| 1. |
- Baldaque-Silva, Francisco, et al.
(författare)
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Endoscopic assessment and grading of Barrett's esophagus using magnification endoscopy and narrow band imaging: Impact of structured learning and experience on the accuracy of the Amsterdam classification system
- 2013
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Ingår i: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 1502-7708 .- 0036-5521. ; 48:2, s. 160-167
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Tidskriftsartikel (refereegranskat)abstract
- Objective. Several classification systems have been launched to characterize Barrett's esophagus (BE) mucosa using magnification endoscopy with narrow band imaging (ME-NBI). The good accuracy and interobserver agreement described in the early reports were not reproduced subsequently. Recently, we reported somewhat higher accuracy of the classification developed by the Amsterdam group. The critical question then formulated was whether a structured learning program and the level of experience would affect the clinical usefulness of this classification. Material & methods: Two hundred and nine videos were prospectively captured from patients with BE using ME-NBI. From these, 70 were randomly selected and evaluated by six endoscopists with different levels of expertise, using a dedicated software application. First, an educational set was studied. Thereafter, the 70 test videos were evaluated. After classification of each video, the respective histological feedback was automatically given. Results. Within the learning process, there was a decrease in the time needed for evaluation and an increase in the certainty of prediction. The accuracy did not increase with the learning process. The sensitivity for detection of intestinal metaplasia ranged between 39% and 57%, and for neoplasia between 62% and 90%, irrespective of assessor's expertise. The kappa coefficient for the interobserver agreement ranged from 0.25 to 0.30 for intestinal metaplasia, and from 0.39 to 0.48 for neoplasia. Conclusion: Using a dedicated learning program, the ME-NBI Amsterdam classification system is suboptimal in terms of accuracy and inter- and intraobserver agreements. These results reiterate the questionable utility of corresponding classification system in clinical routine practice.
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| 2. |
- Marques, Nuno, 1980-, et al.
(författare)
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Dia do Não
- 2018. - 1st
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Annan publikation (populärvet., debatt m.m.)abstract
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| 3. |
- Almeida, Nuno A.F., et al.
(författare)
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Pressure dependent luminescence in titanium dioxide particles modified with europium ions
- 2016
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Ingår i: Sensors and actuators. B, Chemical. - : Elsevier BV. - 0925-4005 .- 1873-3077. ; 234, s. 137-144
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Tidskriftsartikel (refereegranskat)abstract
- Particles of titanium dioxide were prepared in the presence of europium ions (TiO2:Eu) by a solvothermal method and thermal annealed in air at 500 °C. The spectroscopic properties of TiO2:Eu particles were analyzed indicating that the Eu3+ ions are likely distributed at the surface or near the surface of the titanium dioxide particles. The photoluminescence analysis showed that the intraionic emission was strongly sensitive to reduced pressure conditions, as seen by its absence under vacuum conditions. The ion emission was re-established as soon as the atmosphere was restored. Additionally, the ion integrated emission intensity follows a linearly dependence with pressure in the range of 150 to 800 mbar revealing a high sensitivity to small variations in pressure, which is an unprecedented result. This innovation will allow the study of new technologies in the area of low vacuum sensors where TiO2:Eu may act as the active element of an optical sensor for a pressure device.
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| 4. |
- Amaral, Rita, et al.
(författare)
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Profiling Persistent Asthma Phenotypes in Adolescents : A Longitudinal Diagnostic Evaluation from the INSPIRERS Studies
- 2021
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Ingår i: International Journal of Environmental Research and Public Health. - : MDPI. - 1661-7827 .- 1660-4601. ; 18:3
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Tidskriftsartikel (refereegranskat)abstract
- We aimed to identify persistent asthma phenotypes among adolescents and to evaluate longitudinally asthma-related outcomes across phenotypes. Adolescents (13-17 years) from the prospective, observational, and multicenter INSPIRERS studies, conducted in Portugal and Spain, were included (n = 162). Latent class analysis was applied to demographic, environmental, and clinical variables, collected at a baseline medical visit. Longitudinal differences in clinical variables were assessed at a 4-month follow-up telephone contact (n = 128). Three classes/phenotypes of persistent asthma were identified. Adolescents in class 1 (n = 87) were highly symptomatic at baseline and presented the highest number of unscheduled healthcare visits per month and exacerbations per month, both at baseline and follow-up. Class 2 (n = 32) was characterized by female predominance, more frequent obesity, and uncontrolled upper/lower airways symptoms at baseline. At follow-up, there was a significant increase in the proportion of controlled lower airway symptoms (p < 0.001). Class 3 (n = 43) included mostly males with controlled lower airways symptoms; at follow-up, while keeping symptom control, there was a significant increase in exacerbations/month (p = 0.015). We have identified distinct phenotypes of persistent asthma in adolescents with different patterns in longitudinal asthma-related outcomes, supporting the importance of profiling asthma phenotypes in predicting disease outcomes that might inform targeted interventions and reduce future risk.
