| 1. |
- Cruz, Raquel, et al.
(författare)
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Novel genes and sex differences in COVID-19 severity
- 2022
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Ingår i: Human Molecular Genetics. - : Oxford University Press. - 0964-6906 .- 1460-2083. ; 31:22, s. 3789-3806
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Tidskriftsartikel (refereegranskat)abstract
- Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus disease 2019 (COVID-19) positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (P < 5 × 10−8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (P = 1.3 × 10−22 and P = 8.1 × 10−12, respectively), and for variants in 9q21.32 near TLE1 only among females (P = 4.4 × 10−8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (P = 2.7 × 10−8) and ARHGAP33 (P = 1.3 × 10−8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative (HGI) confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, P = 4.1 × 10−8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or ≥60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided.
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| 2. |
- Sánchez Alcón, José A, et al.
(författare)
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Automated determination of security services to ensure personal data protection in the Internet of Things applications
- 2013
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Ingår i: IEEE Third international conference on Innovative Computing Technology - INTECH 2013. - 9781479900473 ; , s. 71-76
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Konferensbidrag (refereegranskat)abstract
- This paper describes a method aimed at automatically determining security services to be implementedin products, services and devices involved on the Internet of Things scenarios. It is important toconsider the specific context, legislative diversity and nature of the information since its main objective is to have correct and fair data processing that avoids users in perceiving any danger to their privacy. This paper gives a brief overview based on several types of security threat scenarios. It tries tointroduce “Utility Matrix” concept that connects involved users, their security needs, and legal imperatives all together. Based on “Utility Matrix”, an expert system is proposed in order to automatesecurity service decisions and solution for personal data protection on the area of Internet of Things. Different approaches are presented, and several applied use cases are given for AWARE product, such as application. This automated system is in the development phase. Nevertheless, this project has toconnect areas of the Industry to the judicial and technology, taking into account that users are in themiddle of the scenario. As a result of this project, a certificate of personal data protection to users and companies could be obtained. It could be a tool to simulate and evaluate the impact of new services, new laws, and new needs in technology and research.
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| 9. |
- Castillejo, Pedro, et al.
(författare)
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An Internet of Things approach for managing smart services provided by wearable devices
- 2013
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Ingår i: International Journal of Distributed Sensor Networks. - : Hindawi Publishing Corporation. - 1550-1329 .- 1550-1477. ; 2013, s. Article number 190813-
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Tidskriftsartikel (refereegranskat)abstract
- The Internet of Things (IoT) is growing at a fast pace with new devices getting connected all the time. A new emerging group of these devices is the wearable devices, and the wireless sensor networks are a good way to integrate them in the IoT concept and bring new experiences to the daily life activities. In this paper, we present an everyday life application involving a WSN as the base of a novel context-awareness sports scenario, where physiological parameters are measured and sent to the WSN by wearable devices. Applications with several hardware components introduce the problem of heterogeneity in the network. In order to integrate different hardware platforms and to introduce a service-oriented semantic middleware solution into a single application, we propose the use of an enterprise service bus (ESB) as a bridge for guaranteeing interoperability and integration of the different environments, thus introducing a semantic added value needed in the world of IoT-based systems. This approach places all the data acquired (e.g., via internet data access) at application developers disposal, opening the system to new user applications. The user can then access the data through a wide variety of devices (smartphones, tablets, and computers) and operating systems (Android, iOS, Windows, Linux, etc.).
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| 10. |
- Castillejo, Pedro, et al.
(författare)
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Integration of wearable devices in a wireless sensor network for an E-health application
- 2013
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Ingår i: IEEE wireless communications. - 1536-1284 .- 1558-0687. ; 20:4, s. 38-49
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Tidskriftsartikel (refereegranskat)abstract
- Applications based on Wireless Sensor Networks for Internet of Things scenarios are on the rise. The multiple possibilities they offer have spread towards previously hard to imagine fields, like e-health or human physiological monitoring. An application has been developed for its usage in scenarios where data collection is applied to smart spaces, aiming at its usage in fire fighting and sports. This application has been tested in a gymnasium with real, non-simulated nodes and devices. A Graphic User Interface has been implemented to suggest a series of exercises to improve a sportsman/woman s condition, depending on the context and their profile. This system can be adapted to a wide variety of e-health applications with minimum changes, and the user will interact using different devices, like smart phones, smart watches and/or tablets.
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| 12. |
- Corredor, Iván, et al.
