs
- 2021
-
Ingår i: Acta Veterinaria Scandinavica. - : Springer Science and Business Media LLC. - 1751-0147. ; 63
-
Tidskriftsartikel (refereegranskat)abstract
- Background Mastectomy is the most common procedure for treatment of mammary tumours. Dogs undergoing mastectomy have a risk of developing surgical site infections (SSI) and other postoperative complications. However, potential risk factors associated with such complications have been sparsely investigated. Thus, the objective of this retrospective study was to determine the incidence of, and identify risk factors for, SSI and non-SSI postoperative complications after mastectomy performed without perioperative antimicrobial prophylaxis in privately owned otherwise clinically healthy dogs. Results Medical records were reviewed retrospectively for 135 client-owned female dogs, 10-35 kg in weight and three to 10 years of age, which had undergone mastectomy due to mammary tumours at three referral animal hospitals in Sweden over a 3-year period. Twelve (8.9%) dogs developed SSI, and 21 dogs (17.1%) dogs suffered a non-SSI postoperative complication. The incidence of SSI and all complications (SSI and non-SSI) were higher in dogs that had two to three (SSI: P = 0.036 and all complications: P = 0.0039) and four to five (SSI and all complications: P = 0.038) mammary glands excised, compared to dogs that had one mammary gland excised. The incidence of SSI was 1.7% (n = 1/60) in dogs that had one gland removed. The incidence of non-SSI postoperative complications was higher in dogs with a higher body weight (P = 0.02). Conclusions The incidence of SSI was lower than or similar to previously reported incidences of SSI in dog populations that have undergone tumour excisional surgery, despite the fact that dogs in the present study had not received perioperative antibiotics. Dogs that had two or more glands excised had an increased risk of developing SSI and non-SSI complications compared to dogs that had one gland excised. Furthermore, higher BW was associated with an increased risk of non-SSI complications. Results from the study indicate that routine use of perioperative antibiotics in tumour excisional surgery can be questioned, at least in single gland mastectomy in otherwise clinically healthy dogs.
|
|
| 2. |
- Anagrius, Kerstin, et al.
(författare)
-
Facial conformation characteristics in Persian and Exotic Shorthair cats
- 2021
-
Ingår i: Journal of Feline Medicine and Surgery. - 1098-612X .- 1532-2750.
-
Tidskriftsartikel (refereegranskat)abstract
- ObjectivesThe primary objectives of the study were to examine the diversity in facial conformation characteristics within a group of Persian (PER) and Exotic Shorthair (EXO) show cats, and to contrast the results to findings within a group of non-purebred domestic shorthair (DSH) and domestic longhair (DLH) cats. The secondary objectives were to determine the PER/EXO show cat owners' perceptions of the breathing status of their cats, and to evaluate if remarks from the cat show judges concerning the cats' head and facial conformation were exclusively related to the aesthetic features of the cats.MethodsSixty-four PER and 12 EXO show cats were prospectively examined at five international cat shows, and 20 DSH/DLH cats were examined at an animal hospital. Facial conformation characteristics were evaluated by examining photos of the cats. Owners of the PER/EXO show cats answered a questionnaire concerning their cats' health status, and they were encouraged to send in the judges' score sheets from the cat shows.ResultsThe PER/EXO show cats had higher diversity in facial conformation characteristics than the DSH/DLH cats, and high incidences of hypoplasia of the nose leather (95%), the nose leather top positioned above the level of the lower eyelid (93%), moderate-to-severe stenotic nares (86%), epiphora (83%) and entropion (32%). Owners of 6/76 PER/EXO show cats stated that their cat had increased respiratory sounds and/or trouble breathing at least once a week. The cat show judges' written comments were exclusively related to aesthetic features of the cats' head and facial conformation details.Conclusions and relevanceHypoplasia of the nose leather, high position of the nose leather top, stenotic nares, epiphora and entropion were common findings in the PER/EXO show cats but not in the DSH/DLH cats. Few of the cat owners perceived that their cat had problems related to the airways.
|
|
| 3. |
- Axelsson, Erik, et al.
