| 1. |
- Kehoe, Laura, et al.
(författare)
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Make EU trade with Brazil sustainable
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Klionsky, Daniel J., et al.
(författare)
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Guidelines for the use and interpretation of assays for monitoring autophagy
- 2012
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Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
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Forskningsöversikt (refereegranskat)abstract
- In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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| 3. |
- Shungin, Dmitry, et al.
(författare)
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New genetic loci link adipose and insulin biology to body fat distribution.
- 2015
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 187-378
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Tidskriftsartikel (refereegranskat)abstract
- Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
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| 4. |
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| 5. |
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| 6. |
- Bengtsson, Stefan, 1961, et al.
(författare)
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Integration of silicon and diamond, aluminum nitride or aluminum oxide for electronic materials
- 1999
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Ingår i: conference proceedings:III-V and IV-IV Materials and Processing Challenges for Highly Integrated Microelectronics and Optoelectronics. Symposium.. ; , s. 133-
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Konferensbidrag (refereegranskat)abstract
- Material integration for the formation of advanced silicon-on-insulator materials by wafer bonding and etch-back is discussed. Wafer bonding allows the combining of materials that it is not possible to grow on top of each other by any other technique. In our experiments, polycrystalline diamond, aluminum nitride or aluminum oxide films with thickness of 0.1-5 μm were deposited on silicon wafers. Bonding experiments were made with these films to bare silicon wafers with the goal of forming silicon-on-insulator structures with buried films of polycrystalline diamond, aluminum nitride or aluminum oxide. These silicon-on-insulator structures are intended to address self-heating effects in conventional silicon-on-insulator materials with buried layers of silicon dioxide. The surfaces of the deposited diamond films were, by order of magnitude, too rough to allow direct bonding to a silicon wafer. In contrast the deposited aluminum nitride and aluminum oxide films did allow direct bonding to silicon. Bonding of the diamond surface to silicon was instead made through a deposited and polished layer of polycrystalline silicon on top of the diamond. In the case of the aluminum nitride electrostatic bonding was also demonstrated. Further, the compatibility of these insulators to silicon process technology was investigated
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| 7. |
- Bydén, Stefan, 1951, et al.
(författare)
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Mark - Människa -Miljö
- 2004
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Boken handlar om hur marken formats och påverkats av spadar och grävskopor, mular och harvar, kemikalier och sura regndroppar. Den fjärde upplagan har reviderade texter som ingående behandlar marken ur alla aspekter: markegenskaper, kulturlandskapet, skogsbruk, exploatering, planering och lagar, naturvård, information m.m. Boken är rikligt illustrerad med foton, diagram, teckningar och kartor. Boken är ett samarbete mellan Stockholms och Göteborgs universitet. Författarna är verksamma inom högskolan eller annan utbildning.
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| 8. |
- Christiansen, Evald H, et al.
(författare)
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Instantaneous Wave-free Ratio versus Fractional Flow Reserve to Guide PCI.
