| 1. |
- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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| 2. |
- Niemi, MEK, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 3. |
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| 4. |
- Ferrario, M., et al.
(författare)
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IRIDE : Interdisciplinary research infrastructure based on dual electron linacs and lasers
- 2014
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 740, s. 138-146
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Tidskriftsartikel (refereegranskat)abstract
- This paper describes the scientific aims and potentials as well as the preliminary technical design of RUDE, an innovative tool for multi-disciplinary investigations in a wide field of scientific, technological and industrial applications. IRIDE will be a high intensity "particles factory", based on a combination of high duty cycle radio-frequency superconducting electron linacs and of high energy lasers. Conceived to provide unique research possibilities for particle physics, for condensed matter physics, chemistry and material science, for structural biology and industrial applications, IRIDE will open completely new research possibilities and advance our knowledge in many branches of science and technology. [RIDE is also supposed to be realized in subsequent stages of development depending on the assigned priorities.
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| 5. |
- Mirza, M. R., et al.
(författare)
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Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer
- 2016
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Ingår i: New England Journal of Medicine. - : MASSACHUSETTS MEDICAL SOC. - 0028-4793 .- 1533-4406. ; 375:22, s. 2154-2164
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND Niraparib is an oral poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) 1/2 inhibitor that has shown clinical activity in patients with ovarian cancer. We sought to evaluate the efficacy of niraparib versus placebo as maintenance treatment for patients with platinum-sensitive, recurrent ovarian cancer. METHODS In this randomized, double-blind, phase 3 trial, patients were categorized according to the presence or absence of a germline BRCA mutation (gBRCA cohort and non-gBRCA cohort) and the type of non-gBRCA mutation and were randomly assigned in a 2: 1 ratio to receive niraparib (300 mg) or placebo once daily. The primary end point was progression-free survival. RESULTS Of 553 enrolled patients, 203 were in the gBRCA cohort (with 138 assigned to niraparib and 65 to placebo), and 350 patients were in the non-gBRCA cohort (with 234 assigned to niraparib and 116 to placebo). Patients in the niraparib group had a significantly longer median duration of progression-free survival than did those in the placebo group, including 21.0 vs. 5.5 months in the gBRCA cohort (hazard ratio, 0.27; 95% confidence interval [CI], 0.17 to 0.41), as compared with 12.9 months vs. 3.8 months in the non-gBRCA cohort for patients who had tumors with homologous recombination deficiency (HRD) (hazard ratio, 0.38; 95% CI, 0.24 to 0.59) and 9.3 months vs. 3.9 months in the overall non-gBRCA cohort (hazard ratio, 0.45; 95% CI, 0.34 to 0.61; P amp;lt; 0.001 for all three comparisons). The most common grade 3 or 4 adverse events that were reported in the niraparib group were thrombocytopenia (in 33.8%), anemia (in 25.3%), and neutropenia (in 19.6%), which were managed with dose modifications. CONCLUSIONS Among patients with platinum-sensitive, recurrent ovarian cancer, the median duration of progression-free survival was significantly longer among those receiving niraparib than among those receiving placebo, regardless of the presence or absence of gBRCA mutations or HRD status, with moderate bone marrow toxicity. (Funded by Tesaro; ClinicalTrials.gov number, NCT01847274.)
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| 6. |
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| 7. |
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| 8. |
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| 9. |
- Park, Joochun, et al.
(författare)
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Toward the limit of nuclear binding on the N = Z line : Spectroscopy of Cd-96
- 2019
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Ingår i: Physical Review C. - : AMER PHYSICAL SOC. - 2469-9985 .- 2469-9993. ; 99:2
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Tidskriftsartikel (refereegranskat)abstract
- A gamma -decaying isomeric state (tau(1/2) = 197(-17)(+19) ns) has been identified in Cd-96, which is one alpha particle away from the last known bound N = Z nucleus, Sn-100. Comparison of the results with shell-model calculations has allowed a tentative experimental level scheme to be deduced and the isomer to be interpreted as a medium-spin negative-parity spin trap based on the coupling of isoscalar (T = 0) and isovector (T = 1) neutron-proton pairs. The data also suggest evidence for the population of a 9(+) T = 1 state, which is predicted by shell-model calculations to be yrast. Such a low-lying T = 1 state, which is unknown in lighter mass even-even self-conjugate nuclei, can also be interpreted in terms of the coupling of T = 0 and T = 1 neutron-proton pairs.
