| 1. |
- Lindfors, Petra, et al.
(författare)
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Allostatic load and clinical risk as related to sense of coherence in middle-aged women.
- 2006
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Ingår i: Psychosomatic Medicine. - : Ovid Technologies (Wolters Kluwer Health). - 0033-3174 .- 1534-7796. ; 68:5, s. 801-807
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To investigate how physiologic dysregulation, in terms of allostatic load and clinical risk, respectively, relates to sense of coherence (SOC) in women with no previously diagnosed pathology. Methods: At baseline, 200 43-year-old women took part in a standardized medical health examination and completed a 3-item measure of SOC, which they completed again 6 years later. According to data from the medical examination, two different measures of physiologic dysregulation were calculated: a) a measure of allostatic load based on empirically derived cut points and b) a measure of clinical risk based on clinically significant cut points. Results: In line with the initial hypotheses, allostatic load was found to predict future SOC, whereas clinical risk did not. In addition to baseline SOC and nicotine consumption, allostatic load was strongly associated with a weak SOC at the follow-up. Conclusions: The better predictive value of allostatic load to clinical risk indicates that focusing solely on clinical risk obscures patterns of physiologic dysregulation that influence future SOC.
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| 2. |
- Lindfors, Petra, et al.
(författare)
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Sense of Coherence and Biomarkers of Health in 43-Year-Old Women.
- 2005
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Ingår i: International Journal of Behavioral Medicine. - 1070-5503. ; 12:2, s. 98-102
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this cross-sectional study was to investigate how sense of coherence (SOC) relates to biomarkers of health in 43-year-old nonsmoking premenopausal women. Before taking part in a standardized medical health examination including assessment of blood pressure, blood lipids, and physical symptoms, participants completed a three-item measure of SOC. On the basis of their SOC scores, the 244 women with complete datasets were categorized into 1 of 3 groups with a weak, intermediate, or strong SOC. Results showed that women with a strong SOC had significantly lower levels of systolic blood pressure (p < .05) and total cholesterol (p < .05) than did women with a weak SOC. It is suggested that the lower levels of systolic blood pressure and total cholesterol found in women with a strong SOC may constitute a biological buffer against ill health and disease.
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| 3. |
- Åsman, Barbro, et al.
(författare)
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A search for flavour changing neutral currents in top-quark decays in pp collision data collected with the ATLAS detector at root s=7 TeV
- 2012
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 72:7, s. 2083-
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Tidskriftsartikel (refereegranskat)abstract
- A search for top quark pair resonances in final states containing at least one electron or muon has been performed with the ATLAS experiment at the CERN Large Hadron Collider. The search uses a data sample corresponding to an integrated luminosity of 2.05 fb(-1), which was recorded in 2011 at a proton-proton centre-of-mass energy of 7 TeV. No evidence for a resonance is found and limits are set on the production cross-section times branching ratio to t (t) over bar for narrow and wide resonances. For narrow Z' bosons, the observed 95 % Bayesian credibility level limits range from 9.3 pb to 0.95 pb for masses in the range of m(Z') = 500 GeV to m(Z') = 1300 GeV. The corresponding excluded mass region for a leptophobic topcolour Z' boson (Kaluza-Klein gluon excitation in the Randall-Sundrum model) is m(Z') < 880 GeV (m(gKK) < 1130 GeV).
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| 4. |
- Abbasi, R., et al.
(författare)
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Limits on a muon flux from Kaluza-Klein dark matter annihilations in the Sun from the IceCube 22-string detector
- 2010
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 81:5, s. 057101-
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Tidskriftsartikel (refereegranskat)abstract
- A search for muon neutrinos from Kaluza-Klein dark matter annihilations in the Sun has been performed with the 22-string configuration of the IceCube neutrino detector using data collected in 104.3 days of live time in 2007. No excess over the expected atmospheric background has been observed. Upper limits have been obtained on the annihilation rate of captured lightest Kaluza-Klein particle (LKP) WIMPs in the Sun and converted to limits on the LKP-proton cross sections for LKP masses in the range 250-3000 GeV. These results are the most stringent limits to date on LKP annihilation in the Sun.
