| 1. |
- Bott, Lukas Thomas, et al.
(författare)
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Coulomb dissociation of O-16 into He-4 and C-12
- 2023
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Ingår i: NUCLEAR PHYSICS IN ASTROPHYSICS - X, NPA-X 2022. - : EDP Sciences. - 2100-014X. ; 279
-
Konferensbidrag (refereegranskat)abstract
- We measured the Coulomb dissociation of O-16 into He-4 and C-12 within the FAIR Phase-0 program at GSI Helmholtzzentrum fur Schwerionenforschung Darmstadt, Germany. From this we will extract the photon dissociation cross section O-16(alpha,gamma)C-12, which is the time reversed reaction to C-12(alpha,gamma)O-16. With this indirect method, we aim to improve on the accuracy of the experimental data at lower energies than measured so far. The expected low cross section for the Coulomb dissociation reaction and close magnetic rigidity of beam and fragments demand a high precision measurement. Hence, new detector systems were built and radical changes to the (RB)-B-3 setup were necessary to cope with the high-intensity O-16 beam. All tracking detectors were designed to let the unreacted O-16 ions pass, while detecting the C-12 and He-4.
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| 2. |
- Butlin, Roger, 1955, et al.
(författare)
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PARALLEL EVOLUTION OF LOCAL ADAPTATION AND REPRODUCTIVE ISOLATION IN THE FACE OF GENE FLOW
- 2014
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Ingår i: Evolution. - : Wiley. - 0014-3820. ; 68:4, s. 935-949
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Tidskriftsartikel (refereegranskat)abstract
- Parallel evolution of similar phenotypes provides strong evidence for the operation of natural selection. Where these phenotypes contribute to reproductive isolation, they further support a role for divergent, habitat-associated selection in speciation. However, the observation of pairs of divergent ecotypes currently occupying contrasting habitats in distinct geographical regions is not sufficient to infer parallel origins. Here we show striking parallel phenotypic divergence between populations of the rocky-shore gastropod, Littorina saxatilis, occupying contrasting habitats exposed to either wave action or crab predation. This divergence is associated with barriers to gene exchange but, nevertheless, genetic variation is more strongly structured by geography than by ecotype. Using approximate Bayesian analysis of sequence data and amplified fragment length polymorphism markers, we show that the ecotypes are likely to have arisen in the face of continuous gene flow and that the demographic separation of ecotypes has occurred in parallel at both regional and local scales. Parameter estimates suggest a long delay between colonization of a locality and ecotype formation, perhaps because the postglacial spread of crab populations was slower than the spread of snails. Adaptive differentiation may not be fully genetically independent despite being demographically parallel. These results provide new insight into a major model of ecologically driven speciation.
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| 3. |
- Cai, Tao, et al.
(författare)
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A TD-LTE prototype system with modules for general-purpose cognitive resource management and radio-environmental mapping
- 2011
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Ingår i: International Journal of Wireless Information Networks. - : Springer Science and Business Media LLC. - 1068-9605 .- 1572-8129. ; 18:3, s. 131-145
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Tidskriftsartikel (refereegranskat)abstract
- In this article we describe a demonstrator that shows how the cognitive resource manager (CRM) and the radio-environmental map (REM) can be efficiently implemented in full commercial grade cellular system (i.e., LTE system). The demonstrator shows how the modular CRM together with its open interface, the universal link-layer API (ULLA), facilitates the implementation of efficient radio resource management techniques guaranteeing the quality of service in the LTE system. The CRM, through ULLA, is able to obtain PHY/MAC status information of the link between the tested eNode B and the user equipment, and reconfigure link parameters. This measure-and-control by CRM/ULLA is independent of the underlying radio access technology, which shows the neutrality of CRM/ULLA towards PHY/MAC characteristics. The article also shows how the REM can be easily implemented in such system and how the REM provides the CRM with environmental information that enhances system management performance
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| 4. |
- Cai, Tao, et al.
