| 1. |
- Albert, Damien, et al.
(författare)
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A Decade with VAMDC : Results and Ambitions
- 2020
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Ingår i: Atoms. - : MDPI. - 2218-2004. ; 8:4
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents an overview of the current status of the Virtual Atomic and Molecular Data Centre (VAMDC) e-infrastructure, including the current status of the VAMDC-connected (or to be connected) databases, updates on the latest technological development within the infrastructure and a presentation of some application tools that make use of the VAMDC e-infrastructure. We analyse the past 10 years of VAMDC development and operation, and assess their impact both on the field of atomic and molecular (A&M) physics itself and on heterogeneous data management in international cooperation. The highly sophisticated VAMDC infrastructure and the related databases developed over this long term make them a perfect resource of sustainable data for future applications in many fields of research. However, we also discuss the current limitations that prevent VAMDC from becoming the main publishing platform and the main source of A&M data for user communities, and present possible solutions under investigation by the consortium. Several user application examples are presented, illustrating the benefits of VAMDC in current research applications, which often need the A&M data from more than one database. Finally, we present our vision for the future of VAMDC.
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| 2. |
- Bergvall, Nils, et al.
(författare)
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Local starburst galaxies and their descendants Statistics from the Sloan Digital Sky Survey
- 2016
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 587
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Tidskriftsartikel (refereegranskat)abstract
- Aims. Despite strong interest in the starburst phenomenon in extragalactic astronomy, the concept remains ill-defined. Here we use a strict definition of starburst to examine the statistical properties of starburst galaxies in the local universe. We also seek to establish links between starburst galaxies, post-starburst (hereafter postburst) galaxies, and active galaxies.Methods. Data were selected from the Sloan Digital Sky Survey DR7. We applied a novel method of treating dust attenuation and derive star formation rates, ages, and stellar masses assuming a two-component stellar population model. Dynamical masses are calculated from the width of the H alpha line. These masses agree excellently with the photometric masses. The mass (gas + stars) range is similar to 10(9)-10(11.5) M-circle dot. As a selection criterion for starburst galaxies, we use, the birthrate parameter, b = SFR/< SFR >, requiring that b >= 3. For postburst galaxies, we use, the equivalent width of H delta in absorption with the criterion EWH delta,abs >= 6 angstrom.Results. We find that only 1% of star-forming galaxies are starburst galaxies. They contribute 3 6% to the stellar production and are therefore unimportant for the local star formation activity. The median starburst age is 70 Myr roughly independent of mass, indicating that star formation is mainly regulated by local feedback processes. The b-parameter strongly depends on burst age. Values close to b = 60 are found at ages similar to 10 Myr, while almost no starbursts are found at ages >1 Gyr. The median baryonic burst mass fraction of sub-L* galaxies is 5% and decreases slowly towards high masses. The median mass fraction of the recent burst in the postburst sample is 5-10%. A smaller fraction of the postburst galaxies, however, originates in non-bursting galaxies. The age-mass distribution of the postburst progenitors (with mass fractions >3%) is bimodal with a break at log M (M-circle dot) similar to 10.6, above which the ages are doubled. The starburst and postburst luminosity functions (LFs) follow each other closely until M-r similar to -21, when active galactic nuclei (AGNs) begin to dominate. The postburst LF continues to follow the AGN LF, while starbursts become less significant. This suggests that the number of luminous starbursts is underestimated by about one dex at high luminosities, because of having large amounts of dust and/or being outshone by an AGN. It also indicates that the starburst phase preceded the AGN phase. Finally, we look at the conditions for global gas outflow caused by stellar feedback and find that massive starburst galaxies are susceptible to such outflows.
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| 3. |
- Bergvall, Nils, et al.