- 2017
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Ingår i: The New England journal of medicine. - : Massachussetts Medical Society. - 1533-4406 .- 0028-4793. ; 376:19, s. 1813-1823
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Tidskriftsartikel (refereegranskat)abstract
- The instantaneous wave-free ratio (iFR) is an index used to assess the severity of coronary-artery stenosis. The index has been tested against fractional flow reserve (FFR) in small trials, and the two measures have been found to have similar diagnostic accuracy. However, studies of clinical outcomes associated with the use of iFR are lacking. We aimed to evaluate whether iFR is noninferior to FFR with respect to the rate of subsequent major adverse cardiac events.We conducted a multicenter, randomized, controlled, open-label clinical trial using the Swedish Coronary Angiography and Angioplasty Registry for enrollment. A total of 2037 participants with stable angina or an acute coronary syndrome who had an indication for physiologically guided assessment of coronary-artery stenosis were randomly assigned to undergo revascularization guided by either iFR or FFR. The primary end point was the rate of a composite of death from any cause, nonfatal myocardial infarction, or unplanned revascularization within 12 months after the procedure.A primary end-point event occurred in 68 of 1012 patients (6.7%) in the iFR group and in 61 of 1007 (6.1%) in the FFR group (difference in event rates, 0.7 percentage points; 95% confidence interval [CI], -1.5 to 2.8; P=0.007 for noninferiority; hazard ratio, 1.12; 95% CI, 0.79 to 1.58; P=0.53); the upper limit of the 95% confidence interval for the difference in event rates fell within the prespecified noninferiority margin of 3.2 percentage points. The results were similar among major subgroups. The rates of myocardial infarction, target-lesion revascularization, restenosis, and stent thrombosis did not differ significantly between the two groups. A significantly higher proportion of patients in the FFR group than in the iFR group reported chest discomfort during the procedure.Among patients with stable angina or an acute coronary syndrome, an iFR-guided revascularization strategy was noninferior to an FFR-guided revascularization strategy with respect to the rate of major adverse cardiac events at 12 months. (Funded by Philips Volcano; iFR SWEDEHEART ClinicalTrials.gov number, NCT02166736 .).
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| 9. |
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| 10. |
- Götberg, Matthias, et al.
(författare)
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5-Year Outcomes of PCI Guided by Measurement of Instantaneous Wave-Free Ratio Versus Fractional Flow Reserve
- 2022
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Ingår i: Journal of the American College of Cardiology. - : Elsevier. - 0735-1097 .- 1558-3597. ; 79:10, s. 965-974
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Instantaneous wave-free ratio (iFR) is a coronary physiology index used to assess the severity of coronary artery stenosis to guide revascularization. iFR has previously demonstrated noninferior short-term outcome compared to fractional flow reserve (FFR), but data on longer-term outcome have been lacking.OBJECTIVES: The purpose of this study was to investigate the prespecified 5-year follow-up of the primary composite outcome of all-cause mortality, myocardial infarction, and unplanned revascularization of the iFR-SWEDEHEART trial comparing iFR vs FFR in patients with chronic and acute coronary syndromes.METHODS: iFR-SWEDEHEART was a multicenter, controlled, open-label, registry-based randomized clinical trial using the Swedish Coronary Angiography and Angioplasty Registry for enrollment. A total of 2,037 patients were randomized to undergo revascularization guided by iFR or FFR.RESULTS: No patients were lost to follow-up. At 5 years, the rate of the primary composite endpoint was 21.5% in the iFR group and 19.9% in the FFR group (HR: 1.09; 95% CI: 0.90-1.33). The rates of all-cause death (9.4% vs 7.9%; HR: 1.20; 95% CI: 0.89-1.62), nonfatal myocardial infarction (5.7% vs 5.8%; HR: 1.00; 95% CI: 0.70-1.44), and unplanned revascularization (11.6% vs 11.3%; HR: 1.02; 95% CI: 0.79-1.32) were also not different between the 2 groups. The outcomes were consistent across prespecified subgroups.CONCLUSIONS: In patients with chronic or acute coronary syndromes, an iFR-guided revascularization strategy was associated with no difference in the 5-year composite outcome of death, myocardial infarction, and unplanned revascularization compared with an FFR-guided revascularization strategy. (Evaluation of iFR vs FFR in Stable Angina or Acute Coronary Syndrome [iFR SWEDEHEART]; NCT02166736)
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| 11. |
- Hempel, Anders, et al.
(författare)
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Developmental perspectives on tutorial groups as projects groups
- 2001
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Ingår i: Studies of Groups and Change. Proceedings from a conference on group and social psychology, Lund University, May 2000. - 9163108992 ; , s. 112-124
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Konferensbidrag (refereegranskat)abstract
- A new system to categorize the content of group diaries is developed and tried out in 12 PBL groups. The theoretically derived and preformed main categories were Boundary manage¬ment, Transformational realms, Awareness of organizational contexts and temporal perspectives. After analysis it is concluded that it may be a more fruitful way to proceed through reading and analyzing the diaries as narratives, evaluating them a holistic perspec¬tive.
