| 1. |
- Abelev, Betty, et al.
(författare)
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Long-range angular correlations on the near and away side in p-Pb collisions at root S-NN=5.02 TeV
- 2013
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 719:1-3, s. 29-41
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Tidskriftsartikel (refereegranskat)abstract
- Angular correlations between charged trigger and associated particles are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV for transverse momentum ranges within 0.5 < P-T,P-assoc < P-T,P-trig < 4 GeV/c. The correlations are measured over two units of pseudorapidity and full azimuthal angle in different intervals of event multiplicity, and expressed as associated yield per trigger particle. Two long-range ridge-like structures, one on the near side and one on the away side, are observed when the per-trigger yield obtained in low-multiplicity events is subtracted from the one in high-multiplicity events. The excess on the near-side is qualitatively similar to that recently reported by the CMS Collaboration, while the excess on the away-side is reported for the first time. The two-ridge structure projected onto azimuthal angle is quantified with the second and third Fourier coefficients as well as by near-side and away-side yields and widths. The yields on the near side and on the away side are equal within the uncertainties for all studied event multiplicity and p(T) bins, and the widths show no significant evolution with event multiplicity or p(T). These findings suggest that the near-side ridge is accompanied by an essentially identical away-side ridge. (c) 2013 CERN. Published by Elsevier B.V. All rights reserved.
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| 2. |
- Abelev, Betty, et al.
(författare)
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Measurement of prompt J/psi and beauty hadron production cross sections at mid-rapidity in pp collisions at root s=7 TeV
- 2012
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; :11
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Tidskriftsartikel (refereegranskat)abstract
- The ALICE experiment at the LHC has studied J/psi production at mid-rapidity in pp collisions at root s = 7 TeV through its electron pair decay on a data sample corresponding to an integrated luminosity L-int = 5.6 nb(-1). The fraction of J/psi from the decay of long-lived beauty hadrons was determined for J/psi candidates with transverse momentum p(t) > 1,3 GeV/c and rapidity vertical bar y vertical bar < 0.9. The cross section for prompt J/psi mesons, i.e. directly produced J/psi and prompt decays of heavier charmonium states such as the psi(2S) and chi(c) resonances, is sigma(prompt J/psi) (p(t) > 1.3 GeV/c, vertical bar y vertical bar < 0.9) = 8.3 +/- 0.8(stat.) +/- 1.1 (syst.)(-1.4)(+1.5) (syst. pol.) mu b. The cross section for the production of b-hadrons decaying to J/psi with p(t) > 1.3 GeV/c and vertical bar y vertical bar < 0.9 is a sigma(J/psi <- hB) (p(t) > 1.3 GeV/c, vertical bar y vertical bar < 0.9) = 1.46 +/- 0.38 (stat.)(-0.32)(+0.26) (syst.) mu b. The results are compared to QCD model predictions. The shape of the p(t) and y distributions of b-quarks predicted by perturbative QCD model calculations are used to extrapolate the measured cross section to derive the b (b) over bar pair total cross section and d sigma/dy at mid-rapidity.
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| 3. |
- Abelev, Betty, et al.
(författare)
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Underlying Event measurements in pp collisions at root s=0.9 and 7 TeV with the ALICE experiment at the LHC
- 2012
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; :7
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Tidskriftsartikel (refereegranskat)abstract
- We present measurements of Underlying Event observables in pp collisions at root s = 0 : 9 and 7 TeV. The analysis is performed as a function of the highest charged-particle transverse momentum p(T),L-T in the event. Different regions are defined with respect to the azimuthal direction of the leading (highest transverse momentum) track: Toward, Transverse and Away. The Toward and Away regions collect the fragmentation products of the hardest partonic interaction. The Transverse region is expected to be most sensitive to the Underlying Event activity. The study is performed with charged particles above three different p(T) thresholds: 0.15, 0.5 and 1.0 GeV/c. In the Transverse region we observe an increase in the multiplicity of a factor 2-3 between the lower and higher collision energies, depending on the track p(T) threshold considered. Data are compared to PYTHIA 6.4, PYTHIA 8.1 and PHOJET. On average, all models considered underestimate the multiplicity and summed p(T) in the Transverse region by about 10-30%.