(författare)
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Lyman continuum leaking galaxies : search strategies and local candidates
- 2013
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 554
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Tidskriftsartikel (refereegranskat)abstract
- Context. Star-forming dwarf galaxies may have played an important role in the reionization of the Universe, provided that some fraction of their ionizing radiation were able to escape into the intergalactic medium. Local galaxies exhibiting such Lyman-continuum (LyC) leakage could potentially shed light on the escape mechanisms involved, but only two low-redshift cases of LyC leakage have been identified so far. Here, we argue that this meager harvest may be caused by unsuitable selection criteria. Candidates for LyC leakage are normally selected by indicators of starburst activity, one of which is a high equivalent width in H alpha. Such a criterion will guarantee a high production of LyC photons but will also bias the selection in favour of a high column density in the neutral gas, effectively ruling out LyC escape. Aims. In this work we want to investigate whether the lack of local LyC emitters can be caused in part by biased selection criteria, and we present a novel method of selecting targets with high escape fractions. By applying these criteria, we assemble a sample of observation targets to study their basic properties. Methods. We introduce a new selection strategy here where the potential LyC leakers are selected by their blue colours and weak emission lines. The selection is based on data from the Sloan Digital Sky Survey (SDSS). We also take a closer look at the properties of 8 LyC leaking candidates at z similar to 0.03 which we have observed with ESO/NTT in broadband B and H alpha. Results. We find that 7 of the 8 target galaxies are involved in interaction with neighbours or show signs of mergers. In 7 cases the young stellar population is clearly displaced relative to the main body of these galaxies, often directly bordering the halo region. In about half of our targets the absorption spectra show young post-starburst signatures. Comparing the scale lengths in H alpha with those of the stellar continua shows that the scale lengths in H alpha typically are 30% smaller, which is characteristic of galaxies influenced by ram pressure stripping. We tentatively identify a few mechanisms that could improve the conditions for leakage: 1) the combined effects of ram pressure stripping with supernova winds from young stars formed in the front, 2) merger events that increase the star formation rate and displace stars from gas, 3) starbursts in the centres of post-starburst galaxies, whose previous activity has cleared channels for leakage into the intergalactic medium, and 4) a low dust content. Although our target galaxies are rare species in the local universe, we argue that related types could have played a major role in producing ionizing radiation at high redshifts.
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| 4. |
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| 5. |
- Bristow, Paul, et al.
(författare)
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CRIRES+ : Characterisation and preparation during the pandemic
- 2022
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Ingår i: Ground-based and Airborne Instrumentation for Astronomy IX. - : SPIE - International Society for Optical Engineering. - 9781510653504 - 9781510653498
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Konferensbidrag (refereegranskat)abstract
- In early 2020 the upgraded(1) CRIRES2 instrument, was installed at the VLT, however the onset of the global pandemic prevented the completion of some aspects of the installation while characterisation and commissioning had to be conducted with a remote connection from Europe. This resulted in a somewhat experimental, ad-hoc, approach to characterisation that required tight co-ordination between Paranal scientists and the instrument team in Europe. Moreover, with the observatory operating at minimal staffing, we had to find workarounds for some unfinished parts of the installation and adapt our characterisation, calibration and operations strategies accordingly. In particular, we discuss the adaptation made to the metrology strategy that illustrates well the pragmatic and ultimately successful approach adopted for getting CRIRES+ ready for operations.
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| 6. |
- Brucalassi, Anna, et al.
(författare)
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Full System Test and early Preliminary Acceptance Europe results for CRIRES
- 2018
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Ingår i: Ground-Based And Airborne Instrumentation For Astronomy VII. - : SPIE. - 9781510619586
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Konferensbidrag (refereegranskat)abstract
- CRIRES+ is the new high-resolution NIR echelle spectrograph intended to be operated at the platform B of VLT Unit telescope UT3. It will cover from Y to M bands (0.95-5.3um) with a spectral resolution of R = 50000 or R = 100000. The main scientific goals are the search of super-Earths in the habitable zone of low-mass stars, the characterisation of transiting planets atmosphere and the study of the origin and evolution of stellar magnetic fields. Based on the heritage of the old adaptive optics (AO) assisted VLT instrument CRIRES, the new spectrograph will present improved optical layout, a new detector system and a new calibration unit providing optimal performances in terms of simultaneous wavelength coverage and radial velocity accuracy (a few m/s). The total observing efficiency will be enhanced by a factor of 10 with respect to CRIRES. An innovative spectro-polarimetry mode will be also offered and a new metrology system will ensure very high system stability and repeatability. Fiinally, the CRIRES+ project will also provide the community with a new data reduction software (DRS) package. CRIRES+ is currently at the initial phase of its Preliminary Acceptance in Europe (PAE) and it will be commissioned early in 2019 at VLT. This work outlines the main results obtained during the initial phase of the full system test at ESO HQ Garching.
