| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Morales, J. C., et al.
(författare)
-
A giant exoplanet orbiting a very-low-mass star challenges planet formation models
- 2019
-
Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 365:6460, s. 1441-1445
-
Tidskriftsartikel (refereegranskat)abstract
- Surveys have shown that super-Earth and Neptune-mass exoplanets are more frequent than gas giants around low-mass stars, as predicted by the core accretion theory of planet formation. We report the discovery of a giant planet around the very-low-mass star GJ 3512, as determined by optical and near-infrared radial-velocity observations. The planet has a minimum mass of 0.46 Jupiter masses, very high for such a small host star, and an eccentric 204-day orbit. Dynamical models show that the high eccentricity is most likely due to planet-planet interactions. We use simulations to demonstrate that the GJ 3512 planetary system challenges generally accepted formation theories, and that it puts constraints on the planet accretion and migration rates. Disk instabilities may be more efficient in forming planets than previously thought.
|
|
| 5. |
|
|
| 6. |
- Mallorquin, M., et al.
(författare)
-
TOI-1801 b: A temperate mini-Neptune around a young M0.5 dwarf
- 2023
-
Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 680
-
Tidskriftsartikel (refereegranskat)abstract
- We report the discovery, mass, and radius determination of TOI-1801 b, a temperate mini-Neptune around a young M dwarf. TOI-1801 b was observed in TESS sectors 22 and 49, and the alert that this was a TESS planet candidate with a period of 21.3 days went out in April 2020. However, ground-based follow-up observations, including seeing-limited photometry in and outside transit together with precise radial velocity (RV) measurements with CARMENES and HIRES revealed that the true period of the planet is 10.6 days. These observations also allowed us to retrieve a mass of 5.74 +/- 1.46 M-circle plus, which together with a radius of 2.08 +/- 0.12 R-circle plus, means that TOI-1801 b is most probably composed of water and rock, with an upper limit of 2% by mass of H-2 in its atmosphere. The stellar rotation period of 16 days is readily detectable in our RV time series and in the ground-based photometry. We derived a likely age of 600-800 Myr for the parent star TOI-1801, which means that TOI-1801 b is the least massive young mini-Neptune with precise mass and radius determinations. Our results suggest that if TOI-1801 b had a larger atmosphere in the past, it must have been removed by some evolutionary mechanism on timescales shorter than 1 Gyr.
|
|
| 7. |
- Martinez-Sanchez, LD, et al.
(författare)
-
Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation
- 2023
-
Ingår i: Gut. - : BMJ. - 1468-3288 .- 0017-5749. ; 72:2, s. 275-294
-
Tidskriftsartikel (refereegranskat)abstract
- Increased apoptotic shedding has been linked to intestinal barrier dysfunction and development of inflammatory bowel diseases (IBD). In contrast, physiological cell shedding allows the renewal of the epithelial monolayer without compromising the barrier function. Here, we investigated the role of live cell extrusion in epithelial barrier alterations in IBD.DesignTaking advantage of conditional GGTase and RAC1 knockout mice in intestinal epithelial cells (Pggt1biΔIECandRac1iΔIECmice), intravital microscopy, immunostaining, mechanobiology, organoid techniques and RNA sequencing, we analysed cell shedding alterations within the intestinal epithelium. Moreover, we examined human gut tissue and intestinal organoids from patients with IBD for cell shedding alterations and RAC1 function.ResultsEpithelialPggt1bdeletion led to cytoskeleton rearrangement and tight junction redistribution, causing cell overcrowding due to arresting of cell shedding that finally resulted in epithelial leakage and spontaneous mucosal inflammation in the small and to a lesser extent in the large intestine. Both in vivo and in vitro studies (knockout mice, organoids) identified RAC1 as a GGTase target critically involved in prenylation-dependent cytoskeleton dynamics, cell mechanics and epithelial cell shedding. Moreover, inflamed areas of gut tissue from patients with IBD exhibited funnel-like structures, signs of arrested cell shedding and impaired RAC1 function. RAC1 inhibition in human intestinal organoids caused actin alterations compatible with arresting of cell shedding.ConclusionImpaired epithelial RAC1 function causes cell overcrowding and epithelial leakage thus inducing chronic intestinal inflammation. Epithelial RAC1 emerges as key regulator of cytoskeletal dynamics, cell mechanics and intestinal cell shedding. Modulation of RAC1 might be exploited for restoration of epithelial integrity in the gut of patients with IBD.
|
|
| 8. |
- Bluhm, P., et al.
