| 1. |
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| 2. |
- Bellenguez, C, et al.
(författare)
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New insights into the genetic etiology of Alzheimer's disease and related dementias
- 2022
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Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 54:4, s. 412-436
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Tidskriftsartikel (refereegranskat)abstract
- Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.
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| 3. |
- Wightman, D. P., et al.
(författare)
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A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease
- 2021
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Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 53:9, s. 1276-1282
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Tidskriftsartikel (refereegranskat)abstract
- Late-onset Alzheimer’s disease is a prevalent age-related polygenic disease that accounts for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying Alzheimer’s disease have been identified. Here we show that increased sample sizes allowed identification of seven previously unidentified genetic loci contributing to Alzheimer’s disease. This study highlights microglia, immune cells and protein catabolism as relevant to late-onset Alzheimer’s disease, while identifying and prioritizing previously unidentified genes of potential interest. We anticipate that these results can be included in larger meta-analyses of Alzheimer’s disease to identify further genetic variants that contribute to Alzheimer’s pathology.
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| 4. |
- Elvsashagen, T, et al.
(författare)
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The genetic architecture of human brainstem structures and their involvement in common brain disorders
- 2020
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 4016-
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Tidskriftsartikel (refereegranskat)abstract
- Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pons, and medulla oblongata volumes, and map them to 305 genes. In a replication sample of 7432 participants most of the loci show the same effect direction and are significant at a nominal threshold. We detect genetic overlap between brainstem volumes and eight psychiatric and neurological disorders. In additional clinical data from 5062 individuals with common brain disorders and 11,257 healthy controls, we observe differential volume alterations in schizophrenia, bipolar disorder, multiple sclerosis, mild cognitive impairment, dementia, and Parkinson’s disease, supporting the relevance of brainstem regions and their genetic architectures in common brain disorders.
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| 5. |
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| 6. |
- Kaufmann, Tobias, et al.
(författare)
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Common brain disorders are associated with heritable patterns of apparent aging of the brain
- 2019
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Ingår i: Nature Neuroscience. - : Nature Publishing Group. - 1097-6256 .- 1546-1726. ; 22:10, s. 1617-
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Tidskriftsartikel (refereegranskat)abstract
- Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.
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| 7. |
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| 8. |
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| 9. |
- Jansen, Iris E, et al.
(författare)
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Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers.
- 2022
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Ingår i: Acta neuropathologica. - : Springer Science and Business Media LLC. - 1432-0533 .- 0001-6322. ; 144:5, s. 821-842
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Tidskriftsartikel (refereegranskat)abstract
- Amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer's disease (AD) more directly than clinical diagnosis. Initiated by the European Alzheimer & Dementia Biobank (EADB), the largest collaborative effort on genetics underlying CSF biomarkers was established, including 31 cohorts with a total of 13,116 individuals (discovery n=8074; replication n=5042 individuals). Besides the APOE locus, novel associations with two other well-established AD risk loci were observed; CR1 was shown a locus for Aβ42 and BIN1 for pTau. GMNC and C16orf95 were further identified as loci for pTau, of which the latter is novel. Clustering methods exploring the influence of all known AD risk loci on the CSF protein levels, revealed 4 biological categories suggesting multiple Aβ42 and pTau related biological pathways involved in the etiology of AD. In functional follow-up analyses, GMNC and C16orf95 both associated with lateral ventricular volume, implying an overlap in genetic etiology for tau levels and brain ventricular volume.
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| 10. |
- Khaydukov, Yu. N., et al.
