| 1. |
- Bravo, L, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 2. |
- Tabiri, S, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 3. |
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| 4. |
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| 5. |
- Khatri, C, et al.
(författare)
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Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
- 2021
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Ingår i: BMJ open. - : BMJ. - 2044-6055. ; 11:11, s. e050830-
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Tidskriftsartikel (refereegranskat)abstract
- Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.SettingProspective, international, multicentre, observational cohort study.ParticipantsPatients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.ResultsThis study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p<0.001), age >80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).ConclusionsPatients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups.Trial registration numberNCT04323644
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| 6. |
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| 7. |
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| 8. |
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| 9. |
- Hosnijeh, Fatemeh Saberi, et al.
(författare)
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Prediagnostic telomere length and risk of B-cell lymphoma-Results from the EPIC cohort study
- 2014
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 135:12, s. 2910-2917
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Tidskriftsartikel (refereegranskat)abstract
- Recent epidemiological investigations have reported on the association between telomere length (TL) and a number of malignancies, including B-cell lymphoma (BCL). The reported results for BCLs are however inconsistent. We carried out a nested case-control study to determine whether TL is associated with future risk of BCL. Using quantitative polymerase chain reaction, the relative TL (i.e. the ratio of telomere repeat copy number to single gene copy number) was measured in mononuclear cell DNA of prediagnostic peripheral blood samples of 464 lymphoma cases and 464 matched controls (median time between blood collection and diagnosis, 4.6 years). Conditional logistic regression was used to analyze the association between TL and the risk of developing lymphoma and histologic subtypes. TL was significantly longer in cases compared to controls (p 5 0.01). Multivariable models showed a significantly increased risk of BCL [odds ratio (OR) = 1.66, 1.80 and 3.20 for quartiles 2-4, respectively, p-trend = 0.001], diffuse large B-cell lymphoma (DLBCL) (OR = 1.20, 2.48 and 2.36 for quartiles 2-4, respectively, p-trend = 0.03) and follicular lymphoma (FL) (OR = 1.39, 1.90 and 2.69 for quartiles 2-4, respectively, p-trend = 0.02) with increasing TL. This study suggests an association between longer leucocyte TL and increased risk of BCL which was most pronounced for DLBCL and FL.
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| 10. |
- Saberi Hosnijeh, Fatemeh, et al.
(författare)
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Mitochondrial DNA copy number and future risk of B-cell lymphoma in a nested case-control study in the prospective EPIC cohort.
- 2014
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Ingår i: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 124:4, s. 530-535
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Tidskriftsartikel (refereegranskat)abstract
- It has been suggested that mitochondrial dysfunction and DNA damage are involved in lymphomagenesis. Increased copy number of mitochondrial DNA (mtDNA) as a compensatory mechanism of mitochondrial dysfunction previously has been associated with B-cell lymphomas, in particular chronic lymphocytic leukemia (CLL). However, current evidence is limited and based on a relatively small number of cases. Using a nested case-control study, we extended these findings with a focus on subtype specific analyses. Relative mtDNA copy number was measured in the buffy coat of prospectively collected blood of 469 lymphoma cases and 469 matched controls. The association between mtDNA copy number and the risk of developing lymphoma and histologic subtypes was examined using logistic regression models. We found no overall association between mtDNA and risk of lymphoma. Subtype analyses revealed, significant increased risks of CLL (n=102) with increasing mtDNA copy number (OR=1.34, 1.44 and 1.80 for quartiles 2-4, respectively P-trend=0.001). mtDNA copy number was not associated with follow-up time suggesting that this observation is not strongly influenced by indolent disease status. This study substantially strengthens the evidence that mtDNA copy number is related to risk of CLL and supports the importance of mitochondrial dysfunction as a possible mechanistic pathway in CLL ontogenesis.
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| 11. |
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| 12. |
- Grip, H. F., et al.