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| 12. |
- Jern, Stefan, et al.
(författare)
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The pair in the group: Boundaries for destruction and creativity
- 2001
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Ingår i: Studies of Groups and Change. Proceedings from a conference on group and social psychology, Lund University, May 2000. - 9163108992 ; , s. 134-157
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Konferensbidrag (refereegranskat)abstract
- A comparative case study is performed of three working groups containing pairs and triads. Effects on cohesion and group development are analyzed and a model is constructed A distinction is made between pairs formed 1. out of earlier relationships, 2. and/or to pursue work and those that form, 3. as a reaction to the former. Pairs can contribute to work and development in constructive ways, but pairs can also destroy work and hinder progress. The outcome depends on how the pair is viewed by the group, what meaning is ascribed to it and on to what degree it is organized and integrated into the group. The outcome partly depends on boundary issues.
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| 13. |
- Lingegård, Sofia, et al.
(författare)
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Sustainable public procurement in large infrastructure projects—policy implementation for carbon emission reductions
- 2021
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Ingår i: Sustainability. - : MDPI AG. - 2071-1050. ; 13:20
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Tidskriftsartikel (refereegranskat)abstract
- The infrastructure construction sector is a significant source of carbon emissions, and more stringent procurement requirements are central to meeting reduction targets in this demand-led and project-based industry. This paper aims to analyze the implementation of international policies for reducing carbon emissions in infrastructure construction, focusing on the interaction between policy ambitions and procurement practices. Based on case studies of large projects and their contexts in five countries worldwide: Australia, the Netherlands, Sweden, the UK, and the US, a cross-country comparison is performed of how policies and practices for carbon reduction develop across multiple implementation levels. Three levels are included in the analysis: policy, industry, and project level. We identify the projects as either drivers of policy goals, frontrunners in industry-level development processes, or translators of national policy. These roles, and the associated pathways for carbon emission reduction, are context-specific and depend on the policy ambitions at the national or regional level, the maturity of the supplier market, and, often, on the strategies of individual champions at the project level. Long-term learning processes, both within and between the various levels, are essential for advancing carbon reduction.
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| 14. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 15. |
- Olsson, Tobias, et al.
(författare)
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Tillit i det digitala samhället – en kartläggning
- 2014
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Ingår i: DigiTrust: Tillit i det digitala. Tvärvetenskapliga perspektiv från ett forskningsprojekt. - 9789197989367 ; , s. 21-40
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Bokkapitel (populärvet., debatt m.m.)abstract
- Det här kapitlet redovisar resultat från den enkätstudie om tillit i det digitala samhället som genomfördes i DigiTrustprojektet i januari, 2014. Den internetbaserade enkätstudien innehöll 1118 svenska respondenter med en jämn fördelning avseende kön och ålder. Enkäten omfattade ca 35 frågor som i huvudsak kunde sorteras under någon av följande fem kategorier: 1) Övervakning, 2) Bank 3) Hälsa, 4) Arbetsliv, och 5) Medier.
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| 16. |
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| 17. |
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| 18. |
- Tyler, Torbjörn, et al.
(författare)
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Recent changes in the frequency of plant species and vegetation types in Scania, S Sweden, compared to changes during the twentieth century
- 2019
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Ingår i: Biodiversity and Conservation. - : Springer Science and Business Media LLC. - 0960-3115 .- 1572-9710.