(författare)
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Evidence for spin-triplet superconducting correlations in metal-oxide heterostructures with noncollinear magnetization
- 2014
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Ingår i: Physical Review B - Condensed Matter and Materials Physics. - 2469-9950 .- 2469-9969. ; 90:3, s. Article no. 035130 -
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Tidskriftsartikel (refereegranskat)abstract
- Heterostructures composed of ferromagnetic La0.7Sr0.3MnO3, ferromagnetic SrRuO3, and superconducting YBa2Cu3O6+x were studied experimentally. Structures of composition Au/La0.7Sr0.3MnO3/SrRuO3/YBa2Cu3O6+x were prepared by pulsed laser deposition, and their high quality was confirmed by x-ray diffraction and reflectometry. Anoncollinear magnetic state of the heterostructureswas revealed by means of superconducting quantum interference device magnetometry and polarized neutron reflectometry. We have further observed superconducting currents in mesa structures fabricated by deposition of a second superconducting Nb layer on top of the heterostructure, followed by patterning with photolithography and ion-beam etching. Josephson effects observed in these mesa structures can be explained by the penetration of a triplet component of the superconducting order parameter into the magnetic layers.
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| 11. |
- Kislinskiǐ, Yu V., et al.
(författare)
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Copper oxide superconducting/antiferromagnetic interface
- 2015
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Ingår i: Solid State Phenomena. - 1662-9779 .- 1012-0394. - 9783038354826 ; 233-234, s. 733-736
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Konferensbidrag (refereegranskat)abstract
- Superconducting Nb/Au/Ca1-xSrxCuO2/YBa2Cu3O7 mesa-heterostructures were investigated. Dependencies of electrical parameters versus inverse capacitance were measured. A band diagram which takes into account an accumulation of holes inCa1-xSrxCuO2 interlayer and band bending due to difference of work functions was proposed. The dependencies of electrical parameters were analyzed by examining the quasipartical and superconducting currents.
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| 12. |
- Ovsyannikov, Gennady, 1948, et al.
(författare)
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Proximity effect and electron transport in oxide hybrid heterostructures with superconducting/magnetic interfaces
- 2011
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Ingår i: Superconductor Science and Technology. - : IOP Publishing. - 0953-2048 .- 1361-6668. ; 24:5, s. Art. no. 055012-
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Tidskriftsartikel (refereegranskat)abstract
- We report on electron transport in oxide heterostructures with superconducting/magnetic (S/M) thin film interfaces. The investigated hybrid mesa-heterostructures consist of a cuprate superconductor, a nonsuperconducting cuprate (antiferromagnetic) or manganite (ferromagnetic) interlayer with thickness d(M) = 5-50 nm and a conventional superconductor (Nb). The superconducting critical current (I-C) with a critical current density j(c) = 10(3) A cm(-2) (for d(M) = 10 nm) and a characteristic voltage ICRN = 100-200 mu V (RN is normal resistance) are observed at liquid helium temperature for a CaXSr1-XCuO2 antiferromagnetic cuprate interlayer with a thickness of d(M) = 10-50 nm. The superconducting current-phase relation of heterostructures deviates from the regular sine type, demonstrating a second harmonic component. These hybrid heterostructures with S/M interfaces show unusually high sensitivity to external magnetic fields. When substituting the cuprate interlayer by a manganite film, no critical current was observed although the manganite interlayer was made several times thinner (down to d(M)
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| 13. |
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| 14. |
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| 15. |
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| 16. |
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| 17. |
- Constantinian, K. Y., et al.
(författare)
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Electron transport and microwave dynamics of hybrid Nb/Au/CaSrCuO/YBaCuO planar Josephson junctions
- 2009
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Ingår i: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 234:4, s. Art. no. 042004-
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Konferensbidrag (refereegranskat)abstract
- We report on measurements of dc electron transport and microwave dynamics of thin film hybrid Josephson junctions with an oxide antiferromagnetic interlayer. The base superconducting electrode YBaCuO and the antiferromagnetic (AF) interlayer CaSrCuO (with thickness d 20 - 70 nm) were grown by laser ablation on NdGaO3 substrates. I-V curves were well fitted to RSJ model and had no excess current, ICRN products were of order 0.2 mV at T=4.2 K. We did not observe any noticeable reduction of I CRN with increasing d. Such "tunnellike" behaviour also resulted in appearance of singularities on I-V curve when magnetic field was applied. Oscillating with microwave power integer and half-integer Shapiro steps were registered along with sub-harmonic detector response. Moreover, for some of junctions a "devil" staircase structure was observed on I-V curves and giant noise-like signals were measured in 1-2 GHz band at the certain levels of microwave power. Observed features, noise performance and the impact of the second harmonic in current-phase relation on junction dynamics are discussed taking into account data for structures without AF interlayer.
