| 1. |
- Yang, Hui, et al.
(författare)
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Growth Factor Changes in Cerebrospinal Fluid of Children with Mental Retardation before and after Neural Precursor Cell Transplantation
- 2018
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Ingår i: CNS & Neurological Disorders. - : BENTHAM SCIENCE PUBL. - 1871-5273 .- 1996-3181. ; 17:2, s. 98-105
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To investigate growth factor changes in cerebrospinal fluid (CSF) of children with mental retardation (MR) before and after neural precursor cell transplantation (NPCT), in an attempt to provide experimental support for the clinical treatment of MR with NPCT.Methods: The study comprised of 28 MR children who received twice NPCT in our hospital. CSF was collected at both times of NPCT to assess growth factors by ELISA. In addition, the content of insulin-like growth factor 1 (IGF-1) in CSF was assayed to determine possible correlations between IGF-1 changes and the short-term therapeutic effect of NPCT.Results: Of all the growth factors detected in CSF, only IGF-1 was increased significantly after NPCT (P<0.05). Fifteen of the twenty-eight MR children achieved short-term therapeutic efficacy, whereby the content of IGF-1 after NPCT was significantly higher than that before NPCT (P<0.05). There was no difference in IGF-1 content before and after NPCT in the remaining 13 MR children without short-term therapeutic effect (P=0.657). There was a significant difference in IGF-change between the two groups of patients (P<0.05).Conclusion: IGF-1 may be one of the mechanisms contributing to the therapeutic effect of NPCT.
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| 2. |
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| 3. |
- Li, Ze, et al.
(författare)
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Asymmetric Modulated Predictive Current Control for Dual Three-Phase PMSM With Improved Performance
- 2024
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Ingår i: 2024 IEEE 10th International Power Electronics and Motion Control Conference, IPEMC 2024 ECCE Asia. - : Institute of Electrical and Electronics Engineers (IEEE). ; , s. 4795-4800
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Konferensbidrag (refereegranskat)abstract
- Dual three-phase PMSM (DTP-PMSM) has gained significant attention benefiting from their exceptional reliability and high torque density. However, DTP-PMSM exhibits poor steady-state performance and large calculation amount with the conventional finite-control-set predictive current control. To address these concerns, an asymmetric modulated predictive current control (AM-PCC) for DTP-PMSM is presented. Therein, the three-phase decomposition and deadbeat control scheme are combined to eliminate the weighting factor and optimize the execution efficiency. An asymmetric modulation strategy is presented and integrated into PCC to reduce the current harmonics and switching frequency. Extensive simulation tests are conducted to demonstrate the effectiveness of the proposed AM-PCC scheme.
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| 4. |
- Qu, Suqing, et al.
(författare)
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Clinical Observation of Electroencephalographic Changes and Risk of Convulsion Occurrence in Children Receiving Neural Precursor Cell Transplantation
- 2018
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Ingår i: CNS & Neurological Disorders. - : Bentham Science Publishers Ltd.. - 1871-5273 .- 1996-3181. ; 17:3, s. 233-239
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: This study was intended to observe electroencephalographic (EEG) changes and convulsion attacks in children receiving neural precursor cell transplantation, and to explore the possibility of electrophysiological changes and risk of convulsion occurrence after cell transplantation.Method: 228 children were included in this study who received neural precursor cell transplantation in our hospital between March 2008 and July 2012. No history of convulsion attacks was elicited before cell transplantation. Data about EEG change and convulsion occurrence before and after cell transplantation were analyzed statistically.Results: Of the 228 pediatric patients, EEG improvement, deterioration and no significant change were observed in 60, 45 and 122 patients, respectively. One month after transplantation, four (1.76%) patients experienced new convulsions. Of the 227 patients, 25 showed increased and/or abnormal discharges on EEG. Of these, 19 underwent EEG re-examination six months post-operation. Except the convulsive cases mentioned above, there were no new cases of convulsions in the remaining patients. Of the 27 patients including those with abnormal discharge, increased discharge and convulsion attacks, 17 achieved varying degrees of therapeutic efficacy.Conclusion: Intraventricular transplantation of neural precursor cells is associated with EEG changes in some children and clinical convulsion attacks in individual patients. However, these abnormal changes do not last long and usually return to normal levels within 1-6 months after surgery, along with disappearance of convulsions. Simultaneous occurrence of EEG changes and convulsions do not appear to affect therapeutic efficacy.
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| 5. |
- Wang, Yupei, et al.
(författare)
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Combined amniotic membrane and self-powered electrical stimulator bioelectronic dress promotes wound healing
- 2024
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Ingår i: ACS Applied Materials and Interfaces. - : American Chemical Society (ACS). - 1944-8244 .- 1944-8252. ; 16:13, s. 15809-15818
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Tidskriftsartikel (refereegranskat)abstract
- Human amniotic membranes (hAMs) are widely used as wound management biomaterials, especially as grafts for corneal reconstruction due to the structure of the extracellular matrix and excellent biological properties. However, their fragile nature and rapid degradation rate hinder widespread clinical use. In this work, we engineered a novel self-powered electronic dress (E-dress), combining the beneficial properties of an amniotic membrane and a flexible electrical electrode to enhance wound healing. The E-dress displayed a sustained discharge capacity, leading to increased epidermal growth factor (EGF) release from amniotic mesenchymal interstitial stem cells. Live/dead staining, CCK-8, and scratch-wound-closure assays were performed in vitro. Compared with amniotic membrane treatment alone, the E-dress promoted cell proliferation and migration of mouse fibroblast cells and lower cytotoxicity. In a mouse full-skin defect model, the E-dress achieved significantly accelerated wound closure. Histological analysis revealed that E-dress treatment promoted epithelialization and neovascularization in mouse skin. The E-dress exhibited a desirable flexibility that aligned with tissue organization and displayed maximum bioactivity within a short period to overcome rapid degradation, implying great potential for clinical applications.
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