| 1. |
- Ibragimov, Nail H., et al.
(författare)
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Utilization of photon orbital angular momentum in the low-frequency radio domain
- 2007
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Ingår i: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 99:8
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Tidskriftsartikel (refereegranskat)abstract
- We show numerically that vector antenna arrays can generate radio beams that exhibit spin and orbital angular momentum characteristics similar to those of helical Laguerre-Gauss laser beams in paraxial optics. For low frequencies (1 GHz), digital techniques can be used to coherently measure the instantaneous, local field vectors and to manipulate them in software. This enables new types of experiments that go beyond what is possible in optics. It allows information-rich radio astronomy and paves the way for novel wireless communication concepts.
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| 2. |
- Kappos, Ludwig, et al.
(författare)
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Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study
- 2018
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Ingår i: The Lancet. - 0140-6736 .- 1474-547X. ; 391, s. 1263-1273
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Tidskriftsartikel (refereegranskat)abstract
- © 2018 Elsevier Ltd Background: No treatment has consistently shown efficacy in slowing disability progression in patients with secondary progressive multiple sclerosis (SPMS). We assessed the effect of siponimod, a selective sphingosine 1-phosphate (S1P) receptor 1,5 modulator, on disability progression in patients with SPMS. Methods: This event-driven and exposure-driven, double-blind, phase 3 trial was done at 292 hospital clinics and specialised multiple sclerosis centres in 31 countries. Using interactive response technology to assign numbers linked to treatme nt arms, patients (age 18–60 years) with SPMS and an Expanded Disability Status Scale score of 3·0–6·5 were randomly assigned (2:1) to once daily oral siponimod 2 mg or placebo for up to 3 years or until the occurrence of a prespecified number of confirmed disability progression (CDP) events. The primary endpoint was time to 3-month CDP. Efficacy was assessed for the full analysis set (ie, all randomly assigned and treated patients); safety was assessed for the safety set. This trial is registered with ClinicalTrials.gov, number NCT01665144. Findings: 1651 patients were randomly assigned between Feb 5, 2013, and June 2, 2015 (1105 to the siponimod group, and 546 to the placebo group). One patient did not sign the consent form, and five patients did not receive study drug, all of whom were in the siponimod group. 1645 patients were included in the analyses (1099 in the siponimod group and 546 in the placebo). At baseline, the mean time since first multiple sclerosis symptoms was 16·8 years (SD 8·3), and the mean time since conversion to SPMS was 3·8 years (SD 3·5); 1055 (64%) patients had not relapsed in the previous 2 years, and 918 (56%) of 1651 needed walking assistance. 903 (82%) patients receiving siponimod and 424 (78%) patients receiving placebo completed the study. 288 (26%) of 1096 patients receiving siponimod and 173 (32%) of 545 patients receiving placebo had 3-month CDP (hazard ratio 0·79, 95% CI 0·65–0·95; relative risk reduction 21%; p=0·013). Adverse events occurred in 975 (89%) of 1099 patients receiving siponimod versus 445 (82%) of 546 patients receiving placebo; serious adverse events were reported for 197 (18%) patients in the siponimod group versus 83 (15%) patients in the placebo group. Lymphopenia, increased liver transaminase concentration, bradycardia and bradyarrhythmia at treatment initiation, macular oedema, hypertension, varicella zoster reactivation, and convulsions occurred more frequently with siponimod than with placebo. Initial dose titration mitigated cardiac first-dose effects. Frequencies of infections, malignancies, and fatalities did not differ between groups. Interpretation: Siponimod reduced the risk of disability progression with a safety profile similar to that of other S1P modulators and is likely to be a useful treatment for SPMS. Funding: Novartis Pharma AG.
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| 3. |
- Mendonca, J. T., et al.
(författare)
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Stimulated Raman and Brillouin Backscattering of Collimated Beams Carrying Orbital Angular Momentum
- 2009
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 102:18, s. 185005-
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Tidskriftsartikel (refereegranskat)abstract
- We study theoretically the exchange of angular momentum between electromagnetic and electrostatic waves in a plasma, due to the stimulated Raman and Brillouin backscattering processes. Angular momentum states for plasmon and phonon fields are introduced for the first time. We demonstrate that these states can be excited by nonlinear wave mixing, associated with the scattering processes. This could be relevant for plasma diagnostics, both in laboratory and in space. Nonlinearly coupled paraxial equations and instability growth rates are derived.
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| 4. |
- Thide, Bo, et al.
(författare)
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Angular Momentum Radio
- 2014
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Ingår i: Complex Light and Optical Forces VIII. - : SPIE. - 9780819499127 ; , s. 89990B-
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Konferensbidrag (refereegranskat)abstract
- Wireless communication amounts to encoding information onto physical observables carried by electromagnetic (EM) fields, radiating them into surrounding space, and detecting them remotely by an appropriate sensor connected to an information-decoding receiver. Each observable is second order in the fields and fulfills a conservation law. In present-day radio only the EM linear momentum observable is fully exploited. A fundamental physical limitation of this observable, which represents the translational degrees of freedom of the charges (typically an oscillating current along a linear antenna) and the fields, is that it is single-mode. This means that a linear-momentum radio communication link comprising one transmitting and one receiving antenna, known as a single-input-single-output (SISO) link, can provide only one transmission channel per frequency (and polarization). In contrast, angular momentum, which represents the rotational degrees of freedom, is multi-mode, allowing an angular-momentum SISO link to accommodate an arbitrary number of independent transmission channels on one and the same frequency (and polarization). We describe the physical properties of EM angular momentum and how they can be exploited, discuss real-world experiments, and outline how the capacity of angular momentum links may be further enhanced by employing multi-port techniques, i.e., the angular momentum counterpart of linear-momentum multiple-input-multiple-output (MIMO).
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