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| 5. |
- Bentham, James, et al.
(författare)
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A century of trends in adult human height
- 2016
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Ingår i: eLIFE. - 2050-084X. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.522.7) and 16.5 cm (13.319.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
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| 6. |
- Bentham, James, et al.
(författare)
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A century of trends in adult human height
- 2016
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Ingår i: eLIFE. - : eLife Sciences Publications Ltd. - 2050-084X. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5–22.7) and 16.5 cm (13.3– 19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8– 144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
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| 7. |
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| 8. |
- Coutinho, Nuno, et al.
(författare)
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Dynamic Dual-Reinforcement-Learning Routing Strategies for Quality of Experience-aware Wireless Mesh Networking
- 2015
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Ingår i: Computer Networks. - : Elsevier. - 1389-1286 .- 1872-7069. ; 88:269
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Tidskriftsartikel (refereegranskat)abstract
- The impact of transmission impairments such as loss and latency on user perceived quality(QoE) depends on the service type. In a real network, multiple service types such as audio,video, and data coexist. This makes resource management inherently complex and difficultto orchestrate. In this paper, we propose an autonomous Quality of Experience managementapproach for multiservice wireless mesh networks, where individual mesh nodes apply rein-forcement learning methods to dynamically adjust their routing strategies in order to maxi-mize the user perceived QoE for each flow. Within the forwarding nodes, we develop a novelpacket dropping strategy that takes into account the impact on QoE. Finally, a novel sourcerate adaptation mechanism is designed that takes into account the expected QoE in order tomatch the sending rate with the available network capacity. An evaluation of our mechanismsusing simulations demonstrates that our approach is superior to the standard approaches,AODV and OLSR, and effectively balances the user perceived QoE between the service flows.
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| 9. |
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| 10. |
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Espaços (Des)Habitados | (Un)Inhabited Spaces
- 2022
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- This theme was defined in the winter of 2019, when no one predicted the pandemic crisis caused by COVID-19, which brought other dimensions and relevance to questions of inhabiting and uninhabiting spaces. At the time, there were other issues whose analysis seemed to be urgent: (1) gentrification and touristization of historical and environmentally protected sites; (2) occupation movements of uninhabited spaces; (3) territorial uprooting or intermittent rootedness, both resulting from mass human and cultural mobility, sometimes fostered by technological development and the globalization of the economy, sometimes determined by war, misery and hunger; (4) new (?) forms of ruralization or de-ruralization of regions with accentuated histories of population desertification. These processes are driven by the seduction of the economic and socio-cultural dynamism of cities, as well as by the search for alternative and more environmentally sustainable ways of re-inhabiting territories; (5)climate change, catastrophes, and processes of resettlement and regeneration; (6) and, among others, the inhabitation of space by art and art as an inhabited space. We therefore invited critical, theoretical-conceptual and artistic reflections on these topics, both in the current context of the Covid19 pandemic as in other contexts and approaches for the number5 of T RANSLOCAL-ContemporaryLocalandUrbanCultures.
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| 11. |
- Graça, Inês, et al.