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| 10. |
- Davies, P. J., et al.
(författare)
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The role of core excitations in the structure and decay of the 16(+) spin-gap isomer in Cd-96
- 2017
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Ingår i: Physics Letters B. - : Elsevier. - 0370-2693 .- 1873-2445. ; 767, s. 474-479
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Tidskriftsartikel (refereegranskat)abstract
- The first evidence for beta-delayed proton emission from the 16(+) spin gap isomer in Cd-96 is presented. The data were obtained from the Rare Isotope Beam Factory, at the RIKEN Nishina Center, using the BigRIPS spectrometer and the EURICA decay station. beta p branching ratios for the ground state and 16(+) isomer have been extracted along with more precise lifetimes for these states and the lifetime for the ground state decay of Cd-95. Large scale shell model (LSSM) calculations have been performed and WKB estimates made for l = 0, 2, 4 proton emission from three resonance-like states in Ag-96, that are populated by the beta decay of the isomer, and the results compared to the new data. The calculations suggest that l = 2 proton emission from the resonance states, which reside similar to 5 MeV above the proton separation energy, dominates the proton decay. The results highlight the importance of core-excited wavefunction components for the 16(+) state.
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| 11. |
- Gontad, F, et al.
(författare)
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Nanomechanical and electrical properties of Nb thin films deposited on Pb substrates by pulsed laser deposition as a new concept photocathode for superconductor cavities
- 2015
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 804, s. 132-136
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Tidskriftsartikel (refereegranskat)abstract
- We report a design of photocathode, which combines the good photoemissive properties of lead (Pb) and the advantages of superconducting performance of niobium (Nb) when installed into a superconducting radio-frequency gun. The new configuration is obtained by a coating of Nb thin film grown on a disk of Pb via pulsed laser deposition. The central emitting area of Pb is masked by a shield to avoid the Nb deposition. The nanomechanical properties of the Nb film, obtained through nanoindentation measurements, reveal a hardness of 2.8±0.3 GPa, while the study of the electrical resistivity of the film shows the appearance of the superconducting transitions at 9.3 K and 7.3 K for Nb and Pb, respectively, very close to the bulk material values. Additionally, morphological, structural and contamination studies of Nb thin film expose a very low droplet density on the substrate surface, a small polycrystalline orientation of the films and a low contamination level. These results, together with the acceptable Pb quantum efficiency of 2×10−5 found at 266 nm, demonstrate the potentiality of the new concept photocathode.
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| 12. |
- Haefner, G., et al.
(författare)
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Properties of γ-decaying Isomers in the 100Sn Region Revisited
- 2019
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Ingår i: Acta Physica Polonica B. - : JAGIELLONIAN UNIV PRESS. - 0587-4254 .- 1509-5770. ; 50:3, s. 431-437
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Tidskriftsartikel (refereegranskat)abstract
- The study of nuclei in the region around the N = Z doubly-magic nucleus 100Sn has been of long standing interest for the nuclear structure and nuclear astrophysics. Recently, Park et al. have reported on properties of γ-decaying isomers and isomeric ratios in the vicinity of 100Sn. That experiment was performed at the Radioactive Ion Beam Factory (RIBF) of the RIKEN Nishina Center in Japan as a part of the EURICA campaign. Neutron-deficient nuclei were produced in a fragmentation reaction of a 124Xe primary beam on a 9Be target at an energy of 345 MeV/A. Secondary ions were separated and identified in the BigRIPS fragment separator and implanted in the silicon detector array WAS3ABi. The data presented here were obtained in another experiment performed at the RIBF using the same reaction but slightly different separator settings. New results of ratios of isomeric population and half-lives of γ-decaying isomers populated in the experiment are presented.
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| 13. |
- Häfner, G., et al.