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| 4. |
- Petrov, Dmitry, et al.
(författare)
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Machine Learning for Large-Scale Quality Control of 3D Shape Models in Neuroimaging
- 2017
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Ingår i: Machine learning in medical imaging. MLMI (Workshop). - Cham : Springer International Publishing. ; 10541, s. 371-378
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Tidskriftsartikel (refereegranskat)abstract
- As very large studies of complex neuroimaging phenotypes become more common, human quality assessment of MRI-derived data remains one of the last major bottlenecks. Few attempts have so far been made to address this issue with machine learning. In this work, we optimize predictive models of quality for meshes representing deep brain structure shapes. We use standard vertex-wise and global shape features computed homologously across 19 cohorts and over 7500 human-rated subjects, training kernelized Support Vector Machine and Gradient Boosted Decision Trees classifiers to detect meshes of failing quality. Our models generalize across datasets and diseases, reducing human workload by 30-70%, or equivalently hundreds of human rater hours for datasets of comparable size, with recall rates approaching inter-rater reliability.
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| 5. |
- Bhatt, Deepak L., et al.
(författare)
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Rationale, design and baseline characteristics of the effect of ticagrelor on health outcomes in diabetes mellitus patients Intervention study
- 2019
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Ingår i: Clinical Cardiology. - : Wiley. - 0160-9289 .- 1932-8737. ; 42:5, s. 498-505
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Tidskriftsartikel (refereegranskat)abstract
- In the setting of prior myocardial infarction, the oral antiplatelet ticagrelor added to aspirin reduced the risk of recurrent ischemic events, especially, in those with diabetes mellitus. Patients with stable coronary disease and diabetes are also at elevated risk and might benefit from dual antiplatelet therapy. The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS, NCT01991795) is a Phase 3b randomized, double-blinded, placebo-controlled trial of ticagrelor vs placebo, on top of low dose aspirin. Patients >= 50 years with type 2 diabetes receiving anti-diabetic medications for at least 6 months with stable coronary artery disease as determined by a history of previous percutaneous coronary intervention, bypass grafting, or angiographic stenosis of >= 50% of at least one coronary artery were enrolled. Patients with known prior myocardial infarction (MI) or stroke were excluded. The primary efficacy endpoint is a composite of cardiovascular death, myocardial infarction, or stroke. The primary safety endpoint is Thrombolysis in Myocardial Infarction major bleeding. A total of 19 220 patients worldwide have been randomized and at least 1385 adjudicated primary efficacy endpoint events are expected to be available for analysis, with an expected average follow-up of 40 months (maximum 58 months). Most of the exposure is on a 60 mg twice daily dose, as the dose was lowered from 90 mg twice daily partway into the study. The results may revise the boundaries of efficacy for dual antiplatelet therapy and whether it has a role outside acute coronary syndromes, prior myocardial infarction, or percutaneous coronary intervention.
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| 6. |
- Boyko, Andrey A., et al.
(författare)
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Intracavity difference-frequency mixing of optical parametric oscillator signal and idler pulses in BaGa4Se7
- 2017
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Ingår i: Applied Optics. - : OPTICAL SOC AMER. - 1559-128X .- 2155-3165. ; 56:10, s. 2783-2786
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Tidskriftsartikel (refereegranskat)abstract
- An overall quantum conversion efficiency of 7.8% is achieved by intracavity mixing the signal and idler of a 1.064 mu m pumped Rb: PPKTP optical parametric oscillator in BaGa4Se7. In this way, a pulse energy of similar to 0.71 mJ is generated at similar to 7 mu m for a repetition rate of 100 Hz. Tuning of the mid-IR radiation is demonstrated by heating of the Rb: PPKTP crystal.
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| 7. |
- Boyko, Andrey A., et al.
