| 1. |
- Bernal, Ximena E., et al.
(författare)
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Empowering Latina scientists
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 363:6429, s. 825-826
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Ruggeri, Kai, et al.
(författare)
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The globalizability of temporal discounting
- 2022
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Ingår i: Nature Human Behaviour. - : Springer Nature. - 2397-3374. ; 6:10, s. 1386-1397
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Tidskriftsartikel (refereegranskat)abstract
- Economic inequality is associated with preferences for smaller, immediate gains over larger, delayed ones. Such temporal discounting may feed into rising global inequality, yet it is unclear whether it is a function of choice preferences or norms, or rather the absence of sufficient resources for immediate needs. It is also not clear whether these reflect true differences in choice patterns between income groups. We tested temporal discounting and five intertemporal choice anomalies using local currencies and value standards in 61 countries (N = 13,629). Across a diverse sample, we found consistent, robust rates of choice anomalies. Lower-income groups were not significantly different, but economic inequality and broader financial circumstances were clearly correlated with population choice patterns. Ruggeri et al. find in a study of 61 countries that temporal discounting patterns are globally generalizable. Worse financial environments, greater inequality and high inflation are associated with extreme or inconsistent long-term decisions.
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| 3. |
- Abelev, Betty, et al.
(författare)
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Long-range angular correlations on the near and away side in p-Pb collisions at root S-NN=5.02 TeV
- 2013
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 719:1-3, s. 29-41
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Tidskriftsartikel (refereegranskat)abstract
- Angular correlations between charged trigger and associated particles are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV for transverse momentum ranges within 0.5 < P-T,P-assoc < P-T,P-trig < 4 GeV/c. The correlations are measured over two units of pseudorapidity and full azimuthal angle in different intervals of event multiplicity, and expressed as associated yield per trigger particle. Two long-range ridge-like structures, one on the near side and one on the away side, are observed when the per-trigger yield obtained in low-multiplicity events is subtracted from the one in high-multiplicity events. The excess on the near-side is qualitatively similar to that recently reported by the CMS Collaboration, while the excess on the away-side is reported for the first time. The two-ridge structure projected onto azimuthal angle is quantified with the second and third Fourier coefficients as well as by near-side and away-side yields and widths. The yields on the near side and on the away side are equal within the uncertainties for all studied event multiplicity and p(T) bins, and the widths show no significant evolution with event multiplicity or p(T). These findings suggest that the near-side ridge is accompanied by an essentially identical away-side ridge. (c) 2013 CERN. Published by Elsevier B.V. All rights reserved.
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| 4. |
- Abelev, Betty, et al.
(författare)
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Measurement of prompt J/psi and beauty hadron production cross sections at mid-rapidity in pp collisions at root s=7 TeV
- 2012
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; :11
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Tidskriftsartikel (refereegranskat)abstract
- The ALICE experiment at the LHC has studied J/psi production at mid-rapidity in pp collisions at root s = 7 TeV through its electron pair decay on a data sample corresponding to an integrated luminosity L-int = 5.6 nb(-1). The fraction of J/psi from the decay of long-lived beauty hadrons was determined for J/psi candidates with transverse momentum p(t) > 1,3 GeV/c and rapidity vertical bar y vertical bar < 0.9. The cross section for prompt J/psi mesons, i.e. directly produced J/psi and prompt decays of heavier charmonium states such as the psi(2S) and chi(c) resonances, is sigma(prompt J/psi) (p(t) > 1.3 GeV/c, vertical bar y vertical bar < 0.9) = 8.3 +/- 0.8(stat.) +/- 1.1 (syst.)(-1.4)(+1.5) (syst. pol.) mu b. The cross section for the production of b-hadrons decaying to J/psi with p(t) > 1.3 GeV/c and vertical bar y vertical bar < 0.9 is a sigma(J/psi <- hB) (p(t) > 1.3 GeV/c, vertical bar y vertical bar < 0.9) = 1.46 +/- 0.38 (stat.)(-0.32)(+0.26) (syst.) mu b. The results are compared to QCD model predictions. The shape of the p(t) and y distributions of b-quarks predicted by perturbative QCD model calculations are used to extrapolate the measured cross section to derive the b (b) over bar pair total cross section and d sigma/dy at mid-rapidity.
