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- Gumz, Michelle L, et al.
(författare)
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Toward Precision Medicine : Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension - 2021 NHLBI Workshop Report
- 2023
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Ingår i: Hypertension. - : Wolters Kluwer. - 0194-911X .- 1524-4563. ; 80:3, s. 503-522
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Tidskriftsartikel (refereegranskat)abstract
- Healthy individuals exhibit blood pressure variation over a 24-hour period with higher blood pressure during wakefulness and lower blood pressure during sleep. Loss or disruption of the blood pressure circadian rhythm has been linked to adverse health outcomes, for example, cardiovascular disease, dementia, and chronic kidney disease. However, the current diagnostic and therapeutic approaches lack sufficient attention to the circadian rhythmicity of blood pressure. Sleep patterns, hormone release, eating habits, digestion, body temperature, renal and cardiovascular function, and other important host functions as well as gut microbiota exhibit circadian rhythms, and influence circadian rhythms of blood pressure. Potential benefits of nonpharmacologic interventions such as meal timing, and pharmacologic chronotherapeutic interventions, such as the bedtime administration of antihypertensive medications, have recently been suggested in some studies. However, the mechanisms underlying circadian rhythm-mediated blood pressure regulation and the efficacy of chronotherapy in hypertension remain unclear. This review summarizes the results of the National Heart, Lung, and Blood Institute workshop convened on October 27 to 29, 2021 to assess knowledge gaps and research opportunities in the study of circadian rhythm of blood pressure and chronotherapy for hypertension.
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| 3. |
- Kalvius, G. M., et al.
(författare)
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Magnetism of Pd1-xNix alloys near the critical concentration for ferromagnetism
- 2014
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Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 89:6, s. 064418-
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Tidskriftsartikel (refereegranskat)abstract
- We report results of a muon spin rotation and relaxation (mu SR) study of dilute Pd1-xNix alloys, with emphasis on Ni concentrations x = 0.0243 and 0.025. These are close to the critical value x(cr) for the onset of ferromagnetic long-range order (LRO), which is a candidate for a quantum critical point. Additional control data were taken for pure nonmagnetic Pd, and for an alloy where ferromagnetism is well established (x = 0.05). The 2.43 and 2.5 at.% Ni alloys exhibit similar mu SR properties. Both samples are fully magnetic, with average zero-temperature muon local fields < B-loc(T = 0)> = 2.0 and 3.8 mT and Curie temperatures T-C = 1.0 and 2.03 K for 2.43 and 2.5 at.% Ni, respectively. The temperature dependence of < B-loc > suggests ordering of Ni spin clusters rather than isolated spins. Just above T-C, the temperature where LRO vanishes, a two-phase region is found with coexisting separate volume fractions of quasistatic short-range order (SRO) and paramagnetism. The SRO fraction decreases to zero with increasing temperature a few kelvin above T-C. This mixture of SRO and paramagnetism is consistent with the notion of an inhomogeneous alloy with Ni clustering. The measured values of T-C extrapolate to x(cr) = 0.0236 +/- 0.0027. The dynamic muon spin relaxation in the vicinity of T-C differs for the two samples: a relaxation-rate maximum at T-C is observed for x = 0.0243, reminiscent of critical slowing down, whereas for x = 0.025 no dynamic relaxation is observed within the mu SR time window. The data suggest a mean-field-like transition in this alloy.
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