(författare)
-
Precise mass and radius of a transiting super-Earth planet orbiting the M dwarf TOI-1235: a planet in the radius gap?
- 2020
-
Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 639
-
Tidskriftsartikel (refereegranskat)abstract
- We report the confirmation of a transiting planet around the bright weakly active M0.5 V star TOI-1235 (TYC 4384-1735-1, V ≈ 11.5 mag), whose transit signal was detected in the photometric time series of sectors 14, 20, and 21 of the TESS space mission. We confirm the planetary nature of the transit signal, which has a period of 3.44 d, by using precise RV measurements with the CARMENES, HARPS-N, and iSHELL spectrographs, supplemented by high-resolution imaging and ground-based photometry. A comparison of the properties derived for TOI-1235 b with theoretical models reveals that the planet has a rocky composition, with a bulk density slightly higher than that of Earth. In particular, we measure a mass of Mp = 5.9 ± 0.6 M⊕ and a radius of Rp = 1.69 ± 0.08 R⊕, which together result in a density of ρp = 6.7- 1.1+ 1.3 g cm-3. When compared with other well-characterized exoplanetary systems, the particular combination of planetary radius and mass places our discovery in the radius gap, which is a transition region between rocky planets and planets with significant atmospheric envelopes. A few examples of planets occupying the radius gap are known to date. While the exact location of the radius gap for M dwarfs is still a matter of debate, our results constrain it to be located at around 1.7 R⊕ or larger at the insolation levels received by TOI-1235 b (~60 S⊕). This makes it an extremely interesting object for further studies of planet formation and atmospheric evolution.
|
|
| 9. |
- Bo, A D, et al.
(författare)
-
Ethyl(hydroxyethyl)cellulose-sodium dodecanoate interaction investigated by surface tension and electrical conductivity techniques
- 2005
-
Ingår i: Colloids and Surfaces A: Physicochemical and Engineering Aspects. - : Elsevier BV. - 0927-7757. ; 256:2-3, s. 171-180
-
Tidskriftsartikel (refereegranskat)abstract
- Mixtures of ethyl (hydroxyethyl)cellulose (EHEC) and sodium dodecanoate (SDoD) were investigated using surface tension, conductivity and transmittance measurements. The parameters of the surfactant to polymer association processes such as the critical aggregation concentration (cac) and saturation of the polymer by SDoD (psp) were determined from the plots of surface tension and specific conductivity versus surfactant concentration. The transmittance versus [SDoD] profiles exhibited bands that, in conjunction with conductivity and surface tension data, gave support to the explanation of the behavior of EHEC-SDoD-water solutions. Transmittance bands determined in the presence of EHEC and surfactant are sensitive to the process of surfactant to polymer binding. In this process, a discontinuity point represented by a second broader peak in the transmittance plots was identified, implying a slight inhibition of the breakdown of the network process. This is explained as a kind of intermediate re-structural network of the complexes produced by the formation of regular SDoD micelles. It was demonstrated that the second conductivity breakpoint marks the polymer saturation by surfactant clusters, and the effect of the EHEC concentration on the process of binding can be described by a linear correlation when the psp breakpoint is plotted against the polymer concentration. (c) 2005 Elsevier B.V. All rights reserved.
|
|
| 10. |
- Boatman, Elizabeth M., et al.