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| 7. |
- Cumming, Robert, 1967, et al.
(författare)
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Stellar dynamics of blue compact galaxies - II. Further indications of a merger in ESO 338-IG04
- 2008
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 479:3, s. 725-733
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Tidskriftsartikel (refereegranskat)abstract
- Context. Luminous blue compact galaxies, common at z similar to 1 but now relatively rare, show disturbed kinematics in emission lines. Aims. As part of a programme to understand their formation and evolution, we have investigated the stellar dynamics of a number of nearby objects in this class. Methods. We obtained long-slit spectra with VLT/FORS2 in the spectral region covering the near-infrared calcium triplet. In this paper we focus on the well-known luminous blue compact galaxy ESO338-IG04 (Tololo 1924 - 416). A previous investigation, using Fabry-Perot interferometry, showed that this galaxy has a chaotic Ha velocity field, indicating that either the galaxy is not in dynamical equilibrium or that Ha does not trace the gravitational potential due to feedback from star formation. Results. Along the apparent major axis, the stellar and ionised gas velocities for the most part follow each other. The chaotic velocity field must therefore be a sign that the young stellar population in ESO338-IG04 is not in dynamical equilibrium. The most likely explanation, which is also supported by its morphology, is that the galaxy has experienced a merger and that this has triggered the current starburst. Summarising the results of our programme so far, we note that emission-line velocity fields are not always reliable tracers of stellar motions, and go on to assess the implications for kinematic studies of similar galaxies at intermediate redshift.
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| 8. |
- Cumming, Robert, et al.
(författare)
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Stellar kinematics in blue compact galaxies
- 2009
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- In a programme of observations of local luminous blue compact galaxies (BCGs), we are investigating kinematics by using tracers of both stars and ionized gas. Here we summarise our program and present new data on the local Lyman break galaxy analogue Haro 11. From spatially-resolved spectroscopy around the near-infrared Ca II triplet, we find that its stars and ionized gas have similar velocity fields. Our programme so far indicates however that emission line velocities can differ locally by a few tens of km/s from the Ca II values. Comparing our data to simple stellar population models, we assess which stellar population the Ca II triplet traces and its potential beyond the local universe.
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| 9. |
- Di Marcantonio, P., et al.
(författare)
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ELT High Resolution Spectrograph : Phase-A software architecture study
- 2018
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Ingår i: SOFTWARE AND CYBERINFRASTRUCTURE FOR ASTRONOMY V. - : SPIE-INT SOC OPTICAL ENGINEERING. - 9781510619685
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Konferensbidrag (refereegranskat)abstract
- High resolution spectroscopy has been considered of a primary importance to exploit the main scientific cases foreseen for ESO ELT, the Extremely Large Telescope, the future largest optical-infrared telescope in the world. In this context ESO commissioned a Phase-A feasibility study for the construction of a high resolution spectrograph for the ELT, tentatively named HIRES. The study, which lasted 1.5 years, started on March 2016 and was completed with a review phase held at Garching ESO headquarters with the aim to assess the scientific and technical feasibility of the proposed instrument. One of the main tasks of the study is the architectural design of the software covering all the aspects relevant to control an astronomical instrument: from observation preparation through instrument hardware and detectors control till data reduction and analysis. In this paper we present the outcome of the Phase-A study for the proposed HIRES software design highlighting its peculiarities, critical areas and performance aspects for the whole data flow. The End-to-End simulator, a tool already capable of simulating HIRES end products and currently being used to drive some design decision, is also shortly described.
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| 10. |
- Dorn, Reinhold J., et al.
(författare)
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CRIRES+ on sky : High spectral resolution at infrared wavelength enabling better science at the ESO VLT
- 2022
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Ingår i: Ground-Based And Airborne Instrumentation For Astronomy IX. - : SPIE - International Society for Optical Engineering. - 9781510653504 - 9781510653498
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Konferensbidrag (refereegranskat)abstract
- CRIRES+ extended the capabilities of CRIRES, the CRyogenic InfraRed Echelle Spectrograph. It transformed this VLT instrument into a cross-dispersed spectrograph to increase the wavelength range that is covered simultaneously by a factor of ten. In addition, a new detector focal plane array of three Hawaii 2RG detectors with a 5.3 mu m cut-off wavelength replaced the existing detectors. Amongst many other improvements a new spectropolarimetric unit was added and the calibration system has been enhanced. The instrument was installed at the VLT on Unit Telescope 3 beginning of 2020 and successfully commissioned and verified for science operations during 2021, partly remote from Europe due to the pandemic. The instrument was subsequently offered to the community from October 2021 onwards. This article describes the performance and capabilities of this development and presents on sky results.