(författare)
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Intracavity-pumped, cascaded AgGaSe2 optical parametric oscillator tunable from 5.8 to 18 mu m
- 2015
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Ingår i: Optics Express. - : Optical Society of America. - 1094-4087. ; 23:26, s. 33460-33465
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Tidskriftsartikel (refereegranskat)abstract
- A AgGaSe2 nonlinear crystal placed in a coupled cavity is intracavity pumped by the similar to 1.85-mu m signal pulses of a 1.064-mu m pumped Rb: PPKTP doubly-resonant optical parametric oscillator (OPO) operating at a repetition rate of 100 Hz. Using two samples cut for type-I and II phase-matching, the overall idler tunability of the singly-resonant AgGeSe2 OPO covers an unprecedented spectral range from 5.8 to similar to 18 mu m in the mid-IR.
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| 8. |
- Boyko, Andrey A., et al.
(författare)
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Optical parametric oscillator pumped at similar to 1 mu m with intracavity mid-IR difference-frequency generation in OPGaAs
- 2018
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Ingår i: Optical Materials Express. - : Optical Society of America. - 2159-3930. ; 8:3, s. 549-554
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Tidskriftsartikel (refereegranskat)abstract
- Intracavity difference-frequency generation (DFG) between signal and idler pulses is investigated in orientation-patterned GaAs inside the cavity of a similar to 1 mu m pumped nanosecond optical parametric oscillator (OPO). Using two different samples and temperature tuning in the non-critical configuration, tunability between 7 and 9.2 mu m is demonstrated. The superior thermo-mechanical properties of OPGaAs enabled also for the first time operation of this cascaded scheme at kilohertz (1-3 kHz) repetition rates reaching average powers similar to 10 mW in the mid-IR.
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| 9. |
- Boyko, Andrey A., et al.
(författare)
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Rb:PPKTP optical parametric oscillator with intracavity difference-frequency generation in AgGaSe2
- 2016
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Ingår i: Optics Letters. - : Optical Society of America. - 0146-9592 .- 1539-4794. ; 41:12, s. 2791-2794
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Tidskriftsartikel (refereegranskat)abstract
- A 1.064 mu m pumped Rb:PPKTP optical parametric oscillator (OPO) generates mid-IR radiation by intracavity mixing the resonant signal and idler waves in AgGaSe2. The similar to 6 ns pulses at similar to 7 mu m have an energy of 670 mu J at 100 Hz, equivalent to an average power of 67 mW. The overall quantum conversion efficiency from 1.064 mu m amounts to 8%, and the power conversion efficiency is 1.2%.
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| 10. |
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| 11. |
- Kapun, Martin, et al.
(författare)
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Drosophila Evolution over Space and Time (DEST) : A New Population Genomics Resource
- 2021
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Ingår i: Molecular biology and evolution. - : Oxford University Press (OUP). - 0737-4038 .- 1537-1719. ; 38:12, s. 5782-5805
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Tidskriftsartikel (refereegranskat)abstract
- Drosophila melanogaster is a leading model in population genetics and genomics, and a growing number of whole-genome data sets from natural populations of this species have been published over the last years. A major challenge is the integration of disparate data sets, often generated using different sequencing technologies and bioinformatic pipelines, which hampers our ability to address questions about the evolution of this species. Here we address these issues by developing a bioinformatics pipeline that maps pooled sequencing (Pool-Seq) reads from D. melanogaster to a hologenome consisting of fly and symbiont genomes and estimates allele frequencies using either a heuristic (PoolSNP) or a probabilistic variant caller (SNAPE-pooled). We use this pipeline to generate the largest data repository of genomic data available for D. melanogaster to date, encompassing 271 previously published and unpublished population samples from over 100 locations in >20 countries on four continents. Several of these locations have been sampled at different seasons across multiple years. This data set, which we call Drosophila Evolution over Space and Time (DEST), is coupled with sampling and environmental metadata. A web-based genome browser and web portal provide easy access to the SNP data set. We further provide guidelines on how to use Pool-Seq data for model-based demographic inference. Our aim is to provide this scalable platform as a community resource which can be easily extended via future efforts for an even more extensive cosmopolitan data set. Our resource will enable population geneticists to analyze spatiotemporal genetic patterns and evolutionary dynamics of D. melanogaster populations in unprecedented detail.
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| 12. |
- Kostyukova, Nadezhda Y., et al.