(författare)
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Comparative Proteomic Analysis of Nodulated and Non-Nodulated Casuarina glauca Sieb. ex Spreng. Grown under Salinity Conditions Using Sequential Window Acquisition of All Theoretical Mass Spectra (SWATH-MS)
- 2020
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Ingår i: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 21:1
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Tidskriftsartikel (refereegranskat)abstract
- Casuarina glauca displays high levels of salt tolerance, but very little is known about how this tree adapts to saline conditions. To understand the molecular basis of C. glauca response to salt stress, we have analyzed the proteome from branchlets of plants nodulated by nitrogen-fixing Frankia Thr bacteria (NOD+) and non-nodulated plants supplied with KNO3 (KNO3+), exposed to 0, 200, 400, and 600 mM NaCl. Proteins were identified by Short Gel, Long Gradient Liquid Chromatography coupled to Tandem Mass Spectrometry and quantified by Sequential Window Acquisition of All Theoretical Mass Spectra -Mass Spectrometry. 600 proteins were identified and 357 quantified. Differentially Expressed Proteins (DEPs) were multifunctional and mainly involved in Carbohydrate Metabolism, Cellular Processes, and Environmental Information Processing. The number of DEPs increased gradually with stress severity: (i) from 7 (200 mM NaCl) to 40 (600 mM NaCl) in KNO3+; and (ii) from 6 (200 mM NaCl) to 23 (600 mM NaCl) in NOD+. Protein-protein interaction analysis identified different interacting proteins involved in general metabolic pathways as well as in the biosynthesis of secondary metabolites with different response networks related to salt stress. Salt tolerance in C. glauca is related to a moderate impact on the photosynthetic machinery (one of the first and most important stress targets) as well as to an enhancement of the antioxidant status that maintains cellular homeostasis.
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| 12. |
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Guinchidos
- 2023
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Konstnärligt arbeteabstract
- Excerpt of my long poem Dia do Não with drawings by André Alves published in the anthology Futuros Multiespecie: Prácticas Vinculantes Para un Planeta en Emergencia. edited by Azucena Castro, Bartlebooth, July 2023 189-202.
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| 13. |
- Humer, Alois, et al.
(författare)
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European Types of Political and Territorial Organisation of Social Services of General Interest
- 2013
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Ingår i: Romanian Journal of Regional Science. - 1843-8520. ; 7:special issue, s. 142-164
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Tidskriftsartikel (refereegranskat)abstract
- It is commonly understood across Europe that the provision of Social Services of General Interest (SSGI) is important. Several official documents guarantee every EU citizen access to, and the availability of, SSGI. Nevertheless, when it comes to producing, financing, administrating and territorially organising SSGI, the approaches and practices used across the various European states differ significantly while often mirroring the functioning of the social welfare and national administrative planning systems that prevail on the ground. The purpose of this paper is to present a systematic analysis of how European states (the EU 27 plus Croatia and the EFTA countries of Iceland, Norway and Switzerland) cope with the organisation of SSGI in the fields of education, care, labour market, social housing and insurance schemes. Outlining the similarities and differences of the various national approaches leads to the creation of a European typology of SSGI organisation. This typology will then be compared to existing typologies and classifications of social welfare and spatial planning systems.
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| 14. |
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| 15. |
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| 16. |
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| 17. |
- Kanoni, Stavroula, et al.
(författare)
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Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
- 2022
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Ingår i: Genome biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906 .- 1474-7596. ; 23:1
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Tidskriftsartikel (refereegranskat)abstract
- Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N=1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism.Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
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| 18. |
- Loureiro, Teresa, et al.
(författare)
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Non-viable cervico-isthmic pregnancy: the importance of an accurate sonographic diagnosis to preserve fertility
- 2003
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Ingår i: Fetal Diagnosis and Therapy. - : S. Karger AG. - 1015-3837 .- 1421-9964. ; 18:5, s. 289-291
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Cervico-isthmic pregnancy is a rare occurrence and until the use of current ultrasonographic techniques was associated with a disastrous outcome for women desiring to maintain their fertility. CASE REPORT: A 39-year-old woman was diagnosed at 12 weeks of amenorrhoea with an intra-uterine non-viable pregnancy and a low implantation of the gestational sac. Medical management of this situation with a regimen of intravaginal misoprostol was unsuccessful. At introduction of a cervical expander severe vaginal bleeding ensued, leading to an emergency curettage followed by a life-saving hysterectomy. Pathologic examination confirmed the peroperative impression of an isthmic implantation of the gestational sac. CONCLUSION: Early ultrasonographic diagnosis is essential to make conservative management of cervico-isthmic pregnancy possible.
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| 19. |
- MacDowall, Anna, et al.