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| 5. |
- Abbasi, R., et al.
(författare)
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Search for muon neutrinos from gamma-ray bursts with the IceCube neutrino telescope
- 2010
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 710:1, s. 346-359
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Tidskriftsartikel (refereegranskat)abstract
- We present the results of searches for high-energy muon neutrinos from 41 gamma-ray bursts (GRBs) in the northern sky with the IceCube detector in its 22 string configuration active in 2007/2008. The searches cover both the prompt and a possible precursor emission as well as a model-independent, wide time window of -1 hr to + 3 hr around each GRB. In contrast to previous searches with a large GRB population, we do not utilize a standard Waxman-Bahcall GRB flux for the prompt emission but calculate individual neutrino spectra for all 41 GRBs from the burst parameters measured by satellites. For all of the three time windows, the best estimate for the number of signal events is zero. Therefore, we place 90% CL upper limits on the fluence from the prompt phase of 3.7 x 10(-3) erg cm(-2) (72 TeV-6.5 PeV) and on the fluence from the precursor phase of 2.3 x 10(-3) erg cm(-2) (2.2-55 TeV), where the quoted energy ranges contain 90% of the expected signal events in the detector. The 90% CL upper limit for the wide time window is 2.7 x 10(-3) erg cm(-2) (3 TeV-2.8 PeV) assuming an E-2 flux.
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| 6. |
- Ahlgren, Benjamin, et al.
(författare)
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A simplified model for linear correlation between annual yield and DNI for parabolic trough collectors
- 2018
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Ingår i: Energy Conversion and Management. - : Elsevier. - 0196-8904 .- 1879-2227. ; 174, s. 295-308
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Tidskriftsartikel (refereegranskat)abstract
- This paper proposes a simple method for estimating annual thermal performance of parabolic trough collectors (PTCs) based on a linear relation with annual DNI for a certain latitude. A case study with simulations for a novel concentrating solar collector in 316 locations for three operating temperature scenarios worldwide was carried out and showed promising results for the latitudes and continents investigated. For a certain latitude and mean operating temperature, the annual yield of a PTC was found to be linearly proportional to yearly DNI. The proposed method will serve as a simplified alternative to the steady-state and quasi-dynamic methods already used. Estimating performance based on yearly DNI can be used by design engineers to do quick preliminary planning of solar plants. Customers can also use this method to evaluate existing solar collector installations. A TRNSYS/TRNSED tool that uses a steady-state model has been developed to carry out the simulations and it has been validated against a PTC array at Technical University of Denmark (DTU). The results show that the simplified method can give reliable estimates of long-term performance of parabolic trough collectors.
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| 7. |
- Albrecht, Inka, et al.
(författare)
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Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies
- 2015
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Ingår i: Journal of Clinical Investigation. - : AMER SOC CLINICAL INVESTIGATION INC. - 0021-9738 .- 1558-8238. ; 125:12, s. 4612-4624
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Tidskriftsartikel (refereegranskat)abstract
- Mutations of the gene encoding four-and-a-half LIM domain 1 (FHL1) are the causative factor of several X-linked hereditary myopathies that are collectively termed FHL1-related myopathies. These disorders are characterized by severe muscle dysfunction and damage. Here, we have shown that patients with idiopathic inflammatory myopathies (IIMs) develop autoimmunity to FHL1, which is a muscle-specific protein. Anti-FHL1 autoantibodies were detected in 25% of IIM patients, while patients with other autoimmune diseases or muscular dystrophies were largely anti-FHL1 negative. Anti-FHL1 reactivity was predictive for muscle atrophy, dysphagia, pronounced muscle fiber damage, and vasculitis. FHL1 showed an altered expression pattern, with focal accumulation in the muscle fibers of autoantibody-positive patients compared with a homogeneous expression in anti-FHL1-negative patients and healthy controls. We determined that FHL1 is a target of the cytotoxic protease granzyme B, indicating that the generation of FHL1 fragments may initiate FHL1 autoimmunity. Moreover, immunization of myositis-prone mice with FHL1 aggravated muscle weakness and increased mortality, suggesting a direct link between anti-FHL1 responses and muscle damage. Together, our findings provide evidence that FHL1 may be involved in the pathogenesis not only of genetic FHL1-related myopathies but also of autoimmune IIM. Importantly, these results indicate that anti-FHL1 autoantibodies in peripheral blood have promising potential as a biomarker to identify a subset of severe IIM.