(författare)
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Rb : PPKTP Optical Parametric Oscillator with Intracavity Difference-Frequency Generation in AgGaSe2
- 2016
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Ingår i: 2016 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO). - Washington, D.C. : IEEE conference proceedings. - 9781943580118
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Konferensbidrag (refereegranskat)abstract
- A 1.064-mu m pumped Rb:PPKTP optical parametric oscillator (OPO) generates mid-IR radiation by intracavity mixing the signal and idler in AgGaSe2. The similar to 6-ns pulses at similar to 7 mu m have an energy of 565 mu J at 100 Hz.
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| 13. |
- Krauss, Tobias, et al.
(författare)
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Preventive medicine of von Hippel-Lindau disease-associated pancreatic neuroendocrine tumors
- 2018
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Ingår i: Endocrine-Related Cancer. - : BIOSCIENTIFICA LTD. - 1351-0088 .- 1479-6821. ; 25:9, s. 783-793
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Tidskriftsartikel (refereegranskat)abstract
- Pancreatic neuroendocrine tumors (PanNETs) are rare in von Hippel-Lindau disease (VHL) but cause serious morbidity and mortality. Management guidelines for VHL-PanNETs continue to be based on limited evidence, and survival data to guide surgical management are lacking. We established the European-American-Asian-VHL-PanNET-Registry to assess data for risks for metastases, survival and long-term outcomes to provide best management recommendations. Of 2330 VHL patients, 273 had a total of 484 PanNETs. Median age at diagnosis of PanNET was 35 years (range 10-75). Fifty-five (20%) patients had metastatic PanNETs. Metastatic PanNETs were significantly larger (median size 5 vs 2 cm; P < 0.001) and tumor volume doubling time (TVDT) was faster (22 vs 126 months; P = 0.001). All metastatic tumors were >= 2.8 cm. Codons 161 and 167 were hotspots for VHL germline mutations with enhanced risk for metastatic PanNETs. Multivariate prediction modeling disclosed maximum tumor diameter and TVDT as significant predictors for metastatic disease (positive and negative predictive values of 51% and 100% for diameter cut-off >= 2.8 cm, 44% and 91% for TVDT cut-off of <= 24 months). In 117 of 273 patients, PanNETs > 1.5 cm in diameter were operated. Ten-year survival was significantly longer in operated vs non-operated patients, in particular for PanNETs < 2.8 cm vs >= 2.8 cm (94% vs 85% by 10 years; P = 0.020; 80% vs 50% at 10 years; P = 0.030). This study demonstrates that patients with PanNET approaching the cut-off diameter of 2.8 cm should be operated. Mutations in exon 3, especially of codons 161/167 are at enhanced risk for metastatic PanNETs. Survival is significantly longer in operated non-metastatic VHL-PanNETs.
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| 14. |
- Moroz, Sergej, et al.
(författare)
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Generalized Efimov Effect in One Dimension
- 2015
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Ingår i: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 115:18
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Tidskriftsartikel (refereegranskat)abstract
- We study a one-dimensional quantum problem of two particles interacting with a third one via a scaleinvariant subcritically attractive inverse square potential, which can be realized, for example, in a mixture of dipoles and charges confined to one dimension. We find that above a critical mass ratio, this version of the Calogero problem exhibits the generalized Efimov effect, the emergence of discrete scale invariance manifested by a geometric series of three-body bound states with an accumulation point at zero energy.