(författare)
-
The genetic consequences of dog breed formation-Accumulation of deleterious genetic variation and fixation of mutations associated with myxomatous mitral valve disease in cavalier King Charles spaniels
- 2021
-
Ingår i: PLOS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 17:9
-
Tidskriftsartikel (refereegranskat)abstract
- Selective breeding for desirable traits in strictly controlled populations has generated an extraordinary diversity in canine morphology and behaviour, but has also led to loss of genetic variation and random entrapment of disease alleles. As a consequence, specific diseases are now prevalent in certain breeds, but whether the recent breeding practice led to an overall increase in genetic load remains unclear. Here we generate whole genome sequencing (WGS) data from 20 dogs per breed from eight breeds and document a similar to 10% rise in the number of derived alleles per genome at evolutionarily conserved sites in the heavily bottlenecked cavalier King Charles spaniel breed (cKCs) relative to in most breeds studied here. Our finding represents the first clear indication of a relative increase in levels of deleterious genetic variation in a specific breed, arguing that recent breeding practices probably were associated with an accumulation of genetic load in dogs. We then use the WGS data to identify candidate risk alleles for the most common cause for veterinary care in cKCs-the heart disease myxomatous mitral valve disease (MMVD). We verify a potential link to MMVD for candidate variants near the heart specific NEBL gene in a dachshund population and show that two of the NEBL candidate variants have regulatory potential in heartderived cell lines and are associated with reduced NEBL isoform nebulette expression in papillary muscle (but not in mitral valve, nor in left ventricular wall). Alleles linked to reduced nebulette expression may hence predispose cKCs and other breeds to MMVD via loss of papillary muscle integrity.
|
|
| 4. |
- Brander, Gustaf, et al.
(författare)
-
Multiple Genetic Loci Associated with Pug Dog Thoracolumbar Myelopathy
- 2023
-
Ingår i: Genes. - : MDPI. - 2073-4425. ; 14:2
-
Tidskriftsartikel (refereegranskat)abstract
- Pug dogs with thoracolumbar myelopathy (PDM) present with a specific clinical phenotype that includes progressive pelvic limb ataxia and paresis, commonly accompanied by incontinence. Vertebral column malformations and lesions, excessive scar tissue of the meninges, and central nervous system inflammation have been described. PDM has a late onset and affects more male than female dogs. The breed-specific presentation of the disorder suggests that genetic risk factors are involved in the disease development. To perform a genome-wide search for PDM-associated loci, we applied a Bayesian model adapted for mapping complex traits (BayesR) and a cross-population extended haplotype homozygosity test (XP-EHH) in 51 affected and 38 control pugs. Nineteen associated loci (harboring 67 genes in total, including 34 potential candidate genes) and three candidate regions under selection (with four genes within or next to the signal) were identified. The multiple candidate genes identified have implicated functions in bone homeostasis, fibrotic scar tissue, inflammatory responses, or the formation, regulation, and differentiation of cartilage, suggesting the potential relevance of these processes to the pathogenesis of PDM.
|
|
| 5. |
- Carnabuci, Cristina, et al.