(författare)
-
An implementation of cognitive resource management on LTE platform
- 2010
-
Ingår i: 2010 IEEE 21st International Symposium on Personal, Indoor and Mobile Radio Communications (PIMRC 2010). - Piscataway, NJ : IEEE Communications Society. - 9781424480166 ; , s. 2663-2668
-
Konferensbidrag (refereegranskat)abstract
- In this paper we describe an LTE based demonstrator of the Universal Link Layer API (ULLA) and Cognitive Resource Manager (CRM) modules that are developed in ARAGORN project. The demonstrated LTE system comprises one LTE TDD eNode B and one User Equipment (UE). We first introduce ULLA and CRM framework and then demonstrate their suitability to be implemented with the existing LTE equipments. We show how, through ULLA, CRM is able to obtain PHY/MAC status information of the link between the eNode B and UE, and in turn change system parameters to achieve better resource utilization and transmission efficiency. The control logic can be implemented with simple adaptation or policy-based intelligent methods. The platform clearly shows the feasibility to use ULLA/CRM architecture for radio resource management in a LTE network. It also shows the neutrality of ULLA/CRM mechanisms towards PHY/MAC characteristics of LTE technology platform; hence the platform is viable to flexibly switch between technology platforms (e.g. between LTE access and WiFi access) under the control of ULLA/CRM.
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| 5. |
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| 6. |
- Johannesson, Kerstin, 1955, et al.
(författare)
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Repeated evolution of reproductive isolation in a marine snail - unveiling mechanisms of speciation
- 2010
-
Ingår i: Philosophical Transactions of the Royal Society Biology. - 0962-8436. ; 365:1547, s. 1735-1747
-
Tidskriftsartikel (refereegranskat)abstract
- Distinct ecotypes of the snail Littorina saxatilis, each linked to a specific shore microhabitat, form a mosaic-like pattern with narrow hybrid zones in between, over which gene flow is 10–30% of within-ecotype gene flow. Multi-locus comparisons cluster populations by geographic affinity independent of ecotype, while loci under selection group populations by ecotype. The repeated occurrence of partially reproductively isolated ecotypes and the conflicting patterns in neutral and selected genes can either be explained by separation in allopatry followed by secondary overlap and extensive introgression that homogenizes neutral differences evolved under allopatry, or by repeated evolution in parapatry, or in sympatry, with the same ecotypes appearing in each local site. Data from Spain, the UK and Sweden give stronger support for a non-allopatric model of ecotype formation than for an allopatric model. Several different non-allopatric mechanisms can, however, explain the repeated evolution of the ecotypes: (i) parallel evolution by new mutations in different populations; (ii) evolution from standing genetic variation; and (iii) evolution in concert with rapid spread of new positive mutations among populations inhabiting similar environments. These models make different predictions that can be tested using comprehensive phylogenetic information combined with candidate loci sequencing.
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| 7. |
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| 8. |
- Lozano, Rafael, et al.