(författare)
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Properties of γ-decaying isomers in the Sn 100 region populated in fragmentation of a Xe 124 beam
- 2019
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Ingår i: Physical Review C. - : American Physical Society. - 2469-9985 .- 2469-9993. ; 100:2
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Tidskriftsartikel (refereegranskat)abstract
- A systematic study was performed of microsecond γ-decaying isomers around Sn100 produced in a fragmentation reaction of a Xe124 beam at 345 MeV/u at the Radioactive Ion Beam Factory of the RIKEN Nishina Center in Saitama, Japan. Half-lives of isomeric states in that region were remeasured allowing us to improve the currently available experimental information. Reduced transition probabilities were deduced and compared to shell-model calculations in various model spaces. The recently reported low-energy transitions in Rh92 and Ag96 were remeasured with improved precision. Additionally, experimental information on isomeric ratios, including five new ones, were extracted and compared to a previous experimental study and the sharp cutoff model of fragmentation reaction.
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| 14. |
- Lorusso, A., et al.
(författare)
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Pulsed laser deposition of yttrium photocathode suitable for use in radio-frequency guns
- 2017
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Ingår i: Applied Physics A. - : SPRINGER. - 0947-8396 .- 1432-0630. ; 123:12
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Tidskriftsartikel (refereegranskat)abstract
- Yttrium (Y) thin film was grown by pulsed laser deposition (PLD) on a copper (Cu) polycrystalline substrate. Ex situ morphological and structural characterisations of the circular Y film of 1.2 mu m thickness and 3 mm diameter have shown a very low droplet density on the film surface and a crystalline feature with a preferred orientation along the Y (100) plane. Moreover, Y thin film resulted in being very adherent to the Cu substrate and more scratch resistant than Cu bulk. A twin thin film was deposited also on a Cu backflange of a radio-frequency (RF) gun to test the suitability of the metallic thin film as photocathode. It was observed that the Y-coated photocathode was characterised by a quantum efficiency (QE) higher than that of the Cu bulk photocathode even if the presence of space charge effects didnt allow deriving the absolute maximum value of QE of Y photocathode.
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| 15. |
- Lorusso, A., et al.
(författare)
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Structural and morphological properties of metallic thin films grown by pulsed laser deposition for photocathode application
- 2016
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Ingår i: Applied Physics A. - : Springer Berlin/Heidelberg. - 0947-8396 .- 1432-0630. ; 122:3, s. 1-5
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Tidskriftsartikel (refereegranskat)abstract
- In this work yttrium and lead thin films have been deposited by pulsed laser deposition technique and characterized by ex situ different diagnostic methods. All the films were adherent to the substrates and revealed a polycrystalline structure. Y films were uniform with a very low roughness and droplet density, while Pb thin films were characterized by a grain morphology with a relatively high roughness and droplet density. Such metallic materials are studied because they are proposed as a good alternative to copper and niobium photocathodes which are generally used in radiofrequency and superconducting radiofrequency guns, respectively. The photoemission performances of the photocathodes based on Y and Pb thin films have been also studied and discussed.
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| 16. |
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| 17. |
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| 18. |
- Moschner, K., et al.
(författare)
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Study of ground and excited state decays in N approximate to Z Ag nuclei
- 2015
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Ingår i: CGS15 - CAPTURE GAMMA-RAY SPECTROSCOPY AND RELATED TOPICS. - : EDP Sciences. - 9782759817948
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Konferensbidrag (refereegranskat)abstract
- A decay spectroscopy experiment was performed within the EURICA campaign at RIKEN in 2012. It aimed at the isomer and particle spectroscopy of excited states and ground states in the mass region below the doubly magic Sn-100. The N = Z nuclei In-98, Cd-96 and Ag-94 were of particular interest for the present study. Preliminary results on the neutron deficient nuclei Ag-93 and Ag-94 are presented. In Ag-94 a more precise value for the half-life of the ground state's superallowed Fermi transition was deduced. In addition the energy spectra of the mentioned decay could be reproduced through precise Geant4 simulations of the used active stopper SIMBA. This will enable us to extract Q(beta) values from the measured data. The decay of Ag-93 is discussed based on the observed implantation-decay correlation events.