(författare)
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Output synchronization for heterogeneous networks of non-introspective, non-right-invertible agents
- 2013
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Ingår i: Proceedings of the American Control Conference 2013. - : American Automatic Control Council. - 9781479901777 ; , s. 5791-5796
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Konferensbidrag (refereegranskat)abstract
- We consider the output synchronization problem for a heterogeneous network of linear agents. The agents are non-introspective, meaning that they do not have access to their own state or output; the only information available to each agent comes from the network, in the form of a linear combination of its output relative to that of neighboring agents. The basis for our study is a design previously presented by the authors, which was based on an additional assumption requiring the agents to be right-invertible. Here we dispense with the assumption of right-invertibility and instead introduce a new assumption based on solvability of a particular set of regulator equations.
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| 13. |
- Haycock, Philip C, et al.
(författare)
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The association between genetically elevated polyunsaturated fatty acids and risk of cancer.
- 2023
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Ingår i: EBioMedicine. - : Elsevier. - 2352-3964. ; 91
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The causal relevance of polyunsaturated fatty acids (PUFAs) for risk of site-specific cancers remains uncertain.METHODS: Using a Mendelian randomization (MR) framework, we assessed the causal relevance of PUFAs for risk of cancer in European and East Asian ancestry individuals. We defined the primary exposure as PUFA desaturase activity, proxied by rs174546 at the FADS locus. Secondary exposures were defined as omega 3 and omega 6 PUFAs that could be proxied by genetic polymorphisms outside the FADS region. Our study used summary genetic data on 10 PUFAs and 67 cancers, corresponding to 562,871 cases and 1,619,465 controls, collected by the Fatty Acids in Cancer Mendelian Randomization Collaboration. We estimated odds ratios (ORs) for cancer per standard deviation increase in genetically proxied PUFA exposures.FINDINGS: Genetically elevated PUFA desaturase activity was associated (P < 0.0007) with higher risk (OR [95% confidence interval]) of colorectal cancer (1.09 [1.07-1.11]), esophageal squamous cell carcinoma (1.16 [1.06-1.26]), lung cancer (1.06 [1.03-1.08]) and basal cell carcinoma (1.05 [1.02-1.07]). There was little evidence for associations with reproductive cancers (OR = 1.00 [95% CI: 0.99-1.01]; Pheterogeneity = 0.25), urinary system cancers (1.03 [0.99-1.06], Pheterogeneity = 0.51), nervous system cancers (0.99 [0.95-1.03], Pheterogeneity = 0.92) or blood cancers (1.01 [0.98-1.04], Pheterogeneity = 0.09). Findings for colorectal cancer and esophageal squamous cell carcinoma remained compatible with causality in sensitivity analyses for violations of assumptions. Secondary MR analyses highlighted higher omega 6 PUFAs (arachidonic acid, gamma-linolenic acid and dihomo-gamma-linolenic acid) as potential mediators. PUFA biosynthesis is known to interact with aspirin, which increases risk of bleeding and inflammatory bowel disease. In a phenome-wide MR study of non-neoplastic diseases, we found that genetic lowering of PUFA desaturase activity, mimicking a hypothetical intervention to reduce cancer risk, was associated (P < 0.0006) with increased risk of inflammatory bowel disease but not bleeding.INTERPRETATION: The PUFA biosynthesis pathway may be an intervention target for prevention of colorectal cancer and esophageal squamous cell carcinoma but with potential for increased risk of inflammatory bowel disease.
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| 14. |
- Hosnijeh, Fatemeh Saberi, et al.
