| 1. |
- Bravo, L, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 2. |
- Tabiri, S, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 6. |
- Carmona-Gutierrez, D., et al.
(författare)
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Guidelines and recommendations on yeast cell death nomenclature
- 2018
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Ingår i: Microbial Cell. - : Shared Science Publishers OG. - 2311-2638. ; 5:1, s. 4-31
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Forskningsöversikt (refereegranskat)abstract
- Elucidating the biology of yeast in its full complexity has major implications for science, medicine and industry. One of the most critical processes determining yeast life and physiology is cellular demise. However, the investigation of yeast cell death is a relatively young field, and a widely accepted set of concepts and terms is still missing. Here, we propose unified criteria for the definition of accidental, regulated, and programmed forms of cell death in yeast based on a series of morphological and biochemical criteria. Specifically, we provide consensus guidelines on the differential definition of terms including apoptosis, regulated necrosis, and autophagic cell death, as we refer to additional cell death routines that are relevant for the biology of (at least some species of) yeast. As this area of investigation advances rapidly, changes and extensions to this set of recommendations will be implemented in the years to come. Nonetheless, we strongly encourage the authors, reviewers and editors of scientific articles to adopt these collective standards in order to establish an accurate framework for yeast cell death research and, ultimately, to accelerate the progress of this vibrant field of research.
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| 7. |
- Durno, C., et al.
(författare)
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Survival Benefit for Individuals With Constitutional Mismatch Repair Deficiency Undergoing Surveillance
- 2021
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Ingår i: Journal of Clinical Oncology. - : American Society of Clinical Oncology (ASCO). - 0732-183X .- 1527-7755. ; 39:25
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE Constitutional mismatch repair deficiency syndrome (CMMRD) is a lethal cancer predisposition syndrome characterized by early-onset synchronous and metachronous multiorgan tumors. We designed a surveillance protocol for early tumor detection in these individuals. PATIENTS AND METHODS Data were collected from patients with confirmed CMMRD who were registered in the International Replication Repair Deficiency Consortium. Tumor spectrum, efficacy of the surveillance protocol, and malignant transformation of low-grade lesions were examined for the entire cohort. Survival outcomes were analyzed for patients followed prospectively from the time of surveillance implementation. RESULTS A total of 193 malignant tumors in 110 patients were identified. Median age of first cancer diagnosis was 9.2 years (range: 1.7-39.5 years). For patients undergoing surveillance, all GI and other solid tumors, and 75% of brain cancers were detected asymptomatically. By contrast, only 16% of hematologic malignancies were detected asymptomatically (P < .001). Eighty-nine patients were followed prospectively and used for survival analysis. Five-year overall survival (OS) was 90% (95% CI, 78.6 to 100) and 50% (95% CI, 39.2 to 63.7) when cancer was detected asymptomatically and symptomatically, respectively (P = .001). Patient outcome measured by adherence to the surveillance protocol revealed 4-year OS of 79% (95% CI, 54.8 to 90.9) for patients undergoing full surveillance, 55% (95% CI, 28.5 to 74.5) for partial surveillance, and 15% (95% CI, 5.2 to 28.8) for those not under surveillance (P < .0001). Of the 64 low-grade tumors detected, the cumulative likelihood of transformation from low-to high-grade was 81% for GI cancers within 8 years and 100% for gliomas in 6 years. CONCLUSION Surveillance and early cancer detection are associated with improved OS for individuals with CMMRD.
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| 8. |
- Tomasi, C., et al.
(författare)
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Aerosols in polar regions : A historical overview based on optical depth and in situ observations
- 2007
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 112:D16, s. D16205-
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Forskningsöversikt (refereegranskat)abstract
- Large sets of filtered actinometer, filtered pyrheliometer and Sun photometer measurements have been carried out over the past 30 years by various groups at different Arctic and Antarctic sites and for different time periods. They were examined to estimate ensemble average, long-term trends of the summer background aerosol optical depth AOD(500 nm) in the polar regions ( omitting the data influenced by Arctic haze and volcanic eruptions). The trend for the Arctic was estimated to be between -1.6% and -2.0% per year over 30 years, depending on location. No significant trend was observed for Antarctica. The time patterns of AOD( 500 nm) and angstrom ngstrom's parameters a and beta measured with Sun photometers during the last 20 years at various Arctic and Antarctic sites are also presented. They give a measure of the large variations of these parameters due to El Chichon, Pinatubo, and Cerro Hudson volcanic particles, Arctic haze episodes most frequent in winter and spring, and the transport of Asian dust and boreal smokes to the Arctic region. Evidence is also shown of marked differences between the aerosol optical parameters measured at coastal and high-altitude sites in Antarctica. In situ optical and chemical composition parameters of aerosol particles measured at Arctic and Antarctic sites are also examined to achieve more complete information on the multimodal size distribution shape parameters and their radiative properties. A characterization of aerosol radiative parameters is also defined by plotting the daily mean values of a as a function of AOD( 500 nm), separately for the two polar regions, allowing the identification of different clusters related to fifteen aerosol classes, for which the spectral values of complex refractive index and single scattering albedo were evaluated.
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| 10. |
- De La Fuente, Eduardo, et al.