(författare)
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Artificial disc replacement versus fusion in patients with cervical degenerative disc disease and radiculopathy : a randomized controlled trial with 5-year outcomes
- 2019
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Ingår i: Journal of Neurosurgery. - 1547-5654 .- 1547-5646. ; 30:3, s. 323-331
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVEThe method of artificial disc replacement (ADR) has been developed as an alternative treatment to fusion surgery after decompression for cervical degenerative disc disease (DDD) with radiculopathy. Preserving the motion of ADR devices aims to prevent immobilization side effects such as adjacent-segment pathology (ASP). However, long-term follow-up evaluations using MRI are needed to investigate if this intent is achieved.METHODSThe authors performed a randomized controlled trial with 153 patients (mean age 47 years) undergoing surgery for cervical radiculopathy. Eighty-three patients received an ADR and 70 patients underwent fusion surgery. Outcomes after 5 years were assessed using patient-reported outcome measures using the Neck Disability Index (NDI) score as the primary outcome; motion preservation and heterotopic ossification by radiography; ASP by MRI; and secondary surgical procedures.RESULTSScores on the NDI were approximately halved in both groups: the mean score after 5 years was 36 (95% confidence interval [CI] 31–41) in the ADR group and 32 (95% CI 27–38) in the fusion group (p = 0.48). There were no other significant differences between the groups in six other patient-related outcome measures. Fifty-four percent of the patients in the ADR group preserved motion at the operated cervical level and 25% of the ADRs were spontaneously fused. Seventeen ADR patients (21%) and 7 fusion patients (10%) underwent secondary surgery (p = 0.11), with 5 patients in each group due to clinical ASP.CONCLUSIONSIn patients with cervical DDD and radiculopathy decompression as well as ADR, surgery did not result in better clinical or radiological outcomes after 5 years compared with decompression and fusion surgery.
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| 20. |
- Marques, Catarina, 1969-, et al.
(författare)
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Accuracy and Reliability of X-ray Measurements in the Cervical Spine
- 2020
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Ingår i: Asian Spine Journal. - : KOREAN SOC SPINE SURGERY. - 1976-1902 .- 1976-7846. ; 14:2, s. 169-176
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Tidskriftsartikel (refereegranskat)abstract
- Study Design: This study is a post hoc analysis of a multicenter prospective randomized controlled trial which compared artificial disc replacement and anterior cervical discectomy and fusion. Purpose: Useful radiographic parameters for assessing cervical alignment include the Cobb angles, T1 slope (TS), occipitocervical inclination (OCI). K-line tilt (KLT), and cervical sagittal vertical axis (cSVA). This study aimed to determine measurement accuracy and reliability for these parameters. Overview of Literature: Various authors have assessed repeatability by comparing different methods of measurement, but knowledge of measurement error and minimal detectable change is scarce. Methods: We evaluated 75B lateral cervical radiographs. One medical student and one spine surgeon (i.e., measured x2 within 4 weeks) independently measured the parameters obtaining 5,850 values. Standard error of measurement (SEm) and minimum detectable change (MDC) were calculated for each parameter. The accuracy and reliability of the Cobb angle measurements were calculated for the different types of angles: cervical lordosis, prosthesis angle, segmental angle with two hone surfaces (SABB), and segmental angle with one bone and one metal surface. Reliability was determined with intraclass correlation coefficient (ICC). Results: SEm was 1.8 degrees and MDC was 5.0 degrees for the Cobb angle, with an intraobserver/interobserver ICC of 0.958/0.8B6. All the different subtypes of Cobb angles had an ICC higher than 0.950, except SABB (intraobserver/interobserver ICC of 0.922/0.716). The most accurate and reliable measurement was for KLT. Conclusions: This study provides normative data on SEm and MDC for Cobb angles, T1S, KLT, OCI, and cSVA in cervicalcervicai lateral radiographs. Reliability was excellent for all parameters except SABB (e.g., good).
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| 21. |
- Marques, Catarina, 1969-, et al.