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| 8. |
- Alvarez, J. L., et al.
(författare)
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Educational inequalities in tuberculosis mortality in sixteen European populations
- 2011
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Ingår i: The International Journal of Tuberculosis and Lung Disease. - : International Union Against Tuberculosis and Lung Disease. - 1027-3719 .- 1815-7920. ; 15:11, s. 1461-1467
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To describe the magnitude of socioeconomic inequalities in tuberculosis (TB) mortality by level of education in male, female, urban and rural populations in several European countries. DESIGN: Data were obtained from the Eurothine Project, covering 16 populations between 1990 and 2003. Age- and sex-standardised mortality rates, the relative index of inequality and the slope index of inequality were used to assess educational inequalities. RESULTS: The number of TB deaths reported was 8530, with a death rate of 3 per 100000 per year, of which 73% were males. Educational inequalities in TB mortality were present in all European populations. Inequalities in TB mortality were greater than in total mortality. Relative and absolute inequalities were large in Eastern European and Baltic countries but relatively small in Southern European countries and in Norway, Finland and Sweden. Inequalities in mortality were observed among both men and women, and in both rural and urban populations. CONCLUSIONS: Socio-economic inequalities in TB mortality exist in all European countries. Firm political commitment is required to reduce inequalities in the social determinants of TB incidence. Targeted public health measures are called for to improve access to treatment of vulnerable groups and thereby reduce TB mortality.
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| 9. |
- Andrén, Peter, 1972-, et al.
(författare)
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Prognosmodeller för tillståndsmått i Trafikverkets Pavement Management System : IRI och spårdjup
- 2014
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Vägytans tillstånd på det statliga svenska vägnätet har inventerats med mätbil sedan 1987. Av kostnadsskäl mäts inte alla vägar varje år, istället kan man använda modeller som prognostiserar tillståndet för de år då mätningar saknas. Syftet med vägytemätningarna är att förse Trafikverkets Pavement Management System (PMS) med tillståndsdata. De främsta användningsområdena för tillståndsmåtten är: • Beskrivning av det övergripande vägtillståndet och tillståndförändringen för att bedöma hur valda drift- och underhållsstrategier lyckats. • Stöd vid underhållsplanering. • Underlag vid beräkning av framtida underhållsbehov. • Stöd vid val av åtgärdsmetod. • Kontroll av utförande av byggnation eller underhåll. • Stöd vid forskning. Trafikverket har behov av en fullständig tillståndsbeskrivning av vägnätet, bland annat för att kunna redovisa för regering och riksdag hur uppdraget att underhålla statens vägar fullföljs. Ett sätt att årligen beskriva tillståndet för hela vägnätet är att använda modeller som prognostiserar tillståndet för de år då mätningar saknas. I valet mellan att använda en global eller lokal modell för att beskriva tillståndsutvecklingen för IRI (International Roughness Index) och spårdjup på enskilda 100-meterssegment visar rapporten att en modell med lokal anpassning är att föredra. Vid anpassning av en global modell får forskarna inte tillräckligt hög förklaringsgrad och ser inte heller ett konsekvent mönster i regressionskoefficienterna för de förklaringsvariabler som provats.
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| 10. |
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| 11. |
- Arvidsson, Anna K, 1971-, et al.
