| 1. |
- Adam, A, et al.
(författare)
-
Abstracts from Hydrocephalus 2016.
- 2017
-
Ingår i: Fluids and Barriers of the CNS. - : Springer Science and Business Media LLC. - 2045-8118. ; 14:Suppl 1
-
Tidskriftsartikel (refereegranskat)
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
- Villa, Luisa L., et al.
(författare)
-
Immunologic responses following administration of a vaccine targeting human papillomavirus Types 6, 11, 16, and 18
- 2006
-
Ingår i: Vaccine. - : Elsevier BV. - 1873-2518 .- 0264-410X. ; 24:27-28, s. 5571-5583
-
Tidskriftsartikel (refereegranskat)abstract
- Human papillomavirus (HPV) infection causes cervical cancer and genital warts. Young women (1106) were randomized to receive one of three formulations of a quadrivalent HPV (Types 6/11/16/18) L1 virus-like particle (VLP) vaccine or one of two placebo formulations. The goal was to assess vaccine safety and immunogenicity in baseline HPV 6/11/16 or 18-naive and previously infected subjects. All three formulations were highly immunogenic. At Month 2 (postdose 1), among women with vaccine-type antibodies at baseline, vaccine-induced anti-HPV responses were similar to 12- to 26-fold higher than those observed in baseline-naive women, suggesting an anamnestic response. Following an initial, similar sized decline, anti-HPV responses plateaued and remained stable through end-of-study (3.0 years). No vaccine-related serious adverse experiences were reported. (c) 2006 Elsevier Ltd. All rights reserved.
|
|
| 8. |
|
|
| 9. |
- Jansson, U, et al.
(författare)
-
Low temperature epitaxial growth of metal carbides using fullerenes
- 2001
-
Ingår i: Surface & Coatings Technology. - 0257-8972 .- 1879-3347. ; 142-144, s. 817-822
-
Tidskriftsartikel (refereegranskat)abstract
- Epitaxial transition metal carbides can be deposited at low temperatures by simultaneous evaporation of C60 and either metal e-beam evaporation or metal d.c. magnetron sputtering. Hitherto, epitaxial films of TiC, VC, NbC, MoC, W2C and WC have been deposited on MgO(100), MgO(111) and in some cases 6H- and 4H-SiC(0001). Epitaxial TiC films with a good quality have been deposited at temperatures as low as 100°C with metal sputtering, while somewhat higher temperatures (> 200°C) are required for the other metals. In general, the plasma-assisted process allows lower deposition temperatures than the co-evaporation process. Most carbides can be deposited in a wide range of compositions within their homogeneity ranges by a fine-tuning of the Me/C60 flux. However, the results suggest that the formation of free surface carbon can be a limiting factor. The processes have also been used to deposit superlattices of TiC/NbC and TiC/VC at 400-500°C as well as epitaxial ternary Tix V1-xCy films. Furthermore, epitaxial films of ternary carbides with well-controlled metal concentration profiles can be deposited at temperatures below 500°C. © 2001 Elsevier Science B.V. All rights reserved.
|
|
| 10. |
- Prentice, Honor C, et al.
(författare)
-
Allozyme and chloroplast DNA variation in island and mainland populations of the rare Spanish endemic, Silene hifacensis (Caryophyllaceae)
- 2003
-
Ingår i: Conservation Genetics. - 1566-0621. ; 4:5, s. 543-555
-
Tidskriftsartikel (refereegranskat)abstract
- Silene hifacensis is a narrowly endemic plant, restricted to a few small populations on limestone cliffs in the Spanish province of Alicante and on the Balearic island of Ibiza. The species was collected to extinction in its original mainland location by the early 20th century. Attempts have been made to reintroduce S. hifacensis to this area but conservation efforts are limited by a lack of information on the geographic structure of genetic variation in the species. We used nuclear (allozyme) and chloroplast DNA (cpDNA) PCR/RFLP markers to investigate the structure of genetic variation in 2 mainland and 6 Ibizan populations. Levels of allozyme variation were low, with a mean of 2 alleles per polymorphic locus. Mean (over polymorphic loci) total allozyme diversity (H-tot) was 0.203 and mean within-population diversity (H-pop) was 0.085. Most diversity was explained by the between-population diversity component (G(pop).reg = 57%). Both mainland populations showed allozyme fixation. Three composite cpDNA haplotypes were identified. The first is unique to a mainland population that is also allozymically distinct from all the other populations. The second haplotype is found in the other mainland population and one Ibizan population: these two populations are allozymically identical. The remaining Ibizan populations contain the third haplotype. The geographic distribution of allozymes and cpDNA haplotypes is discussed in terms of population history, dispersal and, speculatively, in terms of the possibility that there has been undocumented translocation of material between populations.
|
|
| 11. |
|
|
| 12. |
- Turesson, Ingemar, et al.
(författare)
-
Intensive chemotherapy in patients with chronic myelogenous leukaemia (CML) in accelerated or blastic phase - a report from the Swedish CML Group
- 2002
-
Ingår i: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 118, s. 1048-
-
Tidskriftsartikel (refereegranskat)abstract
- In attempting to restore the chronic phase (CP) of chronic myelogenous leukaemia (CML), the Swedish CML group utilized an intensive chemotherapy protocol for 83 patients (aged 16-79 years) in accelerated (AP, n = 22) or blastic phase (BC, n = 61). Most patients received a combination of mitoxantrone (12 mg/m(2) /d) and etoposide (100 mg/m(2) /d) together with cytosine arabinoside (1 g/m(2) b.i.d) for 4 d. Overall, 39 patients (47%) achieved a second CP (CP2)/partial remission (PR). Responding patients < 65 years were eligible for ablative chemotherapy followed by an allogeneic (SCT) or a double autologous stem cell transplant (ASCT). Seventeen of 34 responders < 65 years failed to proceed to transplantation as a result of early disease progression (n = 15) or disease-related complications (n = 2). The remaining 17 patients underwent SCT (n = 9; including four unrelated donor SCT) or ASCT (n = 8). Only one of the eight ASCT patients had a second ASCT; the remaining seven failed because of progression (n = 5) or hypoplasia (n = 2). The median duration of CP2/PR was 6 months (range 1-72 months). Five patients achieved a longer CP2/PR than CP1. The 1 year survival was 70% for SCT/ASCT patients (median survival 21 months), 50% for responding patients overall, but only 7% for non-responders (P < 0.001). Three SCT/ASCT patients are long-term survivors (65+, 66+ and 73+ months). In conclusion, approximately half of the patients achieved a CP2/PR after intensive chemotherapy, with a clear survival advantage for responders vs non-responders. Subsequent SCT/ASCT was feasible for half of the responders (< 65 years), and one individual underwent double ASCT. Novel therapeutic options for CML patients in AP/BP are needed.
|
|
| 13. |
|
|
| 14. |
|
|
| 15. |
- Frohm, Birgitta, et al.
(författare)
-
A peptide from human semenogelin I self-assembles into a pH-responsive hydrogel.
- 2015
-
Ingår i: Soft Matter. - : Royal Society of Chemistry (RSC). - 1744-6848 .- 1744-683X. ; 11:2, s. 414-421
-
Tidskriftsartikel (refereegranskat)abstract
- The peptide GSFSIQYTYHV derived from human semenogelin I forms a transparent hydrogel through spontaneous self-assembly in water at neutral pH. Linear rheology measurements demonstrate that the gel shows a dominating elastic response over a large frequency interval. CD, fluorescence and FTIR spectroscopy and cryo-TEM studies imply long fibrillar aggregates of extended β-sheet. Dynamic light scattering data indicate that the fibril lengths are of the order of micrometers. Time-dependent thioflavin T fluorescence shows that fibril formation by GSFSIQYTYHV is a nucleated reaction. The peptide may serve as basis for development of smart biomaterials of low immunogenicity suitable for biomedical applications, including drug delivery and wound healing.
|
|
| 16. |
|
|
| 17. |
|
|
| 18. |
- Malm, Carl Johan, et al.
(författare)
-
Dual or single antiplatelet therapy after coronary surgery for acute coronary syndrome (TACSI trial): Rationale and design of an investigator-initiated, prospective, multinational, registry-based randomized clinical trial
- 2023
-
Ingår i: American Heart Journal. - : Elsevier BV. - 0002-8703 .- 1097-6744. ; 259, s. 1-8
-
Tidskriftsartikel (refereegranskat)abstract
- The TACSI trial (ClinicalTrials.gov Identifier: NCT03560310) tests the hypothesis that 1-year treatment with dual antiplatelet therapy with acetylsalicylic acid (ASA) and ticagrelor is superior to only ASA after isolated coronary artery bypass grafting (CABG) in patients with acute coronary syndrome. The TACSI trial is an investor-initiated pragmatic, prospective, multinational, multicenter, open-label, registry-based randomized trial with 1:1 randomization to dual antiplatelet therapy with ASA and ticagrelor or ASA only, in patients undergoing first isolated CABG, with a planned enrollment of 2200 patients at Nordic cardiac surgery centers. The primary efficacy end point is a composite of time to all-cause death, myocardial infarction, stroke, or new coronary revascularization within 12 months after randomization. The primary safety end point is time to hospitalization due to major bleeding. Secondary efficacy end points include time to the individual components of the primary end point, cardiovascular death, and rehospitalization due to cardiovascular causes. High-quality health care registries are used to assess primary and secondary end points. The patients will be followed for 10 years. The TACSI trial will give important information useful for guiding the antiplatelet strategy in acute coronary syndrome patients treated with CABG.
|
|
| 19. |
|
|
| 20. |
|
|
| 21. |
- Malm, J U, et al.
(författare)
-
Chloroplast DNA haplotypes in Nordic Silene dioica: postglacial immigration from the east and the south
- 2005
-
Ingår i: Plant Systematics and Evolution. - : Springer Science and Business Media LLC. - 1615-6110 .- 0378-2697. ; 250:1-2, s. 27-38
-
Tidskriftsartikel (refereegranskat)abstract
- Analysis of PCR/RFLP variation in 57 Nordic populations of the herb Silene dioica, revealed 13 composite chloroplast DNA (cpDNA) haplotypes. The geographic distribution of the haplotypes suggests that the postglacial colonization of Fennoscandia by S. dioica may have involved immigration of populations from two main directions. The commonest cpDNA haplotype dominates in populations throughout most of Finland and northern and central Sweden, but is absent from southern Sweden. The distribution of this haplotype is interpreted in terms of immigration from an eastern or northern direction. In contrast, eight haplotypes that are absent from northern Fennoscandia are represented in populations in southern Sweden and in Denmark, suggesting colonization by populations derived from one or several refugial areas further to the south in Europe. The overall NE-SW pattern of cpDNA haplotype variation is similar to, but less diffuse than, the pattern revealed by allozyme markers.
|
|
| 22. |
- Malm, J U, et al.
(författare)
-
Immigration history and gene dispersal: allozyme variation in Nordic populations of the red campion, Silene dioica (Caryophyllaceae)
- 2002
-
Ingår i: Biological Journal of the Linnean Society. - : Oxford University Press (OUP). - 0024-4066 .- 1095-8312. ; 77:1, s. 23-34
-
Tidskriftsartikel (refereegranskat)abstract
- Most of the Nordic region was ice-covered during the last (Weichselian) glaciation. During the postglacial period, plant and animal species recolonized the region from several directions and the geographic structuring of genetic variation within Nordic species may still contain a historic component that reflects patterns of postglacial immigration. The present investigation of 69 populations of Silene dioica represents the first large-scale allozyme study of a widespread herbaceous plant in the Nordic region. Although the frequencies of individual alleles showed a range of different geographic patterns, mapping of the axis scores from an ordination of variation at eight polymorphic loci revealed a division into two main geographic groups of populations. The broadly south-western and northeastern distributions of these two groups of populations suggest that immigration into the region may have involved both eastern and southern geographic sources. However, the geographic boundaries between the two groups of populations are diffuse, and the relatively low between-population component of genetic diversity (G(ST) = 16.4%) suggests a history of extensive gene dispersal by pollen. (C) 2002 The Linnean Society of London, Biological Journal of the Linnean Society, 2002, 77, 23-34.
|
|
| 23. |
|
|
| 24. |
|
|
