| 1. |
- Metzler, R., et al.
(författare)
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Diffusion mechanisms of localised knots along a polymer
- 2006
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Ingår i: Europhysics Letters. - : IOP Publishing. - 0295-5075 .- 1286-4854. ; 76:4, s. 696-702
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Tidskriftsartikel (refereegranskat)abstract
- We consider the diffusive motion of a localised knot along a linear polymer chain. In particular, we derive the mean diffusion time of the knot before it escapes from the chain once it gets close to one of the chain ends. Self-reptation of the entire chain between either end and the knot position, during which the knot is provided with free volume, leads to an L-3 scaling of diffusion time; for sufficiently long chains, subdiffusion will enhance this time even more. Conversely, we propose local "breathing", i.e., local conformational rearrangement inside the knot region (KR) and its immediate neighbourhood, as additional mechanism. The contribution of KR-breathing to the diffusion time scales only quadratically, similar to L-2, speeding up the knot escape considerably and guaranteeing finite knot mobility even for very long chains.
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| 2. |
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| 3. |
- Reisner, W, et al.
(författare)
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The physics of nanoconfined DNA
- 2006
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Ingår i: Book of abstracts: March Meet of the American Phys Soc, Baltimore, MD, USA (2006).
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Konferensbidrag (refereegranskat)
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| 4. |
- Tegenfeldt, Jonas, et al.
(författare)
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The dynamics of genomic-length DNA molecules in 100-nm channels
- 2004
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Ingår i: Proceedings of the National Academy of Sciences. - : Proceedings of the National Academy of Sciences. - 1091-6490 .- 0027-8424. ; 101:30, s. 10979-10983
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Tidskriftsartikel (refereegranskat)abstract
- We show that genomic-length DNA molecules imaged in nano-channels have an extension along the channel that scales linearly with the contour length of the polymer, in agreement with the scaling arguments developed by de Gennes for self-avoiding confined polymers. This fundamental relationship allows us to measure directly the contour length of single DNA molecules confined in the channels, and the statistical analysis of the dynamics of the polymer in the nanochannel allows us to compute the SD of the mean of the extension. This statistical analysis allows us to measure the extension of A DNA multimers with a 130-nm SD in 1 min.
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