(författare)
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Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017
- 2018
-
Ingår i: The Lancet. - : Elsevier. - 1474-547X .- 0140-6736. ; 392:10159, s. 2091-2138
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Efforts to establish the 2015 baseline and monitor early implementation of the UN Sustainable Development Goals (SDGs) highlight both great potential for and threats to improving health by 2030. To fully deliver on the SDG aim of “leaving no one behind”, it is increasingly important to examine the health-related SDGs beyond national-level estimates. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017), we measured progress on 41 of 52 health-related SDG indicators and estimated the health-related SDG index for 195 countries and territories for the period 1990–2017, projected indicators to 2030, and analysed global attainment. Methods: We measured progress on 41 health-related SDG indicators from 1990 to 2017, an increase of four indicators since GBD 2016 (new indicators were health worker density, sexual violence by non-intimate partners, population census status, and prevalence of physical and sexual violence [reported separately]). We also improved the measurement of several previously reported indicators. We constructed national-level estimates and, for a subset of health-related SDGs, examined indicator-level differences by sex and Socio-demographic Index (SDI) quintile. We also did subnational assessments of performance for selected countries. To construct the health-related SDG index, we transformed the value for each indicator on a scale of 0–100, with 0 as the 2·5th percentile and 100 as the 97·5th percentile of 1000 draws calculated from 1990 to 2030, and took the geometric mean of the scaled indicators by target. To generate projections through 2030, we used a forecasting framework that drew estimates from the broader GBD study and used weighted averages of indicator-specific and country-specific annualised rates of change from 1990 to 2017 to inform future estimates. We assessed attainment of indicators with defined targets in two ways: first, using mean values projected for 2030, and then using the probability of attainment in 2030 calculated from 1000 draws. We also did a global attainment analysis of the feasibility of attaining SDG targets on the basis of past trends. Using 2015 global averages of indicators with defined SDG targets, we calculated the global annualised rates of change required from 2015 to 2030 to meet these targets, and then identified in what percentiles the required global annualised rates of change fell in the distribution of country-level rates of change from 1990 to 2015. We took the mean of these global percentile values across indicators and applied the past rate of change at this mean global percentile to all health-related SDG indicators, irrespective of target definition, to estimate the equivalent 2030 global average value and percentage change from 2015 to 2030 for each indicator. Findings: The global median health-related SDG index in 2017 was 59·4 (IQR 35·4–67·3), ranging from a low of 11·6 (95% uncertainty interval 9·6–14·0) to a high of 84·9 (83·1–86·7). SDG index values in countries assessed at the subnational level varied substantially, particularly in China and India, although scores in Japan and the UK were more homogeneous. Indicators also varied by SDI quintile and sex, with males having worse outcomes than females for non-communicable disease (NCD) mortality, alcohol use, and smoking, among others. Most countries were projected to have a higher health-related SDG index in 2030 than in 2017, while country-level probabilities of attainment by 2030 varied widely by indicator. Under-5 mortality, neonatal mortality, maternal mortality ratio, and malaria indicators had the most countries with at least 95% probability of target attainment. Other indicators, including NCD mortality and suicide mortality, had no countries projected to meet corresponding SDG targets on the basis of projected mean values for 2030 but showed some probability of attainment by 2030. For some indicators, including child malnutrition, several infectious diseases, and most violence measures, the annualised rates of change required to meet SDG targets far exceeded the pace of progress achieved by any country in the recent past. We found that applying the mean global annualised rate of change to indicators without defined targets would equate to about 19% and 22% reductions in global smoking and alcohol consumption, respectively; a 47% decline in adolescent birth rates; and a more than 85% increase in health worker density per 1000 population by 2030. Interpretation: The GBD study offers a unique, robust platform for monitoring the health-related SDGs across demographic and geographic dimensions. Our findings underscore the importance of increased collection and analysis of disaggregated data and highlight where more deliberate design or targeting of interventions could accelerate progress in attaining the SDGs. Current projections show that many health-related SDG indicators, NCDs, NCD-related risks, and violence-related indicators will require a concerted shift away from what might have driven past gains—curative interventions in the case of NCDs—towards multisectoral, prevention-oriented policy action and investments to achieve SDG aims. Notably, several targets, if they are to be met by 2030, demand a pace of progress that no country has achieved in the recent past. The future is fundamentally uncertain, and no model can fully predict what breakthroughs or events might alter the course of the SDGs. What is clear is that our actions—or inaction—today will ultimately dictate how close the world, collectively, can get to leaving no one behind by 2030.
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| 9. |
- Munari, Andrea, et al.
