| 1. |
- Regev, A, et al.
(författare)
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The Human Cell Atlas
- 2017
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Ingår i: eLife. - : ELIFE SCIENCES PUBLICATIONS LTD. - 2050-084X. ; 6
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Andrews, B., et al.
(författare)
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Imaging cell biology
- 2022
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Ingår i: Nature Cell Biology. - : Springer Nature. - 1465-7392 .- 1476-4679. ; 24:8, s. 1180-1185
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Tidskriftsartikel (refereegranskat)
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| 3. |
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| 4. |
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| 5. |
- Masocha, W, et al.
(författare)
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Cerebral vessel laminins and IFN-gamma y define Trypanosoma brucei brucei penetration of the blood-brain barrier
- 2004
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Ingår i: Journal of Clinical Investigation. - 0021-9738. ; 114:5, s. 689-694
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Tidskriftsartikel (refereegranskat)abstract
- Subspecies of Trypanosoma brucei cause severe brain diseases after penetration of the blood-brain barrier. We investigated whether cytokines that modulate inflammatory cell infiltration into the brain also influence T. brucei neuroinvasion. Migration of a rodent pathogenic T. brucei strain from the cerebral blood vessels into the brain parenchyma was impeded in IFN-gamma(-/-), IFN-gamma receptor(-/-) (IFN-gammaR(-/-)), IL-12p40(-/-), and recombinant activating gene-1(-/-) (RAG-1(-/-)) mice as compared with their WT littermates despite higher levels of parasitemia in the mutant strains. Parasites accumulated in the perivascular compartment, confined between the endothelial and the parenchymal basement membranes, in certain areas of the brains of IFN-gamma(-/-), IFN-gammaR(-/-), and RAG-1(-/-) mice. This accumulation occurred around endothelial basement membranes containing the laminin alpha4 chain, while blood vessels showing robust laminin alpha5 chain immunostaining were not associated with parasite infiltration. The number of CD4(+) and CD8(+) T cells infiltrating the brain parenchyma was also reduced in the IFN-gamma(-/-) and IFN-gammaR(-/-) mice. Our findings suggest that lymphocyte-derived IFN-gamma facilitates trypanosome penetration across cerebral blood vessels and that the site of penetration is determined by the composition of the basement membranes of these vessels.
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| 6. |
- Mhlanga, L, et al.
(författare)
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Observations on limnological conditions associated with a fish kill of Oreochromis niloticus in Lake Chivero following collapse of an algal bloom
- 2006
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Ingår i: African Journal of Ecology. - : Wiley. - 1365-2028 .- 0141-6707. ; 44:2, s. 199-208
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Tidskriftsartikel (refereegranskat)abstract
- Possible causes of deaths of Oreochromis niloticus in Lake Chivero were examined in relation to changes in limnological conditions monitored over a 25-month period. The fish deaths coincided with the collapse of an algal bloom that had developed and builtup in the lake for 8 months. Chlorophyll a and dissolved oxygen increased to average concentrations of 42.4 mu g l(-1) and 10.9 mg l(-1) respectively prior to the collapse of the bloom. Dissolved oxygen decreased when the bloom started to die off and coincided with the fish deaths when the average surface dissolved oxygen concentration in the lake was 3.9 mg l(-1) and was at a depth of 5 m < 2 mg l(-1). Mortality probably resulted from depressed oxygen levels caused by the high oxygen demand from the massive algal die-off and released algal toxins. This is the first time that die-off of algae has been linked to fish-kills in Lake Chivero as occurs in other hypereutrophic systems.
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