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Sökning: WFRF:(Tetzlaff Andrew)

  • Resultat 1-3 av 3
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1.
  • van Akkooi, Alexander C. J., et al. (författare)
  • Neoadjuvant Systemic Therapy (NAST) in Patients with Melanoma: Surgical Considerations by the International Neoadjuvant Melanoma Consortium (INMC)
  • 2022
  • Ingår i: ANNALS OF SURGICAL ONCOLOGY. - : Springer Science and Business Media LLC. - 1068-9265 .- 1534-4681. ; 29:6, s. 3694-3708
  • Tidskriftsartikel (refereegranskat)abstract
    • Exciting advances in melanoma systemic therapies have presented the opportunity for surgical oncologists and their multidisciplinary colleagues to test the neoadjuvant systemic treatment approach in high-risk, resectable metastatic melanomas. Here we describe the state of the science of neoadjuvant systemic therapy (NAST) for melanoma, focusing on the surgical aspects and the key role of the surgical oncologist in this treatment paradigm. This paper summarizes the past decade of developments in melanoma treatment and the current evidence for NAST in stage III melanoma specifically. Issues of surgical relevance are discussed, including the risk of progression on NAST prior to surgery. Technical aspects, such as the definition of resectability for melanoma and the extent and scope of routine surgery are presented. Other important issues, such as the utility of radiographic response evaluation and method of pathologic response evaluation, are addressed. Surgical complications and perioperative management of NAST related adverse events are considered. The International Neoadjuvant Melanoma Consortium has the goal of harmonizing NAST trials in melanoma to facilitate rapid advances with new approaches, and facilitating the comparison of results across trials evaluating different treatment regimens. Our ultimate goals are to provide definitive proof of the safety and efficacy of NAST in melanoma, sufficient for NAST to become an acceptable standard of care, and to leverage this platform to allow more personalized, biomarker-driven, tailored approaches to subsequent treatment and surveillance.
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2.
  • Lehr, Andrew B., et al. (författare)
  • CA2 beyond social memory : Evidence for a fundamental role in hippocampal information processing
  • 2021
  • Ingår i: Neuroscience and Biobehavioral Reviews. - : Elsevier BV. - 0149-7634 .- 1873-7528. ; 126, s. 398-412
  • Forskningsöversikt (refereegranskat)abstract
    • Hippocampal region CA2 has received increased attention due to its importance in social recognition memory. While its specific function remains to be identified, there are indications that CA2 plays a major role in a variety of situations, widely extending beyond social memory. In this targeted review, we highlight lines of research which have begun to converge on a more fundamental role for CA2 in hippocampus-dependent memory processing. We discuss recent proposals that speak to the computations CA2 may perform within the hippocampal circuit.
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3.
  • Tetzlaff, Andrew, et al. (författare)
  • Tintin Wulia: Secrets
  • 2023
  • Ingår i: Melbourne, RMIT Gallery, 5 Dec 2023 - 27 Jan 2024.
  • Konstnärligt arbete (övrigt vetenskapligt/konstnärligt)abstract
    • Tintin Wulia is an Indonesian Australian artist whose work reflects on globalisation and geopolitics and uses personal stories to unpick and lay them bare. For over 20 years she has researched the histories that have been told by the world’s dominant narrators, scrutinising their blindspots and systemic inequities and retelling them from nonconforming perspectives. Wulia’s recounting brings the past powerfully into the present and centres it on the voices of the periphery. Her works decode, reinterpret and represent history, orienting us to the current global situation in an effort to help collectively navigate towards a more socially just future.
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