(författare)
-
Mechanisms of soft tissue and protein preservation in Tyrannosaurus rex
- 2019
-
Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9
-
Tidskriftsartikel (refereegranskat)abstract
- The idea that original soft tissue structures and the native structural proteins comprising them can persist across geological time is controversial, in part because rigorous and testable mechanisms that can occur under natural conditions, resulting in such preservation, have not been well defined. Here, we evaluate two non-enzymatic structural protein crosslinking mechanisms, Fenton chemistry and glycation, for their possible contribution to the preservation of blood vessel structures recovered from the cortical bone of a Tyrannosaurus rex (USNM 555000 [formerly, MOR 555]). We demonstrate the endogeneity of the fossil vessel tissues, as well as the presence of type I collagen in the outermost vessel layers, using imaging, diffraction, spectroscopy, and immunohistochemistry. Then, we use data derived from synchrotron FTIR studies of the T. rex vessels to analyse their crosslink character, with comparison against two non-enzymatic Fenton chemistry- and glycation-treated extant chicken samples. We also provide supporting X-ray microprobe analyses of the chemical state of these fossil tissues to support our conclusion that non-enzymatic crosslinking pathways likely contributed to stabilizing, and thus preserving, these T. rex vessels. Finally, we propose that these stabilizing crosslinks could play a crucial role in the preservation of other microvascular tissues in skeletal elements from the Mesozoic.
|
|
| 11. |
|
|
| 12. |
- Chaturvedi, P., et al.
(författare)
-
TOI-1468: A system of two transiting planets, a super-Earth and a mini-Neptune, on opposite sides of the radius valley
- 2022
-
Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 666
-
Tidskriftsartikel (refereegranskat)abstract
- We report the discovery and characterization of two small transiting planets orbiting the bright M3.0V star TOI-1468 (LSPM J0106+1913), whose transit signals were detected in the photometric time series in three sectors of the TESS mission. We confirm the planetary nature of both of them using precise radial velocity measurements from the CARMENES and MAROON-X spectrographs, and supplement them with ground-based transit photometry. A joint analysis of all these data reveals that the shorter-period planet, TOI-1468 b (P-b = 1.88 d), has a planetary mass of M-b = 3.21 +/- 0.24M(circle plus) and a radius of R-b = 1.280(-0.039)(+0.038) R-circle plus, resulting in a density of rho(b) = 8.39(-0.92)(+1.05) g cm(-3), which is consistent with a mostly rocky composition. For the outer planet, TOI-1468 c (P-c = 15.53 d), we derive a mass of M-c = 6.64(-0.68)(+0.67) M-circle plus,aradius of R-c = 2.06 +/- 0.04 R-circle plus, and a bulk density of rho(c) = 2.00(-0.19)(+0.21) g cm(-3), which corresponds to a rocky core composition with a H/He gas envelope. These planets are located on opposite sides of the radius valley, making our system an interesting discovery as there are only a handful of other systems with the same properties. This discovery can further help determine a more precise location of the radius valley for small planets around M dwarfs and, therefore, shed more light on planet formation and evolution scenarios.
|
|
| 13. |
- Comai, Glenda Evangelina, et al.
(författare)
-
Local retinoic acid signaling directs emergence of the extraocular muscle functional unit
- 2020
-
Ingår i: PLoS biology. - : Public Library Science. - 1544-9173 .- 1545-7885. ; 18:11
-
Tidskriftsartikel (refereegranskat)abstract
- Coordinated development of muscles, tendons, and their attachment sites ensures emergence of functional musculoskeletal units that are adapted to diverse anatomical demands among different species. How these different tissues are patterned and functionally assembled during embryogenesis is poorly understood. Here, we investigated the morphogenesis of extraocular muscles (EOMs), an evolutionary conserved cranial muscle group that is crucial for the coordinated movement of the eyeballs and for visual acuity. By means of lineage analysis, we redefined the cellular origins of periocular connective tissues interacting with the EOMs, which do not arise exclusively from neural crest mesenchyme as previously thought. Using 3D imaging approaches, we established an integrative blueprint for the EOM functional unit. By doing so, we identified a developmental time window in which individual EOMs emerge from a unique muscle anlage and establish insertions in the sclera, which sets these muscles apart from classical muscle-to-bone type of insertions. Further, we demonstrate that the eyeballs are a source of diffusible all-trans retinoic acid (ATRA) that allow their targeting by the EOMs in a temporal and dose-dependent manner. Using genetically modified mice and inhibitor treatments, we find that endogenous local variations in the concentration of retinoids contribute to the establishment of tendon condensations and attachment sites that precede the initiation of muscle patterning. Collectively, our results highlight how global and site-specific programs are deployed for the assembly of muscle functional units with precise definition of muscle shapes and topographical wiring of their tendon attachments.
|
|
| 14. |
- Hildebrand, Angelica, et al.