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| 5. |
- Abelev, Betty, et al.
(författare)
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Underlying Event measurements in pp collisions at root s=0.9 and 7 TeV with the ALICE experiment at the LHC
- 2012
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; :7
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Tidskriftsartikel (refereegranskat)abstract
- We present measurements of Underlying Event observables in pp collisions at root s = 0 : 9 and 7 TeV. The analysis is performed as a function of the highest charged-particle transverse momentum p(T),L-T in the event. Different regions are defined with respect to the azimuthal direction of the leading (highest transverse momentum) track: Toward, Transverse and Away. The Toward and Away regions collect the fragmentation products of the hardest partonic interaction. The Transverse region is expected to be most sensitive to the Underlying Event activity. The study is performed with charged particles above three different p(T) thresholds: 0.15, 0.5 and 1.0 GeV/c. In the Transverse region we observe an increase in the multiplicity of a factor 2-3 between the lower and higher collision energies, depending on the track p(T) threshold considered. Data are compared to PYTHIA 6.4, PYTHIA 8.1 and PHOJET. On average, all models considered underestimate the multiplicity and summed p(T) in the Transverse region by about 10-30%.
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| 6. |
- Croese, S., et al.
(författare)
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Bringing the Global to the Local: the challenges of multi-level governance for global policy implementation in Africa
- 2021
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Ingår i: International Journal of Urban Sustainable Development. - : Informa UK Limited. - 1946-3138 .- 1946-3146. ; 13:3, s. 435-447
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Tidskriftsartikel (refereegranskat)abstract
- The New Urban Agenda (NUA) and Agenda 2030's Sustainable Development Goals (SDGs) recognise the key role of 'sub-national entities', including cities, in achieving sustainable development. However, since these global policy agendas were agreed and signed by national governments, implementing them at the local level requires a process of localisation to fit local realities. This paper analyses the national guidance (or lack of) and the resultant collaborations emerging between various levels of government in the implementation of these agendas in African cities, namely Kisumu, Kenya and Cape Town, South Africa. It argues that effective implementation of the SDGs requires a strong framework for multi-stakeholder engagement and coordination at all levels of governance, which is possible if both top-down and bottom-up approaches are used concurrently and harmonised.
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| 7. |
- Gorski, Mathias, et al.
(författare)
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Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
- 2021
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Ingår i: Kidney International. - : Elsevier. - 0085-2538 .- 1523-1755. ; 99:4, s. 926-939
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Tidskriftsartikel (refereegranskat)abstract
- Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m2/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m2 at follow-up among those with eGFRcrea 60 mL/min/1.73m2 or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or LARP4B. Individuals at high compared to those at low genetic risk (8-14 vs 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.
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| 8. |
- Hofstad, Hege, et al.
(författare)
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Cities as public agents: A typology of co-creational leadership for urban climate transformation
- 2022
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Ingår i: Earth System Governance. - : Elsevier BV. - 2589-8116. ; 13
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Tidskriftsartikel (refereegranskat)abstract
- This article develops a typology of co-creational leadership for urban climate transformation. The typology is constructed from a combination of governance theory and empirical observations of co-creational leadership in four global, climate-ambitious cities. By applying a framework that differentiates between authority (multilevel or polycentric) and purpose (policy design or implementation) as key dimensions and categories that structure and condition cities’ performance of co-creational leadership, the typology draws out four unique yet interdependent ideal types of leadership. The typology serves two aims. First, it allows a more nuanced understanding of the ways in which contextual features present distinct types of challenges and condition co-creational leadership by cities. Second, it provides a framework for investigating what is required by city officials as leaders of co-creation. The typology underlines how co-creation is an intrinsic element of hybrid city climate governance.