(författare)
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A Stochastic Geometry Approach to Asynchronous Aloha Full-Duplex Networks
- 2017
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Ingår i: IEEE/ACM Transactions on Networking. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 1063-6692 .- 1558-2566. ; 25:6, s. 3695-3708
-
Tidskriftsartikel (refereegranskat)abstract
- In-band full-duplex is emerging as a promising solution to enhance throughput in wireless networks. Allowing nodes to simultaneously send and receive data over the same bandwidth can potentially double the system capacity, and a good degree of maturity has been reached for physical layer design, with practical demonstrations in simple topologies. However, the true potential of full-duplex at a system level is yet to be fully understood. In this paper, we introduce an analytical framework based on stochastic geometry that captures the behavior of large full-duplex networks implementing an asynchronous random access policy based on Aloha. Via exact expressions, we discuss the key tradeoffs that characterize these systems, exploring among the rest the role of transmission duration, imperfect self-interference cancellation, and fraction of full-duplex nodes in the network. We also provide protocol design principles, and our comparison with slotted systems sheds light on the performance loss induced by the lack of synchronism.
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| 10. |
- Murray, Christopher J. L., et al.
(författare)
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Population and fertility by age and sex for 195 countries and territories, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017
- 2018
-
Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 392:10159, s. 1995-2051
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Tidskriftsartikel (refereegranskat)abstract
- Background: Population estimates underpin demographic and epidemiological research and are used to track progress on numerous international indicators of health and development. To date, internationally available estimates of population and fertility, although useful, have not been produced with transparent and replicable methods and do not use standardised estimates of mortality. We present single-calendar year and single-year of age estimates of fertility and population by sex with standardised and replicable methods. Methods: We estimated population in 195 locations by single year of age and single calendar year from 1950 to 2017 with standardised and replicable methods. We based the estimates on the demographic balancing equation, with inputs of fertility, mortality, population, and migration data. Fertility data came from 7817 location-years of vital registration data, 429 surveys reporting complete birth histories, and 977 surveys and censuses reporting summary birth histories. We estimated age-specific fertility rates (ASFRs; the annual number of livebirths to women of a specified age group per 1000 women in that age group) by use of spatiotemporal Gaussian process regression and used the ASFRs to estimate total fertility rates (TFRs; the average number of children a woman would bear if she survived through the end of the reproductive age span [age 10–54 years] and experienced at each age a particular set of ASFRs observed in the year of interest). Because of sparse data, fertility at ages 10–14 years and 50–54 years was estimated from data on fertility in women aged 15–19 years and 45–49 years, through use of linear regression. Age-specific mortality data came from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 estimates. Data on population came from 1257 censuses and 761 population registry location-years and were adjusted for underenumeration and age misreporting with standard demographic methods. Migration was estimated with the GBD Bayesian demographic balancing model, after incorporating information about refugee migration into the model prior. Final population estimates used the cohort-component method of population projection, with inputs of fertility, mortality, and migration data. Population uncertainty was estimated by use of out-of-sample predictive validity testing. With these data, we estimated the trends in population by age and sex and in fertility by age between 1950 and 2017 in 195 countries and territories. Findings: From 1950 to 2017, TFRs decreased by 49·4% (95% uncertainty interval [UI] 46·4–52·0). The TFR decreased from 4·7 livebirths (4·5–4·9) to 2·4 livebirths (2·2–2·5), and the ASFR of mothers aged 10–19 years decreased from 37 livebirths (34–40) to 22 livebirths (19–24) per 1000 women. Despite reductions in the TFR, the global population has been increasing by an average of 83·8 