| 1. |
- Luo, Yifei, et al.
(författare)
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Technology Roadmap for Flexible Sensors
- 2023
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Ingår i: ACS Nano. - : American Chemical Society. - 1936-0851 .- 1936-086X. ; 17:6, s. 5211-5295
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Forskningsöversikt (refereegranskat)abstract
- Humans rely increasingly on sensors to address grand challenges and to improve quality of life in the era of digitalization and big data. For ubiquitous sensing, flexible sensors are developed to overcome the limitations of conventional rigid counterparts. Despite rapid advancement in bench-side research over the last decade, the market adoption of flexible sensors remains limited. To ease and to expedite their deployment, here, we identify bottlenecks hindering the maturation of flexible sensors and propose promising solutions. We first analyze challenges in achieving satisfactory sensing performance for real-world applications and then summarize issues in compatible sensor-biology interfaces, followed by brief discussions on powering and connecting sensor networks. Issues en route to commercialization and for sustainable growth of the sector are also analyzed, highlighting environmental concerns and emphasizing nontechnical issues such as business, regulatory, and ethical considerations. Additionally, we look at future intelligent flexible sensors. In proposing a comprehensive roadmap, we hope to steer research efforts towards common goals and to guide coordinated development strategies from disparate communities. Through such collaborative efforts, scientific breakthroughs can be made sooner and capitalized for the betterment of humanity.
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| 2. |
- Sasaki, Tomohiro, et al.
(författare)
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Population Pharmacokinetic and Concentration-QTc Analysis of Delamanid in Pediatric Participants with Multidrug-Resistant Tuberculosis
- 2022
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Ingår i: Antimicrobial Agents and Chemotherapy. - : American Society for Microbiology. - 0066-4804 .- 1098-6596. ; 66:2
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Tidskriftsartikel (refereegranskat)abstract
- A population pharmacokinetic analysis of delamanid and its major metabolite DM-6705 was conducted to characterize the pharmacokinetics of delamanid and DM-6705 in pediatric participants with multidrug-resistant tuberculosis (MDR-TB). Data from participants between the ages of 0.67 and 17 years, enrolled in 2 clinical trials, were utilized for the analysis. The final data set contained 634 delamanid and 706 DM-6705 valid plasma concentrations from 37 children. A transit model with three compartments best described the absorption of delamanid. Two-compartment models for each component with linear elimination were selected to characterize the dispositions of delamanid and DM-6705, respectively. The covariates included in the model were body weight on the apparent volume of distribution and apparent clearance (for both delamanid and DM-6705); formulation (dispersible versus film-coated tablet) on the mean absorption time; age, formulation, and dose on the bioavailability of delamanid; and age on the fraction of delamanid metabolized to DM-6705. Based on the simulations, doses for participants within different age/weight groups that result in delamanid exposure comparable to that in adults following the approved adult dose were calculated. By concentration-QTc (QTcB [QT corrected by Bazett's formula]) analysis, a significant positive correlation was detected with concentrations of DM-6705. However, the modelpredicted upper bounds of the 90% confidence intervals of Delta QTc values were <10 ms at the simulated maximum concentration (C-max) of DM-6705 following the administration of the maximum doses simulated. This suggests that the effect on the QT interval following the proposed dosing is unlikely to be clinically meaningful in children with MDRTB who receive delamanid.
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| 3. |
- Holm, Lovisa, 1962-
(författare)
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Focal ischemic reperfusion stroke model in rats and the role of galanin
- 2011
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Stroke is the third most common cause for mortality in industrialised countries and amongst the major causes of long- time morbidity. While the mortality due to myocardial infarction has been dramatically reduced during the last 10-15 years, mortality due to stroke remains almost the same, despite the fact that the two share similar basic pathogenic mechanisms including atherosclerosis, hypertension and diabetes. Treatment modalities of reperfusion therapy for acute ischemic stroke, including the use of tissue plasminogen activator for thrombolysis and endovascular treatments, are eff ective if applied early after onset of the first symptoms. The more frequent use of reperfusion therapy, especially in the most common type of stroke aff ecting the middle cerebral artery (MCA), increase the clinical relevance and demand for experimental models of temporary and focal ischemia of the brain. The primary goal of the present work was to develop a model in rats for studying the mechanisms underlying focal and temporary ischemia in brain regions supplied by the MCA.We have modified the intracranial method of occluding the MCA originally described by Tamura et al. in the early 1980es by introducing a microclip to occlude the artery and induce reperfusion under direct visual control through an operating microscope. The goal was to create a mild ischemia model with low morbidity and mortality, optimizing conditions for the animals postoperatively and allowing longterm (weeks) observation periods of high relevance for human stroke. Morbidity and mortality in experimental stroke models are crucial confounders. Change of anesthesia from intraperitoneally administrated chloral hydrate to isoflurane inhalation anesthesia with endotracheal intubation and controlled ventilation reduced mortality markedly from 25% to ~10%. Improved overall skills in anesthesia and surgical techniques further reduced mortality to <3%.Hypothermia reduces brain lesions caused by ischemia not only when administered before and during the ischemic episode, but also afterwards. Several studies have shown that galanin concentrations are increased in response to various types of lesions to the nervous system, and galanin may be amongst the factors supporting neuronal survival and functions. We therefore investigated whether or not hypothermia-induced alterations in galanin concentrations could constitute a part of the established neuroprotective effect of hypothermia in our rat stroke model. Hypothermia induced an overall increase in the concentrations of immunoreactive galanin (p < 0.001). The elevated galanin levels were predominantly found in the non-ischemic control hemisphere. The galanin concentrations were lower in the ischemic hemisphere in both the normo- and hypothermic animals compared to the corresponding contralateral intact hemisphere (p = 0.049). The hypothermia and not the ischemic/reperfusion lesions explained the major part of the observed changes in galanin concentrations. Hypothermia-induced elevation in galanin concentration is therefore not likely to be amongst the major protective mechanisms of hypothermia. Our results support the notion that hypothermia-induced increase in tissue concentrations of galanin in the brain are the result of changes from optimal homeostatic conditions – the hypothermia-induced stress – rather than the ischemic/reperfusion lesion- induced changes in galanin concentrations.Whether the lesion-induced increase in galanin concentrations is primarily a signal that a lesion has occurred, a consequence of the lesion or a mechanism for facilitating neuronal survival is an open question. We therefore infused three different concentrations of galanin intracerebroventricularly in a direct attempt to investigate whether or not galanin has neuroprotective properties in a rat model of MCA occlusion. Furthermore, we infused the GalR2/3 agonist Gal(2-11) (AR-M1896) shown to subserve neuroprotective functions. The lesion was 98% larger seven days after a 60 min transient MCA occlusion and continuous administration of the GalR2/3 agonist Gal(2-11). No differences were found after seven days in the groups treated with galanin in three different concentrations (0.24, 2.4 and 24 nmol/day; p = 0.939, 0.715 and 0.977, respectively). There was also no difference in the size of the ischemic lesion measured after three days in the galanin-treated group (2.4 nmol/d) compared to artificial cerebrospinal fl uid (p = 0.925).The expression of the galanin, GalR1, GalR2 and GalR3 receptor genes were investigated in the female rat brain seven days after a 60-min unilateral occlusion/reperfusion of the MCA. Galanin gene expression showed a 2.5-fold increase and GalR1 a 1.5-fold increase in the locus coeruleus of the ischemic hemisphere compared to the control side, and the GalR1 mRNA levels decreased by 35% in the cortex of the ischemic hemisphere. Thus, stroke-induced forebrain lesion upregulates synthesis of galanin and GalR1 in the locus coeruleus, a noradrenergic cell group projecting to many forebrain areas, including cortex and the hippocampal formation, supporting the notion that galanin may play a role in the response of the central nervous system to injury and have trophic effects.
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| 4. |
- Qiu, Siyi, et al.
(författare)
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A Brief Review on He Ion Irradiation Research of Steel and Iron-Based Alloys in Nuclear Power Plants
- 2023
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Ingår i: Acta Metallurgica Sinica (English Letters). - : Springer Science and Business Media LLC. - 1006-7191 .- 2194-1289. ; 36:4, s. 529-551
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Forskningsöversikt (refereegranskat)abstract
- Nuclear power plays a key role as renewable energy in alleviating the worldwide energy shortage. The material degradation caused by high-temperature and high-flux neutron irradiation is the most concerning issue for nuclear reactor safety. A large number of He atoms produced through the (n, alpha) transmutation reaction diffuse and migrate in metals and accumulate to form He bubbles because of the extremely low solubility of He atoms in metal materials. The helium bubbles gather at the grain boundary or grain to cause swelling, hardening, embrittlement, and other damages to the in-core structural components. This paper mainly summarizes the research progress on He irradiation in steel and iron-based alloys, including the diffusion and accumulation of He atoms, the nucleation and growth of He bubbles, and the microstructure and macroscopic degradation of material performance caused by He irradiation. The mechanism of helium irradiation-induced corrosion in steel and iron-based alloys in recent years is reviewed as well. Moreover, the investigations on irradiation performance in additive manufactured stainless steels are summarized, and the mechanism of irradiation resistance is prospected.
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| 5. |
- Zhong, Wanjun, et al.
(författare)
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MemoryBank: Enhancing Large Language Models with Long-Term Memory
- 2024
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Ingår i: <em>Proceedings Of The Aaai Conference On Artificial Intelligence</em>. - : Association for the Advancement of Artificial Intelligence (AAAI). ; , s. 19724-19731
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Konferensbidrag (refereegranskat)abstract
- Large Language Models (LLMs) have drastically reshaped our interactions with artificial intelligence (AI) systems, showcasing impressive performance across an extensive array of tasks. Despite this, a notable hindrance remains—the deficiency of a long-term memory mechanism within these models. This shortfall becomes increasingly evident in situations demanding sustained interaction, such as personal companion systems, psychological counseling, and secretarial assistance. Recognizing the necessity for long-term memory, we propose MemoryBank, a novel memory mechanism tailored for LLMs. MemoryBank enables the models to summon relevant memories, continually evolve through continuous memory updates, comprehend, and adapt to a user’s personality over time by synthesizing information from previous interactions. To mimic anthropomorphic behaviors and selectively preserve memory, MemoryBank incorporates a memory updating mechanism, inspired by the Ebbinghaus Forgetting Curve theory. This mechanism permits the AI to forget and reinforce memory based on time elapsed and the relative significance of the memory, thereby offering a more human-like memory mechanism and enriched user experience. MemoryBank is versatile in accommodating both closed-source models like ChatGPT and open-source models such as ChatGLM. To validate MemoryBank’s effectiveness, we exemplify its application through the creation of an LLM-based chatbot named SiliconFriend in a long-term AI Companion scenario. Further tuned with psychological dialog data, SiliconFriend displays heightened empathy and discernment in its interactions. Experiment involves both qualitative analysis with real-world user dialogs and quantitative analysis with simulated dialogs. In the latter, ChatGPT acts as multiple users with diverse characteristics and generates long-term dialog contexts covering a wide array of topics. The results of our analysis reveal that SiliconFriend, equipped with MemoryBank, exhibits a strong capability for long-term companionship as it can provide emphatic response, recall relevant memories and understand user personality.
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