(författare)
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Anthropometric characteristics and risk of lymphoid and myeloid leukemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)
- 2013
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Ingår i: Cancer Causes and Control. - : Springer Science and Business Media LLC. - 1573-7225 .- 0957-5243. ; 24:3, s. 427-438
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Tidskriftsartikel (refereegranskat)abstract
- Overweight and obesity have been suggested as a risk factor for leukemia. Impaired immune function associated with obesity, increased insulin-like growth factor-I activity and stimulating effects of leptin suggest a possible biological link between anthropometric measures and leukemia. However, evidence from epidemiological studies has been inconsistent. We examined the potential association between prospective measurements of body size and risk of leukemia among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). During follow-up (mean = 11.52 years, standard deviation = 2.63), 671 leukemia (lymphoid leukemia = 50.1 %, myeloid leukemia = 43.2 %) cases were identified. Anthropometric measures including weight, height, body mass index (BMI), waist circumference (WC), hip circumference, and waist-to-hip ratio (WHR) were measured. Cox proportional hazard models were used to explore the association between anthropometric measures and risk of leukemia. No associations were observed between anthropometric measures and total leukemia, and lymphoid leukemia. Risk of myeloid leukemia significantly increased for higher categories of BMI and WC among women. Analyses by subtype of myeloid leukemia showed an increased risk of acute myeloid leukemia (AML) for higher categories of WHR among women. This association seemed to be reversed for chronic myeloid leukemia. No association between anthropometric measures and myeloid leukemia were observed among men except an increased risk of AML with height. The study showed no associations between anthropometric measures and total leukemia, and lymphoid leukemia among men and women. A possible association between BMI as general obesity and WC as abdominal obesity and increased risk of myeloid leukemia among women were observed.
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| 15. |
- Hosnijeh, Fatemeh Saberi, et al.
(författare)
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Dietary Intakes and Risk of Lymphoid and Myeloid Leukemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)
- 2014
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Ingår i: Nutrition and Cancer. - : Informa UK Limited. - 1532-7914 .- 0163-5581. ; 66:1, s. 14-28
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Tidskriftsartikel (refereegranskat)abstract
- The etiology of leukemias cannot entirely be explained by known risk factors, including ionizing radiation, benzene exposure, and infection with human T cell leukemia virus. A number of studies suggested that diet influences the risk of adult leukemias. However, results have been largely inconsistent. We examined the potential association between dietary factors and risk of leukemias among participants of the European Prospective Investigation into Cancer and Nutrition study. Among the 477,325 participants with mean follow-up of 11.34yr (SD = 2.47), 773 leukemias (373 and 342 cases of lymphoid and myeloid leukemia, respectively) were identified. Diet over the previous 12 mo was assessed at baseline using a validated country-specific dietary questionnaire. Cox proportional hazards regression was used to explore the association between dietary factors that have previously been associated with leukemia risk, including red and processed meat, poultry, offal, fish, dairy products, vegetables, fruits, and seeds/nuts, and risk of both lymphoid and myeloid leukemias. No significant associations were observed between dietary measures and total, lymphoid, and myeloid leukemias. Additional subtype analyses showed no dietary association with risk of major subtypes of leukemias. In summary, this study did not support a possible link between selected dietary factors and risk of leukemias.
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| 16. |
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| 17. |
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| 18. |
- Kolijn, P. Martijn, et al.
(författare)
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High-risk subtypes of chronic lymphocytic leukemia are detectable as early as 16 years prior to diagnosis
- 2022
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 139:10, s. 1557-1563
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Tidskriftsartikel (refereegranskat)abstract
- Chronic lymphocytic leukemia (CLL) is preceded by monoclonal B-cell lymphocytosis (MBL), a CLL precursor state with a prevalence of up to 12% in aged individuals; however, the duration of MBL and the mechanisms of its evolution to CLL remain largely unknown. In this study, we sequenced the B-cell receptor (BcR) immunoglobulin heavy chain (IGH) gene repertoire of 124 patients with CLL and 118 matched controls in blood samples taken up to 22 years prior to diagnosis. Significant skewing in the BcR IGH gene repertoire was detected in the majority of patients, even before the occurrence of lymphocytosis and irrespective of the clonotypic IGH variable gene somatic hypermutation status. Furthermore, we identified dominant clonotypes belonging to major stereotyped subsets associated with poor prognosis up to 16 years before diagnosis in 14 patients with CLL. In 22 patients with longitudinal samples, the skewing of the BcR IGH gene repertoire increased significantly over time to diagnosis or remained stable at high levels. For 14 of 16 patients with available samples at diagnosis, the CLL clonotype was already present in the prediagnostic samples. Overall, our data indicate that the preclinical phase of CLL could be longer than previously thought, even in adverse-prognostic cases.
