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Träfflista för sökning "WFRF:(Mukhopadhyay Asish K.) "

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1.	Bugaytsova, Jeanna, et al. (author) Acid Responsive Helicobacter pylori Adherence : Implications for Chronic Infection and Disease Other publication (other academic/artistic)
2.	Åberg, Anna, et al. (author) Helicobacter pylori adapts to chronic infection and gastric disease via ph-responsive baba-mediated adherence 2017 In: Cell Host and Microbe. - : Elsevier BV. - 1931-3128 .- 1934-6069. ; 21:3, s. 376-389 Journal article (peer-reviewed)abstract The BabA adhesin mediates high-affinity binding of Helicobacter pylori to the ABO blood group antigen-glycosylated gastric mucosa. Here we show that BabA is acid responsive-binding is reduced at low pH and restored by acid neutralization. Acid responsiveness differs among strains; often correlates with different intragastric regions and evolves during chronic infection and disease progression; and depends on pH sensor sequences in BabA and on pH reversible formation of high-affinity binding BabA multimers. We propose that BabA's extraordinary reversible acid responsiveness enables tight mucosal bacterial adherence while also allowing an effective escape from epithelial cells and mucus that are shed into the acidic bactericidal lumen and that bio-selection and changes in BabA binding properties through mutation and recombination with babA-related genes are selected by differences among individuals and by changes in gastric acidity over time. These processes generate diverse H. pylori subpopulations, in which BabA's adaptive evolution contributes to H. pylori persistence and overt gastric disease.
3.	Bugaytsova, Jeanna, et al. (author) pH regulated H. pylori adherence : implications for persistent infection and disease Other publication (other academic/artistic)abstract Helicobacter pylori’s BabA adhesin binds strongly to gastric mucosal ABH/Leb glycans on the stomach epithelium and overlying mucus, materials continuously shed into the acidic gastric lumen. Here we report that this binding is acid labile, acid inactivation is fully reversible; and acid lability profiles vary with BabA sequence and correlate with disease patterns. Isogenic H. pylori strains from the gastric antrum and more acidic corpus were identified that differed in acid lability of receptor binding and in sequence near BabA’s carbohydrate binding domain. We propose that reversible acid inactivation of receptor binding helps H. pylori avoid clearance by mucosal shedding, and that strain differences in acid lability affect tissue tropism and the spectrum of associated gastric diseases.
4.	Nahar, Shamsun, et al. (author) Antimicrobial susceptibility of Helicobacter pylori strains isolated in Bangladesh. 2004 In: J Clin Microbiol. - 0095-1137. ; 42:10, s. 4856-8 Journal article (other academic/artistic)
5.	Rahman, Motiur, et al. (author) DNA-level characterization of Helicobacter pylori strains from patients with overt disease and with benign infections in Bangladesh. 2003 In: J Clin Microbiol. - 0095-1137. ; 41:5, s. 2008-14 Journal article (other academic/artistic)

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Type of publication: journal article (3); other publication (2)

Type of content: other academic/artistic (4); peer-reviewed (1)

Author/Editor: Engstrand, Lars (5); Berg, Douglas E (5); Borén, Thomas (3); Dubois, Andre (3); Oscarson, Stefan (3); Brännström, Kristoff ... (3); show more...; Bylund, Göran (3); Aisenbrey, Christoph ... (3); Gröbner, Gerhard (3); Henriksson, Sara (3); Arnqvist, Anna (3); Sjöström, Rolf (3); Mahdavi, Jafar (3); Gilman, Robert H (3); Ilver, Dag (3); Schedin, Staffan (3); Haas, Rainer (3); Mendez, Melissa (3); Shevtsova, Anna (3); Ögren, Johan (3); Holgersson, Jan (2); Liu, Hui (2); Strömberg, Nicklas (2); Hofer, Anders (2); Björnham, Oscar (2); Schmidt, Alexej (2); Vikström, Susanne (2); Danielsson, Dan (2); Esberg, Anders (2); Bugaytsova, Jeanna (2); Remaut, Han (2); Chernov, Yevgen A (2); Moskalenko, Roman (2); Moonens, Kristof (2); Königer, Verena (2); Rakhimova, Lena (2); Olofsson, Anders (1); Unemo, Magnus (1); Unemo, Magnus, 1970- (1); Lindén, Sara K., 197 ... (1); Morozova-Roche, Ludm ... (1); Morozova-Roche, Ludm ... (1); Landström, Maréne (1); Odenbreit, Stefan (1); Ahmad, Mian Mashhud (1); Björnhamn, Oscar (1); Papadakos, Konstanti ... (1); Johansson, Pär (1); Gideonsson, Pär, 198 ... (1); Quintana-Hayashi, Ma ... (1); show less...

University: Umeå University (3); Karolinska Institutet (3); Uppsala University (2); University of Gothenburg (1); Örebro University (1)

Language: English (5)

Research subject (UKÄ/SCB): Medical and Health Sciences (3)

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