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Tidskriftsartikel (refereegranskat)abstract
- Based on data from three surveys of the vascular flora of the province of Scania, southernmost Sweden, conducted 1938–1971, 1987–2006 and 2008–2015, we analyse the change in frequency of individual species and groups of species associated with particular vegetation types. A majority of all species have experienced a change in frequency since 1938, and this turnover has continued in recent decades. The species showing the most dramatic declines since 1987 represent a mixture of arable weeds, grassland species and ruderals, but excludes forest species. In contrast, a majority of the most increasing species are escapes from cultivation that thrive under shaded conditions. The vegetation types showing the largest decreases since 1987 are all open seminatural grasslands and wetlands, while the vegetation types performing best are wooded. All vegetation types increasing since 1987 also increased during the 1900s; however, species of wooded types performed relatively better in recent decades, as opposed to the minimal increase observed for species of vegetation strongly influenced by human activities. Among decreasing vegetation types, those that have received much attention from conservationists, e.g. sand-steppe andcalcareous fens tend to perform relatively better now than during the 1900s, while those that have received less attention, e.g. poor fens, oligotrophic waters and heaths, now comprise the most rapidly declining vegetation types. A majority of the species that decreased 1938–1996 also decreased 1987–2015, but, in general, species shown to have increased during the 1900s have not continued to increase.
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| 19. |
- van Schaarenburg, Rosanne A., et al.
(författare)
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Marked variability in clinical presentation and outcome of patients with C1q immunodeficiency
- 2015
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Ingår i: Journal of Autoimmunity. - : Elsevier BV. - 0896-8411 .- 1095-9157. ; 62, s. 39-44
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Globally approximately 60 cases of C1q deficiency have been described with a high prevalence of Systemic Lupus Erythematosus (SLE). So far treatment has been guided by the clinical presentation rather than the underlying C1q deficiency. Recently, it was shown that C1q production can be restored by allogeneic hematopoietic stem cell transplantation. Current literature lacks information on disease progression and quality of life of C1q deficient persons which is of major importance to guide clinicians taking care of patients with this rare disease.Methods: We performed an international survey, of clinicians treating C1q deficient patients. A high response rate of >70% of the contacted clinicians yielded information on 45 patients with C1q deficiency of which 25 are published.Results: Follow-up data of 45 patients from 31 families was obtained for a median of 11 years after diagnosis. Of these patients 36 (80%) suffer from SLE, of which 16 suffer from SLE and infections, 5 (11%) suffer from infections only and 4 (9%) have no symptoms. In total 9 (20%) of the C1q deficient individuals had died. All except for one died before the age of 20 years. Estimated survival times suggest 20% case-fatality before the age of 20, and at least 50% of patients are expected to reach their middle ages.Conclusion: Here we report the largest phenotypic data set on C1q deficiency to date, revealing high variance; with high mortality but also a subset of patients with an excellent prognosis. Management of C1q deficiency requires a personalized approach.
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| 20. |
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| 21. |
- Ahrentorp, Fredrik, et al.
(författare)
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Effective particle magnetic moment of multi-core particles
- 2015
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Ingår i: Journal of Magnetism and Magnetic Materials. - : Elsevier BV. - 0304-8853 .- 1873-4766. ; 380, s. 221-226
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Tidskriftsartikel (refereegranskat)abstract
- In this study we investigate the magnetic behavior of magnetic multi-core particles and the differences in the magnetic properties of multi-core and single-core nanoparticles and correlate the results with the nanostructure of the different particles as determined from transmission electron microscopy (TEM). We also investigate how the effective particle magnetic moment is coupled to the individual moments of the single-domain nanocrystals by using different measurement techniques: DC magnetometry, AC susceptometry, dynamic light scattering and TEM. We have studied two magnetic multi-core particle systems BNF Starch from Micromod with a median particle diameter of 100 am and FeraSpin R from nanoPET with a median particle diameter of 70 nm - and one single-core particle system - SHP25 from Ocean NanoTech with a median particle core diameter of 25 nm. (C) 2014 Elsevier B.V. All rights reserved.