million people per year since 1985. The global population increased by 197·2% (193·3–200·8) since 1950, from 2·6 billion (2·5–2·6) to 7·6 billion (7·4–7·9) people in 2017; much of this increase was in the proportion of the global population in south Asia and sub-Saharan Africa. The global annual rate of population growth increased between 1950 and 1964, when it peaked at 2·0%; this rate then remained nearly constant until 1970 and then decreased to 1·1% in 2017. Population growth rates in the southeast Asia, east Asia, and Oceania GBD super-region decreased from 2·5% in 1963 to 0·7% in 2017, whereas in sub-Saharan Africa, population growth rates were almost at the highest reported levels ever in 2017, when they were at 2·7%. The global average age increased from 26·6 years in 1950 to 32·1 years in 2017, and the proportion of the population that is of working age (age 15–64 years) increased from 59·9% to 65·3%. At the national level, the TFR decreased in all countries and territories between 1950 and 2017; in 2017, TFRs ranged from a low of 1·0 livebirths (95% UI 0·9–1·2) in Cyprus to a high of 7·1 livebirths (6·8–7·4) in Niger. The TFR under age 25 years (TFU25; number of livebirths expected by age 25 years for a hypothetical woman who survived the age group and was exposed to current ASFRs) in 2017 ranged from 0·08 livebirths (0·07–0·09) in South Korea to 2·4 livebirths (2·2–2·6) in Niger, and the TFR over age 30 years (TFO30; number of livebirths expected for a hypothetical woman ageing from 30 to 54 years who survived the age group and was exposed to current ASFRs) ranged from a low of 0·3 livebirths (0·3–0·4) in Puerto Rico to a high of 3·1 livebirths (3·0–3·2) in Niger. TFO30 was higher than TFU25 in 145 countries and territories in 2017. 33 countries had a negative population growth rate from 2010 to 2017, most of which were located in central, eastern, and western Europe, whereas population growth rates of more than 2·0% were seen in 33 of 46 countries in sub-Saharan Africa. In 2017, less than 65% of the national population was of working age in 12 of 34 high-income countries, and less than 50% of the national population was of working age in Mali, Chad, and Niger. Interpretation: Population trends create demographic dividends and headwinds (ie, economic benefits and detriments) that affect national economies and determine national planning needs. Although TFRs are decreasing, the global population continues to grow as mortality declines, with diverse patterns at the national level and across age groups. To our knowledge, this is the first study to provide transparent and replicable estimates of population and fertility, which can be used to inform decision making and to monitor progress. Funding: Bill & Melinda Gates Foundation.
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| 11. |
- Parruca, Donald, et al.
(författare)
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On Semi-Static Interference Coordination under Proportional Fair Scheduling in LTE Systems
- 2013
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Ingår i: Proceedings of the 2013 19th European Wireless Conference (EW). - : VDE Verlag GmbH. - 9783800734986
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Konferensbidrag (refereegranskat)abstract
- In this paper we consider the design of semi-static inter-cell interference coordination schemes for LTE networks. In this approach, base stations coordinate the power settings per resource block over long time spans such as seconds. In order to optimize the power settings, one needs to employ models which predict the rate of terminals over the next coordination period under the usage of a given power setting. However, these models are typically quite simple and neglect the impact from fading as well as from dynamic resource allocation performed at the base stations on a millisecond basis. Ignoring such properties of OFDMA networks leads therefore to suboptimal transmit power settings. In this paper, we study the impact from a precise rate prediction model that accurately accounts for fading and dynamic resource allocation. On the down-side, this more precise model leads to a much more involved optimization problem to be solved once per coordination period. We propose two different heuristic methods to deal with this problem. Especially the usage of genetic algorithm results to be promising to counteract the complexity increase. We then study the overall system performance and find precise rate prediction models to be essential for semi-static interference coordination as they provide significant performance improvements in comparison to approaches with simpler models.
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| 12. |
- Rekena, Alina J., et al.