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| 19. |
- Nechaeva, T., et al.
(författare)
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Hosing of a Long Relativistic Particle Bunch in Plasma
- 2024
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Ingår i: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 132:7
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Tidskriftsartikel (refereegranskat)abstract
- Experimental results show that hosing of a long particle bunch in plasma can be induced by wakefields driven by a short, misaligned preceding bunch. Hosing develops in the plane of misalignment, selfmodulation in the perpendicular plane, at frequencies close to the plasma electron frequency, and are reproducible. Development of hosing depends on misalignment direction, its growth on misalignment extent and on proton bunch charge. Results have the main characteristics of a theoretical model, are relevant to other plasma -based accelerators and represent the first characterization of hosing.
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| 20. |
- Ramstedt, Sofia, et al.
(författare)
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DEATHSTAR: Nearby AGB stars with the Atacama Compact Array I. CO envelope sizes and asymmetries: A new hope for accurate mass-loss-rate estimates
- 2020
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 640
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Tidskriftsartikel (refereegranskat)abstract
- Context. This is the first publication from the DEATHSTAR project. The overall goal of the project is to reduce the uncertainties of the observational estimates of mass-loss rates from evolved stars on the Asymptotic Giant Branch (AGB). Aim. The aim in this first publication is to constrain the sizes of the (CO)-C-12 emitting region from the circumstellar envelopes around 42 mostly southern AGB stars, of which 21 are M-type and 21 are C-type, using the Atacama Compact Array (ACA) at the Atacama Large Millimeter/submillimeter Array. The symmetry of the outflows is also investigated. Methods. Line emission from (CO)-C-12 J = 2 -> 1 and 3 -> 2 from all of the sources were mapped using the ACA. In this initial analysis, the emission distribution was fit to a Gaussian distribution in the uv-plane. A detailed radiative transfer analysis will be presented in a future publication. The major and minor axis of the best-fit Gaussian at the line center velocity of the (CO)-C-12 J = 2 -> 1 emission gives a first indication of the size of the emitting region. Furthermore, the fitting results, such as the Gaussian major and minor axis, center position, and the goodness of fit across both lines, constrain the symmetry of the emission distribution. For a subsample of sources, the measured emission distribution is compared to predictions from previous best-fit radiative transfer modeling results. Results. We find that the CO envelope sizes are, in general, larger for C-type than for M-type AGB stars, which is as expected if the CO/H-2 ratio is larger in C-type stars. Furthermore, the measurements show a relation between the measured (Gaussian) (CO)-C-12 J = 2 -> 1 size and circumstellar density that, while in broad agreement with photodissociation calculations, reveals large scatter and some systematic differences between the different stellar types. For lower mass-loss-rate irregular and semi-regular variables of both M- and C-type AGB stars, the (CO)-C-12 J = 2 -> 1 size appears to be independent of the ratio of the mass-loss rate to outflow velocity, which is a measure of circumstellar density. For the higher mass-loss-rate Mira stars, the (CO)-C-12 J = 2 -> 1 size clearly increases with circumstellar density, with larger sizes for the higher CO-abundance C-type stars. The M-type stars appear to be consistently smaller than predicted from photodissociation theory. The majority of the sources have CO envelope sizes that are consistent with a spherically symmetric, smooth outflow, at least on larger scales. For about a third of the sources, indications of strong asymmetries are detected. This is consistent with what was found in previous interferometric investigations of northern sources. Smaller scale asymmetries are found in a larger fraction of sources. Conclusions. These results for CO envelope radii and shapes can be used to constrain detailed radiative transfer modeling of the same stars so as to determine mass-loss rates that are independent of photodissociation models. For a large fraction of the sources, observations at higher spatial resolution will be necessary to deduce the nature and origin of the complex circumstellar dynamics revealed by our ACA observations.
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| 21. |
- Saberi, Maryam, 1988, et al.