(författare)
-
Elastic Neutron Scattering at 96 MeV
- 2004
-
Ingår i: Proc. Int. Conf. on Nuclear Data for Science and Technology.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)
|
|
| 15. |
|
|
| 16. |
|
|
| 17. |
|
|
| 18. |
- Kruszka, Paul, et al.
(författare)
-
Muenke syndrome : An international multicenter natural history study
- 2016
-
Ingår i: American Journal of Medical Genetics. Part A. - : Wiley. - 1552-4825 .- 1552-4833. ; 170:4, s. 918-929
-
Tidskriftsartikel (refereegranskat)abstract
- Muenke syndrome is an autosomal dominant disorder characterized by coronal suture craniosynostosis, hearing loss, developmental delay, carpal, and calcaneal fusions, and behavioral differences. Reduced penetrance and variable expressivity contribute to the wide spectrum of clinical findings. Muenke syndrome constitutes the most common syndromic form of craniosynostosis, with an incidence of 1 in 30,000 births and is defined by the presence of the p.Pro250Arg mutation in FGFR3. Participants were recruited from international craniofacial surgery and genetic clinics. Affected individuals, parents, and their siblings, if available, were enrolled in the study if they had a p.Pro250Arg mutation in FGFR3. One hundred and six patients from 71 families participated in this study. In 51 informative probands, 33 cases (64.7%) were inherited. Eighty-five percent of the participants had craniosynostosis (16 of 103 did not have craniosynostosis), with 47.5% having bilateral and 28.2% with unilateral synostosis. Females and males were similarly affected with bicoronal craniosynostosis, 50% versus 44.4% (P=0.84), respectively. Clefting was rare (1.1%). Hearing loss was identified in 70.8%, developmental delay in 66.3%, intellectual disability in 35.6%, attention deficit/hyperactivity disorder in 23.7%, and seizures in 20.2%. In patients with complete skeletal surveys (upper and lower extremity x-rays), 75% of individuals were found to have at least a single abnormal radiographical finding in addition to skull findings. This is the largest study of the natural history of Muenke syndrome, adding valuable clinical information to the care of these individuals including behavioral and cognitive impairment data, vision changes, and hearing loss.
|
|
| 19. |
- Martucci, Leonardo, et al.
(författare)
-
A Trust-Based Security Architecture for Small and Medium-Sized Mobile Ad Hoc Networks
- 2004
-
Konferensbidrag (refereegranskat)abstract
- This paper describes a trust based security architecture for small/medium-sized mobile ad hoc networks. We designed and implemented a security architecture that extends the traditional PKI model, assigning variable trust values to digital certificates and issuing credentials to grant access to network services. Trust values are not static; they vary during regular network operation as network users provoke security incidents. Depending on the seriousness of the incidents the trust value associated to the offenders certificate will vary. Eventually, a series of security incidents may end up with the certificate revocation. We also developed a security framework for designing secure applications and built prototypes to test and validate our architecture. We considered service-oriented ad hoc networks, where every mobile device is classified as service providers or service users
|
|
| 20. |
- Murgas, F., et al.