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| 9. |
- Krause, Torsten, et al.
(författare)
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A new war on nature and people: taking stock of the Colombian peace agreement
- 2022
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Ingår i: Global Sustainability. - : Cambridge University Press (CUP). - 2059-4798. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Non-technical summary Almost 6 years have passed since the Colombian peace agreement was signed. However, the promise of a 'Stable and lasting peace' is slipping away as the transition towards peace is increasingly tainted and overshadowed with violence. The future of Colombia is at a crossroad and without international support and action taken to monitor global supply chains, these particular drivers of conflict, violence and environmental degradation will persist. We summarize the current situation and shed light on the complexities of building peace in Colombia, with a particular focus on the environmental changes that took place since the peace agreement was signed. Technical summary The Colombian peace agreement officially ended one of the world's longest internal armed conflicts. But the transformation of land use that takes place in the wake of the peace agreement has made the historic inequalities of access to land more visible and revealed inherent and violent struggles over resources that persist across the country. In this briefing we analyse the current status of peacebuilding in Colombia and highlight the major barriers and challenges in the current peacebuilding efforts. We show how the last few years brought severe and negative repercussions for people, communities and the natural environment in Colombia as cattle ranching, 'productive agriculture' and extractive industries are increasingly encroaching into indigenous territories, protected areas and forest ecosystems, replacing diverse natural forests that support biodiversity and contribute to human well-being locally and globally. The resurging presence of numerous armed groups seeking to control the profitable drug trade and mineral deposits are a major problem and obstacle for building lasting and sustainable peace among people and with the natural environment in Colombia. We conclude this briefing with points that we see as crucial to support the implementation of the peace agreement. Social media summary Colombia's peacebuilding effort must foster environmental stewardship and respect its biological and cultural diversity.
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| 10. |
- Nardi, Maria Andrea, et al.
(författare)
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Nature of Peace: An Interdisciplinary Enquiry into Research at the Intersection of Nature, Peace and Post-Conflict
- 2019
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The nexus between the environment, natural resources and (armed) violence has been researched since the end of the nineties, however major theoretical and empirical gaps still exists in research on the precise role of nature or the natural environment during post-conflict and/or peacebuilding, particularly in relation to those countries that have undergone internal armed conflict.This paper presents a state of the art in research conducted at the intersection of nature, peace and post-conflict. It is based on a systematic research review of more than a hundred articles published in English on conceptual and theoretical questions and case studies from all over the world.The aim here is to contribute to enhance the knowledge we have about the relevance of nature or natural environment in peace and post-conflict studies. We seek to do so by trying to answer the following questions:a. What are the main theoretical and empirical gaps in current research in the intersection of peace, post-conflict and nature?b. Is it necessary to develop alternative notions of nature and / or peace in order to expand the academic research field and the political possibilities of peace?The study presented here is the result of the interdisciplinary research project “The Nature of Peace: exploring links between the natural environment and peace in post-conflict societies”, supported by the Pufendorf Institute for Advanced Studies at Lund University, Sweden, between September 2017 and April 2018.
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| 11. |
- Needham, Jessica F., et al.
(författare)
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Demographic composition, not demographic diversity, predicts biomass and turnover across temperate and tropical forests
- 2022
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Ingår i: Global Change Biology. - : Wiley. - 1354-1013 .- 1365-2486. ; 28, s. 2895-2909
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Tidskriftsartikel (refereegranskat)abstract
- The growth and survival of individual trees determine the physical structure of a forest with important consequences for forest function. However, given the diversity of tree species and forest biomes, quantifying the multitude of demographic strategies within and across forests and the way that they translate into forest structure and function remains a significant challenge. Here, we quantify the demographic rates of 1961 tree species from temperate and tropical forests and evaluate how demographic diversity (DD) and demographic composition (DC) differ across forests, and how these differences in demography relate to species richness, aboveground biomass (AGB), and carbon residence time. We find wide variation in DD and DC across forest plots, patterns that are not explained by species richness or climate variables alone. There is no evidence that DD has an effect on either AGB or carbon residence time. Rather, the DC of forests, specifically the relative abundance of large statured species, predicted both biomass and carbon residence time. Our results demonstrate the distinct DCs of globally distributed forests, reflecting biogeography, recent history, and current plot conditions. Linking the DC of forests to resilience or vulnerability to climate change, will improve the precision and accuracy of predictions of future forest composition, structure, and function.