(författare)
-
Assessment of cardiac function using global and regional left ventricular endomyocardial and epimyocardial peak systolic strain and strain rate in healthy Labrador retriever dogs
- 2013
-
Ingår i: Research in Veterinary Science. - : Elsevier BV. - 0034-5288 .- 1532-2661. ; 95, s. 241-248
-
Tidskriftsartikel (refereegranskat)abstract
- Speckle tracking echocardiography (STE) is based on tracking of natural acoustic myocardial markers. The study aimed at quantifying global and regional endomyocardial and epimyocardial left ventricular longitudinal, circumferential and radial peak systolic strain and strain rate, including feasibility and variability; and assessing synchronicity and torsion, in healthy dogs. Cineloops were acquired from left apical 4-chamber, basal and apical right'parasternal short-axis views in 22 healthy Labrador retrievers. A general epimyocardial to endomyocardial strain gradient was found. Strain was higher at apex compared to base. A strain longitudinal base to apex gradient was found. Left ventricular synchronicity could be assessed in all dogs and torsion in 1/3. Short axis apical view had highest variability. Dog and operator contributed most to overall variance. In conclusion, STE allows assessment of myocardial function in healthy Labrador retrievers. A longitudinal base to apex gradient was found and a new synchronicity index for use in dogs was introduced. (c) 2013 Elsevier Ltd. All rights reserved.
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
- Forsberg, Simon, et al.
(författare)
-
The Shepherds' Tale : A Genome-Wide Study across 9 Dog Breeds Implicates Two Loci in the Regulation of Fructosamine Serum Concentration in Belgian Shepherds
- 2015
-
Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 10:5
-
Tidskriftsartikel (refereegranskat)abstract
- Diabetes mellitus is a serious health problem in both dogs and humans. Certain dog breeds show high prevalence of the disease, whereas other breeds are at low risk. Fructosamine and glycated haemoglobin (HbA1c) are two major biomarkers of glycaemia, where serum concentrations reflect glucose turnover over the past few weeks to months. In this study, we searched for genetic factors influencing variation in serum fructosamine concentration in healthy dogs using data from nine dog breeds. Considering all breeds together, we did not find any genome-wide significant associations to fructosamine serum concentration. However, by performing breed-specific analyses we revealed an association on chromosome 3 (rho(corrected) approximate to 1:68 x 10(-6)) in Belgian shepherd dogs of the Malinois subtype. The associated region and its close neighbourhood harbours interesting candidate genes such as LETM1 and GAPDH that are important in glucose metabolism and have previously been implicated in the aetiology of diabetes mellitus. To further explore the genetics of this breed specificity, we screened the genome for reduced heterozygosity stretches private to the Belgian shepherd breed. This revealed a region with reduced heterozygosity that shows a statistically significant interaction (rho = 0.025) with the association region on chromosome 3. This region also harbours some interesting candidate genes and regulatory regions but the exact mechanisms underlying the interaction are still unknown. Nevertheless, this finding provides a plausible explanation for breed-specific genetic effects for complex traits in dogs. Shepherd breeds are at low risk of developing diabetes mellitus. The findings in Belgian shepherds could be connected to a protective mechanism against the disease. Further insight into the regulation of glucose metabolism could improve diagnostic and therapeutic methods for diabetes mellitus.
|
|
| 11. |
- Hanås, Sofia, et al.
(författare)
-
Cardiac troponin I in healthy Norwegian Forest Cat, Birman and domestic shorthair cats, and in cats with hypertrophic cardiomyopathy.
- 2022
-
Ingår i: Journal of feline medicine and surgery. - : Sage Publications. - 1098-612X .- 1532-2750. ; 24:10, s. e370-e379
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: The aims of this study were to assess the potential associations between the serum cardiac troponin I (cTnI) concentration in healthy cats and feline characteristics, systolic blood pressure, heart rate (HR), echocardiographic measurements and storage time; and to compare cTnI concentrations in healthy cats with concentrations in cats with hypertrophic cardiomyopathy (HCM), with or without left atrial enlargement (LAE) and in cats with HCM, to assess potential associations between cTnI concentration and echocardiographic variables.METHODS: Cardiac TnI was analysed using an Abbott ARCHITECT ci16200 analyser in serum from prospectively included healthy Norwegian Forest Cat (NF; n = 33), Birman (n = 33) and domestic shorthair (DSH; n = 30) cats, and from 39 cats with HCM, with or without LAE.RESULTS: In healthy cats, higher cTnI concentrations were found in Birman cats than in NF cats (P = 0.014) and in neutered male cats than in intact females (P = 0.032). Cardiac TnI was positively associated with HR (P <0.0001). In cats with HCM, cTnI concentration was positively associated with left ventricular wall thickness and with left atrial-to-aortic root ratio (all P ⩽0.010). Cats with HCM had higher cTnI concentrations than healthy cats, and cTnI concentrations were higher in cats with HCM and LAE than in those with HCM without LAE (all P = 0.0003).CONCLUSIONS AND RELEVANCE: Breed and sex may affect serum cTnI concentrations in healthy cats. The cTnI concentration increased with increasing severity of HCM.