(författare)
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Bringing pervasive embedded networks to the service cloud : A lightweight middleware approach
- 2011
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Ingår i: Journal of systems architecture. - : Elsevier. - 1383-7621 .- 1873-6165. ; 57:10, s. 916-933
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Tidskriftsartikel (refereegranskat)abstract
- The emergence of novel pervasive networks that consist of tiny embedded nodes have reduced the gap between real and virtual worlds. This paradigm has opened the Service Cloud to a variety of wireless devices especially those with sensorial and actuating capabilities. Those pervasive networks contribute to build new context-aware applications that interpret the state of the physical world at real-time. However, traditional Service-Oriented Architectures (SOA), which are widely used in the current Internet are unsuitable for such resource-constraint devices since they are too heavy. In this research paper, an internetworking approach is proposed in order to address that important issue. The main part of our proposal is the Knowledge-Aware and Service-Oriented (KASO) Middleware that has been designed for pervasive embedded networks. KASO Middleware implements a diversity of mechanisms, services and protocols which enable developers and business processing designers to deploy, expose, discover, compose, and orchestrate real-world services (i.e. services running on sensor/actuator devices). Moreover, KASO Middleware implements endpoints to offer those services to the Cloud in a REST manner. Our internetworking approach has been validated through a real healthcare telemonitoring system deployed in a sanatorium. The validation tests show that KASO Middleware successfully brings pervasive embedded networks to the Service Cloud.
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| 13. |
- Corredor, Iván, et al.
(författare)
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Knowledge-aware and service-oriented middleware for deploying pervasive services
- 2012
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Ingår i: Journal of Network and Computer Applications. - : Elsevier BV. - 1084-8045 .- 1095-8592. ; 35:2, s. 562-576
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Tidskriftsartikel (refereegranskat)abstract
- Many applications and services have emerged in the frame of new Internet of Things paradigm. This novel view has opened the Web services to a variety of devices especially to tiny and resource-constrained devices. Wireless Sensor and Actuator Networks belong to that kind of devices. Those networks have become one of the more promising technologies to take part in the Future Internet. However, the integration of Sensor and Actuator Networks into the Service Cloud is a hard challenge requiring specific new architectures and protocols. This paper presents a middleware approach addressing this important issue. A Knowledge-Aware and Service-Oriented Middleware (KASOM) for pervasive embedded networks is proposed. The major aim of KASOM is to offer advanced and enriched pervasive services to everyone connected to Internet. In this sense, KASOM implements mechanisms and protocols which allow managing the knowledge generated in pervasive embedded networks in order to expose it to Internet users in a readable way. General functional requirements of embedded sensor and actuator platforms have been taken into account when designing KASOM, with special attention in energy consumption, memory and bandwidth. The KASOM evaluation and validation will be demonstrated through a real Wireless Sensor and Actuator Network deployment based on integral healthcare services in a sanatorium.
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| 16. |
- Da Silva Fariña, Antonio, et al.
(författare)
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Design and implementation of a Java Fault Injector for Exhaustif SWIFI tool
- 2009
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Ingår i: Proceedings of 2009 4th International Conference on Dependability of Computer Systems, DepCos-RELCOMEX 2009. - 9780769536743 ; , s. 77-83
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Konferensbidrag (refereegranskat)abstract
- Java is a successful programming environment and its use has grown from little embedded applications until enterprise network servers based on J2EE. This intensive use of Java demands the validation of their fault tolerance mechanisms to avoid unexpected behavior of the applications at runtime. This paper describes the design and implementation of a fault injector for the "Exhaustif®" SWIFI tool. Aspecific fault model for java applications that include class corruption/substitution at loading time, method call interception and unexpected exception thrown is proposed. The injector uses the JVMTI (JavaVirtual Machine Tool Interface) to perform bytecode instrumentation at runtime to carry out the fault model previously defined. Finally a XML formalization of the specific Java fault model is proposed. This approach, JVMTI + XML fault model description, provides complete independency between the system under test and the fault injection tool, as well the interoperability with another SWIFI tools.
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| 18. |
- Da Silva Fariña, Antonio, et al.