(författare)
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Genome-scale metabolic modeling reveals metabolic trade-offs associated with lipid production in Rhodotorula toruloides
- 2023
-
Ingår i: PLoS Computational Biology. - 1553-734X .- 1553-7358. ; 19:4
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Tidskriftsartikel (refereegranskat)abstract
- Rhodotorula toruloides is a non-conventional, oleaginous yeast able to naturally accumulate high amounts of microbial lipids. Constraint-based modeling of R. toruloides has been mainly focused on the comparison of experimentally measured and model predicted growth rates, while the intracellular flux patterns have been analyzed on a rather general level. Hence, the intrinsic metabolic properties of R. toruloides that make lipid synthesis possible are not thoroughly understood. At the same time, the lack of diverse physiological data sets has often been the bottleneck to predict accurate fluxes. In this study, we collected detailed physiology data sets of R. toruloides while growing on glucose, xylose, and acetate as the sole carbon source in chemically defined medium. Regardless of the carbon source, the growth was divided into two phases from which proteomic and lipidomic data were collected. Complemental physiological parameters were collected in these two phases and altogether implemented into metabolic models. Simulated intracellular flux patterns demonstrated the role of phosphoketolase in the generation of acetyl-CoA, one of the main precursors during lipid biosynthesis, while the role of ATP citrate lyase was not confirmed. Metabolic modeling on xylose as a carbon substrate was greatly improved by the detection of chirality of D-arabinitol, which together with D-ribulose were involved in an alternative xylose assimilation pathway. Further, flux patterns pointed to metabolic trade-offs associated with NADPH allocation between nitrogen assimilation and lipid biosynthetic pathways, which was linked to large-scale differences in protein and lipid content. This work includes the first extensive multi-condition analysis of R. toruloides using enzyme-constrained models and quantitative proteomics. Further, more precise k(cat) values should extend the application of the newly developed enzyme-constrained models that are publicly available for future studies. Author summaryTransition towards a biobased, circular economy to reduce the industrial dependence on fossil-based resources requires new technologies. One of the options is to convert available biomass feedstocks into valuable chemicals using microbes as biocatalysts. Rhodotorula toruloides is a nonpathogenic, nonconventional yeast that has recently emerged as one of the most promising yeasts for sustainable production of chemicals and fuels due to its natural ability to synthesize large amounts of lipids. However, its unique metabolic properties are not yet fully understood. We have computationally predicted metabolic fluxes in R. toruloides while growing in economically viable growth conditions inducing lipid accumulation and analyzed them together with absolute proteome quantification. Our holistic approach has highlighted metabolic pathways important for lipid biosynthesis and revealed metabolic trade-offs associated with NADPH allocation during lipogenesis. In addition, our work highlighted the necessity for accurate computational approaches in characterizing enzymatic kinetic properties that would improve the metabolic studies of R. toruloides.
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| 13. |
- Tienaho, Jenni, et al.
(författare)
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Valorizing Assorted Logging Residues : Response Surface Methodology in the Extraction Optimization of a Green Norway Spruce Needle-Rich Fraction To Obtain Valuable Bioactive Compounds
- 2024
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Ingår i: ACS sustainable resource management. - : American Chemical Society (ACS). - 2837-1445. ; 1:2, s. 237-249
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Tidskriftsartikel (refereegranskat)abstract
- During stemwood harvesting, substantial volumes of logging residues are produced as a side stream. Nevertheless, industrially feasible processing methods supporting their use for other than energy generation purposes are scarce. Thus, the present study focuses on biorefinery processing, employing response surface methodology to optimize the pressurized extraction of industrially assorted needle-rich spruce logging residues with four solvents. Eighteen experimental points, including eight center point replicates, were used to optimize the extraction temperature (40–135 °C) and time (10–70 min). The extraction optimization for water, water with Na2CO3 + NaHSO3 addition, and aqueous ethanol was performed using yield, total dissolved solids (TDS), antioxidant activity (FRAP, ORAC), antibacterial properties (E. coli, S. aureus), total phenolic content (TPC), condensed tannin content, and degree of polymerization. For limonene, evaluated responses were yield, TDS, antioxidant activity (CUPRAC, DPPH), and TPC. Desirability surfaces were created using the responses showing a coefficient of determination (R2) > 0.7, statistical significance (p ≀ 0.05), precision > 4, and statistically insignificant lack-of-fit (p > 0.1). The optimal extraction conditions were 125 °C and 68 min for aqueous ethanol, 120 °C and 10 min for water, 111 °C and 49 min for water with Na2CO3 + NaHSO3 addition, and 134 °C and 41 min for limonene. The outcomes contribute insights to industrial logging residue utilization for value-added purposes.