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| 12. |
- Ramírez-Torres, Alberto, et al.
(författare)
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Quantitative Proteomic Analysis of Cervical Cancer Tissues Identifies Proteins Associated With Cancer Progression
- 2022
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Ingår i: Cancer Genomics and Proteomics. - : Anticancer Research USA Inc.. - 1109-6535 .- 1790-6245. ; 19:2, s. 241-258
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Tidskriftsartikel (refereegranskat)abstract
- Background/Aim: To date, several proteomics studies in cervical cancer (CC) have focused mainly on squamous cervical cancer (SCC). Our study aimed to discover and clarify differences in SCC and CAD that may provide valuable information for the identification of proteins involved in tumor progression, in CC as a whole, or specific for SCC or CAD. Materials and Methods: Total protein extracts from 15 individual samples corresponding to 5 different CC tissue types were compared with a non-cancerous control group using bidimensional liquid chromatography-mass spectrometry (2D LC-MS/MS), isobaric tags for relative and absolute quantitation (ITRAQ), principal component analysis (PCA) and gene set enrichment analysis (GSEA). Results: A total of 622 statistically significant different proteins were detected. Exocytosis-related proteins were the most over-represented, accounting for 25% of the identified and quantified proteins. Based on the experimental results, reticulocalbin 3 (RCN3) and Ras-related protein Rab-14 (RAB14) were chosen for further downstream in vitro and vivo analyses. RCN3 was overexpressed in all CC tissues compared to the control and RAB14 was overexpressed in squamous cervical cancer (SCC) compared to invasive cervical adenocarcinoma (CAD). In the tumor xenograft experiment, RAB14 protein expression was positively correlated with increased tumor size. In addition, RCN3-expressing HeLa cells induced a discrete size increment compared to control, at day 47 after inoculation. Conclusion: RAB14 and RCN3 are suggested as potential biomarkers and therapeutic targets in the treatment of CC.
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| 13. |
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| 14. |
- Simon, David, 1957, et al.
(författare)
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The challenges of transdisciplinary knowledge production: from unilocal to comparative research
- 2018
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Ingår i: Environment and Urbanization. - : SAGE Publications. - 0956-2478 .- 1746-0301. ; 30:2, s. 481-500
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Tidskriftsartikel (refereegranskat)abstract
- This reflective paper surveys the lessons learnt and challenges faced by the Mistra Urban Futures (MUF) research centre and its research platforms in Sweden, the UK, South Africa and Kenya in developing and deploying different forms of transdisciplinary co-production of knowledge. Considerable experience with a distinctive portfolio of such methods has been gained and reflective evaluation is now under way. While it is important to understand the local context within which each method has evolved, we seek to explain the potential for adaptation in diverse contexts so that such knowledge co-production methods can be more widely utilized. Furthermore, the current phase of MUF’s work is undertaking innovative comparative transdisciplinary co-production research across its research platforms. Since the specific local projects differ, systematic thematic comparison requires great care and methodological rigour. Transdisciplinary co-production is inherently complex, time consuming and often unpredictable in terms of outcomes, and these challenges are intensified when it is undertaken comparatively.
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| 15. |
- Tengberg, Anna, et al.