(författare)
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Detection of a new molecular cloud in the LHAASO J2108+5157 region supporting a hadronic PeVatron scenario
- 2023
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Ingår i: Publication of the Astronomical Society of Japan. - 2053-051X .- 0004-6264. ; 75:3, s. 546-566
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Tidskriftsartikel (refereegranskat)abstract
- PeVatrons are the most powerful naturally occurring particle accelerators in the Universe. The identification of counterparts associated to astrophysical objects such as dying massive stars, molecular gas, star-forming regions, and star clusters is essential to clarify the underlying nature of the PeV emission, i.e., hadronic or leptonic. We present 12,13CO (J = 2→1) observations made with the 1.85 m radio-Telescope of the Osaka Prefecture University toward the Cygnus OB7 molecular cloud, which contains the PeVatron candidate LHAASO J2108+5157. We investigate the nature of the sub-PeV (gamma-ray) emission by studying the nucleon density determined from the content of H i and H2, derived from the CO observations. In addition to MML[2017]4607, detected via the observations of the optically thick 12CO (J = 1→0) emission, we infer the presence of an optically thin molecular cloud, named [FKT-MC]2022, whose angular size is 1-1 ± 0.}^\circ}}2. We propose this cloud as a new candidate to produce the sub-PeV emission observed in LHAASO J2108+5157. Considering a distance of 1.7 kpc, we estimate a nucleon (H i + H2) density of 37 ± 14 cm-3, and a total nucleon mass(H i + H2) of 1.5 ± 0.6 × 104 M·. On the other hand, we confirm that Kronberger 82 is a molecular clump with an angular size of 0°1, a nucleon density ∼103 cm-3, and a mass ∼103 M·. Although Kronberger 82 hosts the physical conditions to produce the observed emission of LHAASO J2108+5157, [FKT-MC]2022 is located closer to it, suggesting that the latter could be the one associated to the sub-PeV emission. Under this scenario, our results favour a hadronic origin for the emission.
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| 11. |
- De La Fuente, Eduardo, et al.
(författare)
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Evidence for a gamma-ray molecular target in the enigmatic PeVatron candidate LHAASO J2108+5157
- 2023
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Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 675
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Tidskriftsartikel (refereegranskat)abstract
- Context . Peta-eV (PeV) astronomy emerged in 2021 with the discovery of ultra-high-energy gamma-ray sources associated with powerful natural particle accelerators known as PeVatrons. In order to determine the nature of their emission, namely whether it has a hadronic or leptonic origin, it is essential to characterise the physical parameters of the environment where it originates. Aims . We unambiguously confirm the association of molecular gas with the PeVatron candidate LHAASO J2108+5157 using unprecedented high angular-resolution (17′) 12,13CO(J = 1 → 0) observations carried out with the Nobeyama 45m radio telescope. Methods . We characterised a molecular cloud in the vicinity of the PeVatron candidate LHAASO J2108+5157 by determining its physical parameters from our 12,13CO(J = 1 → 0) line observations. We used an updated estimation of the distance to the cloud, which provided a more reliable result. The molecular emission was compared with excess gamma-ray images obtained with Fermi-LAT at energies above 2 GeV to search for spatial correlations and test a possible hadronic (π0 decay) origin for the gamma-ray emission. Results . We find that the morphology of the spatial distribution of the CO emission is strikingly similar to that of the Fermi-LAT excess gamma ray. By combining our observations with archival 21 cm HI line data, the nucleons (HI + H2) number density of the target molecular cloud is found to be 133.0 ± 45.0 cm-3, for the measured angular size of 0.55 ± 0.02 at a distance of 1.6 ± 0.1 kpc. The resulting total mass of the cloud is M(HI + H2) = 7.5±2.9×103M⊙. Under a hadronic scenario, we obtain a total energy of protons of Wp = 4.3 ± 1.5 × 1046 erg with a cutoff of 700±300 TeV, which reproduces the sub-PeV gamma-ray emission. Conclusions . We identified a molecular cloud in the vicinity of LHAASO J2107+5157 as the main target where cosmic rays from an unknown PeVatron produce the observed gamma-ray emission via π0 decay.
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| 15. |
- Mueller, D., et al.
(författare)
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Comparison of optical and microphysical properties of pure Saharan mineral dust observed with AERONET Sun photometer, Raman lidar, and in situ instruments during SAMUM 2006
- 2012
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 117, s. D07211-
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Tidskriftsartikel (refereegranskat)abstract
- The Saharan Mineral Dust Experiment (SAMUM) 2006, Morocco, aimed at the characterization of optical, physical, and radiative properties of Saharan dust. AERONET Sun photometer, several lidars (Raman and high-spectral-resolution instruments), and airborne and ground-based in situ instruments provided us with a comprehensive set of data on particle-shape dependent and particle-shape independent dust properties. We compare 4 measurement days in detail, and we carry out a statistical analysis for some of the inferred data products for the complete measurement period. Particle size distributions and complex refractive indices inferred from the Sun photometer observations and measured in situ aboard a research aircraft show systematic differences. We find differences in the wavelength-dependence of single-scattering albedo, compared to light-scattering computations that use data from SOAP (spectral optical absorption photometer). AERONET data products of particle size distribution, complex refractive index, and axis ratios were used to compute particle extinction-to-backscatter (lidar) ratios and linear particle depolarization ratios. We find differences for these parameters to lidar measurements of lidar ratio and particle depolarization ratio. Differences particularly exist at 355 nm, which may be the result of differences of the wavelength-dependent complex refractive index that is inferred by the methods employed in this field campaign. We discuss various error sources that may lead to the observed differences.
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