|
|
| 12. |
- Hanås, Sofia, et al.
(författare)
-
Effect of feline characteristics on plasma N-terminal-prohormone B-type natriuretic peptide concentration and comparison of a point-of-care test and an ELISA test
- 2020
-
Ingår i: Journal of Veterinary Internal Medicine. - : Wiley. - 0891-6640 .- 1939-1676. ; 34, s. 1187-1197
-
Tidskriftsartikel (refereegranskat)abstract
- Background Increased plasma concentration of N-terminal-prohormone B-type natriuretic peptide (NT-proBNP) can be detected in cats with cardiac disease. Potential effects of feline characteristics on NT-proBNP concentration may influence clinical usefulness.Objectives To evaluate potential effects of feline characteristics on NT-proBNP plasma concentration and to compare NT-proBNP plasma concentrations in healthy cats with results in hypertrophic cardiomyopathy (HCM) cats with or without left atrial enlargement (LAE) using an ELISA and a point-of-care test (POCT), and assess if POCT results reflect ELISA results.Animals One hundred healthy cats of 3 breeds and 39 HCM cats were included.Methods Diseases other than HCM were excluded by physical examination, blood pressure measurement, echocardiography, hematology, and serum biochemistry.Results Higher NT-proBNP concentrations were found in males than in females in healthy (P = .005) and in HCM cats (P = .0021), but breed had no effect on NT-proBNP concentrations. Using >= 100 pmol/L as a cutoff for abnormal samples, ELISA and POCT had similar sensitivity (SE; 72 and 74%) and specificity (SP; 97 and 98%) for detecting cats with HCM, cats with HCM and LAE (SE, both 100%; SP, 97 versus 98%), and cats with HCM without LAE (SE, both 69%; SP, 97 versus 98%), respectively, when compared to healthy cats.Conclusions and Clinical Importance Breed had no effect on plasma NT-proBNP concentrations, but higher concentrations were found in male than in female cats. The ELISA and POCT had similar SE and SP for detecting HCM. Both tests could identify all HCM cats with LAE but not all HCM cats without LAE.
|
|
| 13. |
- Hanås, Sofia, et al.
(författare)
-
Influence of clinical setting and cat characteristics on indirectly measured blood pressure and pulse rate in healthy Birman, Norwegian Forest, and Domestic Shorthair cats
- 2021
-
Ingår i: Journal of Veterinary Internal Medicine. - : Wiley. - 0891-6640 .- 1939-1676. ; 35, s. 801-811
-
Tidskriftsartikel (refereegranskat)abstract
- Background Measured indirect blood pressure (BP) results in cats in a clinical environment might be affected by stress and characteristics of the cats.Hypothesis To investigate the influence of clinical setting, cat characteristics, and life situation on BP and pulse rate (PR) in healthy cats.Animals Ninety-four healthy Domestic Shorthair, Birman and Norwegian Forest cats.Methods Blood pressure measured by high-definition oscillometry in 3 settings: cat placed in its own carrier with veterinarian present; cat placed in carrier with owner alone present; and cat placed on table with veterinarian present. Statistical analyses were performed using mixed linear models.Results Systolic BP (SBP) did not differ among settings. Higher mean arterial pressure (MAP), diastolic BP (DBP), and PR were found when measurements were performed with cat placed on table, rather than in carrier. Coefficients of variation (CVs) higher for SBP, MAP, DBP, and PR when measured with cat placed on table than in carrier. Birman cats had lower BP than other breeds. Systolic BP, MAP, DBP, and PR increased with age. Cats allowed outdoors had lower PR than cats living strictly indoors.Conclusion and Clinical Importance No difference in SBP was found among settings, but measuring BP with the cat placed on the examination table gave higher MAP, DBP, PR, and CV than measuring BP with the cat in its carrier. Breed affected BP, with lower BP in Birman cats than other breeds. Blood pressure increased with age. Pulse rate was lower in cats allowed outdoors than cats living strictly indoors.
