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Sökning: WFRF:(Rajabli F)

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  • Bellenguez, C, et al. (författare)
  • New insights into the genetic etiology of Alzheimer's disease and related dementias
  • 2022
  • Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 54:4, s. 412-436
  • Tidskriftsartikel (refereegranskat)abstract
    • Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.
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  • Babashova, Nazrin, et al. (författare)
  • Review on the challenges and the future of solar cell for space applications
  • 2020
  • Ingår i: International Journal on Technical and Physical Problems of Engineering. - : International Organization on 'Technical and Physical Problems of Engineering'. - 2077-3528. ; 12:3, s. 36-40
  • Tidskriftsartikel (refereegranskat)abstract
    • Solar power systems are one of the major energy sources for spacecrafts and satellites. The first ever satellite was supplied by electricity generated via silicon based solar cells. Thus, solar arrays play integral role for space environment applications. However, space industry encounters various difficulties related to solar cells, and the main challenge is impact of radiation on the performance of solar units. Destructive nature of radiation has adverse effect on solar power systems causing certain damages leading to loss of efficiency and other negative consequences. In addition, there are other issues such as temperature and vacuum environment causing degradation of solar cells which also should be paid particular attention. In this paper, the physics of semiconductors, the history and importance of solar photovoltaics in space industry, the effect of radiation and techniques which can help to reduce or fix the negative impact of radiation, other challenges related to solar power systems, and the future of solar cells are reviewed.
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