(författare)
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Detecting Long Period Variables in M 33 Using UKIRT-WFCAM Images
- 2015
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Ingår i: Why Galaxies Care About AGB Stars III: A Closer Look in Space and Time, Conference on Why Galaxies Care About AGB Stars III: A Closer Look in Space and Time, Vienna JUL 28-AUG 01, 2014. - 9781583818794 ; 497, s. 497-498
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Konferensbidrag (refereegranskat)abstract
- We have used the UK InfraRed Telescope (UKIRT) to conduct a near-IR monitoring campaign to search for variable stars in the Local Group spiral galaxy M 33. Most of the 4643 detected variables appear to be Asymptotic Giant Branch (AGB) stars.
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| 22. |
- Verra, L., et al.
(författare)
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Development of the self-modulation instability of a relativistic proton bunch in plasma
- 2023
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Ingår i: Physics of Plasmas. - : American Institute of Physics (AIP). - 1070-664X .- 1089-7674. ; 30:8
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Tidskriftsartikel (refereegranskat)abstract
- Self-modulation is a beam-plasma instability that is useful to drive large-amplitude wakefields with bunches much longer than the plasma skin depth. We present experimental results showing that, when increasing the ratio between the initial transverse size of the bunch and the plasma skin depth, the instability occurs later along the bunch, or not at all, over a fixed plasma length because the amplitude of the initial wakefields decreases. We show cases for which self-modulation does not develop, and we introduce a simple model discussing the conditions for which it would not occur after any plasma length. Changing bunch size and plasma electron density also changes the growth rate of the instability. We discuss the impact of these results on the design of a particle accelerator based on the self-modulation instability seeded by a relativistic ionization front, such as the future upgrade of the Advanced WAKefield Experiment.
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| 23. |
- Wang, X., et al.
(författare)
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Consensus in the network with uniform constant communication delay
- 2012
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Ingår i: Decision and Control (CDC), 2012 IEEE 51st Annual Conference on. - : IEEE. ; , s. 5318-5323
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Konferensbidrag (refereegranskat)abstract
- This paper studies the consensus among identical agents that are at most critically unstable and coupled through networks with uniform constant communication delay. An achievable upper bound of delay tolerance is obtained which explicitly depends on agent dynamics and network topology. The dependence on network topology disappears in the case of undirected networks. For any delay satisfying this upper bound, a controller design methodology without exact knowledge of the network topology is proposed so that the multi-agent consensus in a set of unknown networks can be achieved. Moreover, when the network topology is known, a larger delay tolerance is possible via a topology-dependent consensus controller. The results are illustrated by simulations.
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| 24. |
- Wang, X., et al.
(författare)
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Synchronization for heterogeneous networks of introspective right-invertible agents with uniform constant communication delay
- 2013
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Ingår i: 2013 IEEE 52nd Annual Conference on Decision and Control (CDC). - : IEEE conference proceedings. - 9781467357142 ; , s. 5198-5203
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Konferensbidrag (refereegranskat)abstract
- This paper studies output synchronization and regulation problem for heterogeneous networks of introspective right-invertible agents with uniform constant communication delay. A decentralized design based on shaping the agent dynamics using their self-knowledge and structural properties is developed. In the output synchronization problem, the proposed controller design tolerates arbitrary bounded communication delay and large network uncertainties. In the output regulation problem, it requires relative output measurement of the exosystem only in one agent. Moreover, the design method can also be applied to formation control problems.
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| 25. |
- Wang, X., et al.
(författare)
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Synchronization for homogeneous networks of non-introspective, non-right-invertible, discrete-time agents with uniform constant communication delay
- 2013
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Ingår i: 2013 IEEE 52nd Annual Conference on Decision and Control (CDC). - : IEEE conference proceedings. - 9781467357142 ; , s. 7351-7357
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Konferensbidrag (refereegranskat)abstract
- This paper studies the synchronization problem for homogeneous networks of non-introspective, non-rightinvertible, discrete-time agents with unknown uniform constant communication delay. We solve the problem for a set of communication topologies via a decentralized low-gain based synchronization controller if the delay satisfies the proposed upper bound, which in general depends on the identical agent model and some characteristics of the communication topology.
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