(författare)
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Exhaustif : a fault injection tool for distributed heterogeneous embedded systems
- 2007
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Ingår i: Euro American Conference on Telematics and Information Systems - Proceedings of the 2007 Euro American Conference on Telematics and Information Systems, EATIS 2007. - New York, NY, USA : ACM Press. - 9781595935984 ; , s. Article number a17-
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Konferensbidrag (refereegranskat)abstract
- This paper presents Exhaustif®, a SWIFI fault injection tool for fault tolerance verification and the validation of embedded software in distributedheterogeneous systems. Exhaustif® mainly consists of two parts: EEM and FIK. Exhaustif® Executive Manager (EEM) is a GUI Java application to define the fault injection campaign that uses a SQL database to save the test results obtained from the System under Test (SUT) in order to carry out a post injection data analysis. FIK is under the command of EEM to cary out fault injections in applications running under diverse operating systems using pure SWIFI techniques. Exhaustif® carries out floating point register and memory corruptions using temporary triggers and uses an optimized routine interception mechanism to cany out argument and return value corruption with a minimal time overhead. Two experimentalFault Injector Kernels (FIK) under the RTEMS operating system for an EADS-Astrium SPARC ERC32-based MCM processor board and i386 standard PC mainboard have been developed.
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| 21. |
- Da Silva Fariña, Antonio, et al.
(författare)
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XML Schema Based Fault-Set Definition to Improve Fault Injection Tools Interoperability
- 2010
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Ingår i: International Journal of Critical Computer-Based Systems. - : InderScience Publishers. - 1757-8779 .- 1757-8787. ; 1:1-3, s. 220-237
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Tidskriftsartikel (refereegranskat)abstract
- Software implemented fault injection tools (SWIFI) use fault injectors to carry out the fault injection campaign defined in a GUI-based application. However, the communication between the fault injector and the application is defined in an ad-hoc manner. This paper describes an XML schema formalisation approach for the definition of fault sets which specify low level memory and/or register value corruptions in embedded microprocessor-based systems and resource usage faults in host based systems. Through this proposed XML schema definition, different injectors could be used to carry out the same fault set injection. To validate this approach an experimental tool called Exhaustif®, consisting of a GUI Java application for defining the fault sets and injection policies, one injector for Windows hosts systems and two injectors for Sparc and i386 architectures under RTEMS have been developed.
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| 23. |
- Familiar, Miguel S, et al.
(författare)
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Building service-oriented Smart Infrastructures over Wireless Ad Hoc Sensor Networks : A middleware perspective
- 2012
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Ingår i: Computer Networks. - : Elsevier BV. - 1389-1286 .- 1872-7069. ; 56:4, s. 1303-1328
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Tidskriftsartikel (refereegranskat)abstract
- The increase in physical resources for the next-generation of embedded computing devices, as well as in the efforts carried out by the scientific and research communities, is paving the way for Smart Infrastructures based on Wireless Sensor Networks. In such manner, not only open and formally defined Service-Oriented Frameworks are required, but also efficient middleware technologies that ease the development of new sensor-based services. From the cornerstone analysis of pervasive computing principles applied to Smart Spaces creation, this article presents the μSMS (micro Subscription Management System) middleware. This approach specifies and develops the notion of virtual sensor services created for Smart Environments over sensor networks from tiny in-network services based on agent technology. In the framework of the μSWN European Research Project, this architecture has been validated in a Smart Hospital real-world scenario using a healthcare virtual sensor service. Considering such purpose, medical status monitoring, location tracking and perimeter surveillance agent-based services have been developed. This study is concluded by a comparative analysis of the system considering memory overhead, packet delivery ratio, average end-to-end delay and battery lifetime as evaluation metrics. The results show a lightweight middleware implementation with good overall system and network performance.
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| 24. |
- Familiar, Miguel S, et al.
(författare)
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Pervasive smart spaces and environments : a service-oriented middleware architecture for wireless Ad Hoc and sensor networks
- 2012
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Ingår i: International Journal of Distributed Sensor Networks. - : SAGE Publications. - 1550-1329 .- 1550-1477. ; , s. Article number 725190-
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Tidskriftsartikel (refereegranskat)abstract
- In the twenty-first century, the impact of wireless and ubiquitous technologies is changing the way people perceive and interact with the physical world. These communication paradigms promise to change and redefine, in a reasonably short period of time, the most common way of our everyday living. The continuous advances in the field of Wireless Sensor Networks and their direct application in Smart Spaces are clear examples of it. However, in order for this kind of new generation infrastructures to have a large-scale dissemination, there are still some open issues to tackle. In this way, this paper presents nSOM, a service-oriented framework based on sensor network design that provides internetworking services with the Internet cloud. This lightweight middleware architecture implements an agent-based virtual sensor service approach which is a compact semantic knowledge management scheme based on a dynamic composition model. Copyright © 2012 Miguel S. Familiar et al.
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