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| 22. |
- Aid, Graham, 1980-
(författare)
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Operationalizing Industrial Ecology in the Waste Sector : Roles and tactics for circular value innovation
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The take-make-waste approach to resource management in human production and consumption systems is contributing to a variety of environmental and social problems worldwide. Additionally, as the world’s population and affluence increase, so do the negative impacts of poor resource management. Lifting the waste management (WM) sector into a new phase of development, which takes its lead from the ideals of Industrial Ecology and circular economy, is seen by many scholars and practitioners as one potential to assist in alleviating these impacts. While there are many studies on how more efficient inter-organizational resource management is (or could be) constructed, there are relatively few business development studies which have explored novel approaches (from roles to tactics) that WM organizations might operationalize toward more efficient resource management.The aim of this thesis is to contribute to the development of knowledge and understanding of how the waste management sector can operationalize more effective and efficient resource management. In approaching this aim, two research questions guided the exploration of: 1) novel roles for WM and 2) support tactics for such roles. Grounded in the broader context of Industrial Ecology (IE) and Business Development, five studies were performed. Two studies, focused on the novel roles of inter-organizational resource management and high value secondary resource extraction, were performed through literature review and interviews, and market driver analysis respectively. In exploring support tactics, two design and proof of concept studies were carried out to investigate data analysis tools for inter-organizational resource management, and one long-term action research engagement project was coordinated to study hands-on inter-organizational collaboration tactics.The studies highlighted that the Swedish WM sector holds some key capacities for operationalizing (and in some cases, is already developing) the novel resource management roles identified: industrial symbiosis facilitator, eco-industrial park manager, holistic facility management, and high value resource extractor. However, depending on the portfolio of services to be performed in such roles, several capacities may need to be developed or strengthened. Main opportunities seen for these roles were – staying ahead of market developments, and aligning activities with organizational goals. The main general risk related to these roles was insufficient returns on investment. Looking forward, the main enablers identified were policy leadership for more balanced market mechanisms, increasing use of external knowledge, developing long term partnerships, lobbying, stockpiling resources, and carefully crafting new business models.The tools developed for strategically applying external information toward the identification of opportunities within new roles showed tactical potential. However, their implementation in broader development processes has yet to be fully validated. The hands-on exploration of change oriented collaboration, highlighted collective system framing and goal setting and face-to-face interaction as key activities for inter-organizational approaches within roles such as industrial symbiosis facilitator.Throughout the studies, several novel roles were investigated. Each of these roles will need to be individually evaluated by directing bodies of WM organizations, and evaluated from the organization’s vision and strategy. If certain roles are chosen to be explored in more detail, they will need to be developed within full business models - addressing issues such as income structure, internal processes and capacities to be developed, and key customers. Through applying IE and business development concepts and findings, WM organizations have possibilities to translate ambitious visions into novel offerings.
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| 23. |
- Al-Naqshabandy, Mohammed Salim
(författare)
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Strength variability in lime-cement columns and its effect on the reliability of embankments
- 2011
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Ground improvement by deep mixing (DM) is a generic term used for a number of methods in which a binding agent, often lime and/or cement, is mechanically mixed with the soil to increase its engineering properties. The inherent variability with respect to the engineering properties of the improved soil is high due to the variations in geology and the complex mixing process. High variability introduces uncertainty in estimating improved soil properties and the performance of the structure.Current design methodology deals with soil properties deterministically and the uncertainties involved are incorporated in a single value represented by a total factor of safety (FS). The chosen FS is highly dependent on the engineer’s judgment and past experience, in which both of these factors vary between different geotechnical designers. Therefore, current design methodology used in practice for DM does not deal with uncertainties in a rational way. In order to design a geotechnical system with the desired level of confidence, the uncertainties involved must be integrated in the DM design. This can be achieved by using reliability-based design (RBD) methods.The research work in this thesis is presented as a collection of three papers. In the first paper, a comprehensive statistical analysis of cone penetration test (CPT) data is described. The objective was to make a contribution to empirical knowledge by evaluating the strength variability of lime-cement columns within the group of tested columns. In the second paper, the effect of the spatial variability and statistical uncertainty with regard to the embankment’s reliability was investigated within the framework of RBD. The study in the third paper investigated the strength variability in lime-cement columns based on two test methods, namely CPT and column penetration test (KPS). In this study, the effect of different test methods on the evaluation of the design value was addressed.The main conclusions from this study can be summarized as follows. First, the probability distribution function (PDF) for the undrained shear strength of lime-cement columns can be modeled in RBD as normal or log-normal distributions. However, the use of log-normal distribution is recommended for RBD analyses. Second, the evaluated scales of fluctuation indicate ranges of 2 to 4 m and 0.2 to 0.8 m in the horizontal and the vertical directions respectively. This means that in order to fulfill the requirements of independent/uncorrelated samples for assessment of the design value, the spacing between samples must exceed the horizontal scale of fluctuation. It is therefore proposed that the spacing between individual samples should be at least 4 meters. Third, the design values evaluated using CPT and KPS were approximately the same. However, the inherent variability evaluated differs due to the larger volume tested with the KPS probe than with the CPT probe. However, this difference was not significant between the two tests. Fourthly, due to the limitation in the deterministic design in terms of dealing with uncertainties, it is recommended that RBD design should be used in parallel with the deterministic design of lime-cement column.