(författare)
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Friktions- och texturutveckling på nya beläggningar
- 2019
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- En ny vägyta bör vara och upplevas som säker av trafikanterna oavsett vilket väglag som råder. Det är därför viktigt att vägbanan har en tillfredställande nivå på friktion redan när vägen öppnas. Det finns begränsade dokumenterade kunskaper hur vägen förändras den första tiden efter en beläggningsåtgärd.Syftet med detta projekt är att fastställa hur friktionen förändras under den första tiden efter att vägbeläggningen är lagd och trafikpåsläpp sker. Ambitionen är att kunna avgöra om nylagda vägavsnitt har nedsatt friktion och ge rekommendationer för när en friktionsmätning ska utföras och hur skyltning ska ske i anslutning till beläggningsarbeten. Upplägget har varit att följa olika objekt med täta friktions- och texturmätningar från strax innan trafikpåsläpp tills nivåerna har stabiliserats.Initialt är friktionen hög för att sen avta med mängden trafik. Efter 1–3 veckor nåddes det lägsta värdet och därefter ökade eller stabiliserades friktionen. Gemensamt för alla undersökta sträckor var att det sker stora förändringar i texturnivåerna från att det första fordonet trafikerar vägen och därefter är den starkaste tendensen en sjunkande texturnivå tills en stabil nivå uppnås efter 1–3 veckor.
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| 12. |
- Asplund, Maria, 1978-, et al.
(författare)
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Biocompatibility of PEDOT/biomolecular composites intended for neural communication electrodes
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Annan publikation (populärvet., debatt m.m.)abstract
- Electrodes of the conjugated polymer poly(3,4-ethylene dioxythiophene) (PEDOT) have been shown to possess very attractive electrochemical properties for functional electrical stimulation (FES) or recording in the nervous system. Biomolecules already present in nervous tissue, added as counter ions in PEDOT electropolymerisation, could be a route to further improve the biomaterial properties of PEDOT, eliminating the need of surfactant counter ions like docedyl benzene sulphonate (DBS) or polystyrene sulphonate (PSS) in the polymerisation process. Such PEDOT/biomolecular composites using heparin, or hyaluronic acid, have been electrochemically investigated in a previous study and have been shown to retain the attractive electrochemical properties already proven for PEDOT:PSS. The aim of the present study is to evaluate biocompatibility of these PEDOT/biomolecular composites in vitro and also evaluate PEDOT:heparin biocompatibility in cortical tissue in vivo. Hereby, we also aim to identify a suitable test protocol, that can be used in future evaluations when further material developments are made. Material toxicity was first tested on cell lines, both through a standardised agarose overlay assay on L929 fibroblasts, and through elution tests on human neuroblastoma SH-SY5Y cells. Subsequently, a biocompatibility in vivo test was performed using PEDOT:heparin coated platinum probes implanted in the cerebral cortex of Sprague-Dawley rats. Tissue was collected at three weeks and six weeks of implantation and evaluated by immunohistochemistry. No cytotoxic response was seen to any of the PEDOT:biomolecular composites tested here. Furthermore, elution tests were found to be a practical and effective way of screening materials for toxicity and had a clear advantage over the agarose overlay assay, which was difficult to apply on other cell types than fibroblasts. Elution tests would therefore be recommendable as a screening method, at all stages of material development. In the in vivo tests, the stiffness of the platinum substrate was a significant problem, and extensive glial scarring was seen in most cases irrespective of implant material. However, quantification of immunological response through distance measurements from implant site to closest neuron, and counting of macrophage densities in proximity to polymer surface, was comparable to those of platinum controls. These results indicate that PEDOT:heparin surfaces were as compatible with cortical tissue as pure platinum controls.
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| 13. |
- Asplund, M, et al.