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| 11. |
- Dorn, R. J., et al.
(författare)
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CRIRES+ on sky at the ESO Very Large Telescope : Observing the Universe at infrared wavelengths and high spectral resolution
- 2023
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 671
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Tidskriftsartikel (refereegranskat)abstract
- The CRyogenic InfraRed Echelle Spectrograph (CRIRES) Upgrade project CRIRES+ extended the capabilities of CRIRES. It transformed this VLT instrument into a cross-dispersed spectrograph to increase the wavelength range that is covered simultaneously by up to a factor of ten. In addition, a new detector focal plane array of three Hawaii 2RG detectors with a 5.3 mu m cutoff wavelength replaced the existing detectors. Amongst many other improvements, a new spectropolarimetric unit was added and the calibration system has been enhanced. The instrument was installed at the VLT on Unit Telescope 3 at the beginning of 2020 and successfully commissioned and verified for science operations during 2021, partly remotely from Europe due to the COVID-19 pandemic. The instrument was subsequently offered to the community from October 2021 onwards. This article describes the performance and capabilities of the upgraded instrument and presents on sky results.
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| 12. |
- Dorn, Reinhold J., et al.
(författare)
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The " plus " for CRIRES : enabling better science at infrared wavelength and high spectral resolution at the ESO VLT
- 2016
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Ingår i: GROUND-BASED AND AIRBORNE INSTRUMENTATION FOR ASTRONOMY VI. - : SPIE. - 9781510601963
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Konferensbidrag (refereegranskat)abstract
- The adaptive optics (AO) assisted CRIRES instrument was a IR (0.92 - 5.2 mu m) high-resolution spectrograph in operation from 2006 to 2014 at the Very Large Telescope (VLT) observatory. CRIRES was a unique instrument, accessing a parameter space (wavelength range and spectral resolution) up to now largely uncharted. It consisted of a single-order spectrograph providing long-slit (40 arcsecond) spectroscopy with a resolving power up to R=100 000. However the setup was limited to a narrow, single-shot, spectral range of about 1/70 of the central wavelength, resulting in low observing efficiency for many scientific programmes requiring a broad spectral coverage. The CRIRES upgrade project, CRIRES, transfouns this VLT instrument into a cross-dispersed spectrograph to increase the simultaneously covered wavelength range by a factor of ten. A new and larger detector focal plane array of three Hawaii 2RG detectors with 5.3 mu m cut-off wavelength will replace the existing detectors. For advanced wavelength calibration, custom-made absorption gas cells and an etalon system will be added. A spectro-polarimetric unit will allow the recording of circular and linear polarized spectra. This upgrade will be supported by dedicated data reduction software allowing the community to take full advantage of the new capabilities. CRIRES has now entered its assembly and integration phase and will return with all new capabilities by the beginning of 2018 to the Very Large Telescope in Chile. This article will provide the reader with an update of the current status of the instrument as well as the remaining steps until final installation at the Paranal Observatory.
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| 13. |
- Dreisig, Karin, et al.
(författare)
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TPMT polymorphisms and minimal residual disease after 6-mercaptopurine post-remission consolidation therapy of childhood acute lymphoblastic leukaemia
- 2021
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Ingår i: Pediatric Hematology and Oncology. - : Informa UK Limited. - 0888-0018 .- 1521-0669. ; 38:3, s. 227-238
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Tidskriftsartikel (refereegranskat)abstract
- © 2020 Taylor & Francis Group, LLC. Bone marrow minimal residual disease (MRD) is the strongest predictor of relapse in children with acute lymphoblastic leukemia (ALL). 6-mercaptopurine (6MP) in ALL therapy has wide inter-individual variation in disposition and is strongly influenced by polymorphisms in the thiopurine methyltransferase (TPMT) gene. In 952 patients treated according to the NOPHO ALL2008 protocol, we explored the association between thiopurine disposition, TPMT genotypes and MRD levels after consolidation therapy with 6MP, high-dose methotrexate (HD-MTX), asparaginase, and vincristine. The levels of the cytotoxic DNA-incorporated thioguanine were significantly higher on day 70-79 in G460A/A719G TPMT heterozygous (TPMT HZ) compared to TPMT wild type (TPMT WT) patients (mean: 230.7 vs. 149.7 fmol/µg DNA, p = 0.002). In contrast, TPMT genotype did not associate with the end of consolidation MRD levels irrespective of randomization of the patients to fixed dose (25 mg/m2/day) or 6MP escalation (up to 50 or 75 mg/m2/day) during consolidation therapy.