(författare)
-
Two super-Earths at the edge of the habitable zone of the nearby M dwarf TOI-2095
- 2023
-
Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 677
-
Tidskriftsartikel (refereegranskat)abstract
- The main scientific goal of TESS is to find planets smaller than Neptune around stars that are bright enough to allow for further characterization studies. Given our current instrumentation and detection biases, M dwarfs are prime targets in the search for small planets that are in (or near) the habitable zone of their host star. In this work, we use photometric observations and CARMENES radial velocity (RV) measurements to validate a pair of transiting planet candidates found by TESS. The data were fitted simultaneously, using a Bayesian Markov chain Monte Carlo (MCMC) procedure and taking into account the stellar variability present in the photometric and spectroscopic time series. We confirm the planetary origin of the two transiting candidates orbiting around TOI-2095 (LSPM J1902+7525). The star is a nearby M dwarf (d = 41.90 ± 0.03 pc, Teff = 3759 ± 87 K, V = 12.6 mag), with a stellar mass and radius of M∗ = 0.44 ± 0.02 M· and R∗ = 0.44 ± 0.02 R·, respectively. The planetary system is composed of two transiting planets: TOI-2095b, with an orbital period of Pb = 17.66484 ± (7 A - 10- 5) days, and TOI-2095c, with Pc = 28.17232 ± (14 A - 10- 5) days. Both planets have similar sizes with Rb = 1.25 ± 0.07 R· and Rc = 1.33 ± 0.08 R· for planet b and planet c, respectively. Although we did not detect the induced RV variations of any planet with significance, our CARMENES data allow us to set stringent upper limits on the masses of these objects. We find Mb < 4.1 M· for the inner and Mc < 7.4 M· for the outer planet (95% confidence level). These two planets present equilibrium temperatures in the range of 300 350 K and are close to the inner edge of the habitable zone of their star.
|
|
| 21. |
|
|
| 22. |
- Sordo, Rosanna, et al.
(författare)
-
Stellar libraries for Gaia
- 2011
-
Ingår i: Journal of Physics, Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 328:Conference 1, s. 012006-
-
Tidskriftsartikel (refereegranskat)abstract
- Gaia will observe up to a billion stellar sources. Automated algorithms are under development to derive the atmospheric parameters of all observed spectra, from low resolution optical spectra alone or in synergy with high resolution spectra in the near-IR Ca II triplet region. To do so, a large database of state-of-the-art stellar libraries has been produced for the Gaia community, computed using different codes optimized for specific purposes. The choice to use different spectral codes in different regions of the H-R diagram raises the problem of the coherence of the different spectra, specifically in the transition zones. We present a comparison between the libraries from the point of view of spectra simulations for training the Gaia algorithms. We also present the implementation of these libraries into a Simple Stellar Population code.
|
|
| 23. |
- Vallenari, A., et al.
(författare)
-
Synthetic stellar libraries and SSP simulations in the Gaia Era
- 2009
-
Ingår i: Proceedings of the International Astronomical Union. ; , s. 444-445
-
Konferensbidrag (refereegranskat)abstract
- The Gaia mission will obtain accurate positions, parallaxes and proper motions for 109 object all over the sky. In addition, it will collect low resolution spectroscopy in the optical range for ∼ 109 objects, stars, galaxies, and QSOs. Parameters of those objects are expected to be part of the final Catalog. Complete and up-to-date libraries of synthetic stellar spectra are needed to train the algorithms to classify this huge amount of data. Here we focus on the use of the synthetic libraries of spectra calculated by the Gaia community to derive grids of Single Stellar Populations as building blocks of population synthesis models. © International Astronomical Union 2010.
|
|
| 24. |
|
|
| 25. |
- Öhrn, Angelica, et al.
(författare)
-
Elastic scattering of 96 MeV neutrons from iron, yttrium, and lead
- 2008
-
Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 77:2, s. 024605-
-
Tidskriftsartikel (refereegranskat)abstract
- Data on elastic scattering of 96 MeV neutrons from Fe-56, Y-89, and Pb-208 in the angular interval 10-70 degrees are reported. The previously published data on Pb-208 have been extended, as a new method has been developed to obtain more information from data, namely to increase the number of angular bins at the most forward angles. A study of the deviation of the zero-degree cross section from Wick's limit has been performed. It was shown that the data on Pb-208 are in agreement with Wick's limit while those on the lighter nuclei overshoot the limit significantly. The results are compared with modern optical model predictions, based on phenomenology and microscopic nuclear theory. The data on Fe-56, Y-89, and Pb-208 are in general in good agreement with the model predictions.
|
|