(författare)
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Unintended fusion in cervical artificial disk replacement : a prospective study on heterotopic ossification, progression, and clinical outcome, with 5-year follow-up
- 2021
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Ingår i: European spine journal. - : Springer. - 0940-6719 .- 1432-0932. ; 30:6, s. 1662-1669
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Tidskriftsartikel (refereegranskat)abstract
- Purpose Heterotopic ossification (HO) may cause unintended fusion in artificial disk replacement (ADR), failing to preserve motion. The reported incidence of HO varies hugely. This study aimed to determine prevalence of HO, progression, predisposing factors to occurrence and to progression, and potential effect on clinical outcomes. Methods Eighty-three patients treated with ADRs for cervical radiculopathy at one or two segments were extracted from a previously published RCT. Of the 83 patients, 59 had remaining ADR (79 implants) and sufficiently high-quality X-rays at 5 years of follow-up to allow analysis. HO was graded on plain films according to Mehren/Suchomel. Prevalence, progression, predisposing factors and effect on clinical outcome (Neck Disability Index-NDI) were analyzed. Results At 2 years, HO was seen in 46/55 ADR implants (84%), severe enough to affect mobility in 27/55 (49%). At 5 years, HO was seen in 92% of 79 implants, severe in 71%. Male sex was a predisposing factor to HO. No predisposing factors to progression were identified. NDI was not affected by the severity of HO. Conclusion Almost all ADR implants in our study have HO at 5 years of follow-up. Male sex is a risk factor. Severe HO did not affect clinical outcome.
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| 22. |
- Marques, Nuno, 1980-
(författare)
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A Máquina Mole : William Burroughs
- 2012
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Ingår i: (In)seguranças no Espaço Urbano. - Húmus : V.N. Famalicão. - 9789898549525 ; , s. 183-189
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Bokkapitel (refereegranskat)
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| 23. |
- Marques, Nuno, 1980-
(författare)
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A Máquina Mole : William Burroughs
- 2013
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Ingår i: (In)seguranças no Espaço Urbano : Perspectivas Culturais. - Húmus : V.N. Famalicão. - 9789898549525 - 9898549521 ; , s. 185-189, s. 185-189
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 24. |
- Marques, Nuno, 1980-
(författare)
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A New Song for Ourselves : Contributions of Gary Snyder’s Poetics of Place to Current Ecopoetics
- 2020
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Ingår i: Ecocene: Cappadocia Journal of Environmental Humanities. - Cappadocia : Cappadocia University. - 2717-8943. ; 1:2, s. 32-46
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Tidskriftsartikel (refereegranskat)abstract
- I propose that Gary Snyder’s bioregional project can contribute to recent ecopoetic thought with its argument for poetry as embodied practice and with its definition of community as place-based, transnational, and multi-species. I start by showing continuities between bioregionalism and ecocriticism with the concept of place. I then turn to Snyder’s conceptualization of place as a dialectics between the biotic and sociopolitical dimensions. For Snyder poetry is a situated and embodied practice of investigation and creation of place. It therefore relates with recent discussions on ecopoetics as a critical and poetic practice extended to ecologically oriented forms of community action and activism (Hume and Osborne 2018,2). As an example of how current ecopoetry practices a poetics of place I briefly discuss Allison Cobb’s Plastic: An Autobiography(2015).
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| 25. |
- Marques, Nuno, 1980-
(författare)
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A Nova Poética da natureza de Gary Snyder : budismo e ecocrítica na sua obra
- 2013
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis presents the work of the poet Gary Snyder (1930) to the Portuguese academia in order to clearly state its original and unique place among North-American poetry. It is divided in three chapters that determine the three different grounds of the author’s syncretism. The first chapter contextualizes Snyder’s work in the history of literary representations of nature. In rupture with the Pastoral literary mode it crystallizes a moment of passing between nature writing and environmental writing. The second chapter discusses the Buddhist elements present in Snyder’s work and stresses the importance of the interrelation between mind and nature. By stating the equivalence between the Buddhist concept of interdependence and ecosystems processes, the poems assume certain formal characteristics that are presented. Finally, the third chapter defines the relation between geographical places and Snyder’s poems. The formal aspects of the author’s poetry reflect Snyder’s notion of the poet as a shaman and its clarification allows for the discussion of the author’s statement of language as a wild ecosystem. Snyder’s syncretism is his most profound, original and long lasting influence in North-American poetry. It extends its influence to environmental ethics, the presence of Buddhism in North-America and the recovery of Native American Myths and lore. It does so in the context of a social, political, poetic, religious and environmental revolution that intends to create a new (and old) place for humans with nature.
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