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| 14. |
- Dubernet, M. L., et al.
(författare)
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The virtual atomic and molecular data centre (VAMDC) consortium
- 2016
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Ingår i: Journal of Physics B. - : IOP Publishing. - 0953-4075 .- 1361-6455. ; 49:7
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Tidskriftsartikel (refereegranskat)abstract
- The Virtual Atomic and Molecular Data Centre (VAMDC) Consortium is a worldwide consortium which federates atomic and molecular databases through an e-science infrastructure and an organisation to support this activity. About 90% of the inter-connected databases handle data that are used for the interpretation of astronomical spectra and for modelling in many fields of astrophysics. Recently the VAMDC Consortium has connected databases from the radiation damage and the plasma communities, as well as promoting the publication of data from Indian institutes. This paper describes how the VAMDC Consortium is organised for the optimal distribution of atomic and molecular data for scientific research. It is noted that the VAMDC Consortium strongly advocates that authors of research papers using data cite the original experimental and theoretical papers as well as the relevant databases.
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| 15. |
- Follert, Roman, et al.
(författare)
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Characterizing the cross dispersion reflection gratings of CRIRES
- 2016
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Ingår i: Advances In Optical And Mechanical Technologies For Telescopes And Instrumentation Ii. - : SPIE. - 9781510602038 - 9781510602045
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Konferensbidrag (refereegranskat)abstract
- The CRIRES+ project attempts to upgrade the CRIRES instrument into a cross dispersed echelle spectrograph with a simultaneous recording of 8-10 diffraction orders. In order to transform the CRIRES spectrograph into a cross-dispersing instrument, a set of six reflection gratings, each one optimized for one of the wavelength bands CRIRES+ will operate in (YJHKLM), will be used as cross dispersion elements in CRIRES+. Due to the upgrade nature of the project, the choice of gratings depends on the fixed geometry of the instrument. Thus, custom made gratings would be required to achieve the ambitious design goals. Custom made gratings have the disadvantage, though, that they come at an extraordinary price and with lead times of more than 12 months. To mitigate this, a set of off-the-shelf gratings was obtained which had grating parameters very close to the ones being identified as optimal. To ensure that the rigorous specifications for CRIRES+ will be fulfilled, the CRIRES+ team started a collaboration with the Physikalisch-Technische Bundesanstalt Berlin (PTB) to characterize gratings under conditions similar to the operating conditions in CRIRES+ (angle of incidence, wavelength range). The respective test setup was designed in collaboration between PTB and the CRIRES+ consortium. The PTB provided optical radiation sources and calibrated detectors for each wavelength range. With this setup, it is possible to measure the absolute efficiency of the gratings both wavelength dependent and polarization state dependent in a wavelength range from 0.9 mu m to 6 mu m.
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| 16. |
- Follert, R., et al.
(författare)
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CRIRES plus : a cross-dispersed high-resolution infrared spectrograph for the ESO VLT
- 2014
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Ingår i: GROUND-BASED AND AIRBORNE INSTRUMENTATION FOR ASTRONOMY V. - : SPIE. - 9780819496157
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Konferensbidrag (refereegranskat)abstract
- High-resolution infrared spectroscopy plays an important role in astrophysics from the search for exoplanets to cosmology. Yet, many existing infrared spectrographs are limited by a rather small simultaneous wavelength coverage. The AO assisted CRIRES instrument, installed at the ESO VLT on Paranal, is one of the few IR (0.92-5.2 mu m) high-resolution spectrographs in operation since 2006. However it has a limitation that hampers its efficient use: the wavelength range covered in a single exposure is limited to similar to 15 nanometers. The CRIRES Upgrade project (CRIRES+) will transform CRIRES into a cross-dispersed spectrograph and will also add new capabilities. By introducing cross-dispersion elements the simultaneously covered wavelength range will be increased by at least a factor of 10 with respect to the present configuration, while the operational wavelength range will be preserved. For advanced wavelength calibration, new custom made absorption gas cells and etalons will be added. A spectro-polarimetric unit will allow one for the first time to record circularly polarized spectra at the highest spectral resolution. This will be all supported by a new data reduction software which will allow the community to take full advantage of the new capabilities of CRIRES+.