(författare)
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Toxicity evaluation of PEDOT/biomolecular composites intended for neural communication electrodes
- 2009
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Ingår i: BIOMEDICAL MATERIALS. - : IOP Publishing. - 1748-6041 .- 1748-605X. ; 4:4, s. 045009-
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Tidskriftsartikel (refereegranskat)abstract
- Electrodes coated with the conducting polymer poly(3,4-ethylene dioxythiophene) (PEDOT) possess attractive electrochemical properties for stimulation or recording in the nervous system. Biomolecules, added as counter ions in electropolymerization, could further improve the biomaterial properties, eliminating the need for surfactant counter ions in the process. Such PEDOT/biomolecular composites, using heparin or hyaluronic acid, have previously been investigated electrochemically. In the present study, their biocompatibility is evaluated. An agarose overlay assay using L929 fibroblasts, and elution and direct contact tests on human neuroblastoma SH-SY5Y cells are applied to investigate cytotoxicity in vitro. PEDOT: heparin was further evaluated in vivo through polymer-coated implants in rodent cortex. No cytotoxic response was seen to any of the PEDOT materials tested. The examination of cortical tissue exposed to polymer-coated implants showed extensive glial scarring irrespective of implant material (Pt:polymer or Pt). However, quantification of immunological response, through distance measurements from implant site to closest neuron and counting of ED1+ cell density around implant, was comparable to those of platinum controls. These results indicate that PEDOT: heparin surfaces were non-cytotoxic and show no marked difference in immunological response in cortical tissue compared to pure platinum controls.
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| 14. |
- Bergman, Lars R, et al.
(författare)
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Perspectives on determinants of social welfare.
- 2006
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Ingår i: International Journal of Social Welfare. ; :15, s. 1-52
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Tidskriftsartikel (refereegranskat)abstract
- This special issue of International Journal of Social Welfare deals with sociological and psychological perspectives on determinants of social welfare to which invited leading researchers in psychology, sociology, social policy, and public health have contributed. In all articles the outcome variables are important factors related to social welfare and psychological or sociological factors are trated as explanatory variables. In the introduction, Lars Bergman and Olle Lundberg overview the issues and contents of the issue. The article by Johannes Siegrist deals with quality of work and health, partly from a sociological perspective. S.V. Subramanian and Ichiro Kawachi study the importance of income for health and they develop a typology of income-health relationships. Income is regarded at both the individual and community level and the importance of a multilevel framework is emphasized.The article by Daiva Daukantaite and Rita Zukauskiene deals with Swedish and Lithuanian women's subjective well-being and Alexander von Eye and Anne Bogat report on mental health in women experiencing intimate partner violence. Ulf Lundberg in his article describes the main physiological stress responses and analyze under which conditions these responses promote or damage health and he also discusses how objective and subjective health are related. Finally, Lars Bergman and Olle Lundberg provide a commentary on the issues raised by the articles.
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| 15. |
- Bergqvist, Kersti, et al.
(författare)
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Understanding the role of welfare state characteristics for health and inequalities - an analytical review
- 2013
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Ingår i: BMC Public Health. - : Springer Science and Business Media LLC. - 1471-2458. ; 13, s. 1234-
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Forskningsöversikt (refereegranskat)abstract
- Background: The past decade has witnessed a growing body of research on welfare state characteristics and health inequalities but the picture is, despite this, inconsistent. We aim to review this research by focusing on theoretical and methodological differences between studies that at least in part may lead to these mixed findings. Methods: Three reviews and relevant bibliographies were manually explored in order to find studies for the review. Related articles were searched for in PubMed, Web of Science and Google Scholar. Database searches were done in PubMed and Web of Science. The search period was restricted to 2005-01-01 to 2013-02-28. Fifty-four studies met the inclusion criteria. Results: Three main approaches to comparative welfare state research are identified; the Regime approach, the Institutional approach, and the Expenditure approach. The Regime approach is the most common and regardless of the empirical regime theory employed and the amendments made to these, results are diverse and contradictory. When stratifying studies according to other features, not much added clarity is achieved. The Institutional approach shows more consistent results; generous policies and benefits seem to be associated with health in a positive way for all people in a population, not only those who are directly affected or targeted. The Expenditure approach finds that social and health spending is associated with increased levels of health and smaller health inequalities in one way or another but the studies are few in numbers making it somewhat difficult to get coherent results. Conclusions: Based on earlier reviews and our results we suggest that future research should focus less on welfare regimes and health inequalities and more on a multitude of different types of studies, including larger analyses of social spending and social rights in various policy areas and how these are linked to health in different social strata. But, we also need more detailed evaluation of specific programmes or interventions, as well as more qualitative analyses of the experiences of different types of policies among the people and families that need to draw on the collective resources.
