| 1. |
- Podsiadlo, P., et al.
(författare)
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Baseline trabecular bone and its relation to incident radiographic knee osteoarthritis and increase in joint space narrowing score : directional fractal signature analysis in the MOST study
- 2016
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Ingår i: Osteoarthritis and Cartilage. - : Elsevier BV. - 1063-4584. ; 24:10, s. 1736-1744
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Tidskriftsartikel (refereegranskat)abstract
- Purpose To explore the association of baseline trabecular bone structure with incident tibiofemoral (TF) osteoarthritis (OA) and with increase in joint space narrowing (JSN) score. Methods The Multicenter Osteoarthritis Study (MOST) includes subjects with or at risk for knee OA. Knee radiographs were scored for Kellgren–Lawrence (KL) grade and JSN at baseline, 30, 60 and 84 months. Knees (KL ≤ 1) at baseline were assessed for incident OA (KL ≥ 2) and increases in JSN score. For each knee image at baseline, a variance orientation transform method (VOT) was applied to subchondral tibial bone regions of medial and lateral compartments. Seventeen fractal parameters were calculated per region. Associations of each parameter with OA incidence and with medial and lateral JSN increases were explored using logistic regression. Analyses were stratified by digitized film (DF) vs computer radiography (CR) and adjusted for confounders. Results Of 894 knees with CR and 1158 knees with DF, 195 (22%) and 303 (26%) developed incident OA. Higher medial bone roughness was associated with increased odds of OA incidence at 60 and 84 months and also, medial and lateral JSN increases (primarily vertical). Lower medial and lateral anisotropy was associated with increased odds of medial and lateral JSN increase. Compared to DF, CR had more associations and also, similar results at overlapping scales. Conclusion Baseline trabecular bone texture was associated with incident radiographic OA and increase of JSN scores independently of risk factors for knee OA. Higher roughness and lower anisotropy were associated with increased odds for radiographic OA change.
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| 2. |
- Woloszynski, T., et al.
(författare)
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Prediction of progression of radiographic knee osteoarthritis using tibial trabecular bone texture
- 2012
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Ingår i: Arthritis and Rheumatism. - : Wiley. - 1529-0131 .- 0004-3591. ; 64:3, s. 688-695
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Tidskriftsartikel (refereegranskat)abstract
- Objective To develop a system for predicting the progression of radiographic knee osteoarthritis (OA) using tibial trabecular bone texture. Methods. We studied 203 knees with (n = 68) or without (n = 135) radiographic tibiofemoral OA in 105 subjects (90 men and 15 women with a mean age of 54 years) in whom 2 sets of knee radiographs were obtained 4 years apart. We determined medial and lateral compartment tibial trabecular bone texture using an automated region selection method. Three texture parameters were calculated: roughness, degree of anisotropy, and direction of anisotropy based on a signature dissimilarity measure method. We evaluated tibiofemoral OA progression using a radiographic semi-quantitative outcome: an increase in the medial joint space narrowing (JSN) grade. We examined the predictive ability of trabecular bone texture in knees with and those without preexisting radiographic OA, with adjustment for age, sex, and body mass index, using logistic regression (generalized estimating equations) and receiver operating characteristic curves. Results. The prediction of increased medial JSN in knees with or without preexisting radiographic OA was the most accurate for medial trabecular bone texture; the area under the curve (AUC) was 0.77 and 0.75, respectively. For lateral trabecular bone texture, the AUC was 0.71 in knees with preexisting OA and 0.72 in knees without preexisting OA. Conclusion. We have developed a system, based on analyzing tibial trabecular bone texture, which yields good prediction of loss of tibiofemoral joint space. The predictive ability of the system needs to be further validated.
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| 3. |
- Wolski, M., et al.