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| 17. |
- Genoni, M., et al.
(författare)
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ELT -HIRES the High Resolution Spectrograph for the ELT : End to End simulator. Design approach and results
- 2018
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Ingår i: MODELING, SYSTEMS ENGINEERING, AND PROJECT MANAGEMENT FOR ASTRONOMY VIII. - : SPIE-INT SOC OPTICAL ENGINEERING. - 9781510619647
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Konferensbidrag (refereegranskat)abstract
- We present the updated design and architecture of the End-to-End simulator model of the high resolution spectrograph HIRES for the future Extremely Large Telescope (ELT). The model allows to simulate the propagation of photons starting from the scientific object of interest up to the detector, allowing to evaluate the performance impact of the different parameters in the spectrograph design. The model also includes a calibration light module, suitable to evaluate data reduction requirements. In this paper, we will detail the architecture of the simulator and the computational model which are strongly characterized by modularity and flexibility that will be crucial in the next generation instrumentation for projects such as the ELT due to of the high complexity and long-time design and development. We also highlight the Cloud Computing Architecture adopted for this software based on Amazon Web Services (AWS). We also present synthetic images obtained with the current version of the End-to-End simulator based on the requirements for ELT-HIRES (especially high radial velocity accuracy) that are then ingested in the Data reduction Software (DRS) of CRIRES+ as case study.
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| 18. |
- Genoni, M., et al.
(författare)
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End to end simulators : a flexible and scalable cloud-based architecture Application to high resolution spectrographs ESPRESSO and ELT-HIRES
- 2020
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Ingår i: Experimental astronomy. - : SPRINGER. - 0922-6435 .- 1572-9508. ; 50:2-3, s. 215-232
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Tidskriftsartikel (refereegranskat)abstract
- Simulations of frames from existing and upcoming high-resolution spectrographs, targeted for high accuracy radial velocity measurements, are computationally demanding (both in time and space). We present in this paper an innovative approach based on both parallelization and distribution of the workload. By using NVIDIA CUDA custom-made kernels and state-of-the-art cloud-computing architectures in a Platform as a Service (PaaS) approach, we implemented a modular and scalable end-to-end simulator that is able to render synthetic frames with an accuracy of the order of few cm/sec, while keeping the computational time low. We applied our approach to two spectrographs. For VLT-ESPRESSO we give a sound comparison between the actual data and the simulations showing the obtained spectral formats and the recovered instrumental profile. We also simulate data for the upcoming HIRES at the ELT and investigate the overall performance in terms of computational time and scalability against the size of the problem. In addition we demonstrate the interface with data-reduction systems and we preliminary show that the data can be reduced successfully by existing methods.
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| 19. |
- Gottschalk Højfeldt, Sofie, et al.
(författare)
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Relapse risk following truncation of PEG-asparaginase in childhood acute lymphoblastic leukemia.