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| 14. |
- Voicu, Andra M., et al.
(författare)
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Risk-Informed Interference Assessment for Shared Spectrum Bands : A Wi-Fi/LTE Coexistence Case Study
- 2017
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Ingår i: IEEE Transactions on Cognitive Communications and Networking. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 2332-7731. ; 3:3, s. 505-519
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Tidskriftsartikel (refereegranskat)abstract
- Interference evaluation is crucial when deciding whether and how wireless technologies should operate. In this paper, we demonstrate the benefit of risk-informed interference assessment to aid spectrum regulators in making decisions, and to readily convey engineering insight. We apply, for the first time, risk assessment to an open question of inter-technology spectrum sharing, i.e., a Wi-Fi/LTE coexistence study in the unlicensed band, and we demonstrate that this method comprehensively quantifies the interference impact. We perform simulations with our newly publicly available tool and we consider throughput degradation and fairness as example metrics to assess the risk for different network densities, numbers of channels, and deployments. The risk assessment study shows that no regulatory intervention is needed to ensure harmonious technical Wi-Fi/LTE coexistence: for the typically large number of channels available in the 5 GHz band, the risk for Wi-Fi from LTE is negligible. As an engineering insight, Wi-Fi coexists better with itself in dense deployments, but better with LTE in sparse deployments. Also, both main LTE-in-unlicensed variants coexist well with Wi-Fi in general. For LTE intra-technology inter-operator coexistence, both variants typically coexist well in the 5 GHz band, but for dense deployments, implementing listen-before-talk causes less interference.
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| 15. |
- Wang, Peng, et al.
(författare)
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DMDL : a Hierarchical Approach to Design, Visualize, and Implement MAC Protocols
- 2018
-
Ingår i: 2018 IEEE WIRELESS COMMUNICATIONS AND NETWORKING CONFERENCE (WCNC). - : IEEE. - 9781538617342
-
Konferensbidrag (refereegranskat)abstract
- This paper describes a new tool aimed for rapid development and modeling of MAC protocols that is based on hierarchical finite state machines with concurrency models. The developed tool is named Decomposite MAC Description Language (DMDL) and we arc going to provide it open source in order to support MAC protocol design, implementation, and exchange of ideas among researchers. Following the modular design philosophy, the atomic elements of DMDL are the elementary MAC function components selected from a large-scale survey on different types of MAC that we have conducted. In DMDL, a MAC protocols is modeled as a directed graph with the MAC function components at the vertices. A token-like controlling unit is defined to pass control signals and data elements among MAC function components via the directed connections. The high decomposability and modularity enables DMDL to be used as a pure graphical language, and the concurrency nature of the synchronous data flow inherently ensures concurrency as a fundamental feature of DMDL. However, the tool supports also low level direct programmability and mixing of different programming languages through a common GNU Radio approach. In order to expands its usability, DMDL is developed on GNU Radio with a number of classic MAC protocols. The performance of the protocols implemented with DMDL is in accordance with the theoretical expectations, which demonstrates that DMDL is an efficient MAC designing and implementing tool with high flexibility and reusability.
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| 16. |
- Waszczak, Cezary, et al.
