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- Cui, Y. X., et al.
(author)
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Giant Optical Transmission through a Metallic Nano-slit Achieved by the Optimization of the Groove Periodicity and Other Parameters
- 2008
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In: PROCEEDINGS OF THE 2008 INTERNATIONAL WORKSHOP ON METAMATERIALS. - NEW YORK : IEEE. - 9781424426089 ; , s. 236-239
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Conference paper (peer-reviewed)abstract
- The extraordinary optical transmission of light through a metallic nano-slit surrounded by groove corrugations can further be increased by optimizing the geometric parameters including the period of the corrugations, the period which has been set to be equal to the surface-plasmon wavelength in most of the previous works. By a global optimization, we are able to enhance the transmission efficiency of light through a silver nano-slit of 25 nm-wide as high as 18500 percent when the slit is surrounded by only 6 pairs of grooves.
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- Mlecnik, B, et al.
(author)
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Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study
- 2022
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In: Cancers. - : MDPI AG. - 2072-6694. ; 14:18
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Journal article (peer-reviewed)abstract
- BACKGROUND: In this study, we evaluated the prognostic value of Immunoscore in patients with stage I–III colon cancer (CC) in the Asian population. These patients were originally included in an international study led by the Society for Immunotherapy of Cancer (SITC) on 2681 patients with AJCC/UICC-TNM stages I–III CC. METHODS: CD3+ and cytotoxic CD8+ T-lymphocyte densities were quantified in the tumor and invasive margin by digital pathology. The association of Immunoscore with prognosis was evaluated for time to recurrence (TTR), disease-free survival (DFS), and overall survival (OS). RESULTS: Immunoscore stratified Asian patients (n = 423) into different risk categories and was not impacted by age. Recurrence-free rates at 3 years were 78.5%, 85.2%, and 98.3% for a Low, Intermediate, and High Immunoscore, respectively (HR[Low-vs-High] = 7.26 (95% CI 1.75−30.19); p = 0.0064). A High Immunoscore showed a significant association with prolonged TTR, OS, and DFS (p < 0.05). In Cox multivariable analysis stratified by center, Immunoscore association with TTR was independent (HR[Low-vs-Int+High] = 2.22 (95% CI 1.10–4.55) p = 0.0269) of the patient’s gender, T-stage, N-stage, sidedness, and MSI status. A significant association of a High Immunoscore with prolonged TTR was also found among MSS (HR[Low-vs-Int+High] = 4.58 (95% CI 2.27−9.23); p ≤ 0.0001), stage II (HR[Low-vs-Int+High] = 2.72 (95% CI 1.35−5.51); p = 0.0052), low-risk stage-II (HR[Low-vs-Int+High] = 2.62 (95% CI 1.21−5.68); p = 0.0146), and high-risk stage II patients (HR[Low-vs-Int+High] = 3.11 (95% CI 1.39−6.91); p = 0.0055). CONCLUSION: A High Immunoscore is significantly associated with the prolonged survival of CC patients within the Asian population.
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- Yamasaki, Y, et al.
(author)
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Mouse chromosome 19 and distal rat chromosome 1: a chromosome segment conserved in evolution.
- 2001
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In: Hereditas. - : Wiley-Blackwell Publishing, Inc.. - 0018-0661 .- 1601-5223. ; 134:1, s. 23-34
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Journal article (peer-reviewed)abstract
- Through a combination of radiation hybrid mapping and studies by FISH and zoo-FISH we have made a comparative investigation of the distal portion of rat chromosome 1 (RNO1) and the entire mouse chromosome 19 (MMU19). It was found that homologous segments of RNO1 and MMU19 are similar in banding morphology and in length as determined by several different methods, and that the gene order of the 46 genes studied appears to be conserved across the homologous segments in the two species. High-resolution zoo-FISH techniques showed that MMU19 probes highlight only a continuous segment on RNO1 (1q43-qter), with no detectable signals on other rat chromosomes. We conclude that these data suggest the evolutionary conservation of a chromosomal segment from a common rodent ancestor. This segment now constitutes the entire MMU19 and a large segment distally on RNO1q in the mouse and rat, respectively.
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- Mlecnik, B, et al.