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| 18. |
- Constantinian, K. Y., et al.
(författare)
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Hybrid superconducting heterostructures with magnetic interlayers
- 2021
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Ingår i: Radioelektronika, Nanosistemy, Informacionnye Tehnologii. - : Editorial Board of Journal Radioelectronics, Nanosystems, Information Technology RENSIT. - 2218-3000 .- 2414-1267. ; 13:4, s. 471-478
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Tidskriftsartikel (refereegranskat)abstract
- Electron transport processes in oxide superconducting heterostructures with epitaxially grown magnetic thin-film interlayers, in which the interaction of superconducting correlations and magnetic ordering occurs due to superconducting and magnetic proximity effects, have been studied experimentally. Hybrid mesa-heterostructures were prepared from thin-film bottom cuprate superconductor (S), magnetic (M) interlayer made of manganite or an antiferromagnetic cuprate, and the upper electrode made from an ordinary superconductor. When the cuprate antiferromagnetic material was replaced by a ferromagnetic manganite interlayer, the superconducting current was suppressed, although the thin magnetic film was several times thinner, 5 nm, and the temperature was lowered to 0.3 K. At low temperatures dependences of differential resistance vs. voltage for mesa-heterostructures with manganite interlayer featured mini-gap low-energy states.
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| 19. |
- Constantinian, K. Y., et al.
(författare)
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Hybrid superconducting mesa-heterostructure with manganite-ruthenate interlayer
- 2014
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Ingår i: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 507:Part 4, s. Art. no. 042007-
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Konferensbidrag (refereegranskat)abstract
- We present experimental data on Josephson effect in hybrid superconducting mesa-heterostructures (HSMH) with composite manganite-ruthenate interlayer. The HSMH base electrode consisted of the cuprate superconductor YBa 2Cu3O7 grown epitaxially on a NdGaO substrate using laser ablation. The interlayer was composed from in-situ deposited SrRuO3 (F1) and La0.7Sr0.3MnO3 (F2) thin films, each characterized by different directions of magnetization. The top electrode was Nb/Au thin film. A superconducting current was observed when the interlayer thickness was well above the correlation length, determined by the exchange field in F1 and F2. Obtained IC (H) dependences and non-sinusoidal current-phase relation evaluated from microwave measurements are discussed in terms of generation of long-range spin triplet superconducting current component in heterostructures with interfaces of singlet superconductors and bilayer ferromagnetic materials with different spatial directions of magnetization.
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| 20. |
- Constantinian, K. Y., et al.
(författare)
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Interfaces in superconducting hybrid heterostructures with an antiferromagnetic interlayer
- 2013
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Ingår i: Physics of the Solid State. - 1063-7834 .- 1090-6460. ; 55:3, s. 461-465
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Tidskriftsartikel (refereegranskat)abstract
- The structural, X-ray diffraction, and electrophysical studies of hybrid superconducting hetero-structures with an interlayer of cuprate antiferromagnetic Ca1 - x Sr (x) CuO2 (CSCO) with the upper electrode Nb/Au and the lower electrode Y(B)a(2)Cu(3)O(7 - delta) (YBCO) have been carried out. It has been experimentally shown that the epitaxial growth of two cuprates, YBCO and CSCO, results in the formation of an interface on which the enrichment of the CSCO interlayer with charge carriers proceeds to a depth of about 20 nm. In this case, the conduction of the enriched CSCO region proves to be closer to metallic, whereas the CSCO film deposited onto the NdGaO3 substrate is a Mott insulator with hopping conduction.