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| 19. |
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| 20. |
- Calisi, A., et al.
(författare)
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Ecotoxicological effects of silver nanoparticles in marine mussels
- 2022
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Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697. ; 851
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Tidskriftsartikel (refereegranskat)abstract
- As the production of silver nanoparticles (AgNPs) is becoming more prevalent, it is becoming increasingly necessary to understand the toxicological effects they can have on different ecosystems. In the marine bioindicator species M. galloprovincialis Lam we predicted toxicity and bioaccumulation of 5 nm alkane-coated and 50 nm uncoated silver nanoparticles (AgNPs) along with silver nitrate as a function of the actual dose level. We generated a time persistence model of silver in seawater and used the Area Under the Curve (AUC) as independent variable in the hazard assessment. This approach allowed us to evaluate unbiased ecotoxicological endpoints for acute (survival) and chronic toxicity (byssal adhesion). Logistic regression analysis rendered an overall LC5096h values of 0.81 & PLUSMN; 0.07 mg h L-1 irrespectively of the silver form. By contrast, for byssal adhesion regression analysis revealed a much higher toxicological potential of silver nitrate vs AgNPs with EC5024h values respectively of 0.0024 & PLUSMN; 0.0009 vs 0.053 & PLUSMN; 0.016 and 0.063 (no computable error for 50 nm AgNP) mg h L-1, undoubtedly confirming a prevalence of ionic silver effects over AgNPs. Bioaccumulation was more efficient for silver nitrate > 5 nm AgNP > 50 nm AgNP reflecting a parallel with the prefer-ential uptake route / target organ. Finally, we derived Risk Quotient (RQs) for acute and chronic effects of nanosilver in shellfish and showed that the RQs are far from the Level of Concern (LoC) at current estimated environmental concentrations (EECs). This information can ultimately help researchers, policy makers, and industry professionals decide how to safely regulate and/or dis-pose of AgNPs.
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| 21. |
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| 22. |
- Glasspool, Rosalind M, et al.
(författare)
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Gynecologic Cancer InterGroup (GCIG) consensus review for squamous cell carcinoma of the ovary.
- 2014
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Ingår i: International Journal of Gynecological Cancer. - : Lippincott Williams & Wilkins. - 1048-891X .- 1525-1438. ; 24:9, s. S26-
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Forskningsöversikt (refereegranskat)abstract
- Squamous cell carcinoma of the ovary is a rare complication of mature cystic teratoma. The epidemiology, pathology, diagnosis, and management of this rare tumor are reviewed. Clinical characteristics, preoperative imaging, and tumor markers may help to predict malignancy preoperatively. Complete cytoreduction should be the aim of surgery. The prognosis for stage 1A disease is good, but for women with advanced or recurrent disease, it is very poor and has not improved in recent years. At present, there are insufficient data to provide clear guidance on the optimal management strategy for advanced disease, and there is a need to gain an understanding of the biology and to develop novel effective therapies. This will require coordinated international collaboration.
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| 23. |
- Lorusso, A., et al.
(författare)
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Tight comparison of Mg and Y thin film photocathodes obtained by the pulsed laser deposition technique
- 2016
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : ELSEVIER SCIENCE BV. - 0168-9002 .- 1872-9576. ; 836, s. 57-60
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Tidskriftsartikel (refereegranskat)abstract
- In this work Magnesium (Mg) and Yttrium (Y) thin films have been deposited on Copper (Cu) polycrystalline substrates by the pulsed laser ablation technique for photocathode application. Such metallic materials are studied for their interesting photoemission properties and are proposed as a good alternative to the Cu photocathode, which is generally used in radio-frequency guns. Mg and Y films were uniform with no substantial differences in morphology; a polycrystalline structure was found for both of them. Photoemission measurements of such cathodes based on thin films were performed, revealing a quantum efficiency higher than Cu bulk. Photoemission theory according to the three-step model of Spicer is invoked to explain the superior photoemission performance of Mg with respect to Y. (C) 2016 Elsevier B.V. All rights reserved.
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