|
|
| 14. |
|
|
| 15. |
- Hillström, Anna, et al.
(författare)
-
Validation and application of a canine-specific automated high-sensitivity C-reactive protein assay
- 2015
-
Ingår i: Journal of Veterinary Diagnostic Investigation. - : SAGE Publications. - 1040-6387 .- 1943-4936. ; 27, s. 182-190
-
Tidskriftsartikel (refereegranskat)abstract
- Measurement of low concentrations of C-reactive protein (CRP) in dogs has previously been performed with nonautomated assays. The aim of this study was to validate an automated high-sensitivity CRP (hsCRP) assay, developed by modifying a routinely used canine-specific immunoturbidimetric CRP test (cCRP). Imprecision, linearity under dilution, limit of blank (LOB), limit of detection (LOD), and limit of quantification (LOQ) were determined for the hsCRP test, as well as the presence of prozone effect and interferences. The imprecision, measured as intra-assay variation, was 2.7%. The assay was acceptably linear under dilution. An analytically relevant prozone effect was present for samples with CRP concentration >150 mg/L, and there were mild interferences from hemolysis and lipemia. The LOB, LOD, and LOQ were 0.10 mg/L, 0.22 mg/L, and 0.50 mg/L, respectively. A method comparison study with a canine-specific enzyme-linked immunosorbent assay (ELISA) was performed, showing poor agreement between the hsCRP test and the ELISA. An additional aim of the study was to apply the hsCRP test to clinical research samples. Serum samples from 7 dogs undergoing ovariohysterectomy were collected pre- and postoperatively, and CRP was measured with both the cCRP and hsCRP assay. The expected postoperative increase in CRP was detected earlier with the hsCRP test, compared with the cCRP test. The hsCRP assay was further applied on samples from 6 lean and 9 overweight dogs. There was no significant difference in CRP concentration between the groups (P = 0.06). In conclusion, the hsCRP test had acceptable analytical performance, and the assay was successfully applied to clinical research samples.
|
|
| 16. |
|
|
| 17. |
- Häggström, Jens, et al.
(författare)
-
Adult-Onset Valvular Heart Disease
- 2017
-
Ingår i: Textbook of Veterinary Internal Medicine. Diseases of Dogs and Cats, Volume 2. - 9780323312394 ; , s. 1249 - 1269
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 18. |
- Häggström, Jens, et al.
(författare)
-
Advances in the therapy of congestive heart failure in dogs and cats
- 2014
-
Ingår i: European Journal of Companion Animal Practice. - 1018-2357. ; 24, s. 4-20
-
Forskningsöversikt (refereegranskat)abstract
- Myxomatous mitral valve disease (MMVD) and dilated cardiomyopathy (DCM) in dogs, and different forms of cardiomyopathy in cats, may lead to signs of congestive heart failure (CHF). Traditionally, signs of CHF have been treated with a diuretic together with other adjunct therapy, such as digoxin, but very little data from clinical trials was available to support treatment strategies. During the last 20 years, an important paradigm shift has occurred in the demand for data to support our clinical decisions in dogs and cats with heart disease. Today, several drugs have in clinical trials been shown to improve outcome in small animal CHF patients, as indicated by improved quality of life and increased survival time. Not only have the growing number of drug trials provided information on drug efficacy, but these trials have also provided important information on prognostic value of clinical tests and a deeper understanding of disease progression. This article reviews current treatment alternatives from asymptomatic to progressed stages, associated with severe clinical signs of CHF, in dogs with MMVD or DCM and in cats with cardiomyopathy.
|
|
| 19. |
- Häggström, Jens, et al.
