| 1. |
- Barausse, Enrico, et al.
(författare)
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Prospects for fundamental physics with LISA
- 2020
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Ingår i: General Relativity and Gravitation. - : SPRINGER/PLENUM PUBLISHERS. - 0001-7701 .- 1572-9532. ; 52:8
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- In this paper, which is of programmatic rather than quantitative nature, we aim to further delineate and sharpen the future potential of the LISA mission in the area of fundamental physics. Given the very broad range of topics that might be relevant to LISA,we present here a sample of what we view as particularly promising fundamental physics directions. We organize these directions through a "science-first" approach that allows us to classify how LISA data can inform theoretical physics in a variety of areas. For each of these theoretical physics classes, we identify the sources that are currently expected to provide the principal contribution to our knowledge, and the areas that need further development. The classification presented here should not be thought of as cast in stone, but rather as a fluid framework that is amenable to change with the flow of new insights in theoretical physics.
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| 2. |
- Stolk, Lisette, et al.
(författare)
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Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways
- 2012
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 44:3, s. 260-268
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Tidskriftsartikel (refereegranskat)abstract
- To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P < 5 × 10(-8)). Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)). Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-κB signaling and mitochondrial dysfunction as biological processes related to timing of menopause.
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| 3. |
- Elhai, M, et al.
(författare)
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Outcomes of patients with systemic sclerosis treated with rituximab in contemporary practice: a prospective cohort study
- 2019
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Ingår i: Annals of the rheumatic diseases. - : BMJ. - 1468-2060 .- 0003-4967. ; 78:7, s. 979-987
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Tidskriftsartikel (refereegranskat)abstract
- To assess the safety and efficacy of rituximab in systemic sclerosis (SSc) in clinical practice.MethodsWe performed a prospective study including patients with SSc from the European Scleroderma Trials and Research (EUSTAR) network treated with rituximab and matched with untreated patients with SSc. The main outcomes measures were adverse events, skin fibrosis improvement, lung fibrosis worsening and steroids use among propensity score-matched patients treated or not with rituximab.Results254 patients were treated with rituximab, in 58% for lung and in 32% for skin involvement. After a median follow-up of 2 years, about 70% of the patients had no side effect. Comparison of treated patients with 9575 propensity-score matched patients showed that patients treated with rituximab were more likely to have skin fibrosis improvement (22.7 vs 14.03 events per 100 person-years; OR: 2.79 [1.47–5.32]; p=0.002). Treated patients did not have significantly different rates of decrease in forced vital capacity (FVC)>10% (OR: 1.03 [0.55–1.94]; p=0.93) nor in carbon monoxide diffusing capacity (DLCO) decrease. Patients having received rituximab were more prone to stop or decrease steroids (OR: 2.34 [1.56–3.53], p<0.0001). Patients treated concomitantly with mycophenolate mofetil had a trend for better outcomes as compared with patients receiving rituximab alone (delta FVC: 5.22 [0.83–9.62]; p=0.019 as compared with controls vs 3 [0.66–5.35]; p=0.012).ConclusionRituximab use was associated with a good safety profile in this large SSc-cohort. Significant change was observed on skin fibrosis, but not on lung. However, the limitation is the observational design. The potential stabilisation of lung fibrosis by rituximab has to be addressed by a randomised trial.
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| 4. |
- Hadid, L. Z., et al.
(författare)
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Solar Orbiter's first Venus flyby : Observations from the Radio and Plasma Wave instrument
- 2021
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 656
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Tidskriftsartikel (refereegranskat)abstract
- Context. On December 27, 2020, Solar Orbiter completed its first gravity assist manoeuvre of Venus (VGAM1). While this flyby was performed to provide the spacecraft with sufficient velocity to get closer to the Sun and observe its poles from progressively higher inclinations, the Radio and Plasma Wave (RPW) consortium, along with other operational in situ instruments, had the opportunity to perform high cadence measurements and study the plasma properties in the induced magnetosphere of Venus.Aims. In this paper, we review the main observations of the RPW instrument during VGAM1. They include the identification of a number of magnetospheric plasma wave modes, measurements of the electron number densities computed using the quasi-thermal noise spectroscopy technique and inferred from the probe-to-spacecraft potential, the observation of dust impact signatures, kinetic solitary structures, and localized structures at the bow shock, in addition to the validation of the wave normal analysis on-board from the Low Frequency Receiver.Methods. We used the data products provided by the different subsystems of RPW to study Venus' induced magnetosphere.Results. The results include the observations of various electromagnetic and electrostatic wave modes in the induced magnetosphere of Venus: strong emissions of similar to 100 Hz whistler waves are observed in addition to electrostatic ion acoustic waves, solitary structures and Langmuir waves in the magnetosheath of Venus. Moreover, based on the different levels of the wave amplitudes and the large-scale variations of the electron number densities, we could identify different regions and boundary layers at Venus.Conclusions. The RPW instrument provided unprecedented AC magnetic and electric field measurements in Venus' induced magnetosphere for continuous frequency ranges and with high time resolution. These data allow for the conclusive identification of various plasma waves at higher frequencies than previously observed and a detailed investigation regarding the structure of the induced magnetosphere of Venus. Furthermore, noting that prior studies were mainly focused on the magnetosheath region and could only reach 10-12 Venus radii (R-V) down the tail, the particular orbit geometry of Solar Orbiter's VGAM1, allowed the first investigation of the nature of the plasma waves continuously from the bow shock to the magnetosheath, extending to similar to 70R(V) in the far distant tail region.
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| 5. |
- Krpic, Z., et al.
(författare)
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Green HPC : MPI vs. OpenMP on a shared memory system
- 2012
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Ingår i: MIPRO 2012 - 35th International Convention on Information and Communication Technology, Electronics and Microelectronics - Proceedings. - 9789532330724 ; , s. 246-250
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Konferensbidrag (refereegranskat)abstract
- A power consumption of a high performance computer (HPC) system has been an issue lately. Many programming techniques are still relying on performance gain, but only few of them are concerning energy footprint of the increased computing power. MPI and OpenMP are considered as a core scientific HPC programming libraries for distributed-memory and shared-memory computer systems respectively. Each of them brings performance when used on a parallel system, but there are dissimilarities in their performance per watt ratio. The key is to find the best appliance for each of them on a shared-memory computer system.
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| 6. |
- Maksimovic, M., et al.
(författare)
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First observations and performance of the RPW instrument on board the Solar Orbiter mission
- 2021
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 656
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Tidskriftsartikel (refereegranskat)abstract
- The Radio and Plasma Waves (RPW) instrument on the ESA Solar Orbiter mission is designed to measure in situ magnetic and electric fields and waves from the continuum up to several hundred kHz. The RPW also observes solar and heliospheric radio emissions up to 16 MHz. It was switched on and its antennae were successfully deployed two days after the launch of Solar Orbiter on February 10, 2020. Since then, the instrument has acquired enough data to make it possible to assess its performance and the electromagnetic disturbances it experiences. In this article, we assess its scientific performance and present the first RPW observations. In particular, we focus on a statistical analysis of the first observations of interplanetary dust by the instrument's Thermal Noise Receiver. We also review the electro-magnetic disturbances that RPW suffers, especially those which potential users of the instrument data should be aware of before starting their research work.
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