- 2021
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Ingår i: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 137:17, s. 2373-2382
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Tidskriftsartikel (refereegranskat)abstract
- Truncation of asparaginase treatment due to asparaginase related toxicities or silent inactivation (SI) is common and may increase relapse risk in acute lymphoblastic leukemia (ALL). We investigated relapse risk following suboptimal asparaginase exposure among 1401 children aged 1-17 years, diagnosed with ALL between July 2008 and February 2016, and treated according to the NOPHO ALL2008 protocol including extended asparaginase exposure (1,000 IU/m2 intramuscularly weeks 5 to 33). Patients were included with delayed entry at their last administered asparaginase treatment or detection of SI and followed until relapse, death, secondary malignancy, or end of follow-up (median: 5.71 years, interquartile range: 4.02-7.64). In a multiple Cox model comparing patients with (n=358) and without (n=1043) truncated asparaginase treatment due to clinical toxicity, the adjusted relapse-specific hazard ratio (aHR) was 1.33 (95% confidence interval [CI]: 0.86-2.06, P=0.20). In a substudy including only patients with information on enzyme activity (n=1115), the 7-year cumulative incidence of relapse for the 301 patients with truncation of asparaginase treatment or SI (157 hypersensitivity, 53 pancreatitis, 14 thrombosis, 31 other, 46 SI) was 11.1% (95% CI: 6.9-15.4) versus 6.7% (95% CI: 4.7-8.6) for the 814 remaining patients. The relapse-specific aHR was 1.69 (95% CI: 1.05-2.74, P=0.03). The unadjusted bone-marrow relapse-specific HR was 1.83 (95% CI: 1.07-3.14, P=0.03) and 1.86 (95% CI: 0.90- 3.87, P=0.095) for any CNS relapse. These results emphasize the importance of therapeutic drug monitoring and appropriate adjustment of asparaginase therapy when feasible.
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| 20. |
- Hahlin, Axel, et al.
(författare)
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Determination of small-scale magnetic fields on Sun-like stars in the near-infrared using CRIRES
- 2023
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 675
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Tidskriftsartikel (refereegranskat)abstract
- Aims: We aim to characterise the small-scale magnetic fields of a sample of 16 Sun-like stars and investigate the capabilities of the newly upgraded near-infrared (NIR) instrument CRIRES+ at the Very Large Telescope in the context of small-scale magnetic field studies. Our targets also had their magnetic fields studied with optical spectra, which allowed us to compare magnetic field properties at different spatial scales on the stellar surface and to contrast small-scale magnetic field measurements at different wavelengths.Methods: We analysed the Zeeman broadening signature for six magnetically sensitive and insensitive Fe I lines in the H-band to measure small-scale magnetic fields on the stellar surfaces of our sample. We used polarised radiative transfer modelling and non-local thermodynamic equilibrium departure coefficients in combination with Markov chain Monte Carlo sampling to determine magnetic field characteristics and non-magnetic stellar parameters. We used two different approaches to describe the small-scale magnetic fields. The first is a two-component model with a single magnetic region and a free magnetic field strength. The second model contains multiple magnetic components with fixed magnetic field strengths.Results: We found average magnetic field strengths ranging from & SIM;0.4 kG down to < 0.1 kG. The results align closely with other results from high-resolution NIR spectrographs, such as SPIRou. It appears that the typical magnetic field strength in the magnetic region is slightly stronger than 1.3 kG, and for most stars in our sample, this strength is between 1 and 2 kG. We also found that the small-scale fields correlate with the large-scale fields and that the small-scale fields are at least ten times stronger than the large-scale fields inferred with Zeeman Doppler imaging. The two- and multi-component models produce systematically different results, as the strong fields from the multi-component model increase the obtained mean magnetic field strength. When comparing our results with the optical measurements of small-scale fields, we found a systematic offset two to three times stronger than fields in the optical results. This discrepancy cannot be explained by uncertainties in stellar parameters. Care should therefore be taken when comparing results obtained at different wavelengths until a clear cause can be established.
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| 21. |
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| 22. |
- Levinsen, Mette, et al.
(författare)
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Leukemic blasts are present at low levels in spinal fluid in one-third of childhood acute lymphoblastic leukemia cases
- 2016
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Ingår i: Pediatric Blood & Cancer. - : Wiley. - 1545-5009 .- 1545-5017. ; 63:11, s. 1935-1942
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Tidskriftsartikel (refereegranskat)abstract
- Background: Central nervous system (CNS) involvement is associated with relapse in childhood acute lymphoblastic leukemia (ALL) and is a diagnostic challenge. Procedure: In a Nordic/Baltic prospective study, we assessed centralized flow cytometry (FCM) of locally fixed cerebrospinal fluid (CSF) samples versus local conventional cytospin-based cytology (CC) for detecting leukemic cells and evaluating kinetics of elimination of leukemic cells in CSF. Results: Among 300 patients with newly diagnosed ALL, 87 (29%) had CSF involvement by FCM, while CC was positive in 30 (10%) of 299 patients with available CC data (P < 0.001). Patients with FCM+/CC+ had higher CSF leukemic blast counts compared to patients positive by FCM only (medians: 0.10 vs. 0.017 leukemic blasts/μl, P = 0.006). Patients positive by FCM had higher white blood cell counts in peripheral blood than patients negative by FCM (medians: 45 × 109/l vs. 10 × 109/l, P < 0.001), were younger (medians: 3 years vs. 4 years, P = 0.03), and more frequently had T-cell ALL (18/87 vs. 16/213, P = 0.001). At treatment day 15, five of 52 patients (10%) who had CSF positive by FCM at diagnosis remained so despite at least two doses of weekly intrathecal chemotherapy. Conclusions: Longer follow-up is needed to clarify whether FCM positivity has prognostic significance and is an indicator for intensified CNS-directed therapy.