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| 16. |
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| 17. |
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| 18. |
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| 19. |
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| 20. |
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| 21. |
- Brønnum-Hansen, Henrik, et al.
(författare)
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Changes in life expectancy and lifespan variability by income quartiles in four Nordic countries : a study based on nationwide register data
- 2021
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Ingår i: BMJ Open. - : BMJ. - 2044-6055. ; 11:6
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Tidskriftsartikel (refereegranskat)abstract
- Objectives Levels, trends or changes in socioeconomic mortality differentials are typically described in terms of means, for example, life expectancies, but studies have suggested that there also are systematic social disparities in the dispersion around those means, in other words there are inequalities in lifespan variation. This study investigates changes in income inequalities in mean and distributional measures of mortality in Denmark, Finland, Norway, and Sweden over two decades.Design Nationwide register-based study.Setting The Danish, Finnish, Norwegian and Swedish populations aged 30 years or over in 1997 and 2017.Main outcome measures Income-specific changes in life expectancy, lifespan variation and the contribution of 'early' and 'late' deaths to increasing life expectancy.Results Increases in life expectancy has taken place in all four countries, but there are systematic differences across income groups. In general, the largest gains in life expectancy were observed in Denmark, and the smallest increase among low-income women in Sweden and Norway. Overall, life expectancy increased and lifespan variation decreased with increasing income level. These differences grew larger over time. In all countries, a marked postponement of early deaths led to a compression of mortality in the top three income quartiles for both genders. This did not occur for the lowest income quartile.Conclusion Increasing life expectancy is typically accompanied by postponement of early deaths and reduction of lifespan inequality in the higher-income groups. However, Nordic welfare societies are challenged by the fact that postponing premature deaths among people in the lowest-income groups is not taking place.
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| 22. |
- Casas, Rosaura, 1954-, et al.
(författare)
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Impaired maturation of monocyte-derived dendritic cells from birch allergic individuals in association with birch-specific immune responses
- 2007
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Ingår i: Scandinavian Journal of Immunology. - : Wiley. - 0300-9475 .- 1365-3083. ; 66:5, s. 591-598
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Tidskriftsartikel (refereegranskat)abstract
- Optimal activation of T lymphocytes requires a costimulatory signal provided by the interaction of molecules on the surface of T cells with their ligands expressed on dendritic cells (DC). We investigated whether DC differentiated from monocytes from healthy and birch allergic asthmatic individuals and further maturated by stimulation with cat and birch allergens and LPS differ in their phenotypic receptor expression. Similar expression of DC surface markers, including HLA-DR, CD80, CD86, CD83, CD1a and CD11c, was detected in monocyte-derived DC from allergic and healthy individuals. Cells from healthy donors stimulated either antigen showed a similar activation of the CD80 and double CD80/CD86 costimulatory molecules when compared with non-stimulated cells. In the case of cells from allergic individuals, birch allergen was unable to produce the same increased expression of CD80 alone or in combination with CD80/CD86, in comparison with cells stimulated with cat and LPS. Levels of IL-6, IL-8, IL-10, MCP-1/MCAF and MIP-1β were similar in the supernatant of non-stimulated DC from both groups of subjects. By contrast, the spontaneous secretion of IL-12p70 and TNF-α was higher in the supernatant of DC from healthy subjects when compared with that from allergic individuals. Stimulation with birch and LPS resulted in an increased secretion of IL-12p70 in samples from healthy when compared with that in allergic individuals. The results suggest an impaired specific maturation of DC from birch allergic individuals in association with birch-specific immune responses. Lower secretion of IL-12p70 from birch-stimulated DC from allergic individuals suggests that not only maturation, but also the specific Th1 function of these cells seems to be affected in those individuals.
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| 23. |
- Crona, Filip, 1977-, et al.