(author)
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Multicenter International Study of the Consensus Immunoscore for the Prediction of Relapse and Survival in Early-Stage Colon Cancer
- 2023
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In: Cancers. - : MDPI AG. - 2072-6694. ; 15:2
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Journal article (peer-reviewed)abstract
- Background: The prognostic value of Immunoscore was evaluated in Stage II/III colon cancer (CC) patients, but it remains unclear in Stage I/II, and in early-stage subgroups at risk. An international Society for Immunotherapy of Cancer (SITC) study evaluated the pre-defined consensus Immunoscore in tumors from 1885 AJCC/UICC-TNM Stage I/II CC patients from Canada/USA (Cohort 1) and Europe/Asia (Cohort 2). METHODS: Digital-pathology is used to quantify the densities of CD3+ and CD8+ T-lymphocyte in the center of tumor (CT) and the invasive margin (IM). The time to recurrence (TTR) was the primary endpoint. Secondary endpoints were disease-free survival (DFS), overall survival (OS), prognosis in Stage I, Stage II, Stage II-high-risk, and microsatellite-stable (MSS) patients. RESULTS: High-Immunoscore presented with the lowest risk of recurrence in both cohorts. In Stage I/II, recurrence-free rates at 5 years were 78.4% (95%-CI, 74.4–82.6), 88.1% (95%-CI, 85.7–90.4), 93.4% (95%-CI, 91.1–95.8) in low, intermediate and high Immunoscore, respectively (HR (Hi vs. Lo) = 0.27 (95%-CI, 0.18–0.41); p < 0.0001). In Cox multivariable analysis, the association of Immunoscore to outcome was independent (TTR: HR (Hi vs. Lo) = 0.29, (95%-CI, 0.17–0.50); p < 0.0001) of the patient’s gender, T-stage, sidedness, and microsatellite instability-status (MSI). A significant association of Immunoscore with survival was found for Stage II, high-risk Stage II, T4N0 and MSS patients. The Immunoscore also showed significant association with TTR in Stage-I (HR (Hi vs. Lo) = 0.07 (95%-CI, 0.01–0.61); P = 0.016). The Immunoscore had the strongest (69.5%) contribution χ2 for influencing survival. Patients with a high Immunoscore had prolonged TTR in T4N0 tumors even for patients not receiving chemotherapy, and the Immunoscore remained the only significant parameter in multivariable analysis. CONCLUSION: In early CC, low Immunoscore reliably identifies patients at risk of relapse for whom a more intensive surveillance program or adjuvant treatment should be considered.
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- Okuno, Y., et al.
(author)
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Sensing applications on refractive index based on metal gratings
- 2006
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In: Proc. Int. Symp. Biophotonics, Nanophotonics Metamaterials. - 0780397746 - 9780780397743 ; , s. 267-271
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Conference paper (peer-reviewed)abstract
- Sensing applications on refractive index based on metal gratings are investigated. The excitation of surface plasmon on a metal grating placed in planer or conical mounting is examined. Numerical results are compared with experimental data. When a TM wave illuminates a metal grating, total or partial absorption of incident light occurs at angles of incidence at which the surface plasmon waves are excited. A conical mounting is introduced in the sensing application in which an enhancement of TM-TE mode conversion is observed in close vicinity to the resonance angle at which almost of the reflected light is in TE polarization. This, hence, makes the reciprocal of the TM-wave efficiency a good measure in finding the angles of incidence at which the surface waves are excited, which leads to a precise measurement. Yasuura's modal-expansion method is introduced in the numerical simulation. The setup for sensing application is represented in details.
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- Yang, L., et al.
(author)
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Optimal design of ultra-broadband, omnidirectional, and polarization-insensitive amorphous silicon solar cells with a core-shell nanograting structure
- 2013
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In: Progress in Photovoltaics. - : Wiley. - 1062-7995 .- 1099-159X. ; 21:5, s. 1077-1086
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Journal article (peer-reviewed)abstract
- We systematically investigated the optical behaviors of an amorphous silicon solar cell with a core-shell nanograting structure. The horizontally propagating Bloch waves and Surface Plasmon Polariton waves lead to significant absorption enhancements and consequently short-circuit current enhancements of this structure, compared with the conventional planar one. The perpendicular carrier collection makes this structure optically thick and electronically thin. An optimal design is achieved through full-field numerical simulation, and a physical explanation is given. Our numerical results show that this configuration has ultra-broadband, omnidirectional, and polarization-insensitive responses and has a great potential in photovoltaics.
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