(författare)
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Synthesis and import of GDP-l-fucose into the Golgi affect plant–water relations
- 2023
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Ingår i: New Phytologist. - 0028-646X .- 1469-8137. ; 241:2, s. 747-63
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Tidskriftsartikel (refereegranskat)abstract
- Land plants evolved multiple adaptations to restrict transpiration. However, the underlying molecular mechanisms are not sufficiently understood. We used an ozone-sensitivity forward genetics approach to identify Arabidopsis thaliana mutants impaired in gas exchange regulation. High water loss from detached leaves and impaired decrease of leaf conductance in response to multiple stomata-closing stimuli were identified in a mutant of MURUS1 (MUR1), an enzyme required for GDP-l-fucose biosynthesis. High water loss observed in mur1 was independent from stomatal movements and instead could be linked to metabolic defects. Plants defective in import of GDP-l-Fuc into the Golgi apparatus phenocopied the high water loss of mur1 mutants, linking this phenotype to Golgi-localized fucosylation events. However, impaired fucosylation of xyloglucan, N-linked glycans, and arabinogalactan proteins did not explain the aberrant water loss of mur1 mutants. Partial reversion of mur1 water loss phenotype by borate supplementation and high water loss observed in boron uptake mutants link mur1 gas exchange phenotypes to pleiotropic consequences of l-fucose and boron deficiency, which in turn affect mechanical and morphological properties of stomatal complexes and whole-plant physiology. Our work emphasizes the impact of fucose metabolism and boron uptake on plant–water relations.
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| 17. |
- Wiegman, Albert, et al.
(författare)
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Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment.
- 2015
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Ingår i: European heart journal. - : Oxford University Press (OUP). - 1522-9645 .- 0195-668X. ; 36, s. 2425-2437
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Tidskriftsartikel (refereegranskat)abstract
- Familial hypercholesterolaemia (FH) is a common genetic cause of premature coronary heart disease (CHD). Globally, one baby is born with FH every minute. If diagnosed and treated early in childhood, individuals with FH can have normal life expectancy. This consensus paper aims to improve awareness of the need for early detection and management of FH children. Familial hypercholesterolaemia is diagnosed either on phenotypic criteria, i.e. an elevated low-density lipoprotein cholesterol (LDL-C) level plus a family history of elevated LDL-C, premature coronary artery disease and/or genetic diagnosis, or positive genetic testing. Childhood is the optimal period for discrimination between FH and non-FH using LDL-C screening. An LDL-C ≥5 mmol/L (190 mg/dL), or an LDL-C ≥4 mmol/L (160 mg/dL) with family history of premature CHD and/or high baseline cholesterol in one parent, make the phenotypic diagnosis. If a parent has a genetic defect, the LDL-C cut-off for the child is ≥3.5 mmol/L (130 mg/dL). We recommend cascade screening of families using a combined phenotypic and genotypic strategy. In children, testing is recommended from age 5 years, or earlier if homozygous FH is suspected. A healthy lifestyle and statin treatment (from age 8 to 10 years) are the cornerstones of management of heterozygous FH. Target LDL-C is <3.5 mmol/L (130 mg/dL) if >10 years, or ideally 50% reduction from baseline if 8-10 years, especially with very high LDL-C, elevated lipoprotein(a), a family history of premature CHD or other cardiovascular risk factors, balanced against the long-term risk of treatment side effects. Identifying FH early and optimally lowering LDL-C over the lifespan reduces cumulative LDL-C burden and offers health and socioeconomic benefits. To drive policy change for timely detection and management, we call for further studies in the young. Increased awareness, early identification, and optimal treatment from childhood are critical to adding decades of healthy life for children and adolescents with FH.
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| 18. |
- Zander, Jens, et al.
(författare)
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On the scalability of cognitive radio: : Assessing the commercial viability of secondary spectrum access
- 2013
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Ingår i: IEEE wireless communications. - 1536-1284 .- 1558-0687. ; 20:2, s. 28-35
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Tidskriftsartikel (refereegranskat)abstract
- We report results from the recently finished QUASAR project, which has studied overall system aspects of cognitive radio technologies and has paid attention particularly to the economic viability of different use cases. We find that successful secondary sharing goes far beyond the detection of spectrum holes. Large-scale commercial success requires that secondary systems are scalable so that a large number of users can be served in an economically viable fashion. Our key finding is that secondary spectrum use is not an attractive method for most of the commercially interesting scenarios, from neither a business nor technical perspective. Perhaps somewhat surprisingly, the likely commercial "sweet spot" for secondary sharing in the lower frequency bands is short-range indoor communications. We also find that regulation does not currently present a significant barrier in Europe or the United States.
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