(författare)
-
Assessment of mitral valve morphology using three-dimensional echocardiography. Feasibility and reference values
- 2016
-
Ingår i: Journal of Veterinary Cardiology. - : Elsevier BV. - 1760-2734 .- 1875-0834. ; 18, s. 156-167
-
Tidskriftsartikel (refereegranskat)abstract
- Objectives: To evaluate the feasibility of real time transthoracic three dimensional echocardiography (RT3DE) for evaluation of normal canine mitral valves (MVs), and to provide reference values for this technique.Animals: Forty-three cardiologically healthy, not sedated dogs.Methods: Transthoracic RT3DE mitral datasets were acquired during two consecutive 6-month periods. The datasets were analyzed using commercially available software. An MV model was drawn using a semiautomated procedure and MV variables were obtained and calculated. The ratio between annulus height and commissural diameter was used as an index of the annulus' saddle-shaped non-planarity. After evaluation of associations between measured variables and body size, the datasets were used to generate reference intervals. Coefficients of variation (CVs), variance components, and repeatability coefficients were calculated for the evaluation of intra-observer, inter-observer, and day-to-day variability.Results: Datasets could be analyzed in 34 of 43 (79%) dogs. 68 percent of datasets obtained during the first 6-month period could be analyzed and 90% obtained during the second period could be analyzed. An allometric relationship was identified for most MV variables. The MV annulus appeared elliptical and saddle-shaped. Inter and intra-observer CVs were less than 20%. Coefficient of variation greater than 20% was calculated for the inter-day variation for some variables. Operator and observer were primarily responsible for the variation of most of the variables.Conclusions: Evaluation of canine mitral valves by transthoracic RT3DE is feasible. Canine MVs of healthy dogs analyzed using RT3DE are elliptical and saddle-shaped. Reference intervals for the measured MV variables are proposed. (C) 2016 Elsevier B.V. All rights reserved.
|
|
| 20. |
- Häggström, Jens, et al.
(författare)
-
Cardiovascular endocrinology in naturally occurring canine and feline models
- 2014
-
Ingår i: Cardiovascular Endocrinology. - 2162-688X. ; 3, s. 32-38
-
Tidskriftsartikel (refereegranskat)abstract
- Rodents are frequently used to study aspects of cardiovascular endocrinology. The present review focuses on opportunities offered by naturally occurring heart disease in dogs and cats, that is larger animal models. In particular, the benefits of using these species include the possibility of studying the same types of naturally occurring diseases as those occurring in humans, and carrying out studies in genetically similar individuals (i.e. breeds) sharing the same environment as humans. Recent findings in neuroendocrine hormones, that is natriuretic peptides, components of the renin–angiotensin–aldosterone system, and endothelin-1, in dogs and cats are reviewed in this article. As in humans, all these hormones have been evaluated as cardiovascular biomarkers in dogs and cats, and natriuretic peptides have shown promise in the diagnosis, staging and prognostication of heart disease. However, components of the renin–angiotensin–aldosterone system and endothelin-1 appear to be more useful as functional biomarkers for monitoring compensatory responses to naturally occurring heart diseases and their treatments.
|
|
| 21. |
- Häggström, Jens, et al.