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| 15. |
- Ramazanali, Hawar, 1979-
(författare)
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Managing Radio and Energy Resources in LTE-Based Military Training Networks
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The number of wireless connected devices are growing exponentially and the importance of this research area is growing as well to meet the known and looming challenges and expectations. The 5:th Generation telecommunications standard is partly embodied by the Machine-to-Machine (M2M) and Internet of Things (IoT) technologies and standards to handle a big part of these devices and connections. An example within the IoT paradigm is military training systems where each system can consist of thousands of battery operated mobile devices and their shifting requirements shall be fullled in an energy-aware manner to increase battery operating times.Military training radio networks enables realistic combat training. The services and features provided in commercial telecommunications networks are desirable in these often proprietary and task specic networks, increasing capabilities and functionalities. To facilitate the current and future R&D of LTE based networks for adoption in military training networks and services this doctoral thesis intends to provide the starting ground for the energy-aware LTE based wireless communications. The thesis first presents general solutions on how to meet traffic deadlines in wireless networks for large number of nodes, and then continues with solutions for energy-aware LTE-based communications for the User Equipments (UEs).The work builds on the problem formulation how to provide energy-aware resource handling for LTE-based military training networks from where three research questions are derived. From the research questions we derive different hypotheses and then test these within the investigated area to answer the research questions.The contributions of this work are within areas of resource handling and power saving for mobile devices. In the first area an admission control using deterministic analysis is proposed fullling traffic requirements for military training mobile nodes. This admission control is enhanced for multiple-channel base stations, and evaluated using mobile nodes with different heterogeneous traffic requirements. In the second part energy-awareness is in focus for LTE/LTE-A based networks. The main power saving method for LTE/LTE-A UEs, Discontinuous Reception (DRX) mechanism, is evaluated and models for DRX in Idle and Connected state are proposed including metrics for wake-up delay and power saving. Additionally a mean queuing delay analysis is proposed for a variant of the Connected state DRX. Using these models and metrics, practical design guidelines for tuning of DRX parameters are proposed, including optimization of DRX parameters for either minimizing delay or maximizing power saving.
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| 16. |
- Udalov, Yu. P., et al.
(författare)
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Monotectic Crystallization of Melts in the ZrO2–Al2O3 System
- 2006
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Ingår i: Glass Physics and Chemistry. - 1087-6596 .- 1608-313X. ; 32:4, s. 479-485
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Tidskriftsartikel (refereegranskat)abstract
- —The morphology of the crystalline phases prepared at different cooling rates, temperatures, andcompositions of melts in the ZrO2–Al2O3system is investigated. It is established that both the quenched andslowly crystallized samples containing 35–70 wt % ZrO2have a submicron structure. Outside this concentrationrange, the ingots have a zonal structure: the peripheral region is formed by large baddeleyite crystals (at a ZrO2content higher than 70 wt %) or corundum crystals (at a ZrO2content lower than 30 wt %). This character ofthe crystallization confirms the presence of the phase separation (liquid immiscibility) region in melts of thissystem. A variant is proposed for the phase diagram of the system under investigation.
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| 17. |
- Zairov, Rustem R., et al.
(författare)
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Terbium(III)-thiacalix[4]arene nanosensor for highly sensitive intracellular monitoring of temperature changes within the 303–313 K range
- 2020
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Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- The work introduces hydrophilic PSS-[Tb2(TCAn)2] nanoparticles to be applied as highly sensitive intracellular temperature nanosensors. The nanoparticles are synthesized by solvent-induced nanoprecipitation of [Tb2(TCAn)2] complexes (TCAn - thiacalix[4]arenes bearing different upper-rim substituents: unsubstituted TCA1, tert-buthyl-substituted TCA2, di- and tetra-brominated TCA3 and TCA4) with the use of polystyrenesulfonate (PSS) as stabilizer. The temperature responsive luminescence behavior of PSS-[Tb2(TCAn)2] within 293–333 K range in water is modulated by reversible changes derived from the back energy transfer from metal to ligand (M* → T1) correlating with the energy gap between the triplet levels of ligands and resonant 5D4 level of Tb3+ ion. The lowering of the triplet level (T1) energies going from TCA1 and TCA2 to their brominated counterparts TCA3 and TCA4 facilitates the back energy transfer. The highest ever reported temperature sensitivity for intracellular temperature nanosensors is obtained for PSS-[Tb2(TCA4)2] (SI = 5.25% K−1), while PSS-[Tb2(TCA3)2] is characterized by a moderate one (SI = 2.96% K−1). The insignificant release of toxic Tb3+ ions from PSS-[Tb2(TCAn)2] within heating/cooling cycle and the low cytotoxicity of the colloids point to their applicability in intracellular temperature monitoring. The cell internalization of PSS-[Tb2(TCAn)2] (n = 3, 4) marks the cell cytoplasm by green Tb3+-luminescence, which exhibits detectable quenching when the cell samples are heated from 303 to 313 K. The colloids hold unprecedented potential for in vivo intracellular monitoring of temperature changes induced by hyperthermia or pathological processes in narrow range of physiological temperatures.
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