(författare)
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Integrated approaches to natural resources management—Theory and practice
- 2018
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Ingår i: Land Degradation and Development. - : Wiley. - 1085-3278. ; 29:6, s. 1845-1857
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Tidskriftsartikel (refereegranskat)abstract
- To meet multiple environmental objectives, integrated programming is becoming increasingly important for the Global Environmental Facility, the financial mechanism of the Multilateral Environmental Agreements, including the UN Convention to Combat Desertification. However, integration is often not well defined. We therefore focus on identifying key aspects of integration and assessing their implementation in natural resources management projects. To that end, we draw on systems thinking literature and carry out an analysis of a random sample of Global Environmental Facility integrated projects and in-depth case studies demonstrating lessons learned and good practice. We highlight the need for projects to identify clearer system boundaries and main feedback mechanisms within those boundaries, in order to effectively address drivers of environmental change. We propose a theory of change for integrated natural resources management projects, where short-term environmental and socioeconomic benefits will first accrue at the local level. Implementation of improved integrated natural resources management technologies and practices at the local level can then be extended through spatial planning and strengthening of innovation systems. Financing and incentive mechanisms at the watershed and/or landscape/seascape level coupled with supporting policies could sustain and enhance ecosystem services at even larger scales and longer time spans. The evolving scientific understanding of factors influencing social, technical, and institutional innovations and transitions towards sustainable management of natural resources should be harnessed and integrated into influencing models and theory of change for complex social-environmental problems, such as land degradation, and be coupled with up-to-date approaches for learning, adaptive management, and scaling up.
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| 16. |
- Tonnesen, A., et al.
(författare)
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Integrative climate leadership in multi-level policy packages for urban mobility-A study of governance systems in two Nordic urban regions
- 2022
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Ingår i: Transport Policy. - : Elsevier BV. - 0967-070X .- 1879-310X. ; 128, s. 309-317
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Tidskriftsartikel (refereegranskat)abstract
- This paper involves a comparative study of policymaking related to urban transport in the Gothenburg and Oslo regions. It sets out to show how strong climate leadership relates to the integration of policy measures and governance systems. Methodologically, we apply document analysis and qualitative interviews with key in-formants. Our clearest finding is the importance of the city's contextual governance framework for integrative climate leadership. The strong components of the leadership in Oslo-involving both horizontal and upward coordination-rely on a well-developed governance framework with operationalised goals, strategies and steering tools. This enables them to utilise multiple types of climate leadership. This contrasts with the lower degree of integration and defensiveness in Gothenburg, in terms of willingness to use effective but politically sensitive policy measures.
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| 17. |
- Valencia, Sandra, 1981, et al.
(författare)
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Adapting the Sustainable Development Goals and the New Urban Agenda to the city level : Initial reflections from a comparative research project
- 2019
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Ingår i: International Journal of Urban Sustainable Development. - : Taylor & Francis. - 1946-3138 .- 1946-3146. ; 11:1, s. 4-23
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Tidskriftsartikel (refereegranskat)abstract
- The Sustainable Development Goals and the New Urban Agenda recognise the role of cities in achieving sustainable development. However, these agendas were agreed and signed by national governments and thus implementing them at the local level requires a process of adaptation or localisation. In this paper, we analyse five aspects that practitioners and researchers need to consider when localising them: (1) delimitation of the urban boundary; (2) integrated governance; (3) actors; (4) synergies and trade-offs and (5) indicators. These considerations are interrelated, and while not exhaustive, provide an important initial step for reflection on the challenges and opportunities of working with these global agendas at the local level. The paper draws on the inception phase of an international comparative transdisciplinary research project in seven cities on four continents: Buenos Aires (Argentina), Cape Town (South Africa), Gothenburg (Sweden), Kisumu (Kenya), Malmo (Sweden), Sheffield (UK) and Shimla (India).