(författare)
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Gene regulation by the lysine demethylase KDM4A in Drosophila
- 2013
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Ingår i: Developmental Biology. - : Elsevier BV. - 0012-1606 .- 1095-564X. ; 373:2, s. 453-463
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Tidskriftsartikel (refereegranskat)abstract
- Lysine methylation of histones is associated with both transcriptionally active chromatin and with silent chromatin, depending on what residue is modified. Histone methyltransferases and demethylases ensure that histone methylations are dynamic and can vary depending on cell cycle- or developmental stage. KDM4A demethylates H3K36me3, a modification enriched in the 3' end of active genes. The genomic targets and the role of KDM4 proteins in development remain largely unknown. We therefore generated KDM4A mutant Drosophila, and identified 99 mis-regulated genes in first instar larvae. Around half of these genes were down-regulated and the other half up-regulated in dKDM4A mutants. Although heterochromatin protein 1a (HP1a) can stimulate dKDM4A demethylase activity in vitro, we find that they antagonize each other in control of dKDM4A-regulated genes. Appropriate expression levels for some dKDM4A-regulated genes rely on the demethylase activity of dKDM4A, whereas others do not. Surprisingly, although highly expressed, many demethylase-dependent and independent genes are devoid of H3K36me3 in wild-type as well as in dKDM4A mutant larvae, suggesting that some of the most strongly affected genes in dKDM4A mutant animals are not regulated by H3K36 methylation. By contrast, dKDM4A over-expression results in a global decrease in H3K36me3 levels and male lethality, which might be caused by impaired dosage compensation. Our results show that a modest increase in global H3K36me3 levels is compatible with viability, fertility, and the expression of most genes, whereas decreased H3K36me3 levels are detrimental in males.
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| 24. |
- Currie, Andrew, et al.
(författare)
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The Impact of Enhanced Recovery Protocol Compliance on Elective Colorectal Cancer Resection Results From an International Registry
- 2015
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Ingår i: Annals of Surgery. - : Lippincott Williams & Wilkins. - 0003-4932 .- 1528-1140. ; 261:6, s. 1153-1159
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Tidskriftsartikel (refereegranskat)abstract
- Background: The ERAS (enhanced recovery after surgery) care has been shown in randomized clinical trials to improve outcome after colorectal surgery compared to traditional care. The impact of different levels of compliance and specific elements, particularly out with a trial setting, is poorly understood.Objective: This study evaluated the individual impact of specific patient factors and perioperative enhanced recovery protocol compliance on postoperative outcome after elective primary colorectal cancer resection.Methods: The international, multicenter ERAS registry data, collected between November 2008 and March 2013, was reviewed. Patient demographics, disease characteristics, and perioperative ERAS protocol compliance were assessed. Linear regression was undertaken for primary admission duration and logistic regression for the development of any postoperative complication.Findings: A total of 1509 colonic and 843 rectal resections were undertaken in 13 centers from 6 countries. Median length of stay for colorectal resections was 6 days, with readmissions in 216 (9.2%), complications in 948 (40%), and reoperation in 167 (7.1%) of 2352 patients. Laparoscopic surgery was associated with reduced complications [odds ratio (OR) = 0.68; P < 0.001] and length of stay (OR = 0.83, P < 0.001). Increasing ERAS compliance was correlated with fewer complications (OR = 0.69, P < 0.001) and shorter primary hospital admission (OR = 0.88, P < 0.001). Shorter hospital stay was associated with preoperative carbohydrate and fluid loading (OR = 0.89, P = 0.001), and totally intravenous anesthesia (OR= 0.86, P < 0.001); longer stay was associated with intraoperative epidural analgesia (OR = 1.07, P = 0.019). Reduced postoperative complications were associated with restrictive perioperative intravenous fluids (OR = 0.35, P < 0.001).Conclusions: This analysis has demonstrated that in a large, international cohort of patients, increasing compliance with an ERAS program and the use of laparoscopic surgery independently improve outcome.
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| 25. |
- Dittrich, Yvonne, et al.
(författare)
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Design for Change
- 2001
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The report summarises the first year of the research project 'Design for Design in Use of Database Applications'. It focuses on end user tailoring and adaptable systems.
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