| 1. |
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| 2. |
- Eriksson, Jan W., et al.
(författare)
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Hydrochlorothiazide, but not Candesartan, aggravates insulin resistance and causes visceral and hepatic fat accumulation : the mechanisms for the diabetes preventing effect of Candesartan (MEDICA) Study
- 2008
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Ingår i: Hypertension. - : American Heart Association. - 0194-911X .- 1524-4563. ; 52:6, s. 1030-1037
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Tidskriftsartikel (refereegranskat)abstract
- Treatment with angiotensin II receptor blockers is associated with lower risk for the development of type 2 diabetes mellitus compared with thiazide diuretics. The Mechanisms for the Diabetes Preventing Effect of Candesartan Study addressed insulin action and secretion and body fat distribution after treatment with candesartan, hydrochlorothiazide, and placebo. Twenty-six nondiabetic, abdominally obese, hypertensive patients were included in a multicenter 3-way crossover trial, and 22 completers (by predefined criteria; 10 men and 12 women) were included in the analyses. They underwent 12-week treatment periods with candesartan (C; 16 to 32 mg), hydrochlorothiazide (H; 25 to 50 mg), and placebo (P), respectively, and the treatment order was randomly assigned and double blinded. Intravenous glucose tolerance tests and euglycemic hyperinsulinemic (56 mU/m(2) per minute) clamps were performed. Intrahepatic and intramyocellular and extramyocellular lipid content and subcutaneous and visceral abdominal adipose tissue were measured using proton magnetic resonance spectroscopy and MRI. Insulin sensitivity (M-value) was reduced following H versus C and P (6.07+/-2.05, 6.63+/-2.04, and 6.90+/-2.10 mg/kg of body weight per minute, mean+/-SD; P
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| 3. |
- Gorczyca, Thomas, et al.
(författare)
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Radiative and Relativistic Effects in the Decay of Highly Excited States in Helium
- 2000
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 85:6, s. 1202-1205
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Tidskriftsartikel (refereegranskat)abstract
- A recent experimental study [J.-E. Rubensson et al., Phys. Rev. Lett. 83, 947 (1999)] measured a significant fluorescence yield of the He( 2lnl′) photoexcited resonances, showing major qualitative differences from nonrelativistic predictions. We present a further theoretical study of these states, and perform R-matrix multichannel quantum defect theory calculations to extract fluorescence and ionization cross sections. These theoretical results are in excellent agreement with newer, higher-resolution measurements. Radiative and spin-orbit effects are quantified and shown to play an important role in the overall characterization of highly excited states.
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| 4. |
- Münch, Andreas, 1970-, et al.
(författare)
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Dynamics of mucosal permeability and inflammation in collagenous colitis before, during, and after loop ileostomy
- 2005
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Ingår i: Gut. - : BMJ. - 0017-5749 .- 1468-3288. ; 54:8, s. 1126-1128
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Tidskriftsartikel (refereegranskat)abstract
- Collagenous colitis has become a more frequent diagnosis but the aetiology of this disease is still unknown. We describe a female patient with intractable collagenous colitis who was treated with a temporary loop ileostomy. She was followed clinically, histopathologically, and functionally by measuring mucosal permeability before surgery, after ileostomy, and after bowel reconstruction. In our case report, active collagenous colitis was combined with increased transcellular and paracellular mucosal permeability. Diversion of the faecal stream decreased inflammation of the mucosa and normalised epithelial degeneration and mucosal permeability. After restoration of bowel continuity, mucosal permeability was altered prior to the appearance of a collagenous layer.
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| 5. |
- Ström, Magnus, et al.
(författare)
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Magnetic-field induced enhancement in the fluorescence yield spectrum of doubly excited states in helium
- 2006
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 97:25, s. 253002-
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Tidskriftsartikel (refereegranskat)abstract
- An influence of static magnetic fields on the fluorescence yield spectrum of He in the vicinity of the N=2 thresholds has been observed. The experimental results are in excellent agreement with predictions based on multichannel quantum defect theory, and it is demonstrated that the Rydberg electron ℓ mixing due to the diamagnetic interaction is essential for the description of the observed fluorescence yield intensity enhancement.
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| 6. |
- Såthe, Conny, et al.
(författare)
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Double Excitations of Helium in Weak Static Electric Fields
- 2006
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 96, s. 043002-
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Tidskriftsartikel (refereegranskat)abstract
- A dramatic electric field dependence has been observed in the fluorescence yield spectrum of the doubly excited states in helium, where a rich phenomenology is encountered below the N=2 threshold. Fluorescence yields of certain states can be tuned to zero, while other dipole-forbidden states are significantly enhanced, for fields much weaker than 1 kV/cm. Using an R-matrix multichannel quantum defect theory, spherical-to-parabolic frame transformation method, we are able to reproduce the main features of the observed spectrum, and we discuss the qualitative behavior in terms of weak electric field mixing.
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| 7. |
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| 8. |
- Yakymenko, Olena, 1988-, et al.
(författare)
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Infliximab restores colonic barrier to adherent-invasive E. coli in Crohn's disease via effects on epithelial lipid rafts
- 2018
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Ingår i: Scandinavian Journal of Gastroenterology. - Oxfordshire, United Kingdom : Taylor & Francis. - 0036-5521 .- 1502-7708. ; 53:6, s. 677-684
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Infliximab is important in the therapeutic arsenal of Crohn’s disease (CD). However, its effect on mucosal barrier function is not fully understood. Adherent-invasive Escherichia coli (AIEC) are important in CD pathophysiology, but the transmucosal uptake routes are partly unknown. We investigated effects of infliximab on uptake of colon-specific AIEC HM427 across CD colonic mucosa.Materials and methods: Endoscopic biopsies from non-inflamed colon of seven patients with CD, before and after two infliximab infusions, and eight non-inflammation controls, were mounted in Ussing chambers. Paracellular permeability (51Cr-EDTA) and transmucosal passage of GFP-expressing HM427 were studied. Mechanisms of HM427 transepithelial transport were investigated in Caco-2 monolayers treated with TNF, in the presence of infliximab and/or endocytosis inhibitors.Results: Before infliximab treatment, colonic passage of HM427 [CD: 2475 CFU (450–3000); controls 1163(225–1950)] and 51Cr-EDTA permeability were increased in CD (p < .05), but were restored to control levels by infliximab (CD: 150 (18.8–1069)). In TNF-exposed Caco-2 monolayers HM427 transport and lipid rafts/HM427 co-localization was decreased by infliximab. The lipid raft inhibitor methyl-β-cyclodextrin decreased HM427 transport.Conclusion: Infliximab restored the colonic barrier to AIEC in CD; an effect partially mediated by blocking lipid rafts in epithelial cells. This ability likely contributes to infliximab’s clinical efficacy in colonic CD.
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