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| 18. |
- Valencia, Sandra
(författare)
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Caught Between Spaces : Socio-Environmental Vulnerability in Formal and Informal Peri-Urban Bogotá and Soacha, Colombia
- 2016
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The world is rapidly urbanizing. To contribute to the understanding of the socio-environmental changes brought about by urban sprawl and densification, this thesis examines wellbeing and vulnerability in low-income peri-urban areas in and around Bogotá, Colombia. For that purpose, I develop a typology of peri-urban settlements that includes four main settlement classifications: agriculture-based, informal, formalized, and state-subsidized housing. Inhabitants of agriculture-based settlements, which includes a community of Muisca indigenous people, have become legally and physically marginalized and are the most negatively impacted by peri-urbanization, as their key resources, land and water, are increasingly degraded. Inhabitants of informal settlements are often exposed to a variety of social and environmental stressors and face significant difficulties in accessing basic services, such as water and sanitation, while, at the same time, have grasped the opportunity to build new homes in the peri-urban landscape.Both in the development of these settlements, and as a method to pressure the state, I show how collective action has been a central strategy for claiming access to basic services and formalization programs. In response, the state has increasingly recognized the rights of informal dwellers. This recognition has been realized through formalization policies, improved access to basic social and physical services, and the introduction of subsidized housing to counteract informality and housing deficits. However, some projects have been developed in areas exposed to environmental hazards, and are characterized by their deficient and low quality physical and social services. Further, I show that the speed and quality of formalization is contingent on institutional capacity, geography and social mobilization, yet another indication that peri-urban areas are complex areas full of contradictions and challenges, but also opportunities.
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| 19. |
- Valencia, Sandra, 1981, et al.
(författare)
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Urban Climate Resilience and Its Link to Global Sustainability Agendas
- 2022
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Ingår i: The Palgrave Handbook of Climate Resilient Societies: Volumes 1-2. - Cham : Springer International Publishing. ; 2, s. 1807-1834
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- This chapter examines urban climate resilience. It provides a conceptual introduction, followed by an explanation of how urban areas have been recognized in recent global agendas related to sustainability, climate change, and disaster risk reduction. The chapter provides a picture of the complexity and diversity of urban climate resilience experiences, through seven case study cities on four continents. The sample of cities includes small, medium, and larger cities, both coastal and landlocked, in diverse political, socioeconomic, and geographical contexts. Drawing on comparative research using co-production between academic researchers and local authority counterparts, the detailed case studies illustrate the climate resilience challenges faced by each city, the work in terms of strategies and initiatives they have carried out and are planning to increase their resilience, as well as the geographical and policy contexts in which those strategies are embedded.
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| 20. |
- Vargas Falla, Ana Maria, et al.
(författare)
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Beyond state regulation of informality: Understanding access to public space by street vendors in Bogotá
- 2019
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Ingår i: International Development Planning Review. - : Liverpool University Press. - 1478-3401 .- 1474-6743. ; 41:1, s. 85-105
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Tidskriftsartikel (refereegranskat)abstract
- Selling goods and providing services in public spaces is one of the most accessible occupations for many urban poor. However, use of public space for such occupations is often prohibited by local regulations, excluding street vendors from legally using this space for their survival. While significant research has been devoted to state efforts to control informality, less is known about the everyday governance of street vendors. This article examines how unorganised street vendors regulate access to public space among themselves. We also analyse the contestation and negotiations between state and street vendors. The article is based on a study of street vendors in Bogotá, Colombia. We argue that informal street vendors do not operate in chaos, instead the 'quiet encroachment' of public space is governed by non-hierachical informal social control mechanisms. Our findings call for a reconsideration of regulations about urban informal activities and public spaces.
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| 21. |
- Wuttke, Matthias, et al.
(författare)
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A catalog of genetic loci associated with kidney function from analyses of a million individuals
- 2019
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Ingår i: Nature Genetics. - : NATURE PUBLISHING GROUP. - 1061-4036 .- 1546-1718. ; 51:6, s. 957-972
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Tidskriftsartikel (refereegranskat)abstract
- Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
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