(författare)
-
Comparison of the mitral valve morphologies of Cavalier King Charles Spaniels and dogs of other breeds using 3D transthoracic echocardiography
- 2018
-
Ingår i: Journal of Veterinary Internal Medicine. - : Wiley. - 0891-6640 .- 1939-1676. ; 32, s. 1564-1569
-
Tidskriftsartikel (refereegranskat)abstract
- BackgroundObjectivesMyxomatous mitral valve disease (MMVD) is more prevalent in Cavalier King Charles Spaniels (CKCSs) compared to dogs of other breeds at a given age. Abnormal valvular stress is thought to contribute to the development and progression of MMVD, and a relationship exists between mitral valve (MV) morphology and stress acting on the valve.To determine whether the MV morphology of healthy adult CKCSs differs from the morphology of healthy adult dogs of other breeds determined by RT-3DTTE.AnimalsMethodsThirty-five healthy CKCSs and 41 healthy dogs of other breeds.Prospective cross-sectional study. Dogs underwent physical examination, conventional echocardiography, and RT-3DTTE. RT-3DTTE datasets were analyzed using dedicated software for MV morphologic analysis. Morphologic variables were compared between CKCSs and dogs of other breeds.ResultsConclusions and Clinical ImportanceThe MV of healthy CKCSs had a smaller annulus height (0.46 0.11 vs. 0.56 +/- 0.17; P = .0021), tenting height (0.26 +/- 0.12 vs. 0.42 +/- 0.18; P < .001), tenting area (0.42 +/- 0.15 vs. 0.79 +/- 0.34; P < .001), normalized tenting volume (0.09 [0.05-0.13] vs. 0.14 [0.10-0.20]; P < .001), and normalized area of the posterior leaflet (0.57 +/- 0.15 vs. 0.66 +/- 0.18; P = .016) compared to healthy dogs of other breeds; this results in CKCSs having a flatter MV with reduced tenting, compared to the MV of other breeds.These morphologic features could confer a mechanical disadvantage and play a role in the predisposition of CKCSs to the early development of MMVD.
|
|
| 22. |
- Häggström, Jens, et al.
(författare)
-
Die Wirkung von Pimobendan bei Hunden mit praklinischer myxomatoser Mitralklappen- erkrankung und Kardiomegalie: Die EPIC-Studie - Eine randomisierte klinische Studie
- 2017
-
Ingår i: Kleintier-praxis. - 0023-2076. ; 62, s. 64-87
-
Tidskriftsartikel (refereegranskat)abstract
- Background Pimobendan is effective in treatment of dogs with congestive heart failure (CHF) secondary to myxomatous mitral valve disease (MMVD). Its effect on dogs before the onset of CHF is unknown.Hypothesis/Objectives Administration of pimobendan (0.4-0.6 mg/kg/d in divided doses) to dogs with increased heart size secondary to preclinical MMVD, not receiving other cardiovascular medications, will delay the onset of signs of CHF, cardiac-related death, or euthanasia.Animals 360 client-owned dogs with MMVD with left atrial-to-aortic ratio >= 1.6, normalized left ventricular internal diameter in diastole >= 1.7, and vertebral heart sum >10.5.Methods Prospective, randomized, placebo-controlled, blinded, multicenter clinical trial. Primary outcome variable was time to a composite of the onset of CHF, cardiac-related death, or euthanasia.Results Median time to primary endpoint was 1228.days (95% CI: 856 -NA) in the pimobendan group and 766 days (95% CI: 667-875) in the placebo group (P =.0038). Hazard ratio for the pimobendan group was 0.64 (95% CI: 0.47-0.87) compared with the placebo group. The benefit persisted after adjustment for other variables. Adverse events were not different between treatment groups. Dogs in the pimobendan group lived longer (median survival time was 1059 days (95% CI: 952-NA) in the pimobendan group and 902 days (95% CI: 747-1061) in the placebo group) (P =.012).Conclusions and Clinical Importance Administration of pimobendan to dogs with MMVD and echocardiographic and radiographic evidence of cardiomegaly results in prolongation of preclinical period and is safe and well tolerated. Prolongation of preclinical period by approximately 15 months represents substantial clinical benefit.
|
|
| 23. |
- Häggström, Jens, et al.
(författare)
-
Effect of Body Weight on Echocardiographic Measurements in 19,866 Pure-Bred Cats with or without Heart Disease
- 2016
-
Ingår i: Journal of Veterinary Internal Medicine. - : Wiley. - 0891-6640 .- 1939-1676. ; 30, s. 1601-1611
-
Tidskriftsartikel (refereegranskat)abstract
- BackgroundEchocardiography is a cost-efficient method to screen cats for presence of heart disease. Current reference intervals for feline cardiac dimensions do not account for body weight (BW).ObjectiveTo study the effect of BW on heart rate (HR), aortic (Ao), left atrial (LA) and ventricular (LV) linear dimensions in cats, and to calculate 95% prediction intervals for these variables in normal adult pure-bred cats.Animals19 866 pure-bred cats.MethodsClinical data from heart screens conducted between 1999 and 2014 were included. Associations between BW, HR, and cardiac dimensions were assessed using univariate linear models and allometric scaling, including all cats, and only those considered normal, respectively. Prediction intervals were created using 95% confidence intervals obtained from regression curves.ResultsAssociations between BW and echocardiographic dimensions were best described by allometric scaling, and all dimensions increased with increasing BW (all P<0.001). Strongest associations were found between BW and Ao, LV end diastolic, LA dimensions, and thickness of LV free wall. Weak linear associations were found between BW and HR and left atrial to aortic ratio (LA:Ao), for which HR decreased with increasing BW (P<0.001), and LA:Ao increased with increasing BW (P<0.001). Marginal differences were found for prediction formulas and prediction intervals when the dataset included all cats versus only those considered normal.Conclusions and ImportanceBW had a clinically relevant effect on echocardiographic dimensions in cats, and BW based 95% prediction intervals may help in screening cats for heart disease.
|
|
| 24. |
- Häggström, Jens, et al.
(författare)
-
Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study-A Randomized Clinical Trial
- 2016
-
Ingår i: Journal of Veterinary Internal Medicine. - : Wiley. - 0891-6640 .- 1939-1676. ; 30, s. 1765-1779
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Pimobendan is effective in treatment of dogs with congestive heart failure (CHF) secondary to myxomatous mitral valve disease (MMVD). Its effect on dogs before the onset of CHF is unknown.Hypothesis/Objectives: Administration of pimobendan (0.4-0.6 mg/kg/d in divided doses) to dogs with increased heart size secondary to preclinical MMVD, not receiving other cardiovascular medications, will delay the onset of signs of CHF, cardiac-related death, or euthanasia.Animals: 360 client-owned dogs with MMVD with left atrial-to-aortic ratio >= 1.6, normalized left ventricular internal diameter in diastole >= 1.7, and vertebral heart sum >10.5.Methods: Prospective, randomized, placebo-controlled, blinded, multicenter clinical trial. Primary outcome variable was time to a composite of the onset of CHF, cardiac-related death, or euthanasia.Results: Median time to primary endpoint was 1228 days (95% CI: 856-NA) in the pimobendan group and 766 days (95% CI: 667-875) in the placebo group (P = .0038). Hazard ratio for the pimobendan group was 0.64 (95% CI: 0.47-0.87) compared with the placebo group. The benefit persisted after adjustment for other variables. Adverse events were not different between treatment groups. Dogs in the pimobendan group lived longer (median survival time was 1059 days (95% CI: 952-NA) in the pimobendan group and 902 days (95% CI: 747-1061) in the placebo group) (P = .012).Conclusions and Clinical Importance: Administration of pimobendan to dogs with MMVD and echocardiographic and radiographic evidence of cardiomegaly results in prolongation of preclinical period and is safe and well tolerated. Prolongation of preclinical period by approximately 15 months represents substantial clinical benefit.
|
|
| 25. |
|
|