(författare)
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Differences in trabecular bone texture between knees with and without radiographic osteoarthritis detected by directional fractal signature method
- 2010
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Ingår i: Osteoarthritis and Cartilage. - : Elsevier BV. - 1063-4584. ; 18:5, s. 684-690
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To evaluate differences in tibial trabecular bone (TB) texture between subjects with and without radiographic knee osteoarthritis (OA) using a variance orientation transform (VOT) method. Design: Subjects with knee OA (Kellgren & Lawrence grade >= 2) and controls without OA (both n = 26, seven women) were matched by sex, age, body mass index and compartment. The VOT method was applied to TB X-ray images and fractal signature and dimension in horizontal (FSH, FDH) and vertical (FSV, FDV) directions and along the roughest part of TB (FSSta, FDSta), texture aspect ratio (Str) and signature (StrS), and mean FD (FDMEAN) were calculated. The VOT method was compared against an augmented Hurst orientation transform (HOT) method using paired t tests, intraclass correlation coefficients (ICCs) and coefficients of variation (CVs%). Longitudinal sensitivity to OA bone changes was not assessed. Results: For the reproducibility of texture parameters, ICCs were >0.75 and CVs% were <8.2% for both methods. Compared with controls, FDMEAN, FDH, FDV and FDSta for OA knees were lower (P < 0.001), while Str was higher in both medial (P = 0.03) and lateral (P = 0.02) compartments. FSH, FSSta were lower for OA knees than for controls at sizes 0.3-0.7 mm (P < 0.001) in both compartments. In lateral compartment, FSV for OA knees was lower than for controls at sizes 0.3-0.5 mm (P < 0.001) and 0.55-0.70 mm (P < 0.02), while in medial compartment at sizes 0.3-0.7 mm (P < 0.001). Compared with controls, StrS for OA knees was higher at sizes 0.3, 0.55-0.70 mm in medial (P < 0.03) and lateral (P < 0.04) compartments. Conclusions: The VOT method is comparable to HOT method in the reproducibility of texture parameters and the ability to discriminate between non-OA and OA TB textures. However, unlike the HOT method, it quantifies texture roughness along the roughest part of the tibial bone, texture anisotropy at individual trabecular sizes and it works over a larger range of trabecular sizes. The VOT method may be a valuable tool for studying OA changes in TB. (C) 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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| 4. |
- Wolski, M., et al.
(författare)
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Trabecular bone texture detected by plain radiography is associated with MRI-defined osteophytes in finger joints of women without radiographic osteoarthritis
- 2018
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Ingår i: Osteoarthritis and Cartilage. - : Elsevier BV. - 1063-4584. ; 26:7, s. 924-928
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To examine associations between trabecular bone (TB) texture and magnetic resonance imaging (MRI)-defined osteophytes in finger joints without radiographic osteoarthritis (OA) using an augmented variance orientation transform (AVOT) method. Design: In a cross-sectional study, associations of the TB texture and osteophytes were examined in 21 women with mean (standard deviation) age of 69.9 (5.3) from the Oslo Hand OA cohort. The AVOT was applied to distal and proximal TB regions selected on hand radiographs of the subjects. The regions were adjacent to 57 finger joints (24 distal and 33 proximal interphalangeal) without radiographic OA (Kellgren–Lawrence [KL] grade 0), without MRI-defined joint space narrowing (JSN), bone marrow lesions (BMLs), attrition, erosion, cysts, sclerosis, malalignment (all MRI grades 0) and without or only with mild synovitis (MRI grade 0 or 1). Bone texture parameters were calculated: mean fractal dimension (FDMEAN), FDs in the horizontal (FDH) and vertical (FDV) directions, and along the roughest part (FDSta). Associations between the parameters categorized into groups using tertiles and osteophytes were evaluated using logistic regression adjusted for age. Results: Lower FDSta and FDV in the distal TB regions were associated with increased odds of MRI-defined osteophytes (P < 0.037 for linear trend). No statistically significant associations were found for the proximal regions. Conclusions: Lower mean roughness and lower roughness in vertical and roughest directions of the proximal TB texture are associated with MRI-defined osteophytes in finger joints without radiographic OA. These findings suggest that TB texture may be a useful marker for detecting early hand OA.
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