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| 21. |
- Constantinian, K. Y., et al.
(författare)
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Spin-Triplet Superconducting Current in Metal-Oxide Heterostructures With Composite Ferromagnetic Interlayer
- 2016
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Ingår i: IEEE Transactions on Applied Superconductivity. - : Institute of Electrical and Electronics Engineers (IEEE). - 1558-2515 .- 1051-8223. ; 26:3
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Tidskriftsartikel (refereegranskat)abstract
- Superconducting heterostructures fabricated from oxide superconductor YBa2Cu2O7-delta and a composite ferromagnet La0.7Sr0.3MnO3/SrRuO3 interlayer and Au/Nb counter electrode were studied experimentally. Superconducting current was observed at magnetic field H raised up to 2000 Oe, which is greater than saturation magnetic field of manganite La0.7Sr0.3MnO3 (of order 100 Oe) and greater by a few orders than the value of magnetic field corresponding to penetration of one magnetic flux quantum. Microwave measurements of integer and half-integer Shapiro steps in conditions when relatively low external magnetic fieldH < 30 Oe was applied showed that the second harmonic in the current-phase relation of superconducting current becomes as big as the first harmonic. Fourier analysis of I-C(H) dependence allows extracting the components of fractional periods in I-C(H) function that also confirms a deviation from the sinusoidal current-phase relation. The obtained experimental data are explained by theoretical models that predict a huge enhancement of the second harmonic of the spin-triplet component in the superconducting current. The current-phase relation could be controlled by an external magnetic field, changing the directions of magnetization in the composite bilayer ferromagnet, which is inserted between two spin-singlet superconductors.
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| 22. |
- Demidov, V. V., et al.
(författare)
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Magnetic anisotropy in strained manganite films and bicrystal junctions
- 2013
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Ingår i: Journal of Applied Physics. - : AIP Publishing. - 0021-8979 .- 1089-7550. ; 113:16
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Tidskriftsartikel (refereegranskat)abstract
- Transport and magnetic properties of La0.67Sr0.33MnO3 (LSMO) manganite thin films and bicrystal junctions were investigated. Epitaxial manganite films were grown on SrTiO3, LaAlO3, NdGaO3 (NGO), and (LaAlO3)(0.3) + (Sr2AlTaO6)(0.7) substrates, and their magnetic anisotropy were determined by two independent techniques of magnetic resonance spectroscopy. It was demonstrated that by using these techniques, a small (0.3%) anisotropy of crystal structure at the (110) surface plane of the orthorhombic NGO substrate leads to uniaxial magnetic anisotropy of the films in the plane of the substrate at least at the room temperature. It was found that on vicinal NGO substrates, the value of magnetic anisotropy strength can be varied in the range 100-200 Oe at T = 295 K by changing the substrate vicinal angle from 0 degrees to 25 degrees. Measurement of the magnetic anisotropy of manganite bicrystal junction demonstrated the presence of two ferromagnetic spin subsystems for both types of bicrystal boundaries with tilting of basal plane of manganite tilted bicrystal (TB-junction) and with rotation of crystallographic axes (RB-junction) used for comparison. The magnetoresistance of TB-junctions increases with decreasing temperature and the misorientation angle. Variation of bicrystal misorientation angle does not lead to change of misorientation of easy magnetic axes in the film parts forming TB-junction. Analysis of the voltage dependencies of bicrystal junction conductivity show that the low value of the magnetoresistance for the LSMO bicrystal junctions can be caused by two scattering mechanisms. The first one is the spin-flip of spin-polarized carriers due to the strong electron-electron interactions in a disordered layer at the bicrystal boundary at low temperatures and the second one is spin-flip by antiferromagnetic magnons at high temperatures.
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| 23. |
- Hou, JH, et al.
(författare)
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Polygenic resilience scores capture protective genetic effects for Alzheimer's disease
- 2022
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Ingår i: Translational psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 12:1, s. 296-
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Tidskriftsartikel (refereegranskat)abstract
- Polygenic risk scores (PRSs) can boost risk prediction in late-onset Alzheimer’s disease (LOAD) beyond apolipoprotein E (APOE) but have not been leveraged to identify genetic resilience factors. Here, we sought to identify resilience-conferring common genetic variants in (1) unaffected individuals having high PRSs for LOAD, and (2) unaffected APOE-ε4 carriers also having high PRSs for LOAD. We used genome-wide association study (GWAS) to contrast “resilient” unaffected individuals at the highest genetic risk for LOAD with LOAD cases at comparable risk. From GWAS results, we constructed polygenic resilience scores to aggregate the addictive contributions of risk-orthogonal common variants that promote resilience to LOAD. Replication of resilience scores was undertaken in eight independent studies. We successfully replicated two polygenic resilience scores that reduce genetic risk penetrance for LOAD. We also showed that polygenic resilience scores positively correlate with polygenic risk scores in unaffected individuals, perhaps aiding in staving off disease. Our findings align with the hypothesis that a combination of risk-independent common variants mediates resilience to LOAD by moderating genetic disease risk.
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| 24. |
- Ovsyannikov, Gennady, 1948, et al.
(författare)
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Triplet superconductivity in oxide ferromagnetic interlayer of mesa-structure
- 2014
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Ingår i: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 592:1, s. Art. no. 012136-
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Konferensbidrag (refereegranskat)abstract
- We present experimental data on Nb-Au/La0.7Sr0.3MnO3/SrRuO3/YBa2Cu3O7-δ mesa- structure with in plane linear size 10÷50 μm. The mesa-structures were patterned from the epitaxial heterostructures fabricated by pulsed laser ablation and magnetron sputtering. Superconducting critical current was observed for mesa-structures with the interlayer thicknesses up to 50 nm. In the mesa-structures with just one, either La0.7Sr0.3MnO3 or SrRuO3 interlayer with a thickness larger than 10 nm no superconducting current was observed. The registered superconducting current for the mesa-structures with a thinner interlayer is attributed to pinholes. Obtained results are discussed in terms of superconducting long-range triplet generation at interfaces of superconductor and a composite ferromagnet consisting of ferromagnetic materials with non-collinear magnetization.
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| 25. |
- Petrzhik, A. M., et al.
(författare)
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Electron transport in hybrid superconductor heterostructures with manganite interlayers
- 2011
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Ingår i: Journal of Experimental and Theoretical Physics. - : Pleiades Publishing Ltd. - 1090-6509 .- 1063-7761. ; 112:6, s. 1042-1050
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Tidskriftsartikel (refereegranskat)abstract
- Hybrid herostructures comprising an YBa(2)Cu(3)O (x) (YBCO) high-temperature superconductor (HTS) layer and Nb/Au low-temperature superconductor (LTS) bilayer (with critical HTS and LTS temperatures T (c) and T'(c), respectively), separated by a thin (d (M) = 5-20 nm) interlayer of LaMnO(3), La(0.7)Ca(0.3)MnO(3), or La(0.7)Sr(0.3)MnO(3) manganite have been studied. The electric resistance and magnetic properties of individual (evaporated directly onto the substrate) manganite films and related hybrid herostructures have been measured. Based on quasi-classical equations, analytical expressions for the conductivity of herostructures at T a parts per thousand currency sign T'(c) are obtained in the case of a low-transparency superconductor/manganite interface. It is established that the conductivity of heterostructures is determined by the proximity effect (related to the penetration of a condensate wavefunction from the Nb/Au bilayer to manganite) and depends strongly on interface transparency. At low temperatures (T a parts per thousand(a) T (c)'), the conductivity peaks are found at voltages determined by the exchange field of the manganite interlayer. At T (c)'
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