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| 24. |
- Aleman, Soo, et al.
(författare)
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Health check-ups and family screening allow detection of hereditary hemochromatosis with less advanced liver fibrosis and survival comparable with the general population
- 2011
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Ingår i: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 0036-5521 .- 1502-7708. ; 46:9, s. 1118-1126
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Tidskriftsartikel (refereegranskat)abstract
- Objective. The information concerning the morbidity and mortality of hereditary hemochromatosis is based primarily on clinical cohorts of symptomatic patients. The major aim of this study was to analyze the long-term prognosis for Swedish patients with this condition, with respect to both clinical features and survival, in relation to the route by which the disease was detected. Patients and methods. 373 patients with hemochromatosis detected through routine health checkups (n = 153), family screening (n = 44), symptoms of arthralgia (n = 23), investigation of other diseases/symptoms (n = 108) or signs of liver disease (n = 45) were monitored for a mean period of 11.9 +/- 5.8 years. The degree of liver fibrosis and survival were analyzed. Results. Overall survival among these patients was not significantly different from that of a matched normal population. The patients diagnosed through health check-ups and family screening were detected at an earlier age and had the highest rate of survival. Liver biopsy at the time of diagnosis revealed cirrhosis in 9% of those detected through the health check-ups and 5% in the case of family screening, compared with 13% for the group with arthralgia, 17% for other diseases/symptoms and 42% for liver disease. Conclusion. Health check-ups and family screening allow detection of hereditary hemochromatosis at an earlier age and with less advanced liver fibrosis, although a few of these patients have already developed cirrhosis. Our study indicates that iron indices should be included in health check-ups, and if abnormal, should lead to further investigation.
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| 25. |
- Almered Olsson, Gunilla, 1951, et al.
(författare)
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Revisiting drivers for Environmental Migration in Africa
- 2016
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Ingår i: Deveopment Research Conference 2016. August 22-24, Stockholm University. - Stockholm : Stockholm University, VR, Formas, SIDA.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- International migration is one of the burning global challenges for sustainable development. Environmental migration is a contested concept since destruction of livelihood conditions that leads to the deterioration of options for securing a living, is caused by a number of interacting variables such as changes in climate, land use, local and regional ecological conditions, socio-cultural-economic and political dynamics. The different factors act at different temporal and spatial scales that makes the outcome difficult to generalize for a specific site, which adds to the confusion of the interpretation and application of the concept. Yet migration due to livelihood deterioration is ongoing and environmental migrants seem to be an increasing challenge. This is also acknowledged by the EU, whose governance system related to migration does not cater for the environmental dimension. In spite of much of environmentally induced migration to the EU originates from Africa, this topic has not until recently been up on the agenda of policy discussions between the EU and Africa. The Valletta Summit on Migration, November 2015, was organised to discuss the ‘migration crisis’ experienced in Europe and Africa. The summit resulted in the EU setting up an Emergency Trust Fund to promote development in Africa, in return for African countries to help out in the crisis. We are reporting from a project on the complex interactions of different drivers acting on the local African livelihoods and thus driving migration. The aim is inform the development of sustainable governance mechanisms at different institutional levels in the EU-Africa relations.
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