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| 23. |
- Lizon, Jean Louis, et al.
(författare)
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Opto-mechanical design of a new Cross Dispersion Unit for the CRIRES plus high resolution spectrograph for the VLT
- 2014
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Ingår i: GROUND-BASED AND AIRBORNE INSTRUMENTATION FOR ASTRONOMY V. - : SPIE. - 9780819496157
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Konferensbidrag (refereegranskat)abstract
- CRIRES is one of the few IR (0.92-5.2 mu m) high-resolution spectrographs in operation at the VLT since 2006. Despite good performance it suffers a limitation that significantly hampers its ability: a small spectral coverage per exposure. The CRIRES upgrade (CRIRES+) proposes to transform CRIRES into a cross-dispersed spectrograph while maintaining the high resolution (100000) and increasing the wavelength coverage by a factor 10 compared to the current capabilities. A major part of the upgrade is the exchange of the actual cryogenic pre-disperser module by a new cross disperser unit. In addition to a completely new optical design, a number of important changes are required on key components and functions like the slit unit and detectors units. We will outline the design of these new units fitting inside a predefined and restricted space. The mechanical design of the new functions including a description and analysis will be presented. Finally we will present the strategy for the implementation of the changes.
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| 24. |
- Lizon, Jean Louis, et al.
(författare)
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Very accurate cryogenic mechanisms for CRIRES
- 2018
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Ingår i: OPTICAL AND INFRARED INTERFEROMETRY AND IMAGING VI. - : SPIE-INT SOC OPTICAL ENGINEERING. - 9781510619562
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Konferensbidrag (refereegranskat)abstract
- After 5 years of operation on the VLT, a large upgrade of CRIRES (the ESO Cryogenic InfraRed Echelle Spectrograph) was decided mainly in order to increase the efficiency. Using a cross dispersion design allows better wavelength coverage per exposure. This means a complete re-design of the cryogenic pre-optic which were including a pre-dispersion stage with a large prism as dispersive element. The new design requires a move of the entrance slit and associated decker toward the first intermediate focal plane right behind the window. Implement 2 functions with high positioning accuracy in a pre-defined and limited space was a real challenge. The design and the test results recorded in the ESO Cryogenic Test Facility are reported in this paper. The second critical function is the grating wheel which positions the 6 cross disperser gratings into the beam. The paper describes the design of the mechanism which includes a detente system in order to guaranty the 5 arc sec positioning reproducibility requested. The design includes also feedback system, based on switches, in order to ensure that the right grating is in position before starting a long exposure. The paper reports on the tests carried out at cryogenic temperature at the sub-system level. It also includes early performances recorded in the instrument along the first phases of the system test.
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| 25. |
- Lockhart, Matthew, et al.
(författare)
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Novel infrared polarimeter for the ESO CRIRES plus instrument
- 2014
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Ingår i: GROUND-BASED AND AIRBORNE INSTRUMENTATION FOR ASTRONOMY V. - : SPIE. - 9780819496157
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Konferensbidrag (refereegranskat)abstract
- The CRIRES infrared spectrograph at the European Southern Observatory (ESO) Very Large Telescope (VLT) facility will soon receive an upgrade. This upgrade will include the addition of a module for performing high-resolution spectropolarimetry. The polarimetry module will incorporate a novel infrared beamsplitter based on polarization gratings (PGs). The beamsplitter produces a pair of infrared output beams, with opposite circular polarizations, which are then fed into the spectrograph. Visible light passes through the module virtually unaltered and is then available for use by the CRIRES adaptive optics system. We present the design of the polarimetry module and measurements of PG behavior in